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KIMURA Yasuaki  木村 康明

… Alternative Names

Kimura Yasuaki  木村 康明

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Researcher Number 80769977
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-3609-602X
Affiliation (Current) 2023: 名古屋大学, 理学研究科, 准教授
Affiliation (based on the past Project Information) *help 2022 – 2023: 名古屋大学, 理学研究科, 准教授
2020 – 2022: 名古屋大学, 理学研究科, 講師
2016 – 2019: 名古屋大学, 理学研究科, 助教
Review Section/Research Field
Principal Investigator
Basic Section 37030:Chemical biology-related / Bio-related chemistry / Biomolecular chemistry / Medium-sized Section 37:Biomolecular chemistry and related fields
Except Principal Investigator
Transition State Control / Science and Engineering
Keywords
Principal Investigator
共有結合医薬 / 核酸アナログ / ポリメラーゼ / RNA / DNA / ケミカルライゲーション / 核酸医薬 / 核酸連結反応 / ホスホロチオエート / 核酸 … More / ライゲーション / 化学合成 / 有機化学 / mRNA / 化学合成法 / 薬学 / 標的選択制 / 抗ウイルス薬 / 抗ガン薬 / 核酸誘導体 / 標的選択性 / 選択性 / 不可逆阻害 / 阻害剤 / リン酸プロドラッグ / 活性化 / リン酸化 / オリゴ核酸医薬 / デリバリー法 / アンチセンス核酸 / siRNA / mRNA / デリバリー … More
Except Principal Investigator
触媒 / 核酸プローブ / 蛍光プローブ / 核酸鋳型反応 / 触媒回転数 / RNAプローブ / RNA / 鋳型反応 / DNA / 蛍光 / センサー / 遷移状態 / 増幅 / 元素効果 / 機能性材料 / 生体機能 Less
  • Research Projects

    (6 results)
  • Research Products

    (31 results)
  • Co-Researchers

    (9 People)
  •  ジスルフィドを利用したオリゴ核酸デリバリー法の深化と技術拡張Principal Investigator

    • Principal Investigator
      木村 康明
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 37030:Chemical biology-related
    • Research Institution
      Nagoya University
  •  Dynamic Element-Effect Design for Unconventional Molecular Functions

    • Principal Investigator
      山口 茂弘
    • Project Period (FY)
      2022 – 2028
    • Research Category
      Fund for the Promotion of Joint International Research (International Leading Research )
    • Review Section
      Science and Engineering
    • Research Institution
      Nagoya University
  •  Molecular design strategy to avoid side effects of covalent drugsPrincipal Investigator

    • Principal Investigator
      Kimura Yasuaki
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 37:Biomolecular chemistry and related fields
    • Research Institution
      Nagoya University
  •  Development of covalent drugs activatable by the target enzymesPrincipal Investigator

    • Principal Investigator
      Kimura Yasuaki
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 37030:Chemical biology-related
    • Research Institution
      Nagoya University
  •  Improvement of catalytic turnover based on transition state control of oligonucleotide template chemical reaction

    • Principal Investigator
      Abe Hiroshi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Transition State Control
    • Research Institution
      Nagoya University
  •  Development of Chemical Ligation Reaction of RNA for Chemical Synthesis of mRNAPrincipal Investigator

    • Principal Investigator
      Kimura Yasuaki
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Bio-related chemistry
      Biomolecular chemistry
    • Research Institution
      Nagoya University

All 2020 2019 2018 2017 2016

All Journal Article Presentation Book Patent

  • [Book] 中分子創薬に資するペプチド・核酸・糖鎖の合成技術 機能性核酸合成を指向した化学的核酸連結反応2018

    • Author(s)
      木村康明、阿部洋
    • Total Pages
      317
    • Publisher
      シーエムシー出版
    • ISBN
      9784781313207
    • Data Source
      KAKENHI-PROJECT-16K21091
  • [Book] Biophilia 電子版 21 特集: 論理薬科学―創薬の基盤2017

    • Author(s)
      阿部洋、木村康明
    • Total Pages
      99
    • Publisher
      アドスリー
    • Data Source
      KAKENHI-PROJECT-16K21091
  • [Journal Article] Disulfide-Unit Conjugation Enables Ultrafast Cytosolic Internalization of Antisense DNA and siRNA2019

