Sato Hajime 佐藤玄

Researcher Number	80782648
Other IDs
Affiliation (Current)	2026: 東京大学, 大学院農学生命科学研究科(農学部), 准教授
Affiliation (based on the past Project Information) *help	2024 – 2025: 東京大学, 大学院農学生命科学研究科(農学部), 助教 2023 – 2024: 山梨大学, 大学院総合研究部, 特任助教 2022: 山梨大学, 工学部, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 37010:Bio-related chemistry / Basic Section 37020:Chemistry and chemical methodology of biomolecules-related Except Principal Investigator Transformative Research Areas, Section (II)
Keywords	Principal Investigator DFT / テルペン / 機械学習 / MD計算 / MD / 立体構造予測 / 酵素 / 天然物化学 / 計算化学 Except Principal Investigator 理論計算 … More / 生合成 / 理論生合成解析 / 生合成経路理論解析 / 逆生合成理論解析 / 生合成経路解析 Less

Analysis and Rational Modification of Variexenol Biosynthesis Reaction Mechanism through the Utilization of Computational ChemistryPrincipal Investigator
- Principal Investigator
  
  佐藤玄
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  The University of Tokyo
Analysis of terpene cyclization reactions based on computational chemistry, synthetic organic chemistry, and biochemistryPrincipal Investigator
- Principal Investigator
  
  Sato Hajime
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  University of Yamanashi
計算科学の利活用による未知生合成経路の解明と未踏天然物の創出
- Principal Investigator
  
  内山真伸
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  The University of Tokyo

All 2025 2024 2023 2022

All Journal Article Presentation

[Journal Article] Discovery and Theoretical Studies of Nonenzymatic Polyketide Dimerizations of Chaetophenols2025
- Author(s)
  Matsui Hiroto、Morishita Yohei、Yamamoto Takashi、Ozaki Taro、Sugawara Akihiro、Masumoto Yui、Watanabe Mamoru、Watanabe Ayumi、Sato Hajime、Kanazawa Junichiro、Taniguchi Tohru、Uchiyama Masanobu、Asai Teigo
- Journal Title
  
  Organic Letters
  
  Volume: 27 Issue: 5 Pages: 1095-1099
- DOI
  10.1021/acs.orglett.4c04346
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22H05125, KAKENHI-PROJECT-23K24038, KAKENHI-PROJECT-23K26782, KAKENHI-PROJECT-24K18294
[Journal Article] Seven-Membered Ring Formation in Triterpene Biosynthesis: A Key Cyclopropane Rearrangement in Ilelic Acid Biosynthesis2025
- Author(s)
  Nakano Moe、Hiasa Kazuma、Sato-Shimizu Satoko、Sato Hajime
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 90 Issue: 8 Pages: 2907-2914
- DOI
  10.1021/acs.joc.4c02541
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22H05125, KAKENHI-PROJECT-24K01626
[Journal Article] Theoretical Study of Natural Product Biosynthesis Using Computational Chemistry.2024
- Author(s)
  Hajime Sato
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K14791
[Journal Article] DFT Study on Retigerane-Type Sesterterpenoid Biosynthesis: Initial Conformation of GFPP Regulates Biosynthetic Pathway, Ring-Construction Order and Stereochemistry2024
- Author(s)
  Watanabe Yuichiro、Hashishin Takahiro、Sato Hajime、Matsuyama Taro、Nakajima Masaya、Haruta Jun-ichi、Uchiyama Masanobu
- Journal Title
  
  JACS Au
  
  Volume: 4 Issue: 9 Pages: 3484-3491
- DOI
  10.1021/jacsau.4c00313
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22H05125, KAKENHI-PROJECT-22H00320, KAKENHI-PROJECT-24K01626, KAKENHI-PROJECT-24KJ0947
[Journal Article] Dearomative Construction of 2D/3D Frameworks from Quinolines via Nucleophilic Addition/Borate‐Mediated Photocycloaddition2024
- Author(s)
  Shimose Asuha、Ishigaki Shiho、Sato Yu、Nogami Juntaro、Toriumi Naoyuki、Uchiyama Masanobu、Tanaka Ken、Nagashima Yuki
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 63 Issue: 41
- DOI
  10.1002/anie.202403461
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22H05125, KAKENHI-PUBLICLY-24H01839, KAKENHI-PROJECT-22H00320, KAKENHI-PROJECT-23K26649, KAKENHI-PROJECT-24KJ1103
[Journal Article] Visible-Light-Induced trans-Hydroboration of Diaryl Alkynes Utilizing Excited State of Borate Complexes2024
- Author(s)
  Komaki Takahiro、Sato Yu、Uchiyama Masanobu、Tanaka Ken、Nagashima Yuki
- Journal Title
  
