KIMURA Yasuaki 木村康明

… Alternative Names

Kimura Yasuaki 木村康明

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Researcher Number	80769977
Other IDs	https://orcid.org/0000-0002-3609-602X
Affiliation (Current)	2023: 名古屋大学, 理学研究科, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 名古屋大学, 理学研究科, 准教授 2020 – 2022: 名古屋大学, 理学研究科, 講師 2016 – 2019: 名古屋大学, 理学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 37030:Chemical biology-related / Bio-related chemistry / Biomolecular chemistry / Medium-sized Section 37:Biomolecular chemistry and related fields Except Principal Investigator Transition State Control / Science and Engineering
Keywords	Principal Investigator 共有結合医薬 / 核酸アナログ / ポリメラーゼ / RNA / DNA / ケミカルライゲーション / 核酸医薬 / 核酸連結反応 / ホスホロチオエート / 核酸 … More / ライゲーション / 化学合成 / 有機化学 / ｍRNA / 化学合成法 / 薬学 / 標的選択制 / 抗ウイルス薬 / 抗ガン薬 / 核酸誘導体 / 標的選択性 / 選択性 / 不可逆阻害 / 阻害剤 / リン酸プロドラッグ / 活性化 / リン酸化 / オリゴ核酸医薬 / デリバリー法 / アンチセンス核酸 / siRNA / mRNA / デリバリー … More Except Principal Investigator 触媒 / 核酸プローブ / 蛍光プローブ / 核酸鋳型反応 / 触媒回転数 / RNAプローブ / RNA / 鋳型反応 / DNA / 蛍光 / センサー / 遷移状態 / 増幅 / 元素効果 / 機能性材料 / 生体機能 Less

ジスルフィドを利用したオリゴ核酸デリバリー法の深化と技術拡張Principal Investigator
- Principal Investigator
  
  木村康明
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Nagoya University
Dynamic Element-Effect Design for Unconventional Molecular Functions
- Principal Investigator
  
  山口茂弘
- Project Period (FY)
  2022 – 2028
- Research Category
  
  Fund for the Promotion of Joint International Research (International Leading Research )
- Review Section
  
  Science and Engineering
- Research Institution
  Nagoya University
Molecular design strategy to avoid side effects of covalent drugsPrincipal Investigator
- Principal Investigator
  
  Kimura Yasuaki
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Nagoya University
Development of covalent drugs activatable by the target enzymesPrincipal Investigator
- Principal Investigator
  
  Kimura Yasuaki
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Nagoya University
Improvement of catalytic turnover based on transition state control of oligonucleotide template chemical reaction
- Principal Investigator
  
  Abe Hiroshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Transition State Control
- Research Institution
  Nagoya University
Development of Chemical Ligation Reaction of RNA for Chemical Synthesis of mRNAPrincipal Investigator
- Principal Investigator
  
  Kimura Yasuaki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bio-related chemistry
  Biomolecular chemistry
- Research Institution
  Nagoya University

All 2020 2019 2018 2017 2016

All Journal Article Presentation Book Patent

[Book] 中分子創薬に資するペプチド・核酸・糖鎖の合成技術　機能性核酸合成を指向した化学的核酸連結反応2018
- Author(s)
  木村康明、阿部洋
- Total Pages
  317
- Publisher
  シーエムシー出版
- ISBN
  9784781313207
- Data Source
  KAKENHI-PROJECT-16K21091
[Book] Biophilia 電子版 21　特集: 論理薬科学―創薬の基盤2017
- Author(s)
  阿部洋、木村康明
- Total Pages
  99
- Publisher
  アドスリー
- Data Source
  KAKENHI-PROJECT-16K21091
[Journal Article] Disulfide-Unit Conjugation Enables Ultrafast Cytosolic Internalization of Antisense DNA and siRNA2019
- Author(s)
  Shu Zhaoma、Tanaka Iku、Ota Azumi、Fushihara Daichi、Abe Naoko、Kawaguchi Saki、Nakamoto Kosuke、Tomoike Fumiaki、Tada Seiichi、Ito Yoshihiro、Kimura Yasuaki、Abe Hiroshi
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 印刷中 Issue: 20 Pages: 6611-6615
- DOI
  10.1002/anie.201900993
- NAID
  130007841763
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16KT0052, KAKENHI-PROJECT-17K15479, KAKENHI-PROJECT-18K14357, KAKENHI-PUBLICLY-18H04398
[Journal Article] A Covalent Inhibitor for Glutathione S‐Transferase Pi (GSTP1‐1) in Human Cells2019
- Author(s)
  Shishido Yuko、Tomoike Fumiaki、Kuwata Keiko、Fujikawa Haruka、Sekido Yoshitaka、Murakami‐Tonami Yuko、Kameda Tomoshi、Abe Naoko、Kimura Yasuaki、Shuto Satoshi、Abe Hiroshi
- Journal Title
  
