Maria Tsoumpra MARIA TSOUMPRA

Researcher Number	80756198
Affiliation (based on the past Project Information) *help	2017 – 2019: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所遺伝子疾患治療研究部, 科研費研究員 2016 – 2018: 徳島大学, 先端酵素学研究所(オープンイノベ), 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Endocrinology Except Principal Investigator Metabolomics
Keywords	Principal Investigator vitamin D receptor / vitamin D / muscle / myogenic differentiation / dystrobrevin alpha / vitamin D3 / muscular dystrophy / dystrophin / dystrobrevin / 生理学 … More / Biglycan / Vitamin D receptor / Vitamin D / ビタミンD … More Except Principal Investigator 骨－脂肪組織連関 / 骨ー脂肪組織関連 / 骨代謝学 / 骨・カルシウム代謝異常 / 骨代謝 / 骨粗鬆症 / 老化 / 脂質 / シグナル伝達 / 遺伝子 Less

Vitamin D - vitamin D receptor axis affects muscle differentiation and improves muscle regenerationPrincipal Investigator
- Principal Investigator
  
  TSOUMPRA MARIA
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  National Center of Neurology and Psychiatry
Role and mechanism of action of IL-11 on the regulation of bone and adipose tissue interaction
- Principal Investigator
  
  MATSUMOTO Toshio
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokushima
The investigation of Vitamin D system on musclePrincipal Investigator
- Principal Investigator
  
  Maria Tsoumpra
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Endocrinology
- Research Institution
  National Center of Neurology and Psychiatry
  The University of Tokushima

All 2020 2019 2018 2017 2016

All Journal Article Presentation Book

[Book] Exon Skipping and Inclusion Therapies. Methods in Molecular Biology2018
- Author(s)
  Nakamura A, Aoki Y, Tsoumpra M, Yokota T, Takeda S
- Total Pages
  12
- Publisher
  Humana Press, New York, NY
- ISBN
  9781493986507
- Data Source
  KAKENHI-PROJECT-18K16236
[Journal Article] Dystrobrevin alpha gene is a direct target of the vitamin D receptor in muscle2020
- Author(s)
  Tsoumpra Maria K、Sawatsubashi Shun、Imamura Michihiro、Fukumoto Seiji、Takeda Shin’ichi、Matsumoto Toshio、Aoki Yoshitsugu
- Journal Title
  
  Journal of Molecular Endocrinology
  
  Volume: 64 Issue: 3 Pages: 195-208
- DOI
  10.1530/jme-19-0229
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07544, KAKENHI-PROJECT-18K19518, KAKENHI-PROJECT-18K16236, KAKENHI-PROJECT-18KT0024
[Journal Article] How do we sense phosphate to regulate serum phosphate level?2020
- Author(s)
  Seiji Fukumoto, Yuichi Takashi, Maria Tsoumpra, Shun Sawatsubashi, Toshio Matsumoto
- Journal Title
  
  Journal of Bone and Mineral Metabolism
  
  Volume: 38 Issue: 1 Pages: 1-6
- DOI
  10.1007/s00774-019-01066-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19518, KAKENHI-PROJECT-19H03676, KAKENHI-PROJECT-18K15980, KAKENHI-PROJECT-18K16236, KAKENHI-PROJECT-18KT0024
[Journal Article] Scavenger Receptor Class A1 Mediates Uptake of Morpholino Antisense Oligonucleotide into Dystrophic Skeletal Muscle2019
- Author(s)
  Shouta Miyatake, Yoshitaka Mizobe, Maria K. Tsoumpra, Kenji Rowel Q. Lim, Yuko Hara, Fazel Shabanpoor, Toshifumi Yokota, Shin'ichi Takeda, Yoshitsugu Aoki
- Journal Title
  
  Molecular Therapy Nucleic Acids
  
  Volume: 14 Pages: 520-535
- DOI
  10.1016/j.omtn.2019.01.008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16236
[Journal Article] Activation of unliganded FGF receptor by extracellular phosphate potentiates proteolytic protection of FGF23 by its O-glycosylation2019
- Author(s)
  Takashi Y, Kosako H, Sawatsubashi S, Kinoshita Y, Ito N, Tsoumpra MK, Nangaku M, Abe M, Matsuhisa M, Kato S, Matsumoto T, Fukumoto S
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 116 Issue: 23 Pages: 11418-11427
- DOI
  10.1073/pnas.1815166116
- NAID
  120006715989
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08329, KAKENHI-PROJECT-18K19518, KAKENHI-PROJECT-18K15980, KAKENHI-PROJECT-18K16236, KAKENHI-PROJECT-18KT0024
[Journal Article] Peptide-conjugate antisense based splice-correction for Duchenne muscular dystrophy and other neuromuscular diseases2019
- Author(s)
  Tsoumpra Maria K.、Fukumoto Seiji、Matsumoto Toshio、Takeda Shin'ichi、Wood Matthew J.A.、Aoki Yoshitsugu
- Journal Title
  
