Nakajima Kosei 中嶋幸生

Researcher Number	80785775
Other IDs	https://orcid.org/0000-0003-4352-7817
Affiliation (Current)	2026: 岡山理科大学, 獣医学部, 准教授
Affiliation (based on the past Project Information) *help	2026: 岡山理科大学, 獣医学部, 准教授 2022 – 2024: 岡山理科大学, 獣医学部, 准教授 2019 – 2021: 岡山理科大学, 獣医学部, 講師 2017 – 2020: 国立研究開発法人国立がん研究センター, 研究所, 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Basic Section 55020:Digestive surgery-related / Orthopaedic surgery Except Principal Investigator Basic Section 49020:Human pathology-related
Keywords	Principal Investigator 悪性骨腫瘍 / 骨微小環境の正常化 / 骨リモデリング / 患肢温存術 / 患者由来腫瘍移植マウスモデル（PDX) / 病的骨折 / 多発性骨髄腫 / 滑膜肉腫 / 線維肉腫 / 軟骨肉腫 … More / 変形性関節症・関節リウマチ / 破骨細胞融合阻害薬 / 悪性骨軟部腫瘍 / 破骨細胞融合抑制剤 / 患者由来同所性移植マウスモデル（PDOX) / 患者由来同所性腫瘍移植マウスモデル（PDOX) / Drug-based limb sparing / 患肢温存法 / 骨微小環境 / 骨肉腫 / 薬理学的患肢温存術 / 破骨細胞融合抑制薬 / 腫瘍性骨リモデリング / 破骨細胞融合抑制 / 破骨細胞融合抑制抗体 / 化合物スクリーニング / 初代培養 / 有効化合物の同定 / 網羅的分子解析 / がん微小環境 / トランスレーショナル・リサーチ / 微小環境 / 難治性がん / オミクス解析 / 骨転移 / 分泌因子 / 破骨細胞 … More Except Principal Investigator 免疫 / 神経束 / 微小環境 / 3次リンパ装置 / 神経 / 免疫微小環境 / 腫瘍免疫 / 膵がん Less

骨肉腫肺転移の制御を目的とした抗Galectin-3ヒト化抗体の前臨床試験Principal Investigator
- Principal Investigator
  
  中嶋幸生
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Okayama University of Science
Normalizing the bone tumor microenvironment : Expanded indicationsPrincipal Investigator
- Principal Investigator
  
  中嶋幸生
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Okayama University of Science
NormalizingNormalizing the bone tumor microenvironment : An innovative therapeutic breakthroughPrincipal Investigator
- Principal Investigator
  
  Nakajima Kosei
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Okayama University of Science
Formation and maintenance of tertiary lymphoid organs
- Principal Investigator
  
  Hiraoka Nobuyoshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  National Cancer Center Japan
Developing integrated approaches for the treatment of refractory tumor microenvironmentPrincipal Investigator
- Principal Investigator
  
  Nakajima Kosei
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Okayama University of Science
  National Cancer Center Japan
悪性骨腫瘍における破骨細胞のオミクス解析：骨転移のマーカーと治療標的の探索Principal Investigator
- Principal Investigator
  
  中嶋幸生
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Orthopaedic surgery
- Research Institution
  National Cancer Center Japan

All 2024 2021 2020 2019 2018

All Journal Article Presentation Patent

[Journal Article] T cell infiltration profile in musculoskeletal tumors.2021
- Author(s)
  Kosei Nakajima, Avraham Raz.
- Journal Title
  
  Journal of Orthopaedic Research
  
  Volume: 39 Pages: 536-542
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K18046
[Journal Article] 悪性骨腫瘍における骨免疫微小環境の正常化.2021
- Author(s)
  中嶋幸生
- Journal Title
  
  細胞
  
  Volume: 53 Pages: 102-106
- NAID
  40022508064
- Data Source
  KAKENHI-PROJECT-20K18046
[Journal Article] Galectin-3: an immune checkpoint target for musculoskeletal tumor patients.2021
- Author(s)
  Kosei Nakajima, Vitaly Balan, Avraham Raz.
- Journal Title
  
  Cancer and Metastasis Reviews
  
  Volume: 40 Pages: 297-302
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18046
[Journal Article] Molecular profiling of bone remodeling occurring in musculoskeletal tumors.2020
- Author(s)
  Kosei Nakajima, Teruki Kidani, Hiromasa Miura.
- Journal Title
  
  Journal of Orthopaedic Research.
  
