Kubo Toshiyuki 久保俊之

Researcher Number	80784313
Other IDs
Affiliation (Current)	2025: 札幌医科大学, 医学部, 訪問研究員
Affiliation (based on the past Project Information) *help	2021 – 2022: 札幌医科大学, 医学部, 訪問研究員 2018 – 2020: 札幌医科大学, 医学部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator 大腸がん / 癌関連線維芽細胞 / 大腸癌 / ACLP / 微小環境 / がん線維芽細胞 / 浸潤 / 前癌病変 / 大腸腫瘍 / 分子マーカー / メチル化 / スクリーニング

Analysis of cancer-associated fibroblasts and its application to cancer diagnosis and treatmentPrincipal Investigator
- Principal Investigator
  
  Toshiyuki Kubo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Sapporo Medical University
Risk prediction and early detection of colorectal cancer by aberrant DNA methylation in bowel lavage fluidPrincipal Investigator
- Principal Investigator
  
  Kubo Toshiyuki
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Sapporo Medical University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Serum amyloid A1 recruits neutrophils to the invasive front of T1 colorectal cancers.2023
- Author(s)
  Yoshido A, Sudo G, Takasawa A, Aoki H, Kitajima H, Yamamoto E, Niinuma T, Harada T, Kubo T, Sasaki H, Ishiguro K, Yorozu A, Kai M, Katanuma A, Yamano HO, Osanai M, Nakase H, Suzuki H.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: 38 Issue: 2 Pages: 301-310
- DOI
  10.1111/jgh.16055
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07985, KAKENHI-PROJECT-22K07964, KAKENHI-PROJECT-21K15556, KAKENHI-PROJECT-21K16846, KAKENHI-PROJECT-22K16001, KAKENHI-PROJECT-20K07409, KAKENHI-PROJECT-20K07662, KAKENHI-PROJECT-20K08335, KAKENHI-PROJECT-23K24186, KAKENHI-PROJECT-23K06445, KAKENHI-PROJECT-23K07420
[Journal Article] Serum Soluble Fas Levels and Incidence of Liver Cancer in Nested Case?Control Study2022
- Author(s)
  Adachi Yasushi、Nojima Masanori、Mori Mitsuru、Kubo Toshiyuki、Akutsu Noriyuki、Sasaki Yasushi、Nakase Hiroshi、Lin Yingsong、Kurozawa Youichi、Wakai Kenji、Tamakoshi Akiko、for the Japan Collaborative Cohort Study
- Journal Title
  
  Cancer Epidemiology, Biomarkers & Prevention
  
  Volume: 32 Issue: 2 Pages: 260-265
- DOI
  10.1158/1055-9965.epi-22-0902
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08390, KAKENHI-PROJECT-21K08801, KAKENHI-PROJECT-20K08335, KAKENHI-PROJECT-20K08312, KAKENHI-PROJECT-22H04923
[Journal Article] Insulin-Like Growth Factor 2 and Incidence of Liver Cancer in a Nested Case?Control Study2021
- Author(s)
  Adachi Yasushi、Nojima Masanori、Mori Mitsuru、Himori Ryogo、Kubo Toshiyuki、Akutsu Noriyuki、Lin Yingsong、Kurozawa Youichi、Wakai Kenji、Tamakoshi Akiko
- Journal Title
  
  Cancer Epidemiology, Biomarkers & Prevention
  
  Volume: 30 Issue: 11 Pages: 2130-2135
- DOI
  10.1158/1055-9965.epi-21-0481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08312, KAKENHI-PROJECT-20K08335
[Journal Article] Esophageal large cell neuroendocrine carcinoma2021
- Author(s)
  Kubo Toshiyuki、Adachi Yasushi、Ishii Yoshifumi、Endo Takao
- Journal Title
  
  Digestive and Liver Disease
  
  Volume: 53 Issue: 4 Pages: 502-503
- DOI
  10.1016/j.dld.2020.05.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08335
[Journal Article] Mediterranean fever gene-associated enterocolitis in an elderly Japanese woman2021
- Author(s)
  Shibata Yasuhiro、Ishigami Keisuke、Kazama Tomoe、Kubo Toshiyuki、Yamano Hiro-o、Sugita Shintaro、Murata Masaki、Nakase Hiroshi
- Journal Title
  
