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Arai Yasuha  荒井 泰葉

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… Alternative Names

ARAI Yasuha  荒井 泰葉

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Researcher Number 80793182
Affiliation (Current) 2022: 京都府立医科大学, 医学(系)研究科(研究院), 研究員
Affiliation (based on the past Project Information) *help 2018 – 2022: 京都府立医科大学, 医学(系)研究科(研究院), 研究員
2017: 京都府立医科大学, 医学研究科, 博士研究員
Review Section/Research Field
Principal Investigator
Basic Section 49060:Virology-related
Except Principal Investigator
Virology / Medium-sized Section 58:Society medicine, nursing, and related fields / Basic Section 49060:Virology-related
Keywords
Principal Investigator
インフルエンザウイルス / 宿主因子 / ヒト適応性 / ウイルス複製 / ウイルス学 / 抗ウイルス薬 / 新型コロナウイルス / 宿主適応 / 重症化
Except Principal Investigator
新興ウイルス … More / ウイルス学 / 人獣共通感染症学 / 感染病態学 / インフルエンザウイルス / ウイルスエコロジー / 進化動態 / 調査研究 / 免疫応答 / 重篤化機序 Less
  • Research Projects

    (5 results)
  • Research Products

    (31 results)
  • Co-Researchers

    (13 People)
  •  Elucidation of the universal aggravation mechanisms caused by emerging viruses focusing on small viral RNAs

    • Principal Investigator
      渡邊 洋平
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 49060:Virology-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Elucidation of the mechanism of disease severity caused by SARS-CoV-2 focusing on the incompatibility between by virus and hostPrincipal Investigator

    • Principal Investigator
      荒井 泰葉
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 49060:Virology-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  アジア・アフリカの新興感染症ホットスポット域におけるウイルス進化動態の調査研究

    • Principal Investigator
      渡邊 洋平
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 58:Society medicine, nursing, and related fields
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Investigation for novel antiviral lead compounds focusing on the host adaptation mechanism of influenza virusPrincipal Investigator

    • Principal Investigator
      Arai Yasuha
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 49060:Virology-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Characterization of avian influenza virus variants isolated from infected patients

    • Principal Investigator
      Watanabe Yohei
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      Kyoto Prefectural University of Medicine

All 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

  • [Journal Article] Double mutations in the H9N2 avian influenza virus PB2 gene act cooperatively to increase viral host adaptation and replication for human infections2021

    • Author(s)
      Elgendy Emad Mohamed、Arai Yasuha、Kawashita Norihito、Isobe Ayana、Daidoji Tomo、Ibrahim Madiha Salah、Ono Takao、Takagi Tatsuya、Nakaya Takaaki、Matsumoto Kazuhiko、Watanabe Yohei
    • Journal Title

      Journal of General Virology

      Volume: 102 Pages: 1-17

    • DOI

      10.1099/jgv.0.001612

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08510, KAKENHI-PROJECT-20K21723, KAKENHI-PROJECT-20KK0199, KAKENHI-PROJECT-20KK0224
  • [Journal Article] Genetic tuning of avian influenza virus host adaptation from birds to humans2021

    • Author(s)
      Arai Yasuha、Watanabe Yohei
    • Journal Title

      Biosafety and Health

      Volume: Online ahead of print Pages: 1-3

    • DOI

      10.1016/j.bsheal.2020.11.006

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21723, KAKENHI-PROJECT-20KK0224, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-PUBLICLY-19H04841, KAKENHI-PROJECT-18K15171, KAKENHI-ORGANIZER-16H06429
  • [Journal Article] H9N2 influenza virus infections in human cells require a balance between NA sialidase activity and HA receptor affinity2020

    • Author(s)
      Arai Yasuha、Elgendy Emad Mohamed、Daidoji Tomo、Ibrahim Madiha Salah、Ono Takao、Sriwilaijaroen Nongluk、Suzuki Yasuo、Nakaya Takaaki、Matsumoto Kazuhiko、Watanabe Yohei
    • Journal Title

      Journal of Virology

      Volume: 94

    • DOI

      10.1128/jvi.01210-20

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21723, KAKENHI-PROJECT-20KK0224, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-PUBLICLY-19H04841, KAKENHI-PROJECT-18K15171, KAKENHI-ORGANIZER-16H06429
  • [Journal Article] PA mutations inherited during viral evolution act cooperatively to increase replication of contemporary H5N1 influenza virus with an expanded host range2020

    • Author(s)
      Arai Yasuha、Kawashita Norihito、Elgendy Emad Mohamed、Ibrahim Madiha Salah、Daidoji Tomo、Ono Takao、Takagi Tatsuya、Nakaya Takaaki、Matsumoto Kazuhiko、Watanabe Yohei
    • Journal Title

