LIN JASON CHING-YAO ＬＩＮＪＡＳＯＮ

… Alternative Names

Lin Jason LIN JASON

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Researcher Number	80774124
Affiliation (Current)	2023: 千葉県がんセンター(研究所), がんゲノムセンター臨床ゲノム研究部, 研究員 2023: 千葉県がんセンター(研究所), がん治療開発グループがん遺伝創薬研究室, 研究員
Affiliation (based on the past Project Information) *help	2019 – 2021: 千葉県がんセンター(研究所), がん治療開発グループがん遺伝創薬研究室, 研究員 2018: 千葉県がんセンター(研究所), がん治療開発グループがん遺伝創薬研究室, 博士研究員 2017: 千葉県がんセンター(研究所), がん遺伝創薬研究室, 博士研究員
Review Section/Research Field	Principal Investigator Medical genome science / Basic Section 43050:Genome biology-related Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator ケミカルバイオロジー / バイオインフォマティクス / ゲノミクス / エピゲノミクス / ゲノミックス / 総合生物 / ゲノム科学 / ゲノム医科学 / ゲノム創薬 / ゲノム解析 / 機械学習 / 核酸関連化学 / ヒトゲノム配列再解析 … More Except Principal Investigator … More DNA副溝結合化合物 / ゲノム創薬 / 分子標的治療 / 効果副作用予測 / 腫瘍特異性 / ミトコンドリア / マイナーグルーブバインダー / ゲノム変異 / 分子標的化合物 / がん / 創薬開発 / 遺伝子変異 / エピゲノム Less

深層学習による人工エピゲノム操作因子におけるゲノム干渉効果の評価及び予測Principal Investigator
- Principal Investigator
  
  LIN JASON
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Development of anticancer drugs targeting the mutated cancer genome
- Principal Investigator
  
  永瀬浩喜
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Analyzing Genomic Binding of Pyrrole-Imidazole Polyamides by Machine LearningPrincipal Investigator
- Principal Investigator
  
  Lin Jason
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical genome science
- Research Institution
  Chiba Cancer Center (Research Institute)

All 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Suppression of non‐small‐cell lung cancer A549 tumor growth?by an mtDNA mutation‐targeting pyrrole‐imidazole polyamide‐triphenylphosphonium and a senolytic drug2022
- Author(s)
  Tsuji Kohei、Kida Yuki、Koshikawa Nobuko、Yamamoto Seigi、Shinozaki Yoshinao、Watanabe Takayoshi、Lin Jason、Nagase Hiroki、Takenaga Keizo
- Journal Title
  
  Cancer Science
  
  Volume: - Pages: 1321-1337
- DOI
  10.1111/cas.15290
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03540, KAKENHI-PROJECT-19K07408, KAKENHI-PROJECT-20K07710
[Journal Article] Elemental analysis by Metallobalance provides a complementary support layer over existing blood biochemistry panel-based cancer risk assessment.2021
- Author(s)
  205. Kusakabe M, Sato M, Nakamura Y, Mikami H, Lin J, Nagase H.
- Journal Title
  
  Peer J
  
  Volume: 9
- DOI
  10.7717/peerj.12247
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03540, KAKENHI-PROJECT-21K15072, KAKENHI-PROJECT-16H06277
[Journal Article] MCT4 is induced by metastasis-enhancing pathogenic mitochondrial NADH dehydrogenase gene mutations and can be a therapeutic target2021
- Author(s)
  Takenaga Keizo、Koshikawa Nobuko、Akimoto Miho、Tatsumi Yasutoshi、Lin Jason、Itami Makiko、Nagase Hiroki
- Journal Title
  
  Scientific reports
  
  Volume: 11 Pages: 13302-13302
- DOI
  10.1038/s41598-021-92772-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03540, KAKENHI-PROJECT-19K07408, KAKENHI-PROJECT-19K07673, KAKENHI-PROJECT-20K08199
[Journal Article] Targeting the mutant PIK3CA gene by DNA-alkylating pyrrole imidazole polyamide in cervical cancer.2021
- Author(s)
  Krishnamurthy S, Yoda H, Hiraoka K, Inoue T, Lin J, Shinozaki Y, Watanabe T, Koshikawa N, Takatori A, Nagase H
- Journal Title
  
