Tatsuno Kenji 辰野健二

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TATSUNO Kenji 辰野健二

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Researcher Number	80775239
Other IDs	https://orcid.org/0000-0002-3046-3941
Affiliation (Current)	2024: 東京大学, 先端科学技術研究センター, 特任准教授 2024: 筑波大学, プレシジョン・メディスン開発研究センター, 客員教授
Affiliation (based on the past Project Information) *help	2023: 東京大学, 先端科学技術研究センター, 特任准教授 2017 – 2020: 東京大学, 先端科学技術研究センター, 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Tumor diagnostics Except Principal Investigator Otorhinolaryngology
Keywords	Principal Investigator ゲノム構造異常 / 空間的遺伝子解析 / 悪性胸膜中皮腫 / 癌 / ゲノム解析 / がんゲノム / MSI / ロングリード解析 / AAV2 / HBV / CNV / がんゲノム解析 … More Except Principal Investigator … More 難聴 / 遺伝子 / 難聴遺伝子 / 遺伝 Less

Spatial genetic analysis of malignant pleural mesothelioma to elucidate the acquisition mechanism of malignant transformationPrincipal Investigator
- Principal Investigator
  
  辰野健二
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  The University of Tokyo
Focal copy number alteration and its functional role in carcinogenesis: unmet needs in cancer genome analysisPrincipal Investigator
- Principal Investigator
  
  Kenji Tatsuno
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor diagnostics
- Research Institution
  The University of Tokyo
Target seqencing of hearing loss patients using next generations sequecing
- Principal Investigator
  
  Sakata Aki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Otorhinolaryngology
- Research Institution
  The University of Tokyo

All 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Spatial and temporal expansion of intrahepatic metastasis by molecularly‐defined clonality in multiple liver cancers2020
- Author(s)
  Yamamoto Shogo、Midorikawa Yutaka、Nagae Genta、Tatsuno Kenji、Ueda Hiroki、Moriyama Mitsuhiko、Takayama Tadatoshi、Aburatani Hiroyuki
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 2 Pages: 601-609
- DOI
  10.1111/cas.14282
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07195, KAKENHI-PROJECT-19H01031, KAKENHI-PROJECT-18K07963
[Journal Article] Defined lifestyle and germline factors predispose Asian populations to gastric cancer2020
- Author(s)
  Suzuki A, Katoh H, Komura D, Kakiuchi M, Tagashira A, Yamamoto S, Tatsuno K, Ueda H, Nagae G, Fukuda S, Umeda T, Totoki Y, Abe H, Ushiku T, Matsuura T, Sakai E, Ohshima T, Nomura S, Seto Y, Shibata T, Rino Y, Nakajima A, Fukayama M, Ishikawa S, Aburatani H.
- Journal Title
  
  Science Advances
  
  Volume: 6 Issue: 19 Pages: 9778-9778
- DOI
  10.1126/sciadv.aav9778
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01031, KAKENHI-PROJECT-17K07195, KAKENHI-PROJECT-18K06983, KAKENHI-PROJECT-18K07963, KAKENHI-PROJECT-16H02481
[Journal Article] Base editors for simultaneous introduction of C-to-T and A-to-G mutations2020
- Author(s)
  Sakata Rina C.、Ishiguro Soh、Mori Hideto、Tanaka Mamoru、Tatsuno Kenji、Ueda Hiroki、Yamamoto Shogo、Seki Motoaki、Masuyama Nanami、Nishida Keiji、Nishimasu Hiroshi、Arakawa Kazuharu、Kondo Akihiko、Nureki Osamu、Tomita Masaru、Aburatani Hiroyuki、Yachie Nozomu
- Journal Title
  