    • Author(s)
      Shu Zhaoma、Tanaka Iku、Ota Azumi、Fushihara Daichi、Abe Naoko、Kawaguchi Saki、Nakamoto Kosuke、Tomoike Fumiaki、Tada Seiichi、Ito Yoshihiro、Kimura Yasuaki、Abe Hiroshi
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 印刷中 Issue: 20 Pages: 6611-6615

    • DOI

      10.1002/anie.201900993

    • NAID

      130007841763

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16KT0052, KAKENHI-PROJECT-17K15479, KAKENHI-PROJECT-18K14357, KAKENHI-PUBLICLY-18H04398
  • [Journal Article] A Covalent Inhibitor for Glutathione S‐Transferase Pi (GSTP1‐1) in Human Cells2019

    • Author(s)
      Shishido Yuko、Tomoike Fumiaki、Kuwata Keiko、Fujikawa Haruka、Sekido Yoshitaka、Murakami‐Tonami Yuko、Kameda Tomoshi、Abe Naoko、Kimura Yasuaki、Shuto Satoshi、Abe Hiroshi
    • Journal Title

      ChemBioChem

      Volume: 20 Issue: 7 Pages: 900-905

    • DOI

      10.1002/cbic.201800671

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K14356, KAKENHI-PROJECT-17K15479, KAKENHI-PUBLICLY-18H04398, KAKENHI-PROJECT-19H01014, KAKENHI-PROJECT-18K06979, KAKENHI-PROJECT-15K08325
  • [Journal Article] Chemical Ligation Reactions of Oligonucleotides for Biological and Medicinal Applications2018

    • Author(s)
      Abe Hiroshi、Kimura Yasuaki
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 66 Issue: 2 Pages: 117-122

    • DOI

      10.1248/cpb.c17-00615

    • NAID

      130006328058

    • ISSN
      0009-2363, 1347-5223
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K21091
  • [Journal Article] Chemical ligation of oligonucleotides using an electrophilic phosphorothioester2017

    • Author(s)
      Maruyama Hideto、Oikawa Ryota、Hayakawa Mayu、Takamori Shono、Kimura Yasuaki、Abe Naoko、Tsuji Genichiro、Matsuda Akira、Shuto Satoshi、Ito Yoshihiro、Abe Hiroshi
    • Journal Title

      Nucleic Acids Research

      Volume: 45 Issue: 12 Pages: 7042-7048

    • DOI

      10.1093/nar/gkx459

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K21091, KAKENHI-PROJECT-16H02484
  • [Patent] β-MODIFIED PHOSPHORIC ACID COMPOUND PRECURSOR, β-MODIFIED PHOSPHORIC ACID COMPOUND, REACTION INHIBITOR, AND MEDICINE INCLUDING SAME, AND REACTION INHIBITION METHOD2019

    • Inventor(s)
      阿部洋 木村康明
    • Industrial Property Rights Holder
      阿部洋 木村康明
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Acquisition Date
      2019
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18K14356
  • [Patent] β修飾リン酸化合物前駆体、β修飾リン酸化合物、反応阻害剤及びこれを含む医薬並びに反応阻害方法2018

    • Inventor(s)
      阿部洋 木村康明
    • Industrial Property Rights Holder
      阿部洋 木村康明
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-043329
    • Filing Date
      2018
    • Data Source
      KAKENHI-PROJECT-18K14356
  • [Presentation] Development of phosphorofluoridate prodrugs2020

    • Author(s)
      吉田祐希, Zheng Ti, 伏原大地 , 新美結士, 中本航介, 橋谷文貴, 木村康明, 日吉貴子, 齋木由利子, 堀井明, 鈴木哲朗, 村上優子, 阿部 洋
    • Organizer
      日本薬学会第140年会
    • Data Source
      KAKENHI-PROJECT-18K14356
  • [Presentation] Development of 2’-β Seleno Nucleoside Analogs as Irreversible Inhibitors for Viral Reverse Transcriptase2019

    • Author(s)
      木村康明、丸山豪斗、笈川涼太、早川真由、吉永静也、辻厳一郎、阿部奈保子、木村康明、周東智、松田彰、南川典昭、阿部洋
    • Organizer
      日本化学会 第99回年会
    • Data Source
      KAKENHI-PROJECT-18K14356
  • [Presentation] Development of 2'-β-Thio or Seleno modified Nucleoside Analogs2019