  Cancer Science
  
  Volume: 112(3) Pages: 1141-1149
- DOI
  10.1111/cas.14785
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07767, KAKENHI-PROJECT-20H03540
[Journal Article] Mitochondria: Endosymbiont bacteria DNA sequence as a target against cancer.2021
- Author(s)
  Nagase Hiroki、Watanabe Takayoshi、Koshikawa Nobuko、Yamamoto Seigi、Takenaga Keizo、Lin Jason
- Journal Title
  
  Cancer Science
  
  Volume: 112 Pages: 4834-4843
- DOI
  10.1111/cas.15143
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03540, KAKENHI-PROJECT-19K07408, KAKENHI-PROJECT-19K07654, KAKENHI-PROJECT-20K07710
[Journal Article] A linear five-ring pyrrole-imidazole polyamide-triphenylphosphonium conjugate targeting a mitochondrial DNA mutation efficiently induces apoptosis of HeLa cybrid cells carrying the mutation2021
- Author(s)
  Koshikawa Nobuko、Kida Yuki、Yasui Nanami、Shinozaki Yoshinao、Tsuji Kohei、Watanabe Takayoshi、Lin Jason、Yamamoto Seigi、Takenaga Keizo、Nagase Hiroki
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 576 Pages: 93-99
- DOI
  10.1016/j.bbrc.2021.08.088
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03540, KAKENHI-PROJECT-19K07408, KAKENHI-PROJECT-20K07710
[Journal Article] The road not taken with pyrrole-imidazole polyamides: off-target effects and genomic binding.2020
- Author(s)
  Lin Jason、Nagase Hiroki
- Journal Title
  
  Biomolecules
  
  Volume: 10 Pages: 544-544
- DOI
  10.3390/biom10040544
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03602, KAKENHI-PROJECT-17K15047, KAKENHI-PROJECT-20H03540
[Journal Article] CRED : a rapid peak caller for Chem-seq data2019
- Author(s)
  Jason Lin, Tony Kuo, Paul Horton, Hiroki Nagase
- Journal Title
  
  Journal of Open Source Software
  
  Volume: 4 Issue: 37 Pages: 1423-1423
- DOI
  10.21105/joss.01423
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03602, KAKENHI-PROJECT-17K15047, KAKENHI-PROJECT-16H06277
[Journal Article] Direct targeting of MYCN gene amplification by site-specific DNA alkylation in neuroblastoma2019
- Author(s)
  H. Yoda, T. Inoue, Y. Shinozaki, J. Lin, T. Watanabe, N. Koshikawa, A. Takatori, H. Nagase
- Journal Title
  
