Saeki Noritaka 佐伯法学

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SAEKI NORITAKA 佐伯法学

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Researcher Number	80791607
Other IDs	https://orcid.org/0000-0002-2520-8292
Affiliation (Current)	2024: 愛媛大学, 学術支援センター, 講師
Affiliation (based on the past Project Information) *help	2024: 愛媛大学, 学術支援センター, 講師 2021 – 2022: 愛媛大学, 学術支援センター, 講師 2017 – 2020: 愛媛大学, 学術支援センター, 助教
Review Section/Research Field	Principal Investigator Basic Section 42030:Animal life science-related / Integrative animal science Except Principal Investigator Basic Section 64010:Environmental load and risk assessment-related
Keywords	Principal Investigator 関節リウマチ / 性差 / エストロゲン受容体 / マクロファージ / 関節炎 / 自己免疫疾患 / Uhrf1 / エピジェネティクス / 滑膜線維芽細胞 / 臓器連関 … More / 性ホルモン / 組織マクロファージ / scRNA-seq / Apoptosis / CCL20 / DNAメチル化 / UHRF1 / シグナル伝達 / 細胞・組織 / 滑膜マクロファージ / 炎症性サイトカイン … More Except Principal Investigator リスク評価 / 神経毒性 / 環境汚染物質 / iPS細胞 / 鯨類 Less

エストロゲンを基軸とした臓器連関による関節リウマチ病態の性差構築機構の解明Principal Investigator
- Principal Investigator
  
  佐伯法学
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Ehime University
Establishment of cetacean iPS cells and application to neurotoxicity assays of environmental pollutants
- Principal Investigator
  
  落合真理
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 64010:Environmental load and risk assessment-related
- Research Institution
  Ehime University
滑膜マクロファージに着目した関節リウマチ病態の性差メカニズムの解明Principal Investigator
- Principal Investigator
  
  佐伯法学
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Ehime University
Investigation of proinflammatory regulation via epigenetics in synoviocytes.Principal Investigator
- Principal Investigator
  
  Saeki Noritaka
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Ehime University
Investigation of physiological functions of epigenetic regulator Uhrf1 in rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  SAEKI NORITAKA
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Integrative animal science
- Research Institution
  Ehime University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] LIM1 contributes to the malignant potential of endometrial cancer2023
- Author(s)
  Kato Hiroaki、Saeki Noritaka、Imai Matome、Onji Hiroshi、Yano Akiko、Yoshida Shuhei、Sakaue Tomohisa、Fujioka Toru、Sugiyama Takashi、Imai Yuuki
- Journal Title
  
  Frontiers in Oncology
  
  Volume: 13
- DOI
  10.3389/fonc.2023.1082441
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05974, KAKENHI-PROJECT-21K09373
[Journal Article] Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue2023
- Author(s)
  Saeki Noritaka、Imai Yuuki
- Journal Title
  
  Journal of Visualized Experiments
  
  Volume: - Issue: 192
- DOI
  10.3791/65196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05974, KAKENHI-PROJECT-23K24462
[Journal Article] Epigenetic regulator UHRF1 orchestrates proinflammatory gene expression in rheumatoid arthritis in a suppressive manner2022
- Author(s)
  Saeki Noritaka、Inoue Kazuki、Ideta-Otsuka Maky、Watamori Kunihiko、Mizuki Shinichi、Takenaka Katsuto、Igarashi Katsuhide、Miura Hiromasa、Takeda Shu、Imai Yuuki
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 132 Issue: 11
- DOI
  10.1172/jci150533
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05974, KAKENHI-PROJECT-21H02949, KAKENHI-PROJECT-23K24462
[Journal Article] DNA maintenance methylation enzyme Dnmt1 in satellite cells is essential for muscle regeneration2021
- Author(s)
  Iio Hiroyuki、Kikugawa Tadahiko、Sawada Yuichiro、Sakai Hiroshi、Yoshida Shuhei、Yanagihara Yuta、Ikedo Aoi、Saeki Noritaka、Fukada So-ichiro、Saika Takashi、Imai Yuuki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 534 Pages: 79-85
- DOI
  10.1016/j.bbrc.2020.11.116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03786, KAKENHI-PROJECT-19K16015, KAKENHI-PROJECT-19K19947
[Journal Article] Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk42021
- Author(s)
  Iori Sakakibara, Yuta Yanagihara, Koichi Himori, Takashi Yamada, Hiroshi Sakai, Yuichiro Sawada, Hirotaka Takahashi, Noritaka Saeki, Hiroyuki Hirakawa, Atsushi Yokoyama, So-Ichiro Fukada, Tatsuya Sawasaki, Yuuki Imai
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 4 Pages: 102303-102303
- DOI
  10.1016/j.isci.2021.102303
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20J01754, KAKENHI-PROJECT-19K19947, KAKENHI-PUBLICLY-21H00287, KAKENHI-PROJECT-20K06611, KAKENHI-PROJECT-21K05974, KAKENHI-PROJECT-21K11439, KAKENHI-PROJECT-21K19230, KAKENHI-PROJECT-21K19723, KAKENHI-PROJECT-21K17568, KAKENHI-PROJECT-23K21587
[Journal Article] Reprogramming of synovial macrophage metabolism by synovial fibroblasts under inflammatory conditions2020
- Author(s)
  Saeki Noritaka、Imai Yuuki
- Journal Title
  