  Nature Biotechnology
  
  Volume: na Issue: 7 Pages: 865-869
- DOI
  10.1038/s41587-020-0509-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02428, KAKENHI-PROJECT-18K19777, KAKENHI-PROJECT-17K07195, KAKENHI-PROJECT-17H04994
[Journal Article] Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression2020
- Author(s)
  Midorikawa Yutaka、(17名）Aburatani Hiroyuki
- Journal Title
  
  Cancer Research
  
  Volume: 80 Issue: 18 Pages: 3810-3819
- DOI
  10.1158/0008-5472.can-20-0225
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-19H05739, KAKENHI-PROJECT-19H01031, KAKENHI-PROJECT-17K07195, KAKENHI-PROJECT-18K07963
[Journal Article] Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin‐fixed paraffin‐embedded specimens2019
- Author(s)
  Kohsaka Shinji、Tatsuno Kenji、Ueno Toshihide、et al.
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 4 Pages: 1464-1479
- DOI
  10.1111/cas.13968
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07250, KAKENHI-PROJECT-18K09249, KAKENHI-PROJECT-15KK0353, KAKENHI-PROJECT-15H04964, KAKENHI-PROJECT-15K09230, KAKENHI-PROJECT-16K15670, KAKENHI-PROJECT-17K19608, KAKENHI-PROJECT-17K08730, KAKENHI-PROJECT-17K09669, KAKENHI-PROJECT-18K08185, KAKENHI-PROJECT-17K07195, KAKENHI-PROJECT-19H03715, KAKENHI-PROJECT-18H02677
[Journal Article] DNA demethylation is associated with malignant progression of lower-grade gliomas2019
- Author(s)
  Nomura Masashi、Saito Kuniaki、Aihara Koki、Nagae Genta、Yamamoto Shogo、Tatsuno Kenji、Ueda Hiroki、Fukuda Shiro、Umeda Takayoshi、Tanaka Shota、…、Narita Yoshitaka、Nagane Motoo、Nishikawa Ryo、Ueki Keisuke、Saito Nobuhito、Aburatani Hiroyuki、Mukasa Akitake
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 1903-1903
- DOI
  10.1038/s41598-019-38510-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07963, KAKENHI-PROJECT-19K21240, KAKENHI-PROJECT-15K08987, KAKENHI-PROJECT-16K15641, KAKENHI-PROJECT-17K10874, KAKENHI-PROJECT-18K09004, KAKENHI-PROJECT-17K07195, KAKENHI-PROJECT-17H04300
[Journal Article] Organoid-based ex vivo reconstitution of Kras-driven pancreatic ductal carcinogenesis2019
- Author(s)
  Matsuura Tetsuya、Maru Yoshiaki、Izumiya Masashi、Hoshi Daisuke、Kato Shingo、Ochiai Masako、Hori Mika、Yamamoto Shogo、Tatsuno Kenji、Imai Toshio、Aburatani Hiroyuki、Nakajima Atsushi、Hippo Yoshitaka
- Journal Title
  
  Carcinogenesis
  
  Volume: - Issue: 4 Pages: 1-12
- DOI
  10.1093/carcin/bgz122
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07195, KAKENHI-PROJECT-18K07932, KAKENHI-PROJECT-19K16840, KAKENHI-PLANNED-19H05744, KAKENHI-PROJECT-17K08755, KAKENHI-PROJECT-17K19624, KAKENHI-PROJECT-18K16823, KAKENHI-ORGANIZER-19H05739
[Journal Article] Impact of AAV2 and Hepatitis B Virus Integration Into Genome on Development of Hepatocellular Carcinoma in Patients with Prior Hepatitis B Virus Infection2019
- Author(s)
  Tatsuno Kenji、Midorikawa Yutaka、Takayama Tadatoshi、Yamamoto Shogo、Nagae Genta、Moriyama Mitsuhiko、Nakagawa Hayato、Koike Kazuhiko、Moriya Kyoji、Aburatani Hiroyuki
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 25 Issue: 20 Pages: 6217-6227
- DOI
  10.1158/1078-0432.ccr-18-4041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07195, KAKENHI-PROJECT-18K07963
[Journal Article] Reduced Neoantigen Expression Revealed by Longitudinal Multiomics as a Possible Immune Evasion Mechanism in Glioma.2019
- Author(s)
  Nejo T, Matsushita H, Karasaki T, Nomura M, Saito K, Tanaka S, Takayanagi S, Hana T, Takahashi S, Kitagawa Y, Koike T, Kobayashi Y, Nagae G, Yamamoto S, Ueda H, Tatsuno K, Narita Y, Nagane M, Ueki K, Nishikawa R, Aburatani H, Mukasa A, Saito N, Kakimi K.
- Journal Title
  
