Sakai Kiyoshi 酒井陽

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SAKAI KIYOSHI 酒井陽

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Researcher Number	80772425
Other IDs	https://orcid.org/0000-0001-7050-1191
Affiliation (Current)	2023: 名古屋大学, 医学部附属病院, 助教 2023: 名古屋大学, 医学系研究科, 助教
Affiliation (based on the past Project Information) *help	2020 – 2023: 名古屋大学, 医学部附属病院, 助教 2016 – 2020: 名古屋大学, 医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 57060:Surgical dentistry-related / Surgical dentistry Except Principal Investigator Basic Section 57060:Surgical dentistry-related
Keywords	Principal Investigator 組織再生 / 幹細胞 / 細胞老化 / 唾液腺 / 細胞外小胞 / 再生 / 老化 / micro RNA / エクソソーム / 歯学 … More / 再生医学 / 分化 / エナメル芽細胞 / 歯原性上皮細胞 / 歯原生上皮幹細胞 / 幹細胞維持 / 細胞分化 / 歯の再生 / 細胞運命決定 / 組織発生 / 転写因子 … More Except Principal Investigator 乳歯歯髄幹細胞 / 細胞外小胞 / 骨粗鬆症 / 再生医学 / 組織再生 / 再生医療 / 歯髄幹細胞 / エクソソーム / 放射線性顎骨壊死 Less

乳歯歯髄幹細胞由来細胞外小胞を用いた骨粗鬆症の骨質改善
- Principal Investigator
  
  上嶋伸知
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  National Hospital Organization Nagoya Medical Center
放射線性萎縮モデルにおける唾液腺幹細胞再生メカニズムの分子基盤Principal Investigator
- Principal Investigator
  
  酒井陽
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Nagoya University
Treatment development and elucidation of mechanism for radiation-induced osteonecrosis of the jaw with exosomes
- Principal Investigator
  
  Okabe Kazuto
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Nagoya University
Regeneration of novel salivary gland tissue by stem cell-derived exosomesPrincipal Investigator
- Principal Investigator
  
  SAKAI KIYOSHI
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Nagoya University
Cascaded bone regeneration method with extracellular vesicles prepared for different purposes under variable culture environment
- Principal Investigator
  
  日比英晴
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Nagoya University
Mechanism of regulation of dental epithelial stem cell differentiation by transcription factor complexesPrincipal Investigator
- Principal Investigator
  
  SAKAI KIYOSHI
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Nagoya University

All 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Book

[Book] Peripheral nerve regeneration in a novel rat model of dysphagia, Stem Cells and Tissue Repair2020
- Author(s)
  Sakai K, Tsuruta T, Watanabe J, Sugimura Y, Sakaguchi K, Katagiri W, Hibi H
- Total Pages
  7
- Publisher
  Humana
- ISBN
  9781071606544
- Data Source
  KAKENHI-PROJECT-19H03851
[Book] Stem Cells and Tissue Repair. Methods in Molecular Biology2020
- Author(s)
  Sakai K, Tsuruta T, Watanabe J, Sugimura Y, Sakaguchi K, Katagiri W, Hibi H
- Total Pages
  213
- Publisher
  Springer Nature
- Data Source
  KAKENHI-PROJECT-19K19191
[Journal Article] Coexistence of Sj?gren's syndrome and bilateral ranulas: A case report and review of the literature2021
- Author(s)
  Koma Yoshiro、Fujimoto Takehiro、Sakai Kiyoshi、Sugimura Yukiko、Yamaguchi Satoshi、Hibi Hideharu
- Journal Title
  