  Volume: Online ahead of print. Issue: 7 Pages: 1402-1410
- DOI
  10.1002/jor.24879
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18046
[Journal Article] Details of human epidermal growth factor receptor 2 status in 454 cases of biliary tract cancer.2020
- Author(s)
  Hiraoka N, Nitta H, Ohba A, Yoshida H, Morizane C, Okusaka T, Nara S, Esaki M, Kishi Y, Shimada K.
- Journal Title
  
  Hum Pathol
  
  Volume: 105 Issue: 1 Pages: 9-19
- DOI
  10.1080/2162402x.2020.1838812
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07008
[Journal Article] Reduction of intrapancreatic neural density in cancer tissue predicts poorer outcome in pancreatic ductal carcinoma.2019
- Author(s)
  Iwasaki T, Hiraoka N, Ino Y, Nakajima K, Kishi Y, Nara S, Esaki M, Shimada K, Katai H.
- Journal Title
  
  Cancer Sci.
  
  Volume: 110 Issue: 4 Pages: 1491-1502
- DOI
  10.1111/cas.13975
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07008
[Patent] 破骨細胞融合抑制剤、及び破骨細胞融合抑制組成物2024
- Inventor(s)
  中嶋幸生　立花太郎
- Industrial Property Rights Holder
  中嶋幸生　立花太郎
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2024-199907
- Filing Date
  2024
- Data Source
  KAKENHI-PROJECT-23K08643
[Patent] 破骨細胞融合抑制剤、及び破骨細胞融合抑制組成物2024
- Inventor(s)
  中嶋幸生　立花太郎
- Industrial Property Rights Holder
  中嶋幸生　立花太郎
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2024-199907
- Filing Date
  2024
- Data Source
  KAKENHI-PROJECT-20K18046
[Presentation] 変形性関節症に対する新しい治療の提案：破骨細胞融合阻害薬2024
- Author(s)
  中嶋幸生, 坂内花恋, 吉村小緒利, 立花太郎, Avraham Raz
- Organizer
  第97回日本整形外科学会学術総会
- Data Source
  KAKENHI-PROJECT-23K08643
[Presentation] 骨軟部腫瘍におけるGalectin-3の発現プロファイル2024
- Author(s)
  中嶋幸生　宮原旭陽　吉村小緒利　立花太郎　Avraham Raz
- Organizer
  第７回日本サルコーマ治療研究学会（JSTAR）学術集会2024
- Data Source
  KAKENHI-PROJECT-20K18046
[Presentation] 骨軟部腫瘍におけるGalectin-3の発現プロファイル：抗Galectin-3中和抗体の適応拡大を目指して2024
- Author(s)
  中嶋幸生, 宮原旭陽, 吉村小緒利, 立花太郎, Avraham Raz
- Organizer
  第7回日本サルコーマ治療研究学会 (JSTAR)
- Data Source
  KAKENHI-PROJECT-23K08643
[Presentation] 骨軟部腫瘍におけるGalectin-3の発現プロファイル：抗Galectin-3中和抗体の適応拡大を目指して2024
- Author(s)
  中嶋幸生　宮原旭陽　吉村小緒利　立花太郎　Avraham Raz
- Organizer
  第7回日本サルコーマ治療研究学会（JSTAR）学術集会2024
- Data Source
  KAKENHI-PROJECT-23K08643
[Presentation] 関節疾患における骨リモデリング因子Galectin-3の発現プロファイル～変形性関節症に対する新しい治療の提案：破骨細胞融合阻害薬～2024
- Author(s)
  中嶋幸生　坂内花恋　吉村小緒利　立花太郎　Avraham Raz
- Organizer
  第97回日本整形外科学会学術総会2024
- Data Source
  KAKENHI-PROJECT-23K08643
[Presentation] Molecular Profiling of Bone Remodeling Occurring in Musculoskeletal Tumors.2021
- Author(s)
  Kosei Nakajima, Teruki Kidani, Hiromasa Miura.
- Organizer
  Orthopedic Research Society Annual meeting 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18046
[Presentation] T cell infiltration profile in musculoskeletal tumors.2020
- Author(s)
  Kosei Nakajima, Avraham Raz.
- Organizer
  European Orthopaedic Research Society 28th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18046
[Presentation] 悪性骨軟部腫瘍1384症例におけるGalectin-3(LGALS3)の発現プロファイリング2020
- Author(s)
  中嶋幸生, 木谷彰岐, Avraham Raz.
- Organizer
  第93回日本整形外科学会学術総会
- Data Source
  KAKENHI-PROJECT-20K18046
[Presentation] Immune landscape of neoadjuvant chemoradiotherapy in refractory cancer.2019
- Author(s)
  Nakajima K, Ino Y, Hiraoka N.
- Organizer
  ASCO (American Society of Clinical Oncology)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16377
[Presentation] Characterization of refractory cancer endothelial cells: Approaching to enhance immune cell infiltration for immunotherapy.2019
- Author(s)
  Nakajima K, Ino Y, Hiraoka N.
- Organizer
  Forth CRI-CIMT-EATI-AACR international cancer immunotherapy conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16377
[Presentation] Neoadjuvant therapy alters collagen architecture of refractory cancer through EFNA5.2019
- Author(s)
  Nakajima K, Ino Y, Nara S, Iwasaki T, Hiraoka N.
- Organizer
  AACR (American Association for Cancer Research)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16377
[Presentation] Characterization of pancreatic cancer endothelial cells: Approaching to enhance immune cell infiltration for immunotherapy.2018
- Author(s)
  Nakajima K, Ino Y, Hiraoka N.
- Organizer
  Forth CRI-CIMT-EATI-AACR international cancer immunotherapy conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16377