  Cancer Immunol Res
  
  Volume: in press Issue: 7 Pages: 1148-1161
- DOI
  10.1158/2326-6066.cir-18-0599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02696, KAKENHI-PROJECT-17K07195, KAKENHI-PROJECT-18K09004, KAKENHI-PROJECT-19H03528, KAKENHI-PROJECT-19H03729, KAKENHI-PROJECT-17K10778, KAKENHI-PROJECT-17H04300
[Journal Article] Epigenetic landscape influences the liver cancer genome architecture2018
- Author(s)
  Natsuko Hama, Yasushi Totoki, Fumihito Miura, Kenji Tatsuno, Mihoko Saito-Adachi, Hiromi Nakamura, Yasuhito Arai, Fumie Hosoda, Tomoko Urushidate, Shoko Ohashi, Wakako Mukai, Nobuyoshi Hiraoka, Hiroyuki Aburatani , Takashi Ito and Tatsuhiro Shibata
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 1643-1643
- DOI
  10.1038/s41467-018-03999-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07956, KAKENHI-PROJECT-17K07195
[Journal Article] BHD-associated kidney cancer exhibits unique molecular characteristics and a wide variety of variants in chromatin remodeling genes2018
- Author(s)
  Hasumi Hisashi、Furuya Mitsuko、Tatsuno Kenji、Aburatani Hiroyuki、Linehan W Marston、Yao Masahiro, et al.
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 印刷中 Issue: 15 Pages: 2712-2724
- DOI
  10.1093/hmg/ddy181
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10600, KAKENHI-PROJECT-17K08745, KAKENHI-PROJECT-17K11162, KAKENHI-PROJECT-18K19619, KAKENHI-PROJECT-18H02938, KAKENHI-PROJECT-16K11020, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-17K07195
[Journal Article] Distinct molecular profile of diffuse cerebellar gliomas2017
- Author(s)
  Nomura M, Mukasa A, Nagae G, Yamamoto S, Tatsuno K, Ueda H, Fukuda S, Umeda T, Suzuki T, Otani R, Kobayashi K, Maruyama T, Tanaka S, Takayanagi S, Nejo T, Takahashi S, Ichimura K, Nakamura T, Muragaki Y, Narita Y, Nagane M, Ueki K, Nishikawa R, Shibahara J, Aburatani H, Saito N
- Journal Title
  
  Acta Neuropathologica
  
  Volume: 134 Issue: 6 Pages: 941-956
- DOI
  10.1007/s00401-017-1771-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08987, KAKENHI-PROJECT-17K07195, KAKENHI-PROJECT-16K15641, KAKENHI-PROJECT-17H04300, KAKENHI-PROJECT-26293321
[Journal Article] Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma2017
- Author(s)
  Ally Adrian, Balasundaram Miruna,,,,Aburatani Hiroyuki, Yamamoto Shogo, Tatsuno Kenji,,,et al
- Journal Title
  