  Cell Communication and Signaling
  
  Volume: 18 Issue: 1 Pages: 188-188
- DOI
  10.1186/s12964-020-00678-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03786, KAKENHI-PROJECT-19K16015
[Journal Article] GPRC5A facilitates cell proliferation through cell cycle regulation and correlates with bone metastasis in prostate cancer2020
- Author(s)
  Sawada Y, Kikugawa T, Iio H, Sakakibara I, Yoshida S, Ikedo A, Yanagihara Y, Saeki N, Gyorffy B, Kishida T, Okubo Y, Nakamura Y, Miyagi Y, Saika T, Imai Y.
- Journal Title
  
  International Journal of Cancer
  
  Volume: 146 Issue: 5 Pages: 1369-1382
- DOI
  10.1002/ijc.32554
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09168, KAKENHI-PROJECT-19K16015, KAKENHI-PROJECT-19H03786, KAKENHI-PROJECT-16H06277
[Journal Article] Zscan10 Suppresses Osteoclast Differentiation by Regulating Expression of Haptoglobin.2019
- Author(s)
  Yanagihara Y, Inoue K, Saeki N, Sawada Y, Yoshida S, Lee JW, Iimura T and Imai Y.
- Journal Title
  
  Bone
  
  Volume: 122 Pages: 93-100
- DOI
  10.1016/j.bone.2019.02.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19728, KAKENHI-PROJECT-17K17929, KAKENHI-PROJECT-18K19649, KAKENHI-PROJECT-18H02983, KAKENHI-PROJECT-19H03786
[Journal Article] The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD2019
- Author(s)
  Uematsu Atsushi、Kido Kohki、Takahashi Hirotaka、Takahashi Chikako、Yanagihara Yuta、Saeki Noritaka、Yoshida Shuhei、Maekawa Masashi、Honda Mamoru、Kai Tsutomu、Shimizu Kouhei、Higashiyama Shigeki、Imai Yuuki、Tokunaga Fuminori、Sawasaki Tatsuya
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 38 Pages: 14135-14148
- DOI
  10.1074/jbc.ra119.010119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22541, KAKENHI-PROJECT-19K16015, KAKENHI-PLANNED-16H06575, KAKENHI-PLANNED-16H06579, KAKENHI-PUBLICLY-19H05292, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-19H03218, KAKENHI-PROJECT-19H03786, KAKENHI-PROJECT-17K07261
[Presentation] 関節リウマチ病態に寄与するエピジェネティック制御因子の同定と新規治療標的としての可能性2023
- Author(s)
  佐伯法学
- Organizer
  PRiME・PROS 第10回学術シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21K05974
[Presentation] Stabilization of UHRF1 in synovial fibroblasts is a novel therapeutic strategy for rheumatoid arthritis.2022
- Author(s)
  Noritaka Saeki, Kazuki Inoue, Maky Ideta-Otsuka, Kunihiko Watamori, Shinichi Mizuki, Katsuto Takenaka, Katsuhide Igarashi, Hiromasa Miura, Yuuki Imai
- Organizer
  European Calcified Tissue Society (ECTS) Congress 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05974
[Presentation] Estrogen receptor-alpha promotes activation of synovium-resident macrophages in arthritis model mice.2022
- Author(s)
  佐伯法学, 今井祐記
- Organizer
  プロテイン・アイランド2022国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05974
[Presentation] 関節炎モデルマウスにおけるマクロファージの ERα 機能解析2022
- Author(s)
  佐伯法学, 今井祐記
- Organizer
  第7回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-21K05974
[Presentation] 滑膜線維芽細胞に発現するUHRF1はDNAメチル化を介して関節リウマチの多様な増悪因子を抑制する2022
- Author(s)
  佐伯法学, 井上和樹, 大塚まき, 渡森一光, 水木伸一, 竹中克斗, 五十嵐勝秀, 三浦裕正, 今井祐記
- Organizer
  第40回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-21K05974
[Presentation] Stabilization of UHRF1 in synovial fibroblasts is a novel therapeutic strategy for rheumatoid arthritis.2021
- Author(s)
  Noritaka Saeki, Kazuki Inoue, Maky Ideta-Otsuka, Watamori Kunihiko, Shinichi Mizuki, Katsuto Takenaka, Katsuhide Igarashi, Hiromasa Miura, Yuuki Imai
- Organizer
  The American Society for Bone and Mineral Research 2021 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05974
[Presentation] UHRF1は関節リウマチの多様な増悪因子を抑制する2021
- Author(s)
  佐伯法学, 井上和樹, 大塚まき, 渡森一光, 水木伸一, 竹中克斗, 五十嵐勝秀, 三浦裕正, 今井祐記
- Organizer
  第6回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-21K05974
[Presentation] エピジェネティック制御因子UHRF1は関節リウマチの多様な増悪因子を抑制する2021
