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OSHIMA JUNKO  OSHIMA JUNKO

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OSHIMA JYUNKO  OSHIMA JUNKO

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Researcher Number 80792275
Other IDs
Affiliation (Current) 2023: 千葉大学, 大学院医学研究院, 特任教授
Affiliation (based on the past Project Information) *help 2023: 千葉大学, 医学(系)研究科(研究院), 教授
2021 – 2022: 千葉大学, 大学院医学研究院, 特任教授
2017 – 2019: 千葉大学, 大学院医学研究院, 特任教授
Review Section/Research Field
Principal Investigator
General medical chemistry / Basic Section 52010:General internal medicine-related
Except Principal Investigator
Basic Section 54040:Metabolism and endocrinology-related
Keywords
Principal Investigator
遺伝学 / ゲノム / 老化 / 内科 / 早老症
Except Principal Investigator
細胞老化 / IncRNA / 転写因子p53 / 脂肪細胞 / 加齢性疾患 / lncRNA / 血管内皮
  • Research Projects

    (3 results)
  • Research Products

    (14 results)
  • Co-Researchers

    (7 People)
  •  早老症モデルを応用した核とミトコンドリアが織りなす老化加速シグナルの基盤的研究Principal Investigator

    • Principal Investigator
      OSHIMA JUNKO
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      Chiba University
  •  脂肪や血管組織老化に伴う機能変容における老化関連長鎖非コードRNAの基盤的研究

    • Principal Investigator
      橋本 直子
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Chiba University
  •  Discovery of novel progeroid syndrome loci and contribution to normative agingPrincipal Investigator

    • Principal Investigator
      OSHIMA JYUNKO
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Chiba University

All 2020 2019 2018 2017

All Journal Article Presentation

  • [Journal Article] Martin1GM. Cell to cell variations in gene expression are differentially modulated by knockdowns of diverse genetic loci: implications for the pathobiology of aging.2020

    • Author(s)
      Zhang J, Burnaevskiy N, Annis J, Han W, Hou D, Ladd P, Lee L, Mendenhall AR, Oshima J,
    • Journal Title

      J Gerontol A Biol Sci Med Sci

      Volume: in press

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04037
  • [Journal Article] Inactivating mutations in exonuclease and polymerase domains in DNA polymerase delta alter sensitivities to inhibitors of dNTP synthesis.2020

    • Author(s)
      .Zhang J, Hou D, Annis J, Sargolzaeiaval F, Appelbaum J, Takahashi E, Martin GM, Herr A, Oshima J.
    • Journal Title

      DNA Cell Biol.

      Volume: 39 Pages: 50-56

    • DOI

      10.1089/dna.2019.5125

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04037
  • [Journal Article] Characteristic Clinical Features of Werner Syndrome with a Novel Compound Heterozygous WRN Mutation c.1720+1G>A Plus c.3139-1G>C2019

    • Author(s)
      Matsumoto Namiko、Ohta Yasuyuki、Deguchi Kentaro、Kishida Masayuki、Sato Kota、Shang Jingwei、Takemoto Mami、Hishikawa Nozomi、Yamashita Toru、Watanabe Aki、Yokote Koutaro、Takemoto Minoru、Oshima Junko、Abe Koji
    • Journal Title

      Internal Medicine

      Volume: 58 Issue: 7 Pages: 1033-1036

    • DOI

      10.2169/internalmedicine.1816-18

    • NAID

      130007622212

    • ISSN
      0918-2918, 1349-7235
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04037
  • [Journal Article] Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes2019

    • Author(s)
      14.Maierhofer M, Flunkert J, Oshima J, Martin GM, Poot M, Nanda I, Dittrich M, Müller T4, Haaf T.
    • Journal Title

      Aging Cell

      Volume: 18

    • DOI

      10.1111/acel.12995

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04037
  • [Journal Article] CTC1 mutations in a Brazilian family with progeroid features and recurrent bone fractures2018

    • Author(s)
      6.Sargolzaeiaval F, Zhang J, Schleit J, Lessel D, Kubisch C, Precioso DR, Sillence D, Hisama FM, Dorschner M, Martin GM, Oshima J.
    • Journal Title

      Molecular Genetics & Genomic Medicine

      Volume: 6 Pages: 1148-1156

    • DOI

      10.1002/mgg3.495

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04037
  • [Journal Article] Precision Medicine and Progress in the Treatment of Hutchinson-Gilford Progeria Syndrome.2018