  ChemBioChem
  
  Volume: 20 Issue: 7 Pages: 900-905
- DOI
  10.1002/cbic.201800671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14356, KAKENHI-PROJECT-17K15479, KAKENHI-PUBLICLY-18H04398, KAKENHI-PROJECT-19H01014, KAKENHI-PROJECT-18K06979, KAKENHI-PROJECT-15K08325
[Journal Article] Chemical Ligation Reactions of Oligonucleotides for Biological and Medicinal Applications2018
- Author(s)
  Abe Hiroshi、Kimura Yasuaki
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 66 Issue: 2 Pages: 117-122
- DOI
  10.1248/cpb.c17-00615
- NAID
  130006328058
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21091
[Journal Article] Chemical ligation of oligonucleotides using an electrophilic phosphorothioester2017
- Author(s)
  Maruyama Hideto、Oikawa Ryota、Hayakawa Mayu、Takamori Shono、Kimura Yasuaki、Abe Naoko、Tsuji Genichiro、Matsuda Akira、Shuto Satoshi、Ito Yoshihiro、Abe Hiroshi
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 45 Issue: 12 Pages: 7042-7048
- DOI
  10.1093/nar/gkx459
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21091, KAKENHI-PROJECT-16H02484
[Patent] β-MODIFIED PHOSPHORIC ACID COMPOUND PRECURSOR, β-MODIFIED PHOSPHORIC ACID COMPOUND, REACTION INHIBITOR, AND MEDICINE INCLUDING SAME, AND REACTION INHIBITION METHOD2019
- Inventor(s)
  阿部洋　木村康明
- Industrial Property Rights Holder
  阿部洋　木村康明
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Acquisition Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-18K14356
[Patent] β修飾リン酸化合物前駆体、β修飾リン酸化合物、反応阻害剤及びこれを含む医薬並びに反応阻害方法2018
- Inventor(s)
  阿部洋　木村康明
- Industrial Property Rights Holder
  阿部洋　木村康明
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-043329
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-18K14356
[Presentation] Development of phosphorofluoridate prodrugs2020
- Author(s)
  吉田祐希, Zheng Ti, 伏原大地 , 新美結士, 中本航介, 橋谷文貴, 木村康明, 日吉貴子, 齋木由利子, 堀井明, 鈴木哲朗, 村上優子, 阿部洋
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K14356
[Presentation] Development of 2’-β Seleno Nucleoside Analogs as Irreversible Inhibitors for Viral Reverse Transcriptase2019
- Author(s)
  木村康明、丸山豪斗、笈川涼太、早川真由、吉永静也、辻厳一郎、阿部奈保子、木村康明、周東智、松田彰、南川典昭、阿部洋
- Organizer
  日本化学会　第99回年会
- Data Source
  KAKENHI-PROJECT-18K14356
[Presentation] Development of 2'-β-Thio or Seleno modified Nucleoside Analogs2019
- Author(s)
  Hirotaka Murase, Chang Jun Shi, Ti Zheng, Fumitaka Hashiya, Yasuaki Kimura, Hiroshi Abe
- Organizer
  International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14356
[Presentation] Synthesis of Anti-viral Selenium Modified Nucleoside Analogues2019
- Author(s)
  Daichi Fushihara, Yushi Nimi, Hideo Katakura, Tetsuro Suzuki, Tsutomu Murakami, Eichi Kodama, Yasuaki Kimura, Hiroshi Abe
- Organizer
  Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14356
[Presentation] 高分子核酸医薬の低分子化戦略：細胞内ビルドアップ法の開発2018
- Author(s)
  木村康明、丸山豪斗、笈川涼太、早川真由、吉永静也、辻厳一郎、阿部奈保子、周東智、松田彰、南川典昭、阿部洋
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] Develpment of 2'-β-modified nucleosides for irreversible viral polymerase inhibitor2018
- Author(s)
  Yushi Niimi, Hideo Katakura, Tetsuro Suzuki, Akito Takato, Tsutomu Murakami, Yasuaki Kimura, Hiroshi Abe
- Organizer
  日本ウイルス学会　第６６回
- Data Source
  KAKENHI-PROJECT-18K14356
[Presentation] Chemical ligation reaction for oligonucleotides based on electrophilic phosphorothioester2018
- Author(s)
  Yasuaki Kimura、Hideto Maruyama、Ryota Oikawa、Mayu Hayakawa、Naoko Abe、Genichiro Tsuji、Akira Matsuda、Satoshi Shuto、Yoshihiro Ito、Hiroshi Abe
- Organizer
  255th ACS National Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] Development of 2’-β Seleno Nucleoside Analogs as Irreversible Inhibitors for Viral2018