  Oral Science International
  
  Volume: 19 Issue: 2 Pages: 111-116
- DOI
  10.1002/osi2.1121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K10067
[Journal Article] Dental pulp stem cell-derived small extracellular vesicle in irradiation-induced senescence2021
- Author(s)
  Dong J, Sakai K, Koma Y, Watanabe J, Liu K, Maruyama H, Sakaguchi K, Hibi H
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 575 Pages: 28-35
- DOI
  10.1016/j.bbrc.2021.08.046
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03851, KAKENHI-PROJECT-21K10067, KAKENHI-PROJECT-19K19050
[Journal Article] Conditioned medium from stem cells derived from human exfoliated deciduous teeth ameliorates NASH via the Gut-Liver axis2021
- Author(s)
  Muto H. Ito T, Tanaka T, Yokoyama S, Yamamoto K, Imai N, Ishizu Y, Maeda K, Honda T, Ishikawa T, Kato A, Ohshiro T, Kano F, Yamamoto A, Sakai K, Hibi H, Ishigami M, Fujishiro M
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 18778-18778
- DOI
  10.1038/s41598-021-98254-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03851, KAKENHI-PROJECT-21K10067, KAKENHI-PROJECT-19K17457, KAKENHI-PROJECT-19K18241, KAKENHI-PROJECT-21K16571
[Journal Article] Extracellular Vesicles of Stem Cells to Prevent BRONJ2020
- Author(s)
  Watanabe J. Sakai K. Urata Y. Toyama N. Nakamichi E. Hibi H.
- Journal Title
  
  Journal of Dental Research
  
  Volume: 99 Issue: 5 Pages: 552-560
- DOI
  10.1177/0022034520906793
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K20569, KAKENHI-PROJECT-19K19191, KAKENHI-PROJECT-19H03851
[Journal Article] Identification of the Novel Tooth-Specific Transcription Factor AmeloD2018
- Author(s)
  He B.、Chiba Y.、Li H.、de Vega S.、Tanaka K.、Yoshizaki K.、Ishijima M.、Yuasa K.、Ishikawa M.、Rhodes C.、Sakai K.、Zhang P.、Fukumoto S.、Zhou X.、Yamada Y.
- Journal Title
  