      Journal of Virology

      Volume: 95

    • DOI

      10.1128/jvi.01582-20

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21723, KAKENHI-PROJECT-20KK0224, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-PUBLICLY-19H04841, KAKENHI-PROJECT-18K15171, KAKENHI-ORGANIZER-16H06429
  • [Journal Article] Genetic Compatibility of Reassortants between Avian H5N1 and H9N2 Influenza Viruses with Higher Pathogenicity in Mammals2019

    • Author(s)
      Arai Y, Ibrahim MS, Elgendy EM, Daidoji T, Ono T, Suzuki Y, Nakaya T, Matsumoto K, Watanabe Y.
    • Journal Title

      Journal of Virology

      Volume: 93(4)

    • DOI

      10.1128/jvi.01969-18

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15171, KAKENHI-PROJECT-15H05295, KAKENHI-PROJECT-18H03040
  • [Journal Article] PB2 mutations arising during H9N2 influenza virus evolution in the Middle East confer enhanced replication and growth in mammals2019

    • Author(s)
      Arai Y, Kawashita N, Ibrahim MS, Elgendy EM, Daidoji T, Ono T, Takagi T, Nakaya T, Matsumoto K, Watanabe Y.
    • Journal Title

      PLoS Pathog

      Volume: 15(7)

    • DOI

      10.1371/journal.ppat.1007919

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15171, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PUBLICLY-19H04841, KAKENHI-PROJECT-15H05295, KAKENHI-PROJECT-18H03040, KAKENHI-PROJECT-18K14107
  • [Journal Article] Characterization of H5N1 influenza virus quasispecies with adaptive hemagglutinin mutations from single-virus infections of human airway cells.2018

    • Author(s)
      1.Watanabe Y**, Arai Y, Kawashita N, Ibrahim MS, Elgendy EM, Daidoji T, Kajikawa J, Hiramatsu H, Sriwilaijaroen N, Ono T, Takagi T, Takahashi K, Shioda T, Matsumoto K, Suzuki Y, Nakaya T
    • Journal Title

      FEBS J.

      Volume: 印刷中

    • DOI

      10.1128/jvi.02004-17

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05287, KAKENHI-PROJECT-15H05295, KAKENHI-PROJECT-16H05194, KAKENHI-PROJECT-15K08497, KAKENHI-PROJECT-15K09576, KAKENHI-PROJECT-18K15171
  • [Journal Article] Multiple polymerase gene mutations for human adaptation occurring in Asian H5N1 influenza virus clinical isolates2018

    • Author(s)
      Arai Y, Kawashita N, Hotta K, Hoang PVM, Nguyen HLK, Nguyen TC, Vuong CD, Le TT, Le MTQ, Soda K, Ibrahim MS, Daidoji T, Takagi T, Shioda T, Nakaya T, Ito T, Hasebe F, Watanabe Y.
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 13066-13066

    • DOI

      10.1038/s41598-018-31397-3

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15171, KAKENHI-PROJECT-15H05295
  • [Journal Article] Unique Infectious Strategy of H5N1 Avian Influenza Virus Is Governed by the Acid-Destabilized Property of Hemagglutinin2017

    • Author(s)
      Daidoji T**, Watanabe Y, Arai Y, Kajikawa J, Hirose R, Nakaya T
    • Journal Title

      Viral Immunology

      Volume: 30 Pages: 398-407

    • DOI

      10.1089/vim.2017.0020

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05287, KAKENHI-PROJECT-15H05295, KAKENHI-PROJECT-15K08497, KAKENHI-PROJECT-15K09576
  • [Journal Article] Identification of polymerase gene mutations that affect viral replication in H5N1 influenza viruses isolated from pigeon2017

    • Author(s)
      Elgendy EM, Arai Y, Kawashita N, Daidoji T, Takagi T, Ibrahim MS, Nakaya T, Watanabe Y
    • Journal Title

      J Gen Virol

      Volume: 98 Pages: 6-17

    • DOI

      10.1099/jgv.0.000674

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05287, KAKENHI-PROJECT-15H05295, KAKENHI-PROJECT-16J00589, KAKENHI-PROJECT-15K08497, KAKENHI-PROJECT-15K09576
  • [Journal Article] Novel Polymerase Gene Mutations for Human Adaptation in Clinical Isolates of Avian H5N1 Influenza Viruses2016

    • Author(s)
      Arai Y, Kawashita N, Daidoji T, Ibrahim MS, El-Gendy EM, Takagi T, Takahashi K, Suzuki Y, Ikuta K, Nakaya T, Shioda T, Watanabe Y
    • Journal Title

      PLoS Pathog

      Volume: 12

    • DOI

      10.1371/journal.ppat.1005583

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09576, KAKENHI-PROJECT-15H05295, KAKENHI-PROJECT-16J00589, KAKENHI-PROJECT-15K08497
  • [Journal Article] Long term detection of seasonal influenza RNA in faces and intestinal tissue2016

    • Author(s)
      Hirose R, Daidoji T, Naito Y, Watanabe Y, Arai Y, Oda T, Konishi H, Yamawaki M, Itoh Y, Nakaya T.
    • Journal Title

      Clin Microbiol Infect.