- Author(s)
  Yasuaki Kimura, Yushi Niimi, Hideo Katakura, Fumiaki Tomoike, Tetsuro Suzuki, Tsutomu Murakami, Eiichi, Kodama, Hiroshi Abe
- Organizer
  The 45th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14356
[Presentation] 抗ウイルス活性を指向した2’-β位修飾ヌクレオシドの合成と評価2018
- Author(s)
  新美結士, 片倉秀雄, 鈴木哲郎, 高田礼人, 村上努, 木村康明, 阿部洋
- Organizer
  日本ケミカルバイオロジー学会第13回年会
- Data Source
  KAKENHI-PROJECT-18K14356
[Presentation] Development of 2’-β Seleno Nucleoside Analogs as Irreversible Inhibitors for Viral Polymerases2018
- Author(s)
  Yasuaki Kimura, Yushi Niimi, Hideo Katakura, Tetsuro Suzuki, Tsutomu Murakami, Eiichi, Kodama, Hiroshi Abe
- Organizer
  日本ウイルス学会　第６６回
- Data Source
  KAKENHI-PROJECT-18K14356
[Presentation] 機能性核酸合成を志向した化学的核酸連結反応2017
- Author(s)
  笈川涼太、早川真由、丸山豪斗、阿部奈保子、木村康明、周東智、松田彰、南川典昭、阿部洋
- Organizer
  日本核酸医薬学会第3回年会
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] 高分子核酸医薬の低分子戦略：細胞内ビルドアップ法の開発2017
- Author(s)
  木村康明、丸山豪斗、笈川涼太、早川真由、吉永静也、辻厳一郎、阿部奈保子、周東智、松田彰、南川典昭、阿部洋
- Organizer
  日本核酸医薬学会第3回年会
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] 環境応答性環状オリゴ核酸による遺伝子発現制御2017
- Author(s)
  吉永静也、阿部奈保子、木村康明、友池史明、阿部洋
- Organizer
  第48回中化連秋季大会
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] 機能性核酸合成を志向した化学的核酸連結反応2017
- Author(s)
  笈川涼太、早川真由、丸山豪斗、阿部奈保子、友池史明、木村康明、周東智、松田彰、南川典昭、阿部洋
- Organizer
  第48回中化連秋季大会
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] 高分子核酸医薬の低分子戦略：細胞内ビルドアップ法の開発2017
- Author(s)
  木村康明、丸山豪斗、笈川涼太、早川真由、吉永静也、辻厳一郎、阿部奈保子、周東智、松田彰、南川典昭、阿部洋
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] RNA Interference by Intracellar Buildup of siRNA2017
- Author(s)
  Yasuaki Kimura、Hideto Maruyama、Ryota Oikawa、Genichiro Tsuji、Shizuya Yoshinaga、Naoko Abe、Satoshi Shuto、Akira Matsuda、Yoshihiro Ito、Hiroshi Abe
- Organizer
  The 44th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] 求電子的ホスホロチオエステルによる核酸の化学的連結反応2017
- Author(s)
  木村康明　丸山豪斗　笈川涼太　早川真由　阿部奈保子　松田彰　周東智　伊藤嘉浩　阿部洋
- Organizer
  日本化学会第97春季年会
- Place of Presentation
  慶応大学日吉キャンパス
- Year and Date
  2017-03-16
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] 高分子核酸医薬の低分子戦略：細胞内ビルドアップ法の開発2017
- Author(s)
  木村康明、丸山豪斗、笈川涼太、早川真由、吉永静也、辻厳一郎、阿部奈保子、周東智、松田彰、南川典昭、阿部洋
- Organizer
  第11回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] 高効率な核酸検出を可能にする核酸鋳型反応の開発2017
- Author(s)
  伊藤真央　柴田綾　阿部奈保子　木村康明　阿部洋
- Organizer
  日本薬学会
- Place of Presentation
  仙台
- Year and Date
  2017-03-26
- Data Source
  KAKENHI-PROJECT-16KT0052
[Presentation] 高分子核酸医薬の低分子戦略：細胞内ビルドアップ法の開発2017
- Author(s)
  木村康明、丸山豪斗、笈川涼太、早川真由、吉永静也、辻厳一郎、阿部奈保子、周東智、松田彰、南川典昭、阿部洋
- Organizer
  日本ケミカルバイオロジー学会　第12回年会
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] Development of novel chemical ligation reaction for RNA strands2016
- Author(s)
  Ryota Oikawa, Hideto Maruyama, Mayu Hayakawa, Naoko Abe, Yasuaki Kimura, Hiroshi Abe
- Organizer
  The 43rd International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  熊本大学
- Year and Date
  2016-09-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] Chemical Ligation Reaction for RNA Strand2016
- Author(s)
  Yasuaki Kimura, Ryota Oikawa, Hideto Maruyama, Mayu Hayakawa, Naoko Abe, Hiroshi Abe
- Organizer
  RNA2016
- Place of Presentation
  京都国際会議場
- Year and Date
  2016-06-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21091
[Presentation] Chemical ligation of oligonucleotides using electrophilic phosphorothioester2016
- Author(s)
  木村康明　丸山豪斗　笈川涼太　早川真由　阿部奈保子　松田彰　周東智　伊藤嘉浩　阿部洋
- Organizer
  第10回バイオ関連化学シンポジウム
- Place of Presentation
  金沢石川県立音楽堂
- Year and Date
  2016-09-07
- Data Source
  KAKENHI-PROJECT-16K21091