  Cell
  
  Volume: 169 Issue: 7 Pages: 1327-1341.e23
- DOI
  10.1016/j.cell.2017.05.046
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07195
[Presentation] ウイルスインテグレーションと肝がん2020
- Author(s)
  辰野健二、緑川泰、濱奈津子、永江玄太、上田宏生、高山忠利、柴田龍弘、油谷浩幸
- Organizer
  第79回日本癌学会学術総会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07195
[Presentation] リキッドバイオプシーによる肝細胞がんのゲノム・エピゲノムプロファイリング2019
- Author(s)
  辰野健二、永江玄太、山本尚吾、福田史郎、緑川泰、高山忠利、油谷浩幸
- Organizer
  第78回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07195
[Presentation] 255検体悪性胸膜中皮腫の変異・免疫プロファイリング2018
- Author(s)
  竹下純平，辰野健二，山本尚吾，鈴木章浩，白石友一，栗林康造，近藤展行，長谷川誠紀，佐藤鮎子，辻村亨，松本大地，大多茂樹，河上裕，中野孝司，関戸好孝，油谷浩幸
- Organizer
  日本人類遺伝学会第63回大会
- Data Source
  KAKENHI-PROJECT-17K07195
[Presentation] 日本人胃癌の遺伝学的素因2018
- Author(s)
  鈴木章浩、垣内美和子、田頭周、加藤洋人、竹下純平、山本尚吾、辰野健二、大島貴、利野靖、中島淳、深山正久、石川俊平、油谷浩幸
- Organizer
  日本人類遺伝学会第63回大会
- Data Source
  KAKENHI-PROJECT-17K07195
[Presentation] All-in-one panel assay for clinical cancer sequencing2018
- Author(s)
  Kenji Tatsuno, Shinji Kosaka, Hiroki Ueda, Shogo Yamamoto, Shuhei Yoshikawa, Toshihide Ueno, Takashi Aoki, Shiro Fukuda, Kunihiro Nishimura, Hiroyuki Mano, Hiroyuki Aburatani
- Organizer
  Precision Medicine in Cancer, Keystone Symposia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07195
[Presentation] 卵巣明細胞癌における生殖細胞系・体細胞系ミスマッチ修復遺伝子異常2018
- Author(s)
  織田克利、西島明、長谷川幸清、浅田佳代、池田悠至、山本尚吾、永江玄太、辰野健二、黒崎亮、藤原恵一、大須賀穣、藤井知行、油谷浩幸
- Organizer
  日本人類遺伝学会第63回大会
- Data Source
  KAKENHI-PROJECT-17K07195
[Presentation] オカルトB型肝炎ウイルス感染患者での肝細胞がんゲノムへのウイルスゲノム挿入部位解析2018
- Author(s)
  辰野健二、緑川泰、高山忠利、永江玄太、山本尚吾、森山光彦、中川勇人、小池和彦、森屋恭爾、油谷浩幸
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07195
[Presentation] Impact of Virus Integration into the Host Genome on Development of HCC in Patients with Occult HB Virus Infection2018
- Author(s)
  Midorikawa Y, Tatsuno K, Takayama T, Yamamoto S, Nagae G, Moriyama M, Nakagawa H, Koike K, Moriya K, Aburatani H
- Organizer
  第69回米国肝臓学会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07195
[Presentation] Occult HBV肝癌患者におけるB型肝炎ウィルスDNA遺伝子組み込みの網羅的解析2018
- Author(s)
  緑川泰、辰野健二、高山忠利、山本尚吾、永江玄太、森山光彦、小池和彦、森屋恭爾、油谷浩幸
- Organizer
  第54回日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-17K07195
[Presentation] 255症例の悪性胸膜中皮腫の網羅的遺伝子解析2018
- Author(s)
  竹下純平，辰野健二，松本大地，栗林康造，近藤展行，長谷川誠紀，佐藤鮎子，辻村亨，大多茂樹，河上裕，中野孝司，関戸好孝，油谷浩幸
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07195
[Presentation] Impact of virus integration into the genomes of hepatocellular carcinoma patients with prior hepatitis B virus infection2018
- Author(s)
  Midorikawa Y, Tatsuno K, Yamamoto S, Nagae G, Koike K, Moriyama M, Takayama T, Moriya K, Aburatani H
- Organizer
  米国がん学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07195
[Presentation] 高異型度卵巣漿液性癌における統合解析を用いた年齢シグネチャー優位群の特徴付け2017
- Author(s)
  浅田佳代、織田克利、長谷川幸清、西島明、池田悠至、山本尚吾、永江玄太、辰野健二、上田宏生、藤原恵一、大須賀穣、藤井知行、油谷浩幸
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07195
[Presentation] エクソームシーケンスデータからのマイクロサテライト不安定解析2017
- Author(s)
  辰野健二、吉川修平、鈴木章浩、山本尚吾、永江玄太、油谷浩幸
- Organizer
  日本人類遺伝学会第62回大会
- Data Source
  KAKENHI-PROJECT-17K07195
[Presentation] ターゲットシークエンス検査による難聴患者の遺伝学的探索2017
- Author(s)
  坂田阿希、星雄二郎、樫尾明憲、松本有、山岨達也、上田宏生、山本尚吾、辰野健二、油谷浩幸
- Organizer
  日本人類遺伝学会第62回大会
- Data Source
  KAKENHI-PROJECT-17K07195
[Presentation] 日本人胃癌ゲノミックプロファイル2017
- Author(s)
  鈴木章浩、垣内美和子、田頭周、加藤洋人、山本尚吾、辰野健二、酒井英嗣、大島貴、利野靖、中島淳、深山正久、石川俊平、油谷浩幸
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07195
[Presentation] 243 症例の悪性胸膜中皮腫の統合的ゲノム解析2017
- Author(s)
  竹下純平、山本尚吾、辰野健二、白石友一、大搗泰一郎、栗林康造、近藤展行、長谷川誠紀、佐藤鮎子、辻村亨、中野孝司、関戸好孝、油谷浩幸
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07195

