OSHIMA JUNKO ＯＳＨＩＭＡＪＵＮＫＯ

… Alternative Names

OSHIMA JYUNKO OSHIMA JUNKO

Less

Researcher Number	80792275
Other IDs
Affiliation (Current)	2023: 千葉大学, 大学院医学研究院, 特任教授
Affiliation (based on the past Project Information) *help	2023: 千葉大学, 医学(系)研究科(研究院), 教授 2021 – 2022: 千葉大学, 大学院医学研究院, 特任教授 2017 – 2019: 千葉大学, 大学院医学研究院, 特任教授
Review Section/Research Field	Principal Investigator General medical chemistry / Basic Section 52010:General internal medicine-related Except Principal Investigator Basic Section 54040:Metabolism and endocrinology-related
Keywords	Principal Investigator 遺伝学 / ゲノム / 老化 / 内科 / 早老症 Except Principal Investigator 細胞老化 / IncRNA / 転写因子p53 / 脂肪細胞 / 加齢性疾患 / lncRNA / 血管内皮

早老症モデルを応用した核とミトコンドリアが織りなす老化加速シグナルの基盤的研究Principal Investigator
- Principal Investigator
  
  OSHIMA JUNKO
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Chiba University
脂肪や血管組織老化に伴う機能変容における老化関連長鎖非コードRNAの基盤的研究
- Principal Investigator
  
  橋本直子
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Chiba University
Discovery of novel progeroid syndrome loci and contribution to normative agingPrincipal Investigator
- Principal Investigator
  
  OSHIMA JYUNKO
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Chiba University

All 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Martin1GM. Cell to cell variations in gene expression are differentially modulated by knockdowns of diverse genetic loci: implications for the pathobiology of aging.2020
- Author(s)
  Zhang J, Burnaevskiy N, Annis J, Han W, Hou D, Ladd P, Lee L, Mendenhall AR, Oshima J,
- Journal Title
  
  J Gerontol A Biol Sci Med Sci
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04037
[Journal Article] Inactivating mutations in exonuclease and polymerase domains in DNA polymerase delta alter sensitivities to inhibitors of dNTP synthesis.2020
- Author(s)
  .Zhang J, Hou D, Annis J, Sargolzaeiaval F, Appelbaum J, Takahashi E, Martin GM, Herr A, Oshima J.
- Journal Title
  
  DNA Cell Biol.
  
  Volume: 39 Pages: 50-56
- DOI
  10.1089/dna.2019.5125
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04037
[Journal Article] Characteristic Clinical Features of Werner Syndrome with a Novel Compound Heterozygous WRN Mutation c.1720+1G>A Plus c.3139-1G>C2019
- Author(s)
  Matsumoto Namiko、Ohta Yasuyuki、Deguchi Kentaro、Kishida Masayuki、Sato Kota、Shang Jingwei、Takemoto Mami、Hishikawa Nozomi、Yamashita Toru、Watanabe Aki、Yokote Koutaro、Takemoto Minoru、Oshima Junko、Abe Koji
- Journal Title
  
  Internal Medicine
  
  Volume: 58 Issue: 7 Pages: 1033-1036
- DOI
  10.2169/internalmedicine.1816-18
- NAID
  130007622212
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04037
[Journal Article] Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes2019
- Author(s)
  14.Maierhofer M, Flunkert J, Oshima J, Martin GM, Poot M, Nanda I, Dittrich M, Müller T4, Haaf T.
- Journal Title
  
  Aging Cell
  
  Volume: 18
- DOI
  10.1111/acel.12995
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04037
[Journal Article] CTC1 mutations in a Brazilian family with progeroid features and recurrent bone fractures2018
- Author(s)
  6.Sargolzaeiaval F, Zhang J, Schleit J, Lessel D, Kubisch C, Precioso DR, Sillence D, Hisama FM, Dorschner M, Martin GM, Oshima J.
- Journal Title
  
  Molecular Genetics & Genomic Medicine
  
  Volume: 6 Pages: 1148-1156
- DOI
  10.1002/mgg3.495
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04037
[Journal Article] Precision Medicine and Progress in the Treatment of Hutchinson-Gilford Progeria Syndrome.2018
- Author(s)
  Hisama FM, Oshima J.
- Journal Title
  
  JAMA
  
  Volume: 319 Pages: 1663-1664
- DOI
  10.1001/jama.2018.2199
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04037
[Journal Article] Biallelic WRN Mutations in Newly Identified Japanese Werner Syndrome Patients.2018
- Author(s)
  Maezawa Y, Kato H, Takemoto M, Watanabe A, Koshizaka M, Ishikawa T, Sargolzaeiaval F, Kuzuya M, Wakabayashi H, Kusaka T, Yokote K, Oshima J
- Journal Title
  