1. Abe Hiroshi (80415067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 村上努 (50336385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 山口茂弘 (60260618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 大井貴史 (80271708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 斎藤進 (90273268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 八木亜樹子 (20803282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 松田亮太郎 (00402959)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 荘司長三 (90379587)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 柳井毅 (00462200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KIMURA Yasuaki 木村 康明

Kimura Yasuaki 木村 康明

Research Projects

Research Products

Co-Researchers

ジスルフィドを利用したオリゴ核酸デリバリー法の深化と技術拡張Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Dynamic Element-Effect Design for Unconventional Molecular Functions

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular design strategy to avoid side effects of covalent drugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of covalent drugs activatable by the target enzymesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Improvement of catalytic turnover based on transition state control of oligonucleotide template chemical reaction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of Chemical Ligation Reaction of RNA for Chemical Synthesis of mRNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 中分子創薬に資するペプチド・核酸・糖鎖の合成技術 機能性核酸合成を指向した化学的核酸連結反応2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] Biophilia 電子版 21 特集: 論理薬科学―創薬の基盤2017

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Disulfide-Unit Conjugation Enables Ultrafast Cytosolic Internalization of Antisense DNA and siRNA2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] A Covalent Inhibitor for Glutathione S‐Transferase Pi (GSTP1‐1) in Human Cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chemical Ligation Reactions of Oligonucleotides for Biological and Medicinal Applications2018

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Chemical ligation of oligonucleotides using an electrophilic phosphorothioester2017

Author(s)

Journal Title

DOI

Data Source

[Patent] β-MODIFIED PHOSPHORIC ACID COMPOUND PRECURSOR, β-MODIFIED PHOSPHORIC ACID COMPOUND, REACTION INHIBITOR, AND MEDICINE INCLUDING SAME, AND REACTION INHIBITION METHOD2019

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

KIMURA Yasuaki 木村康明

Kimura Yasuaki 木村康明

[Book] 中分子創薬に資するペプチド・核酸・糖鎖の合成技術　機能性核酸合成を指向した化学的核酸連結反応2018

[Book] Biophilia 電子版 21　特集: 論理薬科学―創薬の基盤2017