  Organic Letters
  
  Volume: 26 Issue: 11 Pages: 2180-2185
- DOI
  10.1021/acs.orglett.4c00268
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22H05125, KAKENHI-PROJECT-22H00320, KAKENHI-PROJECT-23K26649
[Journal Article] Metalla‐Carbaporphyrinoids Consisting of an Acyclic N‐Confused Tetrapyrrole Analogue Served as Stable Near‐Infrared‐II Dyes2024
- Author(s)
  Basumatary Biju、Tsuruda Hidetoshi、Szczepanik Dariusz W.、Lee Jiyeon、Ryu Jaehyeok、Mori Shigeki、Yamagata Kyo、Tanaka Takayuki、Muranaka Atsuya、Uchiyama Masanobu、Kim Jiwon、Ishida Masatoshi、Furuta Hiroyuki
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 63 Issue: 23
- DOI
  10.1002/anie.202405059
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22H05125, KAKENHI-PROJECT-22H00320
[Journal Article] Structural-model-based genome mining can efficiently discover novel non-canonical terpene synthases hidden in genomes of diverse species2024
- Author(s)
  Abe Tohru、Shiratori Haruna、Kashiwazaki Kosuke、Hiasa Kazuma、Ueda Daijiro、Taniguchi Tohru、Sato Hajime、Abe Takashi、Sato Tsutomu
- Journal Title
  
  Chemical Science
  
  Volume: 15 Issue: 27 Pages: 10402-10407
- DOI
  10.1039/d4sc01381f
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22H05125, KAKENHI-PUBLICLY-23H04550, KAKENHI-PROJECT-23K26782, KAKENHI-PROJECT-24K01626, KAKENHI-PROJECT-24K23120
[Journal Article] Theoretical Study of Natural Product Biosynthesis Using Computational Chemistry2024
- Author(s)
  Sato Hajime
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 72 Issue: 6 Pages: 524-528
- DOI
  10.1248/cpb.c24-00082
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2024-06-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22H05125
[Journal Article] Cycloisomerization of enynones by aluminum halides: construction of bicyclo[3.1.0]hexanes by introducing halides2023
- Author(s)
  Sato Daisuke、Tsubouchi Akira、Watanabe Yuichiro、Noguchi Keiichi、Miyamoto Kazunori、Uchiyama Masanobu、Saito Akio
- Journal Title
  
  Organic Chemistry Frontiers
  
  Volume: 10 Issue: 5 Pages: 1112-1118
- DOI
  10.1039/d2qo01845d
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22H05125, KAKENHI-PROJECT-22H00320, KAKENHI-PROJECT-20H02720
[Journal Article] TEAD1 trapping by the Q353R?Lamin A/C causes dilated cardiomyopathy2023
- Author(s)
  Yamada S、et al.,
- Journal Title
  
  Science Advances
  
  Volume: 9 Issue: 15 Pages: 1-1
- DOI
  10.1126/sciadv.ade7047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06809, KAKENHI-PROJECT-21K16082, KAKENHI-PROJECT-21H05045, KAKENHI-PROJECT-21K16047, KAKENHI-PROJECT-22H00471, KAKENHI-PLANNED-19H05744, KAKENHI-PLANNED-21H05254, KAKENHI-PLANNED-22H05125, KAKENHI-PROJECT-22H00320, KAKENHI-PROJECT-23K24057
[Journal Article] Concertedness and Activation Energy Control by Distal Methyl Group during Ring Contraction/Expansion in Scalarane‐Type Sesterterpenoid Biosynthesis2023
- Author(s)
  Sato Hajime、Nakano Moe
- Journal Title
  
  Chemistry ? A European Journal
  
  Volume: 29 Issue: 11
- DOI
  10.1002/chem.202203076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K14791
[Journal Article] Mechanistic Investigation of the Degradation Pathways of α-β/α-α Bridged Epipolythiodioxopiperazines (ETPs)2023
- Author(s)
  Daiki Kurita, Hajime Sato, Kazunori Miyamoto, Masanobu Uchiyama
- Journal Title
  
  J. Org. Chem.
  
  Volume: 88 Issue: 17 Pages: 12797-12801
- DOI
  10.1021/acs.joc.3c01061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K14791, KAKENHI-PLANNED-22H05125, KAKENHI-PROJECT-22H00320
[Journal Article] Revision of Peniroquesine Biosynthetic Pathway by Retro-biosynthetic Theoretical Analysis: Ring Strain Controls the Unique Carbocation Rearrangement Cascade2023
- Author(s)
  Taro Matsuyama, Ko Togashi, Moe Nakano, Hajime Sato, Masanobu Uchiyama
- Journal Title
  
  JACS Au
  
  Volume: 3 Issue: 6 Pages: 1596-1603
- DOI
  10.1021/jacsau.3c00039
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K14791, KAKENHI-PLANNED-22H05125, KAKENHI-PROJECT-22H00320
[Journal Article] Unraveling the Role of Prenyl Side-Chain Interactions in Stabilizing the Secondary Carbocation in the Biosynthesis of Variexenol B2023
- Author(s)
  Moe Nakano, Rintaro Gemma, Hajime Sato
- Journal Title
  
  Beilstein J. Org. Chem.
  
