Kobayashi Keisuke 小林啓介

Researcher Number	80794734
Other IDs	https://orcid.org/0000-0001-9580-2484
Affiliation (Current)	2025: 北里大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2025: 北里大学, 薬学部, 講師 2023: 北里大学, 薬学部, 講師 2018 – 2022: 北里大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields
Keywords	Principal Investigator 天然物化学 / ケミカルバイオロジー / 天然物 / アムホテリシン / 真菌 / ペプチド / 感染症 / アムホテリシンB / 抗真菌 / 脂質 … More / 細胞膜 / 真菌感染症 / オートファジー / プロテオミクス / 標的分子 / ケミカルプロテオミクス / 微生物資源 / 天然化合物 / トリアシルグリセロール / コレステリルエステル / 脂肪滴 / 中性脂質 … More Except Principal Investigator 探索 / ライブラリー / 創薬 / シード探索 / ライブラリ / 天然資源 Less

真菌細胞膜脂質を標的とする低分子ペプチドの機能解析と抗真菌感染症薬への応用Principal Investigator
- Principal Investigator
  
  小林啓介
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Kitasato University
Studies on the potentiators of antifungal activities of amphotericin BPrincipal Investigator
- Principal Investigator
  
  Keisuke Kobayashi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Kitasato University
The study of mechanism of action of fungal dinapinone A that enhances neutral lipid degradation in mammalian cellsPrincipal Investigator
- Principal Investigator
  
  Kobayashi Keisuke
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Kitasato University
Collection and utilization of bioresources and natural products from Indonesia
- Principal Investigator
  
  Tomoda Hiroshi
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Kitasato University

All 2024 2023 2022 2020 2019

All Journal Article Presentation Patent

[Journal Article] Synthesis and biological evaluation of nectriatide derivatives, potentiators of amphotericin B activity2024
- Author(s)
  Nagai, K.; Kobayashi, K.; Miyake, R.; Sato, Y.; Seki, R.; Fukuda, T.; Yagi, A.; Uchida, R.; Ohshiro, T.; Tomoda, H
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 77 Issue: 4 Pages: 214-220
- DOI
  10.1038/s41429-023-00700-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K05333, KAKENHI-PROJECT-21K15284
[Journal Article] Screening for microbial potentiators of neutral lipid degradation in CHO-K1 cells2022
- Author(s)
  Nur Elyza Aiman Azizah、Kobayashi Keisuke、Ohte Satoshi、Tomoda Hiroshi、Ohshiro Taichi
- Journal Title
  
  Drug Discoveries & Therapeutics
  
  Volume: 16 Issue: 6 Pages: 273-279
- DOI
  10.5582/ddt.2022.01087
- ISSN
  1881-7831, 1881-784X
- Year and Date
  2022-12-25
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18KK0219, KAKENHI-PROJECT-19K16320
[Journal Article] Inhibition of cholesteryl ester synthesis by polyacetylenes from Atractylodes rhizome.2020
- Author(s)
  Nur EAA, Ohshiro T, Kobayashi K, Wu J, Wahyudin E, Zhang H, Hayashi F, Kawagishi H, Tomoda H.
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 30 Issue: 7 Pages: 126997-126997
- DOI
  10.1016/j.bmcl.2020.126997
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06555, KAKENHI-PLANNED-17H06402, KAKENHI-PROJECT-18K05345, KAKENHI-PROJECT-18KK0219
[Journal Article] New Terpendole Congeners, Inhibitors of Sterol O-Acyltransferase, Produced by Volutella citrinella BF-04402020
- Author(s)
  Nur Elyza Aiman Azizah、Kobayashi Keisuke、Amagai Ai、Ohshiro Taichi、Tomoda Hiroshi
- Journal Title
  
