LIN JASON CHING-YAO ＬＩＮＪＡＳＯＮ

… Alternative Names

Lin Jason LIN JASON

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Researcher Number	80774124
Other IDs
Affiliation (Current)	2025: 千葉県がんセンター(研究所), がん治療開発グループ細胞治療開発研究部, 客員研究員 2025: 千葉県がんセンター(研究所), がんゲノムセンター臨床ゲノム研究部, 研究員 2025: 千葉県がんセンター(研究所), がん治療開発グループがん遺伝創薬研究室, 研究員
Affiliation (based on the past Project Information) *help	2023: 千葉県がんセンター(研究所), がん治療開発グループがん遺伝創薬研究室, 研究員 2022: 千葉県がんセンター(研究所), がん治療開発グループ, 研究員 2019 – 2021: 千葉県がんセンター(研究所), がん治療開発グループがん遺伝創薬研究室, 研究員 2018: 千葉県がんセンター(研究所), がん治療開発グループがん遺伝創薬研究室, 博士研究員 2017: 千葉県がんセンター(研究所), がん遺伝創薬研究室, 博士研究員
Review Section/Research Field	Principal Investigator Basic Section 43050:Genome biology-related / Medical genome science Except Principal Investigator Basic Section 49020:Human pathology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator ケミカルバイオロジー / ヒトゲノム配列再解析 / 核酸関連化学 / ゲノム解析 / 機械学習 / 深層学習 / ゲノム干渉 / オフターゲット効果 / ゲノム創薬 / ゲノム医科学 … More / ゲノム科学 / 総合生物 / ゲノミックス / エピゲノミクス / ゲノミクス / バイオインフォマティクス … More Except Principal Investigator in situ hybridization / メチル化 / ナノポアシーケンサー / 病理 / 肉腫 / エピゲノム / 遺伝子変異 / 創薬開発 / がん / 分子標的化合物 / ゲノム変異 / マイナーグルーブバインダー / ミトコンドリア / 腫瘍特異性 / 効果副作用予測 / 分子標的治療 / ゲノム創薬 / DNA副溝結合化合物 Less

新世代in situ hybridization法の確立と多形肉腫の進化過程の解明
- Principal Investigator
  
  牧瀬尚大
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Chiba Cancer Center (Research Institute)
深層学習による人工エピゲノム操作因子におけるゲノム干渉効果の評価及び予測Principal Investigator
- Principal Investigator
  
  LIN JASON
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Development of anticancer drugs targeting the mutated cancer genome
- Principal Investigator
  
  永瀬浩喜
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Analyzing Genomic Binding of Pyrrole-Imidazole Polyamides by Machine LearningPrincipal Investigator
- Principal Investigator
  
  Lin Jason
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical genome science
- Research Institution
  Chiba Cancer Center (Research Institute)

All 2024 2023 2022 2021 2020 2019 2018 2017 Other

All Journal Article Presentation Other

[Journal Article] Implications of Transglutaminase-Mediated Protein Serotonylation in the Epigenetic Landscape, Small Cell Lung Cancer, and Beyond2023
- Author(s)
  Lin Jason、Wu Shang-Chuen
- Journal Title
  
  Cancers
  
  Volume: 15 Issue: 4 Pages: 1332-1332
- DOI
  10.3390/cancers15041332
- Data Source
  KAKENHI-PROJECT-21K15072
[Journal Article] Suppression of NSCLC A549 tumor growth by a mtDNA mutation‐targeting pyrrole‐imidazole polyamide‐TPP and a senolytic drug2022
- Author(s)
  Tsuji Kohei、Kida Yuki、Koshikawa Nobuko、Yamamoto Seigi、Shinozaki Yoshinao、Watanabe Takayoshi、Lin Jason、Nagase Hiroki、Takenaga Keizo
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 4 Pages: 1321-1337
- DOI
  10.1111/cas.15290
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03540, KAKENHI-PROJECT-19K07408, KAKENHI-PROJECT-20K07710, KAKENHI-PROJECT-19K07654, KAKENHI-PROJECT-22H04923
[Journal Article] Elemental analysis by Metallobalance provides a complementary support layer over existing blood biochemistry panel-based cancer risk assessment2021
- Author(s)
  Kusakabe Miho、Sato Masahiro、Nakamura Yohko、Mikami Haruo、Lin Jason、Nagase Hiroki
- Journal Title
  
  PeerJ
  
  Volume: 9 Pages: e12247-e12247
- DOI
  10.7717/peerj.12247
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03540, KAKENHI-PROJECT-21K15072, KAKENHI-PROJECT-16H06277
[Journal Article] Targeting the mutant PIK3CA gene by DNA-alkylating pyrrole-imidazole polyamide in cervical cancer2021
- Author(s)
  Krishnamurthy S, Yoda H, Hiraoka K, Inoue T, Lin J, Shinozaki Y, Watanabe T, Koshikawa N, Takatori A, Nagase H
- Journal Title
  
