Morikawa Masato 森川真大

Researcher Number	80775833
Other IDs	https://orcid.org/0000-0002-6191-7176
Affiliation (Current)	2026: 帝京大学, 先端総合研究機構, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 帝京大学, 先端総合研究機構, 准教授 2016 – 2021: 東京大学, 大学院医学系研究科(医学部), 助教
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Basic Section 50010:Tumor biology-related / Pathological medical chemistry / General medical chemistry Except Principal Investigator Complex systems
Keywords	Principal Investigator 悪液質 / FSTL3 / フォリスタチン / ミオスタチン / アクチビン / 再生医学 / シグナル伝達 / エピゲノム / 骨形成因子 / 骨格筋 … More / サルコペニア / ミオスタチン阻害薬 / 乳がん / 抗ミオスタチン療法 / 骨格筋肥大 / TGF-β / Fc融合蛋白 / 筋ジストロフィー / 癌 / ヘテロクロマチン / BMP / エピジェネティック / ES細胞 / 腫瘍化 / 未分化性維持 / 骨形成因子（BMP） / 上皮間葉転換 / 次世代シークエンサー / 発生・分化 / 脱メチル化酵素 … More Except Principal Investigator 癌 / シグナル伝達 / 発生・分化 Less

Evaluation of FSTL3-based therapeutics targeting activin and myostatin in a muscle atrophy modelPrincipal Investigator
- Principal Investigator
  
  Masato Morikawa
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Teikyo University
Development of a selective inhibitor of Activin and its application in a cancer-bearing mouse modelPrincipal Investigator
- Principal Investigator
  
  Morikawa Masato
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Teikyo University
  The University of Tokyo
Roles of bone morphogenetic protein (BMP) in pluripotency and tumorigenesisPrincipal Investigator
- Principal Investigator
  
  Morikawa Masato
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo
Molecular mechanisms of cell differentiation and diversity by TGF-beta family members
- Principal Investigator
  
  Miyazono Kohei
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
骨形成因子（BMP）シグナルによる細胞分化・運命決定と可塑性の制御Principal Investigator
- Principal Investigator
  
  森川真大
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokyo

All 2022 2021 2019 2018 2017

All Journal Article Presentation

[Journal Article] Systemic administration of monovalent follistatin-like 3-Fc-fusion protein increases muscle mass in mice2021
- Author(s)
  Ozawa T., Morikawa M., Morishita Y., Ogikubo K., Itoh F., Koinuma D., Nygren P.-A., Miyazono K.
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 5 Pages: 102488-102488
- DOI
  10.1016/j.isci.2021.102488
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07683, KAKENHI-PROJECT-20K07430, KAKENHI-PLANNED-17H06326
[Journal Article] Preparation of monovalent follistatin-like 3-Fc-fusion protein and evaluation of its effects on muscle mass in mice2021
- Author(s)
  Ozawa T., Miyazono K., Morikawa M.
- Journal Title
  
  STAR Protocols
  
  Volume: 2 Issue: 4 Pages: 100839-100839
- DOI
  10.1016/j.xpro.2021.100839
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07683, KAKENHI-PLANNED-17H06326
[Journal Article] PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma‐initiating cell properties via DNA methyltransferase 3A2021
- Author(s)
  Tanabe Ryo、Miyazono Kohei、Todo Tomoki、Saito Nobuhito、Iwata Caname、Komuro Akiyoshi、Sakai Satoshi、Raja Erna、Koinuma Daizo、Morikawa Masato、Westermark Bengt、Heldin Carl‐Henrik
- Journal Title
  
  Molecular Oncology
  
  Volume: 16 Issue: 1 Pages: 269-288
- DOI
  10.1002/1878-0261.13051
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06829, KAKENHI-PLANNED-17H06326
[Journal Article] Tyrosine kinase Eph receptor A6 sensitizes glioma-initiating cells towards bone morphogenetic protein-induced apoptosis2019
- Author(s)
  Raja E, Morikawa M, Nishida J, Tanabe R, Takahashi K, Seeherman HJ, Saito N, Todo T, Miyazono K.
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 11 Pages: 3486-3496
- DOI
  10.1111/cas.14187
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06326
[Journal Article] The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension2019
- Author(s)
  Morikawa M、Mitani Y、Holmborn K、Kato T、Koinuma D、Maruyama J、Vasilaki E、Sawada H、Kobayashi M、Ozawa T、Morishita i、Bessho Y、Maeda S、Ledin J、Aburatani H、Kageyama R、Maruyama K、Heldin C-H、Miyazono K
- Journal Title
  
  Science Signaling
  
  Volume: 12 Issue: 607 Pages: 607-607
- DOI
  10.1126/scisignal.aay4430
- NAID
  120006902530
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08192, KAKENHI-PROJECT-19K22433, KAKENHI-PLANNED-17H06326, KAKENHI-PUBLICLY-19H04782, KAKENHI-PROJECT-18H02451, KAKENHI-PROJECT-17K11075, KAKENHI-PROJECT-18K07841
[Journal Article] Intracellular and extracellular TGF-β signaling in cancer: some recent topics.2018
- Author(s)
  Kohei Miyazono, Yoko Katsuno, Daizo Koinuma, Shogo Ehata, Masato Morikawa
- Journal Title
  