1. Hiraoka Nobuyoshi (40276217)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 石川義典 (90291137)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Nakajima Kosei 中嶋 幸生

Research Projects

Research Products

Co-Researchers

骨肉腫肺転移の制御を目的とした抗Galectin-3ヒト化抗体の前臨床試験Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Normalizing the bone tumor microenvironment : Expanded indicationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

NormalizingNormalizing the bone tumor microenvironment : An innovative therapeutic breakthroughPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Formation and maintenance of tertiary lymphoid organs

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Developing integrated approaches for the treatment of refractory tumor microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

悪性骨腫瘍における破骨細胞のオミクス解析：骨転移のマーカーと治療標的の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] T cell infiltration profile in musculoskeletal tumors.2021

Author(s)

Journal Title

Data Source

[Journal Article] 悪性骨腫瘍における骨免疫微小環境の正常化.2021

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Galectin-3: an immune checkpoint target for musculoskeletal tumor patients.2021

Author(s)

Journal Title

Data Source

[Journal Article] Molecular profiling of bone remodeling occurring in musculoskeletal tumors.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Details of human epidermal growth factor receptor 2 status in 454 cases of biliary tract cancer.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reduction of intrapancreatic neural density in cancer tissue predicts poorer outcome in pancreatic ductal carcinoma.2019

Author(s)

Journal Title

DOI

Data Source

[Patent] 破骨細胞融合抑制剤、及び破骨細胞融合抑制組成物2024

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Patent] 破骨細胞融合抑制剤、及び破骨細胞融合抑制組成物2024

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Nakajima Kosei 中嶋幸生