      Volume: 22 Pages: 813-813

    • DOI

      10.1016/j.cmi.2016.06.015

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05287, KAKENHI-PROJECT-15H05295, KAKENHI-PROJECT-15K08497, KAKENHI-PROJECT-15K09576
  • [Journal Article] Genetic characterization of highly pathogenic avian influenza H5N1 viruses isolated from naturally infected pigeons in Egypt2016

    • Author(s)
      Elgendy EM, Watanabe Y, Daidoji T, Arai Y, Ikuta K, Ibrahim MS, Nakaya T
    • Journal Title

      Virus Genes.

      Volume: 52 Pages: 867-871

    • DOI

      10.1007/s11262-016-1369-z

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05295, KAKENHI-PROJECT-16J00589, KAKENHI-PROJECT-15K08497, KAKENHI-PROJECT-15K09576
  • [Journal Article] Characterization of H5N1 Influenza Virus Variants with Hemagglutinin Mutations Isolated from Patients2015

    • Author(s)
      1.Watanabe Y, Arai Y, Daidoji T, Kawashita N, Ibrahim MS, El-Gendy E, Hiramatsu H, Kubota-Kokestu R, Takagi T, Murata T, Takahashi K, Okuno Y, Nakaya T, Suzuki Y, Ikuta K.
    • Journal Title

      mBio

      Volume: 6

    • DOI

      10.1128/mbio.00081-15

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390146, KAKENHI-PROJECT-24591480, KAKENHI-PROJECT-15K08497, KAKENHI-PROJECT-15H05287, KAKENHI-PROJECT-15H05295, KAKENHI-PROJECT-23406017
  • [Presentation] 近年中国で優勢に流行するH9N2亜型鳥インフルエンザウイルスのPB2遺伝子に選択された同時変異群はヒト適応性を高く変化させている2021

    • Author(s)
      荒井泰葉、Emad M. Elgendy, 川下理日人、磯邉綾菜、大道寺智、中屋隆明、渡邊洋平
    • Organizer
      第68回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-20KK0224
  • [Presentation] Accumulation of PA mutations in Egyptian H5N1 viruses during viral evolution conferred the increased replication ability.2019

    • Author(s)
      Yasuha Arai, Emad M. Elgendy, Tomo Daidoji, Madiha S. Ibrahim, Takaaki Nakaya, Yohei Watanabe.
    • Organizer
      第67回日本ウイルス学会学術集会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15171
  • [Presentation] Evaluation of avian influenza virus infection in human tracheal epithelial cell clones2018

    • Author(s)
      Tomo Daidoji, Junichi Kajikawa, Yohei Watanabe, Yasuha Arai, Takaaki Nakaya.
    • Organizer
      第66回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K15171
  • [Presentation] GENETIC COMPATIBILITY AND VIRULENCE OF REASSORTANTS DERIVED FROM H9N2 AND H5N1 AVIAN INFLUENZA VIRUSES CO-CIRCULATING IN EGYPT2018

    • Author(s)
      Yasuha Arai*, Madiha Ibrahim, Takaaki Nakaya, Yohei Watanabe.
    • Organizer
      Negative Strand Virus 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15171
  • [Presentation] Evolutionally dynamics of Egyptian H9N2 avian influenza virus in nature conferred enhanced replication ability in humans.2018

    • Author(s)
      Yasuha Arai*, Madiha S. Ibrahim, Emad M. Elgendy, Tomo Daidoji, Takaaki Nakaya, Yohei Watanabe.
    • Organizer
      第66回日本ウイルス学会学術集会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15171
  • [Presentation] Novel polymerase gene mutations for human adaptation in clinical isolates of Avian H5N1 influenza virus in Asia.2017

    • Author(s)
      Arai Y, Kawashita N, Hotta K, Hoang MPV, Nguyen KHL, Nguyen TC, Vuong CD, Le MQ, Soda K, Kajikawa J, Daidoji T, Nakaya T, Takagi T, Ito T, Hasebe H, Shioda T, Watanabe Y.
    • Organizer
      第65回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K08497
  • [Presentation] Evaluation of avian influenza virus infection in differentiated airway epithelial cells.2017