  Cancer Science
  
  Volume: 112(3) Issue: 3 Pages: 1141-1149
- DOI
  10.1111/cas.14785
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07767, KAKENHI-PROJECT-20H03540
[Journal Article] Mitochondria: Endosymbiont bacteria DNA sequence as a target against cancer2021
- Author(s)
  Nagase Hiroki、Watanabe Takayoshi、Koshikawa Nobuko、Yamamoto Seigi、Takenaga Keizo、Lin Jason
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 12 Pages: 4834-4843
- DOI
  10.1111/cas.15143
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03540, KAKENHI-PROJECT-19K07408, KAKENHI-PROJECT-19K07654, KAKENHI-PROJECT-20K07710
[Journal Article] A linear five-ring pyrrole-imidazole polyamide-triphenylphosphonium conjugate targeting a mitochondrial DNA mutation efficiently induces apoptosis of HeLa cybrid cells carrying the mutation2021
- Author(s)
  Koshikawa Nobuko、Kida Yuki、Yasui Nanami、Shinozaki Yoshinao、Tsuji Kohei、Watanabe Takayoshi、Lin Jason、Yamamoto Seigi、Takenaga Keizo、Nagase Hiroki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 576 Pages: 93-99
- DOI
  10.1016/j.bbrc.2021.08.088
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03540, KAKENHI-PROJECT-19K07408, KAKENHI-PROJECT-20K07710
[Journal Article] The Road Not Taken with Pyrrole-Imidazole Polyamides: Off-Target Effects and Genomic Binding2020
- Author(s)
  Lin Jason、Nagase Hiroki
- Journal Title
  
  Biomolecules
  
  Volume: 10 Issue: 4 Pages: 544-544
- DOI
  10.3390/biom10040544
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03602, KAKENHI-PROJECT-17K15047, KAKENHI-PROJECT-20H03540
[Journal Article] CRED: a rapid peak caller for Chem-seq data2019
- Author(s)
  Lin Jason、Kuo Tony、Horton Paul、Nagase Hiroki
- Journal Title
  
  Journal of Open Source Software
  
  Volume: 4 Issue: 37 Pages: 1423-1423
- DOI
  10.21105/joss.01423
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03602, KAKENHI-PROJECT-17K15047, KAKENHI-PROJECT-16H06277
[Journal Article] Estimating genome-wide off-target effects for pyrrole-imidazole polyamide binding by a pathway-based expression profiling approach.2019
- Author(s)
  Lin J, Krishnamurthy S, Yoda H, Shinozaki Y, Watanabe T, Koshikawa N, Takatori A, Horton P and Nagase H.
- Journal Title
  
  PLoS One.
  
  Volume: 14 Issue: 4 Pages: 4-4
- DOI
  10.1371/journal.pone.0215247
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03602, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-17K15047
[Journal Article] Hydrophobic structure of hairpin ten-ring pyrrole-imidazole polyamides enhances tumor tissue accumulation/retention in vivo2018
- Author(s)
  Inoue Takahiro、Shimozato Osamu、Matsuo Nina、Mori Yusuke、Shinozaki Yoshinao、Lin Jason、Watanabe Takayoshi、Takatori Atsushi、Koshikawa Nobuko、Ozaki Toshinori、Nagase Hiroki
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 26 Issue: 9 Pages: 2337-2344
- DOI
  10.1016/j.bmc.2018.03.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10559, KAKENHI-PUBLICLY-16H01579, KAKENHI-PROJECT-16J05439, KAKENHI-PROJECT-15K08412, KAKENHI-PROJECT-17K15047, KAKENHI-PROJECT-17H03602
[Journal Article] Direct Targeting of MYCN Gene Amplification by Site-Specific DNA Alkylation in Neuroblastoma2018
- Author(s)
  Yoda Hiroyuki、Inoue Takahiro、Shinozaki Yoshinao、Lin Jason、Watanabe Takayoshi、Koshikawa Nobuko、Takatori Atsushi、Nagase Hiroki
- Journal Title
  
