Chang Song Ho 張成虎

Researcher Number	80780551
Other IDs
Affiliation (based on the past Project Information) *help	2019: 東京大学, 医学部附属病院, 助教 2019: 東京大学, 医学部附属病院, 特任臨床医 2018: 東京大学, 医学部附属病院, 登録研究員 2017: 東京大学, 医学部附属病院, 特任臨床医
Review Section/Research Field	Principal Investigator Orthopaedic surgery Except Principal Investigator Orthopaedic surgery
Keywords	Principal Investigator メカニカルストレス / VEGFR2 / NF-kBシグナル / 力学的負荷 / 軟骨代謝 / 力学的ストレス / 変形性関節症 Except Principal Investigator 骨・軟骨代謝学 / 変形性関節症 / 骨軟骨代謝学 … More / 関節最表層 / 整形外科学 / メカニカルストレス / 滑膜組織 / 軟骨前駆細胞 / メカノセンサー / Fluid Flow Shear Stress / Lubricin / 軟骨分化 / メカノトランスデューサー / 関節軟骨表層 / 軟骨細胞 / Trpv2 / メカノセンシティブイオンチャネル / 変形性膝関節症 / 医療・福祉 / laser micro dissection / FACS / RNAシークエンス / LMD / 腱再生 / 腱 Less

Elucidation of tendon regeneration mechanism using achilles tendon resection model.
- Principal Investigator
  
  Uehara Kosuke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
Mechano-sensor TRPV2 is involved in lubricin induction and suppression of ectopic endochondral ossification in articular joints
- Principal Investigator
  
  Kawaguchi Kohei
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
Investigation of new osteoarthritis treatment targeting GREM1 induced by excessive mechanical stress loading.Principal Investigator
- Principal Investigator
  
  Chang Song Ho
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
Regulation of Articular Chondrocyte Differentiation
- Principal Investigator
  
  Saito Taku
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo

All 2020 2019 2017

All Journal Article Presentation

[Journal Article] Association between fall history and performance-based physical function and postural sway in patients with rheumatoid arthritis.2020
- Author(s)
  Kawabata K, Matsumoto T, Kasai T, Chang SH, Hirose J, Tanaka S.
- Journal Title
  
  Mod Rheumatol
  
  Volume: 1-7 Issue: 2 Pages: 373-379
- DOI
  10.1080/14397595.2020.1731134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10956
[Journal Article] Hypoxia-inducible factor-1 alpha maintains mouse articular cartilage through suppression of NF-κB signaling2020
- Author(s)
  Okada Keita、Mori Daisuke、Makii Yuma、Nakamoto Hideki、Murahashi Yasutaka、Yano Fumiko、Chang Song Ho、Taniguchi Yuki、Kobayashi Hiroshi、Semba Hiroaki、Takeda Norihiko、Piao Wen、Hanaoka Kenjiro、Nagano Tetsuo、Tanaka Sakae、Saito Taku
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 5425-5425
- DOI
  10.1038/s41598-020-62463-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09568, KAKENHI-PROJECT-19K22677, KAKENHI-PUBLICLY-18H04609, KAKENHI-PUBLICLY-19H05414, KAKENHI-PROJECT-17H04310, KAKENHI-PROJECT-18H02360, KAKENHI-PROJECT-20K20473, KAKENHI-PROJECT-17K10956, KAKENHI-PROJECT-17K10996, KAKENHI-PROJECT-17K10998, KAKENHI-PROJECT-20K09452, KAKENHI-PROJECT-16H05099, KAKENHI-PROJECT-18K09017, KAKENHI-PROJECT-18K09055, KAKENHI-PROJECT-19K09641, KAKENHI-PROJECT-17K10955, KAKENHI-PROJECT-17K10997
[Journal Article] Alleviation of murine osteoarthritis by deletion of the focal adhesion mechanosensitive adapter, Hic-52019
- Author(s)
  Miyauchi Aya、Kim-Kaneyama Joo-ri、Lei Xiao-Feng、Chang Song Ho、Saito Taku、Haraguchi Shogo、Miyazaki Takuro、Miyazaki Akira
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 15770-15770
- DOI
  10.1038/s41598-019-52301-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08404, KAKENHI-PROJECT-19K08590, KAKENHI-PROJECT-19K09033, KAKENHI-PROJECT-19H03110, KAKENHI-PROJECT-17K09869, KAKENHI-PROJECT-17K10713, KAKENHI-PROJECT-17K10955, KAKENHI-PROJECT-17K10997
[Journal Article] Excessive mechanical loading promotes osteoarthritis through the gremlin-1?NF-κB pathway2019
- Author(s)
  Chang Song Ho、Mori Daisuke、Kobayashi Hiroshi、Mori Yoshifumi、Nakamoto Hideki、Okada Keita、Taniguchi Yuki、Sugita Shurei、Yano Fumiko、Chung Ung-il、Kim-Kaneyama Joo-ri、Yanagita Motoko、Economides Aris、Canalis Ernesto、Chen Di、Tanaka Sakae、Saito Taku
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 1442-1442
- DOI
  10.1038/s41467-019-09491-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10997, KAKENHI-PROJECT-17K16675, KAKENHI-PROJECT-17H04310, KAKENHI-PROJECT-16K10553, KAKENHI-PROJECT-17K19715, KAKENHI-PROJECT-19K08404, KAKENHI-PROJECT-19K22620, KAKENHI-PUBLICLY-18H04673, KAKENHI-PROJECT-17H04187, KAKENHI-PROJECT-17K10956, KAKENHI-PROJECT-17K10998, KAKENHI-PROJECT-17K10955
[Journal Article] Sandwich-type PLLA-nanosheets loaded with BMP-2 induce bone regeneration in critical-sized mouse calvarial defects2017
- Author(s)
  Huang KC, Yano F, Murahashi Y, Takano S, Kitaura Y, Chang SH, Soma K, Ueng SWN, Tanaka S, Ishihara K, Okamura Y, Moro T, Saito T
- Journal Title
  
  Acta Biomater
  
  Volume: 59 Pages: 12-20
- DOI
  10.1016/j.actbio.2017.06.041
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10998, KAKENHI-PROJECT-17H04310, KAKENHI-PROJECT-15K10461, KAKENHI-PROJECT-15K10462
[Journal Article] A Mouse Intervertebral Disc Degeneration Model by Surgically-Induced Instability2017
- Author(s)
  Oichi T, Taniguchi Y, Soma K, Chang SH, Yano F, Tanaka S, Saito T
- Journal Title
  
  Spine
  
  Volume: ― Issue: 10 Pages: 1-1
- DOI
  10.1097/brs.0000000000002427
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10811, KAKENHI-PROJECT-17K10956, KAKENHI-PROJECT-15K10461, KAKENHI-PROJECT-15K10462, KAKENHI-PROJECT-15K15536, KAKENHI-PROJECT-17K10998, KAKENHI-PROJECT-17K10955
[Journal Article] Regulation of Chondrocyte Survival in Mouse Articular Cartilage by p63.2017
- Author(s)
  Taniguchi Y, Kawata M, Chang SH, Mori D, Okada K, Kobayashi H, Sugita S, Hosaka Y, Inui H, Taketomi S, Yano F, Ikeda T, Akiyama H, Mills AA, Chung UI, Tanaka S, Kawaguchi H, and Saito T*
- Journal Title
  
  Arthritis Rheumatol.
  
  Volume: 69 Issue: 3 Pages: 598-609
- DOI
  10.1002/art.39976
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253087, KAKENHI-PROJECT-15K10461, KAKENHI-PROJECT-16K10887, KAKENHI-PROJECT-15K15536, KAKENHI-PROJECT-15K15535, KAKENHI-PROJECT-17K10997, KAKENHI-PROJECT-17H04310, KAKENHI-PROJECT-17H04311, KAKENHI-PROJECT-15K10462, KAKENHI-PROJECT-26293330, KAKENHI-PROJECT-26462285, KAKENHI-PROJECT-25713052
[Presentation] 過剰なメカニカルストレスは Gremlin-1-NF-kB シグナルを介して変形性関節症を引き起こす2020
- Author(s)
  張成虎
- Organizer
  第33回　日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-17K16675
[Presentation] GREMLIN1 INDUCED BY EXCESSIVE MECHANICAL STRESS LOADING ENHANCES CARTILAGE　DEGRADATION.2019
- Author(s)
  張成虎
- Organizer
  The 7th Seoul Symposium on Bone Health,Seoul,Korea 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16675

1. Saito Taku (30456107)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. Uehara Kosuke (20599063)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Kawaguchi Kohei (40794227)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 森崎裕 (30508099)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 矢野文子 (80529040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 武冨修治 (70570018)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 小林寛 (20407951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OKA Hiroyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 金山朱里

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 川口浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 鄭雄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 乾洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 岡田慶太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 森大典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Chang Song Ho 張 成虎

Research Projects

Research Products

Co-Researchers

Elucidation of tendon regeneration mechanism using achilles tendon resection model.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechano-sensor TRPV2 is involved in lubricin induction and suppression of ectopic endochondral ossification in articular joints

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of new osteoarthritis treatment targeting GREM1 induced by excessive mechanical stress loading.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of Articular Chondrocyte Differentiation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Association between fall history and performance-based physical function and postural sway in patients with rheumatoid arthritis.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hypoxia-inducible factor-1 alpha maintains mouse articular cartilage through suppression of NF-κB signaling2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Alleviation of murine osteoarthritis by deletion of the focal adhesion mechanosensitive adapter, Hic-52019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Excessive mechanical loading promotes osteoarthritis through the gremlin-1?NF-κB pathway2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sandwich-type PLLA-nanosheets loaded with BMP-2 induce bone regeneration in critical-sized mouse calvarial defects2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Mouse Intervertebral Disc Degeneration Model by Surgically-Induced Instability2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of Chondrocyte Survival in Mouse Articular Cartilage by p63.2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] 過剰なメカニカルストレスは Gremlin-1-NF-kB シグナルを介して変形性関節症を引き起こす2020

Author(s)

Organizer

Data Source

[Presentation] GREMLIN1 INDUCED BY EXCESSIVE MECHANICAL STRESS LOADING ENHANCES CARTILAGE DEGRADATION.2019

Author(s)

Organizer

Data Source

Chang Song Ho 張成虎

[Presentation] GREMLIN1 INDUCED BY EXCESSIVE MECHANICAL STRESS LOADING ENHANCES CARTILAGE　DEGRADATION.2019