  Cancer Research
  
  Volume: 79 Issue: 4 Pages: 830-840
- DOI
  10.1158/0008-5472.can-18-1198
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15047, KAKENHI-PROJECT-17H03602, KAKENHI-PROJECT-16H06277
[Journal Article] Estimating genome-wide off-target effects for pyrrole-imoidazole polyamide binding by a pathway-based expression profiling approach2019
- Author(s)
  J, Lin, S, Krishnamurthy, H. Yoda, Y. Shinozaki, T. Watanabe, N. Koshikawa, A. Takatori, P. Horton, H. Nagase
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Pages: 4-4
- DOI
  10.1371/journal.pone.0215247
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03602, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-17K15047
[Journal Article] Hydrophobic structure of hairpin ten-ring pyrrole-imidazole polyamides enhanced tumor tissue accumulation/retention in vivo.2018
- Author(s)
  Inoue Takahiro、Shimozato Osamu、Matsuo Nina、Mori Yusuke、Shinozaki Yoshinao、Lin Jason、Watanabe Takayoshi、Takatori Atsushi、Koshikawa Nobuko、Ozaki Toshinori、Nagase Hiroki
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 26 Pages: 2337-2344
- DOI
  10.1016/j.bmc.2018.03.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10559, KAKENHI-PUBLICLY-16H01579, KAKENHI-PROJECT-16J05439, KAKENHI-PROJECT-15K08412, KAKENHI-PROJECT-17K15047, KAKENHI-PROJECT-17H03602
[Presentation] 変異mtDNA標的PIP-TPPとBcl-xL阻害剤の併用による非小細胞肺癌A549腫瘍のSenotherapy2021
- Author(s)
  山本　清義、辻　航平、越川　信子、木田　裕貴、渡部隆義、リンジェイソン、竹永啓三、永瀬浩喜
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03540
[Presentation] 機械学習を用いた配列特異的ピロールイミダゾールポリアミド・ボリノスタット複合体によるがんゲノム結合の評価2021
- Author(s)
  リンジェイソン、細矢　和、佐久間　誠、木田　裕貴、渡部　隆義、山本　清義、高取　敦志、越川　信子、永瀬　浩喜
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03540
[Presentation] 機械学習を用いた配列特異的ピロールイミダゾールポリアミド・ボリノスタット複合体によるがんゲノム結合の評価2021
- Author(s)
  Lin J, Hosoya I, Sakuma S, Kida Y, Watanabe T, Yamamoto S, Takatori A, Koshikawa N, Nagase H
- Organizer
  第80回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15072
[Presentation] 機械学習に基づくPIポリアミドの抗がん剤としての副作用予測モデルの開発2020
- Author(s)
  佐久間誠、リンジェイソン、高取敦志、渡部隆義、山本清義、越川信子、木田裕貴、永瀬浩喜
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03540
[Presentation] 塩基配列選択的な新規エピゲノム制御分子PIP-SAHAにおける機械学習法による遺伝子発現量影響の予測2020
- Author(s)
  リン・ジェイソン、渡部隆義、杉山弘、永瀬浩喜
- Organizer
  第5回AMEDがん若手研究者ワークショップ
- Data Source
  KAKENHI-PROJECT-17K15047
[Presentation] 機械学習によるSAHA化ピロールイミダゾールポリアミドで特異な遺伝子クラスター活性化現象の評価2020
- Author(s)
  Jason Lin、佐久間誠、木田裕貴、渡部隆義、山本清義、高取敦志、越川信子、永瀬浩喜
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03540
[Presentation] 発現プロファイリングによるDNA副溝結合剤のピロールイミダゾールポリアミドでのオフターゲット及び副作用の評価・予測2019
- Author(s)
  Jason Lin, Sakthisri Krishnamurthy, Hiroyuki Yoda, Yoshinao Shinozaki, Takayoshi Watanabe, Nobuko Koshikawa, Atsushi Takatori, Paul Horton, Hiroki Nagase
- Organizer
  第78回日本癌学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15047
[Presentation] 臨床検体を用いた網羅的遺伝子発現解析によるがん増悪化分子フロントに関連するバイオマーカーの開発研究2019
- Author(s)
  Lin Jason, 奥村和弘, 寺島裕也, 遠田悦子, 板倉明司, 松島綱治, 永瀬浩喜
- Organizer
  AMEDがん若手研究者ワークショップ
- Data Source
  KAKENHI-PROJECT-17K15047
[Presentation] ピロールイミダゾールポリアミドでの非特異的なゲノム結合および副作用の予測2019
- Author(s)
  リン・ジェイソン、クリシュナムーティ・サクテイシリ、養田裕行、篠崎喜脩、渡部隆義、越川信子、高取敦志、ホートン・ポール、永瀬浩喜
- Organizer
  第28回日本癌病態治療研究会
- Data Source
  KAKENHI-PROJECT-17K15047
[Presentation] Estimation of Phenotypes and Side Effects from DNA Minor-Groove-Binding Pyrrole-Imidazole Polyamides2019
- Author(s)
  Jason Lin, Atsushi Takatori, Hiroki Nagase, Paul Horton
- Organizer
  27th Conference on Intelligent Systems for Molecular Biology and the 18th European Conference on Computational Biology (ISMB/ECCB 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15047
[Presentation] Chem-seq: Evaluation of Genomewide Binding Effects of DNA Minor Groove-Binding Pyrrole Imidazole Polyamides2018
- Author(s)
  Lin Jason, Takatori Atsushi, Horton Paul, Nagase Hiroki
- Organizer
  RECOMB/ISCB Conference on Regulatory & Systems Genomics with DREAM Challenges
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15047
[Presentation] ピロールイミダゾールポリアミドによるがん治療の評価：Chem-seq2018
- Author(s)
  Lin Jason, 平岡桐子, Krishnamurthy Sakthisri, 井上貴博, 養田裕行, 篠崎喜脩, 渡部隆義, 高取敦志, 越川信子, 永瀬浩喜
- Organizer
  第77回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15047
[Presentation] ゲノム解析によるピロールイミダゾールポリアミドで生化学的機能および臨床的副作用の予測2018
- Author(s)
  Lin Jason, 平岡桐子, 養田裕行, Krishnamurthy Sakthisri, 篠崎喜脩, 渡部隆義, 高取敦志, 越川信子, Horton Paul, 永瀬浩喜
- Organizer
  第27回日本癌病態治療研究会
- Data Source
  KAKENHI-PROJECT-17K15047
[Presentation] Design of a next-generation affinity-enrichment Chem-seq sequencing procedure to assess the biochemistry of minor-groove-binding pyrrole-imidazole polyamides2017
- Author(s)
  J. Lin, A. Tataktori, K. Hiraoka, H. Yoda, S. Krishnamurthy, T. Inoue, T. Watanabe, T. Kuo, Y. Shinozaki, N. Koshikawa, P. Horton, H. Nagase
- Organizer
  2017年度生命科学系学会合同年次大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15047
[Presentation] 機械学習によるピロールイミダゾールポリアミドでのゲノム結合の解析2017
- Author(s)
  Jason Lin
- Organizer
  "文部科学省先端モデル動物支援プラットフォーム・若手支援技術講習会
- Data Source
  KAKENHI-PROJECT-17K15047
[Presentation] Assessing oncotherapeutic efficacy of minor-groove-binding pyrrole-imidazole polyamides by Chem-seq sequencing2017
- Author(s)
  J. Lin, K. Hiraoka, H. Yoda, A. Takatori, T. Watanabe, T. Kuo, Y. Shinozaki, N. Koshikawa, P. Horton, H. Nagase
- Organizer
  "第76回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15047