  Journal of Dental Research
  
  Volume: 98 Issue: 2 Pages: 234-241
- DOI
  10.1177/0022034518808254
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08770, KAKENHI-PROJECT-18K09082, KAKENHI-PROJECT-18K09110, KAKENHI-PROJECT-17K19765, KAKENHI-PROJECT-16K20569, KAKENHI-PROJECT-17H01606, KAKENHI-PROJECT-18H03012, KAKENHI-PROJECT-19K21375
[Journal Article] Dental pulp-derived stem cell conditioned medium to regenerate peripheral nerves in a novel animal model of dysphagia2018
- Author(s)
  Tsuruta Takeshi、Sakai Kiyoshi、Watanabe Junna、Katagiri Wataru、Hibi Hideharu
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 12 Pages: e0208938-e0208938
- DOI
  10.1371/journal.pone.0208938
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K20569, KAKENHI-PROJECT-16H05540
[Presentation] ヒト歯髄幹細胞の無血清培養上清が皮弁の生着に与える効果の検討2022
- Author(s)
  王芸霖，山口聡，陳暉，渡辺純奈，酒井陽，日比英晴
- Organizer
  第21回日本再生医療学会
- Data Source
  KAKENHI-PROJECT-19H03851
[Presentation] ヒト歯髄幹細胞の無血清培養上清がパクリタキセルによる脱毛症に与える効果の検討2022
- Author(s)
  陳暉，山口聡，王芸霖，上之郷健人，酒井陽，日比英晴
- Organizer
  第21回日本再生医療学会
- Data Source
  KAKENHI-PROJECT-19H03851
[Presentation] ヒト歯髄幹細胞の無血清培養上清が皮弁の生着に与える効果の検討2021
- Author(s)
  王芸霖，山口聡，陳暉，渡邊純奈，酒井陽，日比英晴
- Organizer
  第20回日本再生医療学会
- Data Source
  KAKENHI-PROJECT-19H03851
[Presentation] シェーグレン症候群の唾液腺細胞老化に幹細胞由来細胞外小胞が与える影響2021
- Author(s)
  小間義朗，酒井陽，渡邊純奈，椙村有紀子，坂口晃平，丸山裕，日比英晴
- Organizer
  第75回日本口腔科学会
- Data Source
  KAKENHI-PROJECT-19H03851
[Presentation] Exosomes derived from mesenchymal stem cells stimulated by hypoxia accelerated osteogenesis2021
- Author(s)
  Sakaguchi K, Sakai K, Sugimura-Wakayama Y, Koma Y, Watanabe J, Maruyama H, Kehong L, Jiao D, Hibi H
- Organizer
  2021 IADR/AADR/CADR General Session & Exhibition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03851
[Presentation] Human Dental Pulp Stem Cell-Derived Extracellular Vesicles Prevent the Functional Damage to Salivary Gland Caused by Irradiation2021
- Author(s)
  Jiao Dong, Kiyoshi Sakai, Yoshiro Koma, Kehong Liu, Hiroshi Maruyama, Junna Watanabe, Hideharu Hibi
- Organizer
  The 2nd CIBoG Retreat
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K10067
[Presentation] Effects of hDPSCs-derived Exosomes in Novel Salivary Gland Disease Model2020
- Author(s)
  Yoshiro Koma, Kiyoshi Sakai, Dong Jiao, Junna Watanabe, Hideharu Hibi
- Organizer
  98th General Session & Exhibition of the IADR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K19191
[Presentation] Effects of hDPSCs-derived exosomes in novel salivary gland disease model2020
- Author(s)
  Koma Y, Sakai K, Jiao D, Watanabe J, Hibi H
- Organizer
  2020 IADR/AADR/CADR General Session
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K19191
[Presentation] マウス唾液腺原基・脾細胞共培養系を用いた ex vivo シェーグレン症候群モデルにおけるヒト歯髄幹細胞由来細胞外小胞の効果2020
- Author(s)
  小間義朗，酒井陽，Dong Jiao，丸山裕，Liu Kehong，渡邊純奈，日比英晴
- Organizer
  第62回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-19K19191
[Presentation] Effects of hDPSCs-derived Exosomes in Novel Salivary Gland Disease Model2020
- Author(s)
  Yoshiro Koma, Kiyoshi Sakai, Dong Jiao, Junna Watanabe, Hideharu Hibi
- Organizer
  98th General Session & Exhibition of the IADR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20569
[Presentation] 唾液腺機能障害におけるヒト歯髄幹細胞由来細胞外小胞による予防効果の検討2020
- Author(s)
  董嬌，酒井陽，小間義朗，渡邊純奈，日比英晴
- Organizer
  第62回歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-19H03851
[Presentation] 唾液腺機能障害におけるヒト歯髄幹細胞由来細胞外小胞による予防効果の検討2020
- Author(s)
  董嬌，酒井陽，小間義朗，渡邊純奈，日比英晴
- Organizer
  第62回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-19K19191
[Presentation] 骨再生についてのわれわれの取り組みの変遷2020
- Author(s)
  岡部一登，藤尾正人，酒井陽，椙村有紀子，坂口晃平，渡邊純奈，日比英晴
- Organizer
  第50回日本口腔インプラント学会
- Data Source
  KAKENHI-PROJECT-19H03851
[Presentation] Effects of hDPSCs-derived exosomes in novel salivary gland disease model2020
- Author(s)
  Koma Y, Sakai K, Jiao D, Watanabe J, Hibi H
- Organizer
  2020 IADR/AADR/CADR General Session
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03851
[Presentation] マウス唾液腺原基・脾細胞共培養系を用いた ex vivo シェーグレン症候群モデルにおけるヒト歯髄幹細胞由来細胞外小胞の効果2020
- Author(s)
  小間義朗，酒井陽，Dong Jiao，丸山裕，Liu Kehong，渡邊純奈，日比英晴
- Organizer
  第62回歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-19H03851
[Presentation] 転写因子Epfn-Tbx1複合体を用いた歯原性上皮幹細胞分化制御の解明2019
- Author(s)
  酒井　陽 , 山本朗仁, 日比英晴
- Organizer
  第64回(公社)日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-16K20569
[Presentation] 歯原性上皮幹細胞の分化におけるEpiprofinとT-box1の役割2019
- Author(s)
  酒井陽, 吉崎恵悟, 山本朗仁, 日比英晴, 山田吉彦
- Organizer
  第64回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-16K20569
[Presentation] 転写因子Epfn-Tbx1 複合体を用いた歯原性上皮幹細胞分化制御の解明2019
- Author(s)
  酒井陽，山本朗仁，日比英晴
- Organizer
  第64回日本口腔外科学会
- Data Source
  KAKENHI-PROJECT-19H03851
[Presentation] Bone regeneration using exosomes derived from hMSCs stimulated by hypoxia2019
- Author(s)
  Sakaguchi K, Sakai K, Sugimura Y, Watanabe J, Hibi H
- Organizer
  28th Annual Scientific Meeting EAO Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03851
[Presentation] Exosomes derived from mesenchymal stem cells enhanced bone regeneration2018
- Author(s)
  Sakaguchi K, Sakai K, Sugimura Y, Tsuruta T, Watanabe J, Katagiri W, Hibi H
- Organizer
  96th General Session & Exhibition of the IADR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20569
[Presentation] Effects of mesenchymal stem cell-derived exosomes for rat BRONJ model2018
- Author(s)
  Watanabe J, Sakai K, Okabe K, Sugimura Y, Sakaguchi K, Tsuruta T, Hibi H
- Organizer
  96th General Session & Exhibition of the IADR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20569
[Presentation] Epiprofin is a multi-functional factor essential to promote dental epithelial stem cell commitment to the ameloblast lineage and its proliferation and differentiation2017
- Author(s)
  Yoshihiko Yamada, Kiyoshi Sakai , Yuta Chiba, Bing He, Darius Mahboubi, Craig Rhodes, Yasuo Yoshitomi, Satoshi Fukumoto, Takashi Nakamura
- Organizer
  The 2017 Japan-NIH Joint Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-16K20569
[Presentation] Epiprofin and T-box1 regulate the ameloblast linage development2017
- Author(s)
  Yuta Chiba, Kiyoshi Sakai, Tomoko Ikeuchi, Keigo Yoshizaki, Darius Mahboubi, and Yoshihiko Yamada
- Organizer
  2017 IADR/AADR/CADR General Session & Exhibition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20569
[Presentation] 歯原性上皮細胞のエナメル芽細胞への分化におけるEpiprofinとT-box1の役割2016
- Author(s)
  酒井陽，吉崎恵悟，千葉雄太，池内友子，山本朗仁，日比英晴，山田吉彦
- Organizer
  第58回歯科基礎医学会学術大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-08-24
- Data Source
  KAKENHI-PROJECT-16K20569