    • Author(s)
      Daidoji T, Noguchi M, Kajikawa J, Watanabe Y, Arai Y, Hirose R, Morimoto M, Nakaya T.
    • Organizer
      第65回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K08497
  • [Presentation] Mechanism of seasonal influenza virus persistence in human digestive tract: Mucus protects virions from acid and digestive juices.2017

    • Author(s)
      Nakaya T, Hirose R, Daidoji T, Naito Y, Watanabe Y, Arai Y, Kawada K, Kajikawa J, Yamawaki M, Itoh Y.
    • Organizer
      第65回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K08497
  • [Presentation] Characterization of H5N1 influenza virus with HA mutations diversified in human airway epithelial cells as minor variants.2017

    • Author(s)
      Watanabe Y, Arai Y, Kawashita N, Daidoji T, Elgendy EM, Ibrahim MS, Kajikawa J, Hiramatsu H, Takagi T, Takahashi K, Shioda T, Suzuki Y, Nakaya T.
    • Organizer
      第65回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K08497
  • [Presentation] Establishment of immortalized cell clones from human tracheal epithelial cells and their different susceptibility to influenza viruses.2017

    • Author(s)
      Kajikawa J, Daidoji T, Watanabe Y, Arai Y, Hirose R, Nakaya T.
    • Organizer
      第65回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K08497
  • [Presentation] Hemagglutinin acid stability and viral infection in H7 influenza virus2016

    • Author(s)
      Daidoji T, Elgendy EM, Watanabe Y, Arai Y, Ibrahim MS, Ikuta K, Nakaya T
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Data Source
      KAKENHI-PROJECT-15K08497
  • [Presentation] Characterization of H5N1 influenza virus variants with HA mutations selected during the viral replication in human airway epithelial cells2016

    • Author(s)
      Watanabe Y, Arai Y, Daidoji T, Elgendy EM, Ibrahim MS, Takahashi K, Shioda T, Ikuta K, Suzuki Y, Nakaya T
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Data Source
      KAKENHI-PROJECT-15K08497
  • [Presentation] Identification of unique mutations that influence the polymerase activity of H5N1 avian influenza virus isolated from pigeons2016

    • Author(s)
      Elgendy EM, Arai Y, Ibrahim MS, Daidoji T, Ikuta K, Nakaya T, Watanabe Y
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Data Source
      KAKENHI-PROJECT-15K08497
  • [Presentation] Novel polymerase gene mutations for human adaptation in clinical isolates of avian H5N1 influenza viruses2016

    • Author(s)
      Arai Y, Kawashita N, Daidoji T, Ibrahim MS, Takayashi K, Suzuki Y, Nakaya T, Shioda T, Ikuta K, Watanabe Y
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Data Source
      KAKENHI-PROJECT-15K08497
  • [Presentation] Genetic characterization of H5N1 avian influenza virus from pigeon in Egypt 20092015

    • Author(s)
      Emad Elgendy, Madiha S. Ibrahim, Arai Yasuha, Tomo Daidoji, Yohei Watanabe, Takaaki Nakaya
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-22
    • Data Source
      KAKENHI-PROJECT-15K08497
  • [Presentation] Identification of human adaptive mutations in the polymerase complex of H5N1 avian influenza virus in Egypt2015

    • Author(s)
      Yasuha Arai, Tomo Didoji, Madiha S. Ibrahim, Kazuo Takahashi, Yasuo Suzuki, Takaaki Nakaya, Tatsuo Shioda, Kazuyoshi Ikuta, Yohei Watanabe
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-22
    • Data Source
      KAKENHI-PROJECT-15K08497
  • [Presentation] Genetic diversification of H5N1 avian influenza virus variants during replication in human airway epithelial cells2015

    • Author(s)
      Yohei Watanabe, Yasuha Arai, Tomo Daidoji, Madiha S Ibrahim, Emad Elgendy, Kazuo Takahashi, Yasuo Suzuki, Tatsuo Shioda, Kazuyoshi Ikuta, Takaaki Nakaya
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-22
    • Data Source
      KAKENHI-PROJECT-15K08497
  • 1.  Watanabe Yohei (50452462)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 27 results
  • 2.  鈴木 康夫 (00046278)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 3.  大道寺 智 (80432433)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 22 results
  • 4.  小川 晴子 (10400079)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  武田 洋平 (30804447)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  NAKAYA Takaaki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 10 results
  • 7.  Ibrahim Madiha S.
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 8.  高橋 和郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 9.  塩田 達雄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  鈴木 信弘
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  渡辺 登喜子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 12.  小野 尭生
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  生田 和良
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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