1. Sakata Aki (80783860)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. YAMASOBA Tatsuya (60251302)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. KASHIO Akinori (20451809)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. ABURATANI Hiroyuki (10202657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 永江玄太

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 新井康仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 上野敏秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 谷内江望

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 矢尾正祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 古屋充子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 蓮見壽史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 垣見和宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tatsuno Kenji 辰野 健二

TATSUNO Kenji 辰野 健二

Research Projects

Research Products

Co-Researchers

Spatial genetic analysis of malignant pleural mesothelioma to elucidate the acquisition mechanism of malignant transformationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Focal copy number alteration and its functional role in carcinogenesis: unmet needs in cancer genome analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Target seqencing of hearing loss patients using next generations sequecing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Spatial and temporal expansion of intrahepatic metastasis by molecularly‐defined clonality in multiple liver cancers2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Defined lifestyle and germline factors predispose Asian populations to gastric cancer2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Base editors for simultaneous introduction of C-to-T and A-to-G mutations2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin‐fixed paraffin‐embedded specimens2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DNA demethylation is associated with malignant progression of lower-grade gliomas2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Organoid-based ex vivo reconstitution of Kras-driven pancreatic ductal carcinogenesis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of AAV2 and Hepatitis B Virus Integration Into Genome on Development of Hepatocellular Carcinoma in Patients with Prior Hepatitis B Virus Infection2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reduced Neoantigen Expression Revealed by Longitudinal Multiomics as a Possible Immune Evasion Mechanism in Glioma.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epigenetic landscape influences the liver cancer genome architecture2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] BHD-associated kidney cancer exhibits unique molecular characteristics and a wide variety of variants in chromatin remodeling genes2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distinct molecular profile of diffuse cerebellar gliomas2017

Author(s)

Tatsuno Kenji 辰野健二

TATSUNO Kenji 辰野健二

[Presentation] 高異型度卵巣漿液性癌における統合解析を用いた年齢シグネチャー優位群の特徴付け2017