1. 永瀬浩喜 (90322073)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
2. 山本清義 (80783521)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
3. SATO Shinya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. MIKAMI Haruo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. KOSHIKAWA Nobuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
6. TATSUMI Yasutoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. HINO Okio

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. ATSUSHI Takatori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. WATANABE Takayoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
10. 下里修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 尾崎俊文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 中村洋子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 竹永啓三

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
14. 秋元美穂

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 渡辺能行

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 渡辺俊樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

LIN JASON CHING-YAO ＬＩＮ ＪＡＳＯＮ

Lin Jason LIN JASON

Research Projects

Research Products

Co-Researchers

深層学習による人工エピゲノム操作因子におけるゲノム干渉効果の評価及び予測Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of anticancer drugs targeting the mutated cancer genome

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analyzing Genomic Binding of Pyrrole-Imidazole Polyamides by Machine LearningPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Suppression of non‐small‐cell lung cancer A549 tumor growth?by an mtDNA mutation‐targeting pyrrole‐imidazole polyamide‐triphenylphosphonium and a senolytic drug2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Elemental analysis by Metallobalance provides a complementary support layer over existing blood biochemistry panel-based cancer risk assessment.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MCT4 is induced by metastasis-enhancing pathogenic mitochondrial NADH dehydrogenase gene mutations and can be a therapeutic target2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting the mutant PIK3CA gene by DNA-alkylating pyrrole imidazole polyamide in cervical cancer.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mitochondria: Endosymbiont bacteria DNA sequence as a target against cancer.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A linear five-ring pyrrole-imidazole polyamide-triphenylphosphonium conjugate targeting a mitochondrial DNA mutation efficiently induces apoptosis of HeLa cybrid cells carrying the mutation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The road not taken with pyrrole-imidazole polyamides: off-target effects and genomic binding.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CRED : a rapid peak caller for Chem-seq data2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Direct targeting of MYCN gene amplification by site-specific DNA alkylation in neuroblastoma2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Estimating genome-wide off-target effects for pyrrole-imoidazole polyamide binding by a pathway-based expression profiling approach2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hydrophobic structure of hairpin ten-ring pyrrole-imidazole polyamides enhanced tumor tissue accumulation/retention in vivo.2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] 変異mtDNA標的PIP-TPPとBcl-xL阻害剤の併用による非小細胞肺癌A549腫瘍のSenotherapy2021

Author(s)

LIN JASON CHING-YAO ＬＩＮＪＡＳＯＮ

[Presentation] 機械学習を用いた配列特異的ピロールイミダゾールポリアミド・ボリノスタット複合体によるがんゲノム結合の評価2021

[Presentation] 発現プロファイリングによるDNA副溝結合剤のピロールイミダゾールポリアミドでのオフターゲット及び副作用の評価・予測2019