  EBioMedicine
  
  Volume: 45 Pages: 630-645
- DOI
  10.1016/j.ebiom.2019.06.036
- NAID
  120006941112
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07544, KAKENHI-PROJECT-18K16236
[Presentation] The Vitamin D- Vitamin D Receptor Axis Positively Regulates the Expression of Dystrobrevin Alpha During Murine Myogenic Differentiation2019
- Author(s)
  Maria K. Tsoumpra, Michihiro Imamura, Yoshitaka Mizobe, Shin’ichi Takeda, Seiji Fukumoto, Toshio Matsumoto and Yoshitsugu Aoki
- Organizer
  American Society Bone Mineral Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16236
[Presentation] The vitamin D/vitamin D receptor axis positively regulates the expression of dystrobrevin alpha during murine myogenic differentiation2019
- Author(s)
  Maria K. Tsoumpra, Michihiro Imamura, Yoshitaka Mizobe, Shin’ichi Takeda, Seiji Fukumoto, Toshio Matsumoto, Yoshitsugu Aoki
- Organizer
  Vitamin D workshop, Japan
- Data Source
  KAKENHI-PROJECT-18K16236
[Presentation] The member of dystrophin associated protein complex dystrobrevin alpha, is a direct target of vitamin D2019
- Author(s)
  Maria K. Tsoumpra, Michihiro Imamura, Yoshitaka Mizobe, Shin’ichi Takeda, Seiji Fukumoto, Toshio Matsumoto and Yoshitsugu Aoki
- Organizer
  Annual Molecular Biology Meeting (MBSJ)
- Data Source
  KAKENHI-PROJECT-18K16236
[Presentation] Dual PPMO combinations drive multi-exon skipping and dystrophin expression in CXMDJ2019
- Author(s)
  Maria K. Tsoumpra, Loïc Roux, Graham McClorey, Mutsuki Kuraoka, Sayuri Arima, Yoshitaka Mizobe, Yuko Hara, Andrey A. Arzumanov, Michael J. Gait, Koichi Kimura, Michihiro Imamura, Shin’ichi Takeda, Toshifumi Yokota, Caroline Godfrey, Matthew A. Wood, and Yoshitsugu Aoki
- Organizer
  ASAS-Japanese muscle society
- Invited
- Data Source
  KAKENHI-PROJECT-18K16236
[Presentation] Novel peptide-conjugated morpholino oligomer (PPMO) combinations induce multi-exon skipping and dystrophin restoration in the beagle-based canine X-linked muscular dystrophy (CXMDJ) dog model2019
- Author(s)
  Maria K. Tsoumpra, Graham McClorey, Mutsuki Kuraoka, Yoshitaka Mizobe, Yuko Hara, Andrey A. Arzumanov, Michihiro Imamura, Michael J. Gait, Shin’ichi Takeda, Toshifumi Yokota, Matthew A. Wood and Yoshitsugu Aoki
- Organizer
  European Myology Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16236
[Presentation] The vitamin D/VDR axis regulates the expression of selected components of dystrophin associated protein complex2018
- Author(s)
  Maria K. Tsoumpra
- Organizer
  Vitamin D Workshop, Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-18K16236
[Presentation] The vitamin D/VDR axis regulates expression of selected DAPC genes2018
- Author(s)
  Maria K. Tsoumpra
- Organizer
  The 41st Annual Meeting of the Molecular Biology Society of Japan
- Data Source
  KAKENHI-PROJECT-18K16236
[Presentation] The Vitamin D/VDR axis regulates selected components of dystrophin associated protein complex in healthy and atrophying myotubes2018
- Author(s)
  Maria K. Tsoumpra
- Organizer
  Sarcopenia Meeting, Japan
- Data Source
  KAKENHI-PROJECT-18K16236
[Presentation] Muscle-Specific Vitamin D Receptor (VDR) Ablation Results in Altered Biglycan Expression in Mice2017
- Author(s)
  Maria K. Tsoumpra
- Organizer
  The 3rd Annual Meeting of Japan Muscle Society
- Data Source
  KAKENHI-PROJECT-16K19555
[Presentation] Muscle-Specific Vitamin D Receptor (VDR) Ablation Results in Reduced Grip Power and Altered Gene Expression Pattern in Mice2017
- Author(s)
  Maria K Tsoumpra
- Organizer
  American Society for Bone and Mineral Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19555
[Presentation] Muscle-Specific Vitamin D Receptor (VDR) Ablation Results in Reduced Grip Power and Altered Gene Expression Pattern in Mice.2017
- Author(s)
  Maria K Tsoumpra, Itsuro Endo, Shun Sawatsubashi, Yuichi Takashi, Seiji Fukumoto and Toshio Matsumoto.
- Organizer
  Annual meeting of America Society of Bone and Mineral Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05327
[Presentation] Muscle-specific Vitamin D Receptor (VDR) ablation results in reduced grip power and altered gene expression pattern in mice2017
- Author(s)
  Maria K. Tsoumpra
- Organizer
  The 35th Annual Meeting of the Japanese Society for Bone and Mineral Research
- Data Source
  KAKENHI-PROJECT-16K19555
[Presentation] Administration of 1,25(OH)2D3 regulates the expression of selective members of dystrophin associated protein complex genes in C2C12 murine cells2017
- Author(s)
  Maria K Tsoumpra
- Organizer
  Japan Bone Biology Forum
- Data Source
  KAKENHI-PROJECT-16K19555
[Presentation] FGF23 enhances CYP24A1 transcription in Klotho-dependent way via ERK-Egr-1 pathway2017
- Author(s)
  Maria K. Tsoumpra
- Organizer
  90th Annual Congress of Japan Endocrine Society
- Data Source
  KAKENHI-PROJECT-16K19555
[Presentation] The regulatory mechanisms of FGF23 activity via GALNT3 by phosphate2016
- Author(s)
  Yuichi Takashi, Yuka Kinoshita, Nobuaki Ito, Maria K Tsoumpra, Shun Sawatsubashi, Toshio Matsumoto, Seiji Fukumoto.
- Organizer
  Amer Soc Bone Miner Res 2016 Annual Meeting
- Place of Presentation
  Atlanta, USA
- Year and Date
  2016-09-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05327
[Presentation] 1,25(OH)2D3 regulates myogenesis and suppresses myostatin promoter activity in an in vitro murine skeletal muscle model2016
- Author(s)
  Maria Tsoumpra, Shun Sawatsubashi, Toshio Matsumoto, Seiji Fukumoto
- Organizer
  13th Meeting of Bone Biology Forum
- Place of Presentation
  X Wave Makuhari (Chiba・Makuhari)
- Year and Date
  2016-08-19
- Data Source
  KAKENHI-PROJECT-16K19555
[Presentation] Vitamin D receptor (VDR) deletion in fast fibers of murine skeletal muscle results in reduced grip power and altered expression of myoregulatory genes2016
- Author(s)
  Maria K Tsoumpra, Itsuro Endo, Shun Sawatsubashi, Yuichi Takashi, Seiji Fukumoto, Toshio Matsumoto
- Organizer
  第2回 Neo Vitamin D Workshop 学術集会
- Place of Presentation
  TKP Garden City Shinagawa (Tokyo・Shinagawa)
- Year and Date
  2016-08-26
- Data Source
  KAKENHI-PROJECT-16K19555
[Presentation] FGF23 enhances CYP24A1 transcription in Klotho-dependent way via ERK pathway2016
- Author(s)
  Maria K Tsoumpra, Shun Sawatsubashi, Yuichi Takashi, Toshio Matsumoto and Seiji Fukumoto.
- Organizer
  Amer Soc Bone Miner Res 2016 Annual Meeting
- Place of Presentation
  Atlanta, USA
- Year and Date
  2016-09-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05327