  Frontiers of Medicine
  
  Volume: 12 Issue: 4 Pages: 387-411
- DOI
  10.1007/s11684-018-0646-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06324, KAKENHI-PROJECT-15H05774, KAKENHI-PLANNED-17H06326
[Journal Article] Identification of a novel fusion gene HMGA2-EGFR in glioblastoma2017
- Author(s)
  Komuro Akiyoshi、Raja Erna、Iwata Caname、Soda Manabu、Isogaya Kazunobu、Yuki Keiko、Ino Yasushi、Morikawa Masato、Todo Tomoki、Aburatani Hiroyuki、Suzuki Hiromichi、Ranjit Melissa、Natsume Atsushi、Mukasa Akitake、Saito Nobuhito、Okada Hitoshi、Mano Hiroyuki、Miyazono Kohei、Koinuma Daizo
- Journal Title
  
  International Journal of Cancer
  
  Volume: 142 Issue: 8 Pages: 1627-1639
- DOI
  10.1002/ijc.31179
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15641, KAKENHI-PLANNED-17H06326, KAKENHI-PROJECT-15H05774, KAKENHI-PROJECT-26253073, KAKENHI-PROJECT-16H05436, KAKENHI-PROJECT-15K06831, KAKENHI-PROJECT-17H04300, KAKENHI-PROJECT-26293321, KAKENHI-PROJECT-26830067
[Presentation] Systemic administration of monovalent follistatin-like 3-Fc-fusion protein increases muscle mass in mice (Poster)2022
- Author(s)
  Morikawa M, Ozawa TA, Miyazono K.
- Organizer
  2nd Annual TGF-β for Immuno-Oncology Drug Development Summit (online) 2022年
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06326
[Presentation] Follistatin-like 3-based ligand trap increases muscle mass in mice2022
- Author(s)
  Morikawa Masato、Miyazono Kohei
- Organizer
  13th International BMP Conference, Dubrovnik, Croatia
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07683
[Presentation] Systemic administration of monovalent follistatin-like 3-Fc-fusion protein increases muscle mass in mice2021
- Author(s)
  Morikawa M., Ozawa T., Miyazono K.
- Organizer
  virtual FASEB Science Research Conference, The TGF-β Superfamily Conference: Signaling in Development and Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07683
[Presentation] Systemic administration of monovalent follistatin-like 3-Fc-fusion protein increases muscle mass in mice (Oral, Award for the Best Short Talk)2021
- Author(s)
  Morikawa M, Ozawa T, Miyazono K.
- Organizer
  FASEB Science Research Conference, The TGF-β Superfamily: Signaling in Development and Disease (online)
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06326
[Presentation] Identification of genes and their regulatory mechanisms related to the metastasis of triple-negative breast cancer (Oral)2021
- Author(s)
  Ogikubo K, Tamura Y, Nishida J, Takahashi K, Morikawa M, Ehata S, Koinuma D, Miyazono K.
- Organizer
  第80回日本癌学会学術総会（横浜、hybrid）
- Data Source
  KAKENHI-PLANNED-17H06326
[Presentation] Tyrosine kinase receptor EphA6 sensitizes glioblastoma cells towards BMP-induced apoptosis2019
- Author(s)
  Raja E, Morikawa M, Tanabe R, Ino Y, Saito N, Todo T, Miyazono K.
- Organizer
  Elventh AACR-JCA Joint Conference on Breakthroughs in Cancer Research: Biology to Precision Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06326
[Presentation] Tyrosine kinase Eph receptor A6 sensitizes glioma-initiating cells towards bone morphogenetic protein-induced apoptosis2019
- Author(s)
  Morikawa M, Raja E, Miyazono K
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PLANNED-17H06326
[Presentation] JUNB governs a feed-forward network of TGF-beta signaling that aggravates breast cancer invasion2019
- Author(s)
  Masato Morikawa, Anders Sundqvist, Jiang Ren, Eleftheria Vasilaki, Natsumi Kawasaki, Mai Kobayashi, Daizo Koinuma, Hiroyuki Aburatani, Kohei Miyazono, Carl-Henrik Heldin, Hans van Dam, Peter ten Dijke
- Organizer
  11th AACR-JCA Joint Conference on Breakthroughs in Cancer Research: From Biology to Precision Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15610

1. Miyazono Kohei (90209908)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
2. 鯉沼代造 (80375071)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 江幡正悟 (90506726)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. MUKASA Akitake

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 丸山一男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 丸山淳子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 古室暁義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Morikawa Masato 森川 真大

Research Projects

Research Products

Co-Researchers

Evaluation of FSTL3-based therapeutics targeting activin and myostatin in a muscle atrophy modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a selective inhibitor of Activin and its application in a cancer-bearing mouse modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Roles of bone morphogenetic protein (BMP) in pluripotency and tumorigenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of cell differentiation and diversity by TGF-beta family members

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

骨形成因子（BMP）シグナルによる細胞分化・運命決定と可塑性の制御Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Systemic administration of monovalent follistatin-like 3-Fc-fusion protein increases muscle mass in mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preparation of monovalent follistatin-like 3-Fc-fusion protein and evaluation of its effects on muscle mass in mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma‐initiating cell properties via DNA methyltransferase 3A2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tyrosine kinase Eph receptor A6 sensitizes glioma-initiating cells towards bone morphogenetic protein-induced apoptosis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Intracellular and extracellular TGF-β signaling in cancer: some recent topics.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of a novel fusion gene HMGA2-EGFR in glioblastoma2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] Systemic administration of monovalent follistatin-like 3-Fc-fusion protein increases muscle mass in mice (Poster)2022

Author(s)

Organizer

Data Source

[Presentation] Follistatin-like 3-based ligand trap increases muscle mass in mice2022

Author(s)

Organizer

Data Source

[Presentation] Systemic administration of monovalent follistatin-like 3-Fc-fusion protein increases muscle mass in mice2021

Author(s)

Morikawa Masato 森川真大