    • Author(s)
      Hisama FM, Oshima J.
    • Journal Title

      JAMA

      Volume: 319 Pages: 1663-1664

    • DOI

      10.1001/jama.2018.2199

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04037
  • [Journal Article] Biallelic WRN Mutations in Newly Identified Japanese Werner Syndrome Patients.2018

    • Author(s)
      Maezawa Y, Kato H, Takemoto M, Watanabe A, Koshizaka M, Ishikawa T, Sargolzaeiaval F, Kuzuya M, Wakabayashi H, Kusaka T, Yokote K, Oshima J
    • Journal Title

      Oshima J.Mol Syndromol

      Volume: 9 Pages: 214-218

    • DOI

      10.1159/000489055

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09292, KAKENHI-PROJECT-17K09687, KAKENHI-PROJECT-17H01558, KAKENHI-PROJECT-17H04037, KAKENHI-PROJECT-16K09229, KAKENHI-PROJECT-16K09341, KAKENHI-PROJECT-16K19530
  • [Journal Article] ERCC4 variants identified in a cohort of patients with segmental progeroid syndromes.2018

    • Author(s)
      Mori Takayasu、Yousefzadeh Matthew J.、Faridounnia Maryam、Chong Jessica X.、Hisama Fuki M.、Hudgins Louanne、Mercado Gabriela、Wade Erin A.、Barghouthy Amira S.、Lee Lin、Martin George M.、Nickerson Deborah A.、Bamshad Michael J.、Niedernhofer Laura J.、Oshima Junko
    • Journal Title

      Hum Mutat

      Volume: 39 Pages: 255-265

    • DOI

      10.1002/humu.23367

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04037, KAKENHI-PROJECT-17H06657
  • [Journal Article] Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies.2018

    • Author(s)
      Horvath S, Oshima J, Martin GM, Lu AT, Quach A, Cohen H, Felton S, Matsuyama M, Lowe D, Kabacik S, Wilson JG, Reiner AP, Maierhofer A, Flunkert J, Aviv A, Hou L, Baccarelli AA, Li Y, Stewart JD, Whitsel EA, Ferrucci L, Matsuyama S, Raj K.
    • Journal Title

      Aging (Albany NY)

      Volume: 10 Pages: 1758-1775

    • DOI

      10.18632/aging.101508

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04037
  • [Journal Article] RECQ helicase disease and related progeroid syndromes: RECQ2018 meeting.2018

    • Author(s)
      Oshima J, Kato H, Maezawa Y, Yokote K
    • Journal Title

      Mech Ageing Dev.

      Volume: 173 Pages: 80-83

    • DOI

      10.1016/j.mad.2018.05.002

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09292, KAKENHI-PROJECT-17H01558, KAKENHI-PROJECT-17H04037, KAKENHI-PROJECT-16K09341
  • [Journal Article] High incidence ofBSCL2intragenic recombinational mutation in Peruvian type 2 Berardinelli-Seip syndrome2017

    • Author(s)
      Purizaca-Rosillo Nelson、Mori Takayasu、Benites-Condor Yamali、Hisama Fuki M.、Martin George M.、Oshima Junko
    • Journal Title

      American Journal of Medical Genetics Part A

      Volume: 173 Pages: 471-478

    • DOI

      10.1002/ajmg.a.38053

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04037
  • [Presentation] “Genetics of Aging: Molecular Mechanisms of Progeroid Syndromes2019

    • Author(s)
      Oshima Junko
    • Organizer
      Leading Seminar, Chiba University
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04037
  • [Presentation] Genetics of Aging: Molecular Mechanisms of Progeroid Syndromes2019

    • Author(s)
      Oshima Junko
    • Organizer
      Seminars in Medical Sciences Series
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04037
  • [Presentation] International Registry of Werner Syndrome: Search for progeroid syndrome mutations and mechanisms2018

    • Author(s)
      Junko Oshima
    • Organizer
      The International Meeting on RECQ Helicases and Related Diseases 2018
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04037
  • 1.  田中 知明 (50447299)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  横手 幸太郎 (20312944)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 3.  橋本 直子 (10724875)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  竹本 稔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  前澤 善朗
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 6.  石川 崇広
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  森 崇寧
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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