  Volume: 19 Pages: 1503-1510
- DOI
  10.3762/bjoc.19.107
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K14791
[Journal Article] Theoretical Study of the Rearrangement Reaction in Bisorbicillinoid Biosynthesis: Insights into the Molecular Mechanisms Involved2023
- Author(s)
  Moe Nakano, Hajime Sato
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 21 Issue: 26 Pages: 5366-5371
- DOI
  10.1039/d3ob00728f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K14791
[Journal Article] DFT Study on the Biosynthesis of Asperterpenol and Preasperterpenoid Sesterterpenoids: Exclusion of Secondary Carbocation Intermediates and Origin of Structural Diversification2022
- Author(s)
  Sakamoto Kyoka、Sato Hajime、Uchiyama Masanobu
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 87 Issue: 9 Pages: 6432-6437
- DOI
  10.1021/acs.joc.2c00291
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22H05125, KAKENHI-PROJECT-22H00320
[Journal Article] General Design Strategy to Precisely Control the Emission of Fluorophores via a Twisted Intramolecular Charge Transfer (TICT) Process2022
- Author(s)
  Hanaoka Kenjiro、Iwaki Shimpei、Yagi Kiyoshi、Myochin Takuya、Ikeno Takayuki、Ohno Hisashi、Sasaki Eita、Komatsu Toru、Ueno Tasuku、Uchigashima Motokazu、Mikuni Takayasu、Tainaka Kazuki、Tahara Shinya、Takeuchi Satoshi、Tahara Tahei、Uchiyama Masanobu、Nagano Tetsuo、Urano Yasuteru
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 144 Issue: 43 Pages: 19778-19790
- DOI
  10.1021/jacs.2c06397
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19355, KAKENHI-ORGANIZER-20H05914, KAKENHI-PLANNED-20H05918, KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-21H05262, KAKENHI-PLANNED-22H05125, KAKENHI-PUBLICLY-22H05491, KAKENHI-PROJECT-19H05632, KAKENHI-PROJECT-19H00889, KAKENHI-PROJECT-22H00320, KAKENHI-PROJECT-20H02701, KAKENHI-PROJECT-20H03337, KAKENHI-PROJECT-20H03349, KAKENHI-PROJECT-21F21113, KAKENHI-PUBLICLY-21H00188, KAKENHI-PROJECT-23K23484, KAKENHI-PROJECT-23K24198
[Journal Article] Elucidation of Late-Stage Biosynthesis of Phomoidride: Proposal of Cyclization Mechanism Affording Characteristic Nine-Membered Ring of Fungal Dimeric Anhydride2022
- Author(s)
  Yamamoto Shintaro、Matsuyama Taro、Ozaki Taro、Takino Junya、Sato Hajime、Uchiyama Masanobu、Minami Atsushi、Oikawa Hideaki
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 144 Issue: 46 Pages: 20998-21004
- DOI
  10.1021/jacs.2c09308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K14791, KAKENHI-PLANNED-22H05125, KAKENHI-PROJECT-22H00320, KAKENHI-PROJECT-20J20880, KAKENHI-PROJECT-23K23471
[Presentation] 分子の舞台裏を解き明かす - 計算化学が導く新発見2024
- Author(s)
  佐藤玄
- Organizer
  令和6年度日本化学会関東支部講演会
- Invited
- Data Source
  KAKENHI-PROJECT-24K01626
[Presentation] 逆生合成理論解析を用いた peniroquesine の生合成機構解明2024
- Author(s)
  松山太郎, 中野萌恵, 佐藤玄, 内山真伸
- Organizer
  日本薬学会第１４４年会（横浜）
- Data Source
  KAKENHI-PROJECT-22K14791
[Presentation] 計算化学が挑むテルペン生合成の研究2024
- Author(s)
  佐藤玄
- Organizer
  先魁プロジェクト2024セミナー　新規ケミカルモダリティがつなぐ光生命科学拠点
- Invited
- Data Source
  KAKENHI-PROJECT-24K01626
[Presentation] 計算化学を基軸とした分子設計・反応解析2024
- Author(s)
  佐藤玄
- Organizer
  横浜国立大学　招待講演
- Invited
- Data Source
  KAKENHI-PROJECT-24K01626
[Presentation] Mechanistic Investigation and Functional Modification of Terpene Cyclases and Oxidases using Computational Chemistry2024
- Author(s)
  佐藤玄
- Organizer
  第66回日本植物生理学会年会
- Data Source
  KAKENHI-PROJECT-24K01626
[Presentation] ジテルペン生合成における 2 級カルボカチオンの安定化における側鎖相互作用の役割の解明2023
- Author(s)
  中野萌恵, 佐藤玄
- Organizer
  第67回香料・テルペンおよび精油化学に関する討論会
- Data Source
  KAKENHI-PROJECT-22K14791
[Presentation] 理論計算を基軸とした天然物の生合成機構研究2023
- Author(s)
  佐藤玄
- Organizer
  日本薬学会関東支部オンラインシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-22K14791
[Presentation] Spiroalbatene 生合成におけるカルボカチオン転位反応の理論解析2023
- Author(s)
  中野萌恵、内山真伸、佐藤玄
- Organizer
  日本農芸化学会 2023 年度大会
- Data Source
  KAKENHI-PLANNED-22H05125
[Presentation] 理論計算を用いたジスルフィド結合を持つETP化合物群の分解機構の解明2023
- Author(s)
  栗田大樹、佐藤玄、宮本和範、内山真伸
- Organizer
  日本薬学会第 143 年会
- Data Source
  KAKENHI-PLANNED-22H05125
[Presentation] 理論計算を基軸とした天然物の生合成研究2023
- Author(s)
  佐藤玄
- Organizer
  東京理科大学薬学部　招待講演
- Invited
- Data Source
  KAKENHI-PROJECT-22K14791
[Presentation] Variexenol 生合成における反応経路の分岐と側鎖からの 2 級カルボカチオンの安定化2023
- Author(s)
  中野萌恵, 佐藤玄
- Organizer
  第13回CSJ化学フェスタ
- Data Source
  KAKENHI-PROJECT-22K14791
[Presentation] 理論計算を基軸とした天然物の生合成機構研究2023
- Author(s)
  佐藤玄
- Organizer
  日本薬学会第 143 年会
- Invited
- Data Source
  KAKENHI-PLANNED-22H05125
[Presentation] Spiroalbatene生合成におけるカルボカチオン転移反応の理論解析2022
- Author(s)
  佐藤玄、内山真伸、中野萌恵
- Organizer
  第 12 回 CSJ 化学フェスタ
- Data Source
  KAKENHI-PLANNED-22H05125
[Presentation] 理論計算と実験科学の融合によるSetosusin生合成機構の解明2022
- Author(s)
  松山太郎、佐藤玄、松田侑大、内山真伸
- Organizer
  第 12 回 CSJ 化学フェスタ
- Data Source
  KAKENHI-PLANNED-22H05125
[Presentation] 理論計算と実験科学の融合による Setosusin 生合成機構の解明2022
- Author(s)
  松山太郎、佐藤玄、松田侑大、内山真伸
- Organizer
  第 48 回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PLANNED-22H05125