- Author(s)
  佐伯法学, 井上和樹, 大塚まき, 渡森一光, 水木伸一, 竹中克斗, 五十嵐勝秀, 三浦裕正, 今井祐記
- Organizer
  第39回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-21K05974
[Presentation] DNA メチル化制御分子 UHRF1 は関節リウマチの病態増悪を抑制する2020
- Author(s)
  佐伯法学, 井上和樹, 大塚まき, 渡森一光, 水木伸一, 竹中克斗, 五十嵐勝秀, 三浦裕正, 今井祐記
- Organizer
  第38回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16015
[Presentation] Epigenetic regulator UHRF1 orchestrates expressions of cytokine-related genes in rheumatoid arthritis.2019
- Author(s)
  Noritaka Saeki, Kazuki Inoue, Maky Ideta-Otsuka, Watamori Kunihiko, Shinichi Mizuki, Katsuto Takenaka, Katsuhide Igarashi, Hiromasa Miura, Yuuki Imai
- Organizer
  29th Australian and New Zealand Bone and Mineral Society Annual Scientific Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16015
[Presentation] エピジェネティック制御因子Uhrf1はサイトカイン関連遺伝子発現を抑制し関節リウマチ病態を制御する2019
- Author(s)
  佐伯法学, 井上和樹, 渡森一光, 水木伸一, 竹中克斗, 三浦裕正, 今井祐記
- Organizer
  第5回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-19K16015
[Presentation] Epigenetic regulator Uhrf1 suppresses progression of arthritis in CAIA mouse model2019
- Author(s)
  Noritaka Saeki, Kazuki Inoue, Yuuki Imai
- Organizer
  International Federation of Musculoskeletal Research Societies 3rd Herbert Fleisch Workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17929
[Presentation] エピジェネティック制御因子Uhrf1は関節リウマチにおける増悪因子発現を制御する2019
- Author(s)
  佐伯法学, 井上和樹, 渡森一光, 水木伸一, 竹中克斗, 三浦裕正, 今井祐記
- Organizer
  第37回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16015
[Presentation] Epigenetic regulator, Uhrf1, positively controls skeletal muscle differentiation2018
- Author(s)
  Yuichiro Sawada, Tadahiko Kikugawa, Iori Sakakibara, Yusuke Ono, Yuta Yanagihara, Noritaka Saeki, Hiroyuki Iio, Takashi Saika, Yuuki Imai
- Organizer
  The American Society for Bone and Mineral Research 2018 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17929
[Presentation] Zscan10 Suppresses Osteoclast Differentiation through Expression of Haptoglobin.2018
- Author(s)
  Yuta Yanagihara, Kazuki Inoue, Noritaka Saeki, Yuichiro Sawada, Jiwon Lee, Tadahiro Iimura, Yuuki Imai
- Organizer
  The American Society for Bone and Mineral Research 2018 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17929
[Presentation] Zscan10はHaptoglobinの転写を介して破骨細胞分化を負に制御する2018
- Author(s)
  柳原裕太,井上和樹,佐伯法学,沢田雄一郎,李智媛,飯村忠浩,今井祐記
- Organizer
  第36回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-17K17929
[Presentation] エピジェネティック制御因子Uhrf1は関節炎病態の抑制に働く2018
- Author(s)
  佐伯法学,今井祐記,井上和樹
- Organizer
  第36回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-17K17929
[Presentation] エピゲノム制御因子Uhrf1は筋分化を正に制御する2018
- Author(s)
  沢田雄一郎,榊原伊織,柳原裕太,佐伯法学,菊川忠彦,雑賀隆史,小野悠介,今井祐記
- Organizer
  第36回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-17K17929
[Presentation] Zscan10 Suppresses Osteoclast Differentiation by Regulating Expression of Haptoglobin2018
- Author(s)
  Yuta Yanagihara, Kazuki Inoue, Noritaka Saeki, Yuichiro Sawada, Jiwon Lee, Tadahiro Iimura, Yuuki Imai
- Organizer
  第15回Bone Biology Forum
- Data Source
  KAKENHI-PROJECT-17K17929
[Presentation] Epigenetic regulator Uhrf1 suppresses progression of arthritis in CAIA mice model2018
- Author(s)
  Noritaka Saeki, Kazuki Inoue, Yuuki Imai
- Organizer
  プロテイン・アイランド松山2018国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17929
[Presentation] エピゲノム制御因子Uhrf1は筋分化を正に制御する2018
- Author(s)
  沢田雄一郎, 菊川忠彦, 飯尾浩之, 酒井大史, 榊原伊織, 小野悠介, 柳原裕太, 佐伯法学, 雑賀隆史, 今井祐記
- Organizer
  第６回若手による骨格筋細胞研究会
- Data Source
  KAKENHI-PROJECT-17K17929
[Presentation] Zscan10 Suppresses Osteoclast Differentiation by Regulating Expression of Haptoglobin2018
- Author(s)
  Yuta Yanagihara, Kazuki Inoue, Noritaka Saeki, Yuichiro Sawada, Jiwon Lee, Tadahiro Iimura, Yuuki Imai
- Organizer
  プロテイン・アイランド2018国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17929