1. MATSUMOTO Toshio (20157374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 福本誠二 (30202287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 沢津橋俊 (70535103)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. 青木吉嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 安部正博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Maria Tsoumpra MARIA TSOUMPRA

Research Projects

Research Products

Co-Researchers

Vitamin D - vitamin D receptor axis affects muscle differentiation and improves muscle regenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role and mechanism of action of IL-11 on the regulation of bone and adipose tissue interaction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The investigation of Vitamin D system on musclePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Exon Skipping and Inclusion Therapies. Methods in Molecular Biology2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Dystrobrevin alpha gene is a direct target of the vitamin D receptor in muscle2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] How do we sense phosphate to regulate serum phosphate level?2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Scavenger Receptor Class A1 Mediates Uptake of Morpholino Antisense Oligonucleotide into Dystrophic Skeletal Muscle2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of unliganded FGF receptor by extracellular phosphate potentiates proteolytic protection of FGF23 by its O-glycosylation2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Peptide-conjugate antisense based splice-correction for Duchenne muscular dystrophy and other neuromuscular diseases2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] The Vitamin D- Vitamin D Receptor Axis Positively Regulates the Expression of Dystrobrevin Alpha During Murine Myogenic Differentiation2019

Author(s)

Organizer

Data Source

[Presentation] The vitamin D/vitamin D receptor axis positively regulates the expression of dystrobrevin alpha during murine myogenic differentiation2019

Author(s)

Organizer

Data Source

[Presentation] The member of dystrophin associated protein complex dystrobrevin alpha, is a direct target of vitamin D2019

Author(s)

Organizer

Data Source

[Presentation] Dual PPMO combinations drive multi-exon skipping and dystrophin expression in CXMDJ2019

Author(s)

Organizer

Data Source

[Presentation] Novel peptide-conjugated morpholino oligomer (PPMO) combinations induce multi-exon skipping and dystrophin restoration in the beagle-based canine X-linked muscular dystrophy (CXMDJ) dog model2019

Author(s)

Organizer

Data Source

[Presentation] The vitamin D/VDR axis regulates the expression of selected components of dystrophin associated protein complex2018

Author(s)

Organizer

Data Source

[Presentation] The vitamin D/VDR axis regulates expression of selected DAPC genes2018