  Clinical Journal of Gastroenterology
  
  Volume: 14 Issue: 6 Pages: 1661-1666
- DOI
  10.1007/s12328-021-01497-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08335
[Journal Article] Activated macrophages promote invasion by early colorectal cancer via an interleukin 1β‐serum amyloid A1 axis2021
- Author(s)
  Sudo Gota、Aoki Hironori、Yamamoto Eiichiro、Takasawa Akira、Niinuma Takeshi、Yoshido Ayano、Kitajima Hiroshi、Yorozu Akira、Kubo Toshiyuki、Harada Taku、Ishiguro Kazuya、Kai Masahiro、Katanuma Akio、Yamano Hiro‐o、Osanai Makoto、Nakase Hiroshi、Suzuki Hiromu
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 10 Pages: 4151-4165
- DOI
  10.1111/cas.15080
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08398, KAKENHI-PROJECT-20K17057, KAKENHI-PROJECT-19H03518, KAKENHI-PROJECT-20K07409, KAKENHI-PROJECT-20K07662, KAKENHI-PROJECT-20K08335, KAKENHI-PROJECT-21K07985, KAKENHI-PROJECT-21K16846
[Journal Article] Insulin-like Growth Factor-1, Insulin-like Growth Factor Binding Protein-3 and the Incidence of Malignant Neoplasms in a Nested Case?Control Study2020
- Author(s)
  Adachi Yasushi、Nojima Masanori、Mori Mitsuru、Himori Ryogo、Kubo Toshiyuki、Yamano Hiro-o.、Lin Yingsong、Wakai Kenji、Tamakoshi Akiko
- Journal Title
  
  Cancer Prevention Research
  
  Volume: － Issue: 4 Pages: 385-394
- DOI
  10.1158/1940-6207.capr-19-0375
- NAID
  120007018430
- Data Source
  KAKENHI-PROJECT-18K15325
[Journal Article] Upregulation of AEBP1 in endothelial cells promotes tumor angiogenesis in colorectal cancer2020
- Author(s)
  Yorozu Akira、Yamamoto Eiichiro、Niinuma Takeshi、Tsuyada Akihiro、Maruyama Reo、Kitajima Hiroshi、Numata Yuto、Kai Masahiro、Sudo Gota、Kubo Toshiyuki、Nishidate Toshihiko、Okita Kenji、Takemasa Ichiro、Nakase Hiroshi、Sugai Tamotsu、Takano Kenichi、Suzuki Hiromu
- Journal Title
  
  Cancer Science
  
  Volume: － Issue: 5 Pages: 1631-1644
- DOI
  10.1111/cas.14360
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07949, KAKENHI-PROJECT-17K08700, KAKENHI-PROJECT-18K15325, KAKENHI-PROJECT-20K07412, KAKENHI-PROJECT-20K08335, KAKENHI-PROJECT-19H03518, KAKENHI-PROJECT-18K15220, KAKENHI-PROJECT-19K18736
[Journal Article] Gastric Xanthomas and Fundic Gland Polyps as Endoscopic Risk Indicators of Gastric Cancer2019
- Author(s)
  Yamashita Kentaro、Suzuki Ryo、Kubo Toshiyuki、Onodera Kei、Iida Tomoya、Saito Mayuko、Arimura Yoshiaki、Endo Takao、Nojima Masanori、Nakase Hiroshi
- Journal Title
  
  Gut and Liver
  
  Volume: 13 Issue: 4 Pages: 409-414
- DOI
  10.5009/gnl17136
- Data Source
  KAKENHI-PROJECT-18K15325
[Journal Article] Percutaneous endoscopic gastrojejunostomy for treating superior mesenteric artery syndrome2019
- Author(s)
  Kubo Toshiyuki、Adachi Yasushi、Kikuchi Takefumi、Mita Hiroaki、Endo Takao
- Journal Title
  
  Gastrointestinal Endoscopy
  
  Volume: 90 Issue: 6 Pages: 983-984
- DOI
  10.1016/j.gie.2019.07.001
- Data Source
  KAKENHI-PROJECT-18K15325
[Journal Article] Circulating insulin‐like growth factor binding protein‐3 and risk of gastrointestinal malignant tumors2019
- Author(s)
  Adachi Yasushi、Nojima Masanori、Mori Mitsuru、Kubo Toshiyuki、Yamano Hiro‐o、Lin Yingsong、Wakai Kenji、Tamakoshi Akiko、for JACC Study
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: 34 Issue: 12 Pages: 2104-2111
- DOI
  10.1111/jgh.14753
- Data Source
  KAKENHI-PROJECT-18K15325
[Journal Article] 拡大内視鏡診断と分子生物学的解析が可能であったTSA の癌化症例2018
- Author(s)
  久保俊之、山野泰穂、山本英一郎、三橋慧、鈴木拓、長谷川匡、永塚真、菅井有、仲瀬裕志
- Journal Title
  