  Oshima J.Mol Syndromol
  
  Volume: 9 Pages: 214-218
- DOI
  10.1159/000489055
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09292, KAKENHI-PROJECT-17K09687, KAKENHI-PROJECT-17H01558, KAKENHI-PROJECT-17H04037, KAKENHI-PROJECT-16K09229, KAKENHI-PROJECT-16K09341, KAKENHI-PROJECT-16K19530
[Journal Article] ERCC4 variants identified in a cohort of patients with segmental progeroid syndromes.2018
- Author(s)
  Mori Takayasu、Yousefzadeh Matthew J.、Faridounnia Maryam、Chong Jessica X.、Hisama Fuki M.、Hudgins Louanne、Mercado Gabriela、Wade Erin A.、Barghouthy Amira S.、Lee Lin、Martin George M.、Nickerson Deborah A.、Bamshad Michael J.、Niedernhofer Laura J.、Oshima Junko
- Journal Title
  
  Hum Mutat
  
  Volume: 39 Pages: 255-265
- DOI
  10.1002/humu.23367
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04037, KAKENHI-PROJECT-17H06657
[Journal Article] Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies.2018
- Author(s)
  Horvath S, Oshima J, Martin GM, Lu AT, Quach A, Cohen H, Felton S, Matsuyama M, Lowe D, Kabacik S, Wilson JG, Reiner AP, Maierhofer A, Flunkert J, Aviv A, Hou L, Baccarelli AA, Li Y, Stewart JD, Whitsel EA, Ferrucci L, Matsuyama S, Raj K.
- Journal Title
  
  Aging (Albany NY)
  
  Volume: 10 Pages: 1758-1775
- DOI
  10.18632/aging.101508
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04037
[Journal Article] RECQ helicase disease and related progeroid syndromes: RECQ2018 meeting.2018
- Author(s)
  Oshima J, Kato H, Maezawa Y, Yokote K
- Journal Title
  
  Mech Ageing Dev.
  
  Volume: 173 Pages: 80-83
- DOI
  10.1016/j.mad.2018.05.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09292, KAKENHI-PROJECT-17H01558, KAKENHI-PROJECT-17H04037, KAKENHI-PROJECT-16K09341
[Journal Article] High incidence ofBSCL2intragenic recombinational mutation in Peruvian type 2 Berardinelli-Seip syndrome2017
- Author(s)
  Purizaca-Rosillo Nelson、Mori Takayasu、Benites-Condor Yamali、Hisama Fuki M.、Martin George M.、Oshima Junko
- Journal Title
  
  American Journal of Medical Genetics Part A
  
  Volume: 173 Pages: 471-478
- DOI
  10.1002/ajmg.a.38053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04037
[Presentation] “Genetics of Aging: Molecular Mechanisms of Progeroid Syndromes2019
- Author(s)
  Oshima Junko
- Organizer
  Leading Seminar, Chiba University
- Invited
- Data Source
  KAKENHI-PROJECT-17H04037
[Presentation] Genetics of Aging: Molecular Mechanisms of Progeroid Syndromes2019
- Author(s)
  Oshima Junko
- Organizer
  Seminars in Medical Sciences Series
- Invited
- Data Source
  KAKENHI-PROJECT-17H04037
[Presentation] International Registry of Werner Syndrome: Search for progeroid syndrome mutations and mechanisms2018
- Author(s)
  Junko Oshima
- Organizer
  The International Meeting on RECQ Helicases and Related Diseases 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04037

1. 田中知明 (50447299)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 横手幸太郎 (20312944)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 橋本直子 (10724875)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 竹本稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 前澤善朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 石川崇広

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 森崇寧

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OSHIMA JUNKO ＯＳＨＩＭＡ ＪＵＮＫＯ

OSHIMA JYUNKO OSHIMA JUNKO

Research Projects

Research Products

Co-Researchers

早老症モデルを応用した核とミトコンドリアが織りなす老化加速シグナルの基盤的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脂肪や血管組織老化に伴う機能変容における老化関連長鎖非コードRNAの基盤的研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Discovery of novel progeroid syndrome loci and contribution to normative agingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Martin1GM. Cell to cell variations in gene expression are differentially modulated by knockdowns of diverse genetic loci: implications for the pathobiology of aging.2020

Author(s)

Journal Title

Data Source

[Journal Article] Inactivating mutations in exonuclease and polymerase domains in DNA polymerase delta alter sensitivities to inhibitors of dNTP synthesis.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characteristic Clinical Features of Werner Syndrome with a Novel Compound Heterozygous WRN Mutation c.1720+1G&gt;A Plus c.3139-1G&gt;C2019

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CTC1 mutations in a Brazilian family with progeroid features and recurrent bone fractures2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Precision Medicine and Progress in the Treatment of Hutchinson-Gilford Progeria Syndrome.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biallelic WRN Mutations in Newly Identified Japanese Werner Syndrome Patients.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ERCC4 variants identified in a cohort of patients with segmental progeroid syndromes.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RECQ helicase disease and related progeroid syndromes: RECQ2018 meeting.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High incidence ofBSCL2intragenic recombinational mutation in Peruvian type 2 Berardinelli-Seip syndrome2017

Author(s)

Journal Title

DOI

Data Source

OSHIMA JUNKO ＯＳＨＩＭＡＪＵＮＫＯ

[Journal Article] Characteristic Clinical Features of Werner Syndrome with a Novel Compound Heterozygous WRN Mutation c.1720+1G>A Plus c.3139-1G>C2019