  Cancer Research
  
  Volume: 79 Issue: 4 Pages: 830-840
- DOI
  10.1158/0008-5472.can-18-1198
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15047, KAKENHI-PROJECT-17H03602, KAKENHI-PROJECT-16H06277
[Presentation] EWSR1/DDIT3の複雑な再構成をナノポアシーケンサーで同定した粘液型脂肪肉腫の一例2024
- Author(s)
  牧瀬尚大, リンジェイソン, 影山肇, 竹田直生, 及川麻理子, 杉山孝弘, 川名秀忠, 荒木章伸, 河津正人, 伊丹真紀子
- Organizer
  第113回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-23K06438
[Presentation] ロングリードシーケンス技術を用いたがんの悪性化に関わる転写スプライスバリアントの探索パイプライン: MuSTA22023
- Author(s)
  J. Lin, T. Morinaga, M. Kawazu
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K15072
[Presentation] Characterizating localized effect in the epigenome from histone deacetylase inhibitors by motif specific DNA minor groove binders2023
- Author(s)
  J. Lin
- Organizer
  RSGDREAM 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15072
[Presentation] 変異mtDNA標的PIP-TPPとBcl-xL阻害剤の併用による非小細胞肺癌A549腫瘍のSenotherapy2021
- Author(s)
  山本　清義、辻　航平、越川　信子、木田　裕貴、渡部隆義、リンジェイソン、竹永啓三、永瀬浩喜
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03540
[Presentation] 機械学習を用いた配列特異的ピロールイミダゾールポリアミド・ボリノスタット複合体によるがんゲノム結合の評価2021
- Author(s)
  リンジェイソン、細矢　和、佐久間　誠、木田　裕貴、渡部　隆義、山本　清義、高取　敦志、越川　信子、永瀬　浩喜
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03540
[Presentation] 機械学習を用いた配列特異的ピロールイミダゾールポリアミド・ボリノスタット複合体によるがんゲノム結合の評価2021
- Author(s)
  Lin J, Hosoya I, Sakuma S, Kida Y, Watanabe T, Yamamoto S, Takatori A, Koshikawa N, Nagase H
- Organizer
  第80回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15072
[Presentation] 機械学習に基づくPIポリアミドの抗がん剤としての副作用予測モデルの開発2020
- Author(s)
  佐久間誠、リンジェイソン、高取敦志、渡部隆義、山本清義、越川信子、木田裕貴、永瀬浩喜
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03540
[Presentation] 塩基配列選択的な新規エピゲノム制御分子PIP-SAHAにおける機械学習法による遺伝子発現量影響の予測2020
- Author(s)
  リン・ジェイソン、渡部隆義、杉山弘、永瀬浩喜
- Organizer
  第5回AMEDがん若手研究者ワークショップ
- Data Source
  KAKENHI-PROJECT-17K15047
[Presentation] 機械学習によるSAHA化ピロールイミダゾールポリアミドで特異な遺伝子クラスター活性化現象の評価2020
- Author(s)
  Jason Lin、佐久間誠、木田裕貴、渡部隆義、山本清義、高取敦志、越川信子、永瀬浩喜
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03540
[Presentation] 発現プロファイリングによるDNA副溝結合剤のピロールイミダゾールポリアミドでのオフターゲット及び副作用の評価・予測2019
- Author(s)
  Jason Lin, Sakthisri Krishnamurthy, Hiroyuki Yoda, Yoshinao Shinozaki, Takayoshi Watanabe, Nobuko Koshikawa, Atsushi Takatori, Paul Horton, Hiroki Nagase
- Organizer
  第78回日本癌学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15047
[Presentation] 臨床検体を用いた網羅的遺伝子発現解析によるがん増悪化分子フロントに関連するバイオマーカーの開発研究2019
- Author(s)
  Lin Jason, 奥村和弘, 寺島裕也, 遠田悦子, 板倉明司, 松島綱治, 永瀬浩喜
- Organizer
  AMEDがん若手研究者ワークショップ
- Data Source
  KAKENHI-PROJECT-17K15047
[Presentation] ピロールイミダゾールポリアミドでの非特異的なゲノム結合および副作用の予測2019
- Author(s)
  リン・ジェイソン、クリシュナムーティ・サクテイシリ、養田裕行、篠崎喜脩、渡部隆義、越川信子、高取敦志、ホートン・ポール、永瀬浩喜
- Organizer
  第28回日本癌病態治療研究会
- Data Source
  KAKENHI-PROJECT-17K15047
[Presentation] Estimation of Phenotypes and Side Effects from DNA Minor-Groove-Binding Pyrrole-Imidazole Polyamides2019
- Author(s)
  Jason Lin, Atsushi Takatori, Hiroki Nagase, Paul Horton
- Organizer
  27th Conference on Intelligent Systems for Molecular Biology and the 18th European Conference on Computational Biology (ISMB/ECCB 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15047
[Presentation] Chem-seq: Evaluation of Genomewide Binding Effects of DNA Minor Groove-Binding Pyrrole Imidazole Polyamides2018
- Author(s)
  Lin Jason, Takatori Atsushi, Horton Paul, Nagase Hiroki
- Organizer
  RECOMB/ISCB Conference on Regulatory & Systems Genomics with DREAM Challenges
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15047
[Presentation] ピロールイミダゾールポリアミドによるがん治療の評価：Chem-seq2018
- Author(s)
  Lin Jason, 平岡桐子, Krishnamurthy Sakthisri, 井上貴博, 養田裕行, 篠崎喜脩, 渡部隆義, 高取敦志, 越川信子, 永瀬浩喜
- Organizer
  第77回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15047
[Presentation] ゲノム解析によるピロールイミダゾールポリアミドで生化学的機能および臨床的副作用の予測2018
- Author(s)
  Lin Jason, 平岡桐子, 養田裕行, Krishnamurthy Sakthisri, 篠崎喜脩, 渡部隆義, 高取敦志, 越川信子, Horton Paul, 永瀬浩喜
- Organizer
  第27回日本癌病態治療研究会
- Data Source
  KAKENHI-PROJECT-17K15047
[Presentation] Design of a next-generation affinity-enrichment Chem-seq sequencing procedure to assess the biochemistry of minor-groove-binding pyrrole-imidazole polyamides2017
- Author(s)
  J. Lin, A. Tataktori, K. Hiraoka, H. Yoda, S. Krishnamurthy, T. Inoue, T. Watanabe, T. Kuo, Y. Shinozaki, N. Koshikawa, P. Horton, H. Nagase
- Organizer
  2017年度生命科学系学会合同年次大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15047
[Presentation] 機械学習によるピロールイミダゾールポリアミドでのゲノム結合の解析2017
- Author(s)
  Jason Lin
- Organizer
  "文部科学省先端モデル動物支援プラットフォーム・若手支援技術講習会
- Data Source
  KAKENHI-PROJECT-17K15047
[Presentation] Assessing oncotherapeutic efficacy of minor-groove-binding pyrrole-imidazole polyamides by Chem-seq sequencing2017
- Author(s)
  J. Lin, K. Hiraoka, H. Yoda, A. Takatori, T. Watanabe, T. Kuo, Y. Shinozaki, N. Koshikawa, P. Horton, H. Nagase
- Organizer
  "第76回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15047
[]