1. Okabe Kazuto (50801453)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. 日比英晴 (90345885)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
3. 黒田健介 (00283408)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 藤尾正人 (90612804)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 興戸正純 (50126843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 土屋周平 (20569785)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 上嶋伸知 (80877069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 渡邊純奈 (00877102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. デベガスサーナ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakai Kiyoshi 酒井 陽

SAKAI KIYOSHI 酒井 陽

Research Projects

Research Products

Co-Researchers

乳歯歯髄幹細胞由来細胞外小胞を用いた骨粗鬆症の骨質改善

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

放射線性萎縮モデルにおける唾液腺幹細胞再生メカニズムの分子基盤Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Treatment development and elucidation of mechanism for radiation-induced osteonecrosis of the jaw with exosomes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regeneration of novel salivary gland tissue by stem cell-derived exosomesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cascaded bone regeneration method with extracellular vesicles prepared for different purposes under variable culture environment

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of regulation of dental epithelial stem cell differentiation by transcription factor complexesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Peripheral nerve regeneration in a novel rat model of dysphagia, Stem Cells and Tissue Repair2020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] Stem Cells and Tissue Repair. Methods in Molecular Biology2020

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Coexistence of Sj?gren's syndrome and bilateral ranulas: A case report and review of the literature2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dental pulp stem cell-derived small extracellular vesicle in irradiation-induced senescence2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Conditioned medium from stem cells derived from human exfoliated deciduous teeth ameliorates NASH via the Gut-Liver axis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extracellular Vesicles of Stem Cells to Prevent BRONJ2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of the Novel Tooth-Specific Transcription Factor AmeloD2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dental pulp-derived stem cell conditioned medium to regenerate peripheral nerves in a novel animal model of dysphagia2018

Author(s)

Journal Title

Sakai Kiyoshi 酒井陽

SAKAI KIYOSHI 酒井陽