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Isobe Kiyoshi  磯部 清志

ORCIDConnect your ORCID iD *help
Researcher Number 80804591
Other IDs
Affiliation (Current) 2023: 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師
Affiliation (based on the past Project Information) *help 2020 – 2021: 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師
2018 – 2019: 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座助教
Review Section/Research Field
Principal Investigator
Basic Section 53040:Nephrology-related
Keywords
Principal Investigator
WNK4 / メタボリックシンドローム / 塩分感受性高血圧 / リン酸化プロテオミクス / 脂肪分化 / 3T3-L1 / PPARγ / C/EBPα / WNK4 / 3T3-L1 … More / SILAC / WNK / アクアポリン2 / ミオシン軽鎖キナーゼ / 高血圧 / WNKキナーゼ / WNK1 / Proteomics Less
  • Research Projects

    (2 results)
  • Research Products

    (11 results)
  • Co-Researchers

    (11 People)
  •  Development of new antihypertensive drug by comprehensive analysis of WNK signalPrincipal Investigator

    • Principal Investigator
      ISOBE KIYOSHI
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Tokyo Medical and Dental University
  •  New drug development for metabolic syndrome via WNK4 singnaling analysisPrincipal Investigator

    • Principal Investigator
      Isobe Kiyoshi
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Tokyo Medical and Dental University

All 2021 2020 2019 2018

All Journal Article

  • [Journal Article] Structural Development of Salicylanilide‐Based SPAK Inhibitors as Candidate Antihypertensive Agents2021

    • Author(s)
      Fujii Shinya、Kikuchi Eriko、Suzuyama Honoka、Watanabe Yuko、Ishigami‐Yuasa Mari、Masuno Hiroyuki、Mori Takayasu、Isobe Kiyoshi、Uchida Shinichi、Kagechika Hiroyuki
    • Journal Title

      ChemMedChem

      Volume: 16 Pages: 2817-2822

    • DOI

      10.1002/cmdc.202100273

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K22486, KAKENHI-PROJECT-20K17244, KAKENHI-PROJECT-17H03997
  • [Journal Article] Structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK inhibitors blocking WNK kinase signaling2020

    • Author(s)
      Fujii Shinya、Kikuchi Eriko、Watanabe Yuko、Suzuyama Honoka、Ishigami-Yuasa Mari、Mori Takayasu、Isobe Kiyoshi、Uchida Shinichi、Kagechika Hiroyuki
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 30 Pages: 127408-127408

    • DOI

      10.1016/j.bmcl.2020.127408

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K22486, KAKENHI-PROJECT-20K17244, KAKENHI-PROJECT-17H03997
  • [Journal Article] CRISPR-Cas9/phosphoproteomics identifies multiple noncanonical targets of myosin light chain kinase2020

    • Author(s)
      Isobe Kiyoshi、Raghuram Viswanathan、Krishnan Laya、Chou Chung-Lin、Yang Chin-Rang、Knepper Mark A.
    • Journal Title

      American Journal of Physiology-Renal Physiology

      Volume: 318

    • DOI

      10.1152/ajprenal.00431.2019

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K15970
  • [Journal Article] Sodium?calcium exchanger 1 is the key molecule for urinary potassium excretion against acute hyperkalemia2020

    • Author(s)
      Shoda W, Nomura N, Ando F, Tagashira H, Iwamoto T, Ohta A, Isobe K, Mori T, Susa K, Sohara E, Rai T, Uchida S.
    • Journal Title

      PLOS ONE

      Volume: 15(6) Pages: 0235360-0235360

    • DOI

      10.1371/journal.pone.0235360

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K16509, KAKENHI-PROJECT-20K17244, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-19K23982
  • [Journal Article] Nationwide in-hospital mortality following major fractures among hemodialysis patients and the general population: An observational cohort study2020

    • Author(s)
      Mandai Shintaro、Sato Hidehiko、Iimori Soichiro、Naito Shotaro、Tanaka Haruna、Ando Fumiaki、Susa Koichiro、Isobe Kiyoshi、Mori Takayasu、Nomura Naohiro、Sohara Eisei、Okado Tomokazu、Uchida Shinichi、Fushimi Kiyohide、Rai Tatemitsu
    • Journal Title

      Bone

      Volume: 130 Pages: 115122-115122

    • DOI

      10.1016/j.bone.2019.115122

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-18K15970
  • [Journal Article] Renal TNFα activates the WNK phosphorylation cascade and contributes to salt-sensitive hypertension in chronic kidney disease2020

    • Author(s)
      Furusho T, Sohara E, Mandai S, Kikuchi H, Takahashi N, Fujimaru T, Hashimoto H, Arai Y, Ando F, Zeniya M, Mori T, Susa K, Isobe K, Nomura N, Yamamoto K, Okado T, Rai T, Uchida S
    • Journal Title

      Kidney International

      Volume: 97 Pages: 713-727

    • DOI

      10.1016/j.kint.2019.11.021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15970, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-19K21299, KAKENHI-PROJECT-20K17244, KAKENHI-PROJECT-20K17276, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672
  • [Journal Article] Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease.2019

    • Author(s)
      Kikuchi H, Sasaki E, Nomura N, Mori T, Minamishima YA, Yoshizaki Y, Takahashi N, Furusho T, Arai Y, Mandai S, Yamashita T, Ando F, Maejima Y, Isobe K, Okado T, Rai T, Uchida S, Sohara E
    • Journal Title

      Kidney International

      Volume: 95 Pages: 123-137

    • DOI

      10.1016/j.kint.2018.08.030

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-16K09642, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-18K15970, KAKENHI-PROJECT-16H04723
  • [Journal Article] Tacrolimus ameliorates the phenotypes of type 4 Bartter syndrome model mice through activation of sodium?potassium?2 chloride cotransporter and sodium?chloride cotransporter2019

    • Author(s)
      Matsuura Yoshiaki、Nomura Naohiro、Shoda Wakana、Mori Takayasu、Isobe