1. 今井祐記 (10423873)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
2. 落合真理 (70612662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 岩田久人 (10271652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Yanagihara Yuta

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. Iimura Tadahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. Lee Jiwon

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 雑賀隆史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 菊川忠彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 徳永文稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Saeki Noritaka 佐伯 法学

SAEKI NORITAKA 佐伯 法学

Research Projects

Research Products

Co-Researchers

エストロゲンを基軸とした臓器連関による関節リウマチ病態の性差構築機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of cetacean iPS cells and application to neurotoxicity assays of environmental pollutants

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

滑膜マクロファージに着目した関節リウマチ病態の性差メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of proinflammatory regulation via epigenetics in synoviocytes.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of physiological functions of epigenetic regulator Uhrf1 in rheumatoid arthritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] LIM1 contributes to the malignant potential of endometrial cancer2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epigenetic regulator UHRF1 orchestrates proinflammatory gene expression in rheumatoid arthritis in a suppressive manner2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DNA maintenance methylation enzyme Dnmt1 in satellite cells is essential for muscle regeneration2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk42021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reprogramming of synovial macrophage metabolism by synovial fibroblasts under inflammatory conditions2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GPRC5A facilitates cell proliferation through cell cycle regulation and correlates with bone metastasis in prostate cancer2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Zscan10 Suppresses Osteoclast Differentiation by Regulating Expression of Haptoglobin.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD2019

Author(s)

Journal Title

DOI

Data Source

Saeki Noritaka 佐伯法学

SAEKI NORITAKA 佐伯法学