    • Author(s)
      Hirotaka Murase, Chang Jun Shi, Ti Zheng, Fumitaka Hashiya, Yasuaki Kimura, Hiroshi Abe
    • Organizer
      International Symposium on Nucleic Acids Chemistry
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K14356
  • [Presentation] Synthesis of Anti-viral Selenium Modified Nucleoside Analogues2019

    • Author(s)
      Daichi Fushihara, Yushi Nimi, Hideo Katakura, Tetsuro Suzuki, Tsutomu Murakami, Eichi Kodama, Yasuaki Kimura, Hiroshi Abe
    • Organizer
      Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K14356
  • [Presentation] 高分子核酸医薬の低分子化戦略:細胞内ビルドアップ法の開発2018

    • Author(s)
      木村康明、丸山豪斗、笈川涼太、早川真由、吉永静也、辻厳一郎、阿部奈保子、周東智、松田彰、南川典昭、阿部洋
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-16K21091
  • [Presentation] Develpment of 2'-β-modified nucleosides for irreversible viral polymerase inhibitor2018

    • Author(s)
      Yushi Niimi, Hideo Katakura, Tetsuro Suzuki, Akito Takato, Tsutomu Murakami, Yasuaki Kimura, Hiroshi Abe
    • Organizer
      日本ウイルス学会 第66回
    • Data Source
      KAKENHI-PROJECT-18K14356
  • [Presentation] Chemical ligation reaction for oligonucleotides based on electrophilic phosphorothioester2018

    • Author(s)
      Yasuaki Kimura、Hideto Maruyama、Ryota Oikawa、Mayu Hayakawa、Naoko Abe、Genichiro Tsuji、Akira Matsuda、Satoshi Shuto、Yoshihiro Ito、Hiroshi Abe
    • Organizer
      255th ACS National Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K21091
  • [Presentation] Development of 2’-β Seleno Nucleoside Analogs as Irreversible Inhibitors for Viral2018

    • Author(s)
      Yasuaki Kimura, Yushi Niimi, Hideo Katakura, Fumiaki Tomoike, Tetsuro Suzuki, Tsutomu Murakami, Eiichi, Kodama, Hiroshi Abe
    • Organizer
      The 45th International Symposium on Nucleic Acids Chemistry
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K14356
  • [Presentation] 抗ウイルス活性を指向した2’-β位修飾ヌクレオシドの合成と評価2018

    • Author(s)
      新美結士, 片倉秀雄, 鈴木哲郎, 高田礼人, 村上努, 木村康明, 阿部洋
    • Organizer
      日本ケミカルバイオロジー学会 第13回年会
    • Data Source
      KAKENHI-PROJECT-18K14356
  • [Presentation] Development of 2’-β Seleno Nucleoside Analogs as Irreversible Inhibitors for Viral Polymerases2018

    • Author(s)
      Yasuaki Kimura, Yushi Niimi, Hideo Katakura, Tetsuro Suzuki, Tsutomu Murakami, Eiichi, Kodama, Hiroshi Abe
    • Organizer
      日本ウイルス学会 第66回
    • Data Source
      KAKENHI-PROJECT-18K14356
  • [Presentation] 機能性核酸合成を志向した化学的核酸連結反応2017

    • Author(s)
      笈川涼太、早川真由、丸山豪斗、阿部奈保子、木村康明、周東智、松田彰、南川典昭、阿部洋
    • Organizer
      日本核酸医薬学会第3回年会
    • Data Source
      KAKENHI-PROJECT-16K21091
  • [Presentation] 高分子核酸医薬の低分子戦略:細胞内ビルドアップ法の開発2017

    • Author(s)
      木村康明、丸山豪斗、笈川涼太、早川真由、吉永静也、辻厳一郎、阿部奈保子、周東智、松田彰、南川典昭、阿部洋
    • Organizer
      日本核酸医薬学会第3回年会
    • Data Source
      KAKENHI-PROJECT-16K21091
  • [Presentation] 環境応答性環状オリゴ核酸による遺伝子発現制御2017

    • Author(s)
      吉永静也、阿部奈保子、木村康明、友池史明、阿部洋
    • Organizer
      第48回中化連秋季大会
    • Data Source
      KAKENHI-PROJECT-16K21091
  • [Presentation] 機能性核酸合成を志向した化学的核酸連結反応2017