1. 永瀬浩喜 (90322073)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
2. 山本清義 (80783521)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
3. 牧瀬尚大 (70815373)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 河津正人 (20401078)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. ATSUSHI Takatori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. WATANABE Takayoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 下里修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 尾崎俊文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

LIN JASON CHING-YAO ＬＩＮ ＪＡＳＯＮ

Lin Jason LIN JASON

Research Projects

Research Products

Co-Researchers

新世代in situ hybridization法の確立と多形肉腫の進化過程の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

深層学習による人工エピゲノム操作因子におけるゲノム干渉効果の評価及び予測Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of anticancer drugs targeting the mutated cancer genome

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analyzing Genomic Binding of Pyrrole-Imidazole Polyamides by Machine LearningPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Implications of Transglutaminase-Mediated Protein Serotonylation in the Epigenetic Landscape, Small Cell Lung Cancer, and Beyond2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Suppression of NSCLC A549 tumor growth by a mtDNA mutation‐targeting pyrrole‐imidazole polyamide‐TPP and a senolytic drug2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Elemental analysis by Metallobalance provides a complementary support layer over existing blood biochemistry panel-based cancer risk assessment2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting the mutant PIK3CA gene by DNA-alkylating pyrrole-imidazole polyamide in cervical cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mitochondria: Endosymbiont bacteria DNA sequence as a target against cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A linear five-ring pyrrole-imidazole polyamide-triphenylphosphonium conjugate targeting a mitochondrial DNA mutation efficiently induces apoptosis of HeLa cybrid cells carrying the mutation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Road Not Taken with Pyrrole-Imidazole Polyamides: Off-Target Effects and Genomic Binding2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CRED: a rapid peak caller for Chem-seq data2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Estimating genome-wide off-target effects for pyrrole-imidazole polyamide binding by a pathway-based expression profiling approach.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hydrophobic structure of hairpin ten-ring pyrrole-imidazole polyamides enhances tumor tissue accumulation/retention in vivo2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Direct Targeting of MYCN Gene Amplification by Site-Specific DNA Alkylation in Neuroblastoma2018

LIN JASON CHING-YAO ＬＩＮＪＡＳＯＮ

[Presentation] 機械学習を用いた配列特異的ピロールイミダゾールポリアミド・ボリノスタット複合体によるがんゲノム結合の評価2021

[Presentation] 発現プロファイリングによるDNA副溝結合剤のピロールイミダゾールポリアミドでのオフターゲット及び副作用の評価・予測2019