  INTESTINE
  
  Volume: 22 Pages: 485-492
- Data Source
  KAKENHI-PROJECT-18K15325
[Presentation] 活性化マクロファージはIL-1β-SAA1 axisを介して早期大腸がんの浸潤を促進する．2022
- Author(s)
  須藤豪太，山本英一郎，青木敬則，高澤啓，吉戸文乃，新沼猛，久保俊之，原田拓，萬顕，北嶋洋志，甲斐正広，小山内誠，仲瀬裕志，鈴木拓．
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08335
[Presentation] 大腸粘膜の抑制的ヒストン修飾はCIMP陽性の大腸腫瘍リスクと相関する．2022
- Author(s)
  山本英一郎，須藤豪太，久保俊之，原田拓，佐々木基，青木敬則，北嶋洋志，新沼猛，甲斐正広，山野泰穂，菅井有，仲瀬裕志，鈴木拓．
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08335
[Presentation] Serum amyloid A1は好中球をリクルートして早期大腸癌の浸潤を促進する．2022
- Author(s)
  吉戸文乃，須藤豪太，高澤啓，北嶋洋志，山本英一郎，青木敬則，新沼猛，石黒一也，久保俊之，原田拓，甲斐正広，小山内誠，仲瀬裕志，鈴木拓．
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08335
[Presentation] SMOC1の大腸腫瘍診断マーカーとしての臨床的有用性の検討．2022
- Author(s)
  青木敬則，高澤啓，山本英一郎，新沼猛，山野泰穂，北嶋洋志，甲斐正広，久保俊之，原田拓，小山内誠，仲瀬裕志，菅井有，鈴木拓．
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08335
[Presentation] 活性化マクロファージはIL-1β-SAA1 axisを介して早期大腸がんの浸潤を促進する．2021
- Author(s)
  須藤豪太，山本英一郎，青木敬則，髙澤啓，新沼猛，久保俊之，萬顕，吉戸文乃，北嶋洋志，甲斐正広，小山内誠，仲瀬裕志，鈴木拓．
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08335
[Presentation] Helicobacter pylori除菌後胃がんと背景胃粘膜におけるDNAメチローム解析．2021
- Author(s)
  山本英一郎，吉戸文乃，須藤豪太，三橋慧，北嶋洋志，新沼猛，甲斐正広，原田拓，佐々木基，久保俊之，山野泰穂，仲瀬裕志，菅井有，鈴木拓．
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08335
[Presentation] 新規頭頸部癌関連long non-coding RNAの同定と機能解析．2021
- Author(s)
  新沼猛，北嶋洋志，畠中柚衣，関口翔平，萬顕，久保俊之，佐々木基，原田拓，甲斐正広，仲瀬裕志，鈴木拓．
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08335

1. 山本英一郎 (60567915)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
2. 阿久津典之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 佐々木泰史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 青木敬則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kubo Toshiyuki 久保 俊之

Research Projects

Research Products

Co-Researchers

Analysis of cancer-associated fibroblasts and its application to cancer diagnosis and treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Risk prediction and early detection of colorectal cancer by aberrant DNA methylation in bowel lavage fluidPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Serum amyloid A1 recruits neutrophils to the invasive front of T1 colorectal cancers.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Serum Soluble Fas Levels and Incidence of Liver Cancer in Nested Case?Control Study2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Insulin-Like Growth Factor 2 and Incidence of Liver Cancer in a Nested Case?Control Study2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Esophageal large cell neuroendocrine carcinoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mediterranean fever gene-associated enterocolitis in an elderly Japanese woman2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activated macrophages promote invasion by early colorectal cancer via an interleukin 1β‐serum amyloid A1 axis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Insulin-like Growth Factor-1, Insulin-like Growth Factor Binding Protein-3 and the Incidence of Malignant Neoplasms in a Nested Case?Control Study2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Upregulation of AEBP1 in endothelial cells promotes tumor angiogenesis in colorectal cancer2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gastric Xanthomas and Fundic Gland Polyps as Endoscopic Risk Indicators of Gastric Cancer2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Percutaneous endoscopic gastrojejunostomy for treating superior mesenteric artery syndrome2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Circulating insulin‐like growth factor binding protein‐3 and risk of gastrointestinal malignant tumors2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 拡大内視鏡診断と分子生物学的解析が可能であったTSA の癌化症例2018

Author(s)

Journal Title

Data Source

[Presentation] 活性化マクロファージはIL-1β-SAA1 axisを介して早期大腸がんの浸潤を促進する．2022

Author(s)

Organizer

Data Source

Kubo Toshiyuki 久保俊之