  Molecules
  
  Volume: 25 Issue: 13 Pages: 3079-3079
- DOI
  10.3390/molecules25133079
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16320, KAKENHI-PROJECT-18KK0219, KAKENHI-PROJECT-18K06555
[Patent] 抗真菌薬に対する活性増強作用を有する新規化合物及びその製造方法2023
- Inventor(s)
  大城太一、供田洋、小林啓介、長井賢一郎
- Industrial Property Rights Holder
  大城太一、供田洋、小林啓介、長井賢一郎
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-21K15284
[Presentation] Fungal srimane sesquiterpenoids from BF-1613 strain as sterol O-acyltransferase (SOAT) inhibitors2024
- Author(s)
  Nur Elyza, Keisuke Kobayashi, Hiroshi Tomoda, Taichi Ohshiro
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-18KK0219
[Presentation] 抗真菌薬amphotericin B活性増強剤nectriatide類の機能解析2023
- Author(s)
  小林啓介、長井賢一郎、三宅良介、関怜子、西村慎一、福田隆志、内田龍児、供田洋、大城太一
- Organizer
  第65回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-21K15284
[Presentation] なぜnectriatideは抗真菌剤amphotericin Bの活性を増強するのか？2023
- Author(s)
  三宅良介、小林啓介、長井賢一郎、西村慎一、供田洋、大城太一
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K15284
[Presentation] Searching for Lipid Metabolism Regulators in Mammalian Cells from Microorganism2023
- Author(s)
  Elyza Aiman Azizah Nur, Keisuke Kobayashi, Satoshi Ohte, Hiroshi Tomoda, and Taichi Ohshiro
- Organizer
  13th ISISM, 10th ISIBio, and 20th ACM meeting
- Data Source
  KAKENHI-PROJECT-18KK0219
[Presentation] 真菌Volutella citrinella BF-0440株が生産する新規テルペンドール類に関する研究2022
- Author(s)
  Elyza Nur、小林啓介、大城太一、供田洋
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-18KK0219
[Presentation] 真菌 Volutella citrinella BF-0440株が生産する新規テルペンドール類に関する研究2022
- Author(s)
  Elyza Nur、小林啓介、大城太一、供田洋
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K16320
[Presentation] 抗真菌剤amphotericin B活性増強化合物nectriatide誘導体に関する研究2022
- Author(s)
  三宅良介、小林啓介、長井賢一郎、西村慎一、供田洋、大城太一
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K15284
[Presentation] カイコを用いた抗真菌剤amphotericin B活性増強化合物nectriatideの簡易in vivo評価2022
- Author(s)
  三宅良介、小林啓介、長井賢一郎、大城太一、供田洋
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K15284
[Presentation] 真菌 Volutella citrinella BF-0440 株が生産する新規 voluhemin 類と terpendole 類に関する研究2022
- Author(s)
  Nur Elyza、小林啓介、供田洋、大城太一
- Organizer
  第12回AKPS北里化学シンポジウム（優秀ポスター賞）
- Data Source
  KAKENHI-PROJECT-18KK0219
[Presentation] 真菌 Volutella citrinella BF-0440株が生産する sterol O-acyltarnsferase阻害剤とその構造活性相関2020
- Author(s)
  小林啓介、大城太一、Elyza Nur、森田遥、内田龍児、供田洋
- Organizer
  第62回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-19K16320
[Presentation] 細胞内中性脂質蓄積阻害活性を示す天然物ダイナピノンの標的分子の解析2020
- Author(s)
  小林　啓介、奥畑　颯眞、供田　洋
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K16320
[Presentation] 中性脂質蓄積阻害活性を示す真菌由来化合物 dinapinone A の結合タンパク質の探索2019
- Author(s)
  奥畑　颯眞、小林　啓介、供田　洋
- Organizer
  第61回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-19K16320
[Presentation] 中性脂質の分解を促進する中分子化合物ダイナピノンAの結合タンパク質の探索2019
- Author(s)
  小林　啓介、奥畑　颯眞、供田　洋
- Organizer
  第92回日本生化学大会
- Data Source
  KAKENHI-PROJECT-19K16320

1. Tomoda Hiroshi (70164043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. 大城太一 (30458765)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. 大手聡 (00547979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. NAGAI Kenichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kobayashi Keisuke 小林 啓介

Research Projects

Research Products

Co-Researchers

真菌細胞膜脂質を標的とする低分子ペプチドの機能解析と抗真菌感染症薬への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on the potentiators of antifungal activities of amphotericin BPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The study of mechanism of action of fungal dinapinone A that enhances neutral lipid degradation in mammalian cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Collection and utilization of bioresources and natural products from Indonesia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Synthesis and biological evaluation of nectriatide derivatives, potentiators of amphotericin B activity2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Screening for microbial potentiators of neutral lipid degradation in CHO-K1 cells2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Inhibition of cholesteryl ester synthesis by polyacetylenes from Atractylodes rhizome.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] New Terpendole Congeners, Inhibitors of Sterol O-Acyltransferase, Produced by Volutella citrinella BF-04402020

Author(s)

Journal Title

DOI

Data Source

[Patent] 抗真菌薬に対する活性増強作用を有する新規化合物及びその製造方法2023

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Presentation] Fungal srimane sesquiterpenoids from BF-1613 strain as sterol O-acyltransferase (SOAT) inhibitors2024

Author(s)

Organizer

Data Source

[Presentation] 抗真菌薬amphotericin B活性増強剤nectriatide類の機能解析2023

Author(s)

Organizer

Data Source

[Presentation] なぜnectriatideは抗真菌剤amphotericin Bの活性を増強するのか？2023

Author(s)

Organizer

Data Source

[Presentation] Searching for Lipid Metabolism Regulators in Mammalian Cells from Microorganism2023

Author(s)

Organizer

Data Source

[Presentation] 真菌Volutella citrinella BF-0440株が生産する新規テルペンドール類に関する研究2022

Author(s)

Organizer

Data Source

[Presentation] 真菌 Volutella citrinella BF-0440株が生産する新規テルペンドール類に関する研究2022

Author(s)

Organizer

Kobayashi Keisuke 小林啓介