    • Author(s)
      笈川涼太、早川真由、丸山豪斗、阿部奈保子、友池史明、木村康明、周東智、松田彰、南川典昭、阿部洋
    • Organizer
      第48回中化連秋季大会
    • Data Source
      KAKENHI-PROJECT-16K21091
  • [Presentation] 高分子核酸医薬の低分子戦略:細胞内ビルドアップ法の開発2017

    • Author(s)
      木村康明、丸山豪斗、笈川涼太、早川真由、吉永静也、辻厳一郎、阿部奈保子、周東智、松田彰、南川典昭、阿部洋
    • Organizer
      第35回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-16K21091
  • [Presentation] RNA Interference by Intracellar Buildup of siRNA2017

    • Author(s)
      Yasuaki Kimura、Hideto Maruyama、Ryota Oikawa、Genichiro Tsuji、Shizuya Yoshinaga、Naoko Abe、Satoshi Shuto、Akira Matsuda、Yoshihiro Ito、Hiroshi Abe
    • Organizer
      The 44th International Symposium on Nucleic Acids Chemistry
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K21091
  • [Presentation] 求電子的ホスホロチオエステルによる核酸の化学的連結反応2017

    • Author(s)
      木村康明 丸山豪斗 笈川涼太 早川真由 阿部奈保子 松田彰 周東智 伊藤嘉浩 阿部洋
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶応大学日吉キャンパス
    • Year and Date
      2017-03-16
    • Data Source
      KAKENHI-PROJECT-16K21091
  • [Presentation] 高分子核酸医薬の低分子戦略:細胞内ビルドアップ法の開発2017

    • Author(s)
      木村康明、丸山豪斗、笈川涼太、早川真由、吉永静也、辻厳一郎、阿部奈保子、周東智、松田彰、南川典昭、阿部洋
    • Organizer
      第11回バイオ関連化学シンポジウム
    • Data Source
      KAKENHI-PROJECT-16K21091
  • [Presentation] 高効率な核酸検出を可能にする核酸鋳型反応の開発2017

    • Author(s)
      伊藤真央 柴田綾 阿部奈保子 木村康明 阿部洋
    • Organizer
      日本薬学会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-26
    • Data Source
      KAKENHI-PROJECT-16KT0052
  • [Presentation] 高分子核酸医薬の低分子戦略:細胞内ビルドアップ法の開発2017

    • Author(s)
      木村康明、丸山豪斗、笈川涼太、早川真由、吉永静也、辻厳一郎、阿部奈保子、周東智、松田彰、南川典昭、阿部洋
    • Organizer
      日本ケミカルバイオロジー学会 第12回年会
    • Data Source
      KAKENHI-PROJECT-16K21091
  • [Presentation] Development of novel chemical ligation reaction for RNA strands2016

    • Author(s)
      Ryota Oikawa, Hideto Maruyama, Mayu Hayakawa, Naoko Abe, Yasuaki Kimura, Hiroshi Abe
    • Organizer
      The 43rd International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      熊本大学
    • Year and Date
      2016-09-27
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K21091
  • [Presentation] Chemical Ligation Reaction for RNA Strand2016

    • Author(s)
      Yasuaki Kimura, Ryota Oikawa, Hideto Maruyama, Mayu Hayakawa, Naoko Abe, Hiroshi Abe
    • Organizer
      RNA2016
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2016-06-28
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K21091
  • [Presentation] Chemical ligation of oligonucleotides using electrophilic phosphorothioester2016

    • Author(s)
      木村康明 丸山豪斗 笈川涼太 早川真由 阿部奈保子 松田 彰 周東智 伊藤嘉浩 阿部洋
    • Organizer
      第10回バイオ関連化学シンポジウム
    • Place of Presentation
      金沢 石川県立音楽堂
    • Year and Date
      2016-09-07
    • Data Source
      KAKENHI-PROJECT-16K21091
  • 1.  Abe Hiroshi (80415067)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 2.  村上 努 (50336385)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  山口 茂弘 (60260618)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  大井 貴史 (80271708)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  斎藤 進 (90273268)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  八木 亜樹子 (20803282)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  松田 亮太郎 (00402959)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  荘司 長三 (90379587)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  柳井 毅 (00462200)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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