1. 内山真伸 (00271916)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
2. 三國貴康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sato Hajime 佐藤 玄

Research Projects

Research Products

Co-Researchers

Analysis and Rational Modification of Variexenol Biosynthesis Reaction Mechanism through the Utilization of Computational ChemistryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of terpene cyclization reactions based on computational chemistry, synthetic organic chemistry, and biochemistryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

計算科学の利活用による未知生合成経路の解明と未踏天然物の創出

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Discovery and Theoretical Studies of Nonenzymatic Polyketide Dimerizations of Chaetophenols2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Seven-Membered Ring Formation in Triterpene Biosynthesis: A Key Cyclopropane Rearrangement in Ilelic Acid Biosynthesis2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Theoretical Study of Natural Product Biosynthesis Using Computational Chemistry.2024

Author(s)

Journal Title

Data Source

[Journal Article] DFT Study on Retigerane-Type Sesterterpenoid Biosynthesis: Initial Conformation of GFPP Regulates Biosynthetic Pathway, Ring-Construction Order and Stereochemistry2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dearomative Construction of 2D/3D Frameworks from Quinolines via Nucleophilic Addition/Borate‐Mediated Photocycloaddition2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Visible-Light-Induced trans-Hydroboration of Diaryl Alkynes Utilizing Excited State of Borate Complexes2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metalla‐Carbaporphyrinoids Consisting of an Acyclic N‐Confused Tetrapyrrole Analogue Served as Stable Near‐Infrared‐II Dyes2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural-model-based genome mining can efficiently discover novel non-canonical terpene synthases hidden in genomes of diverse species2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Theoretical Study of Natural Product Biosynthesis Using Computational Chemistry2024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Cycloisomerization of enynones by aluminum halides: construction of bicyclo[3.1.0]hexanes by introducing halides2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TEAD1 trapping by the Q353R?Lamin A/C causes dilated cardiomyopathy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Concertedness and Activation Energy Control by Distal Methyl Group during Ring Contraction/Expansion in Scalarane‐Type Sesterterpenoid Biosynthesis2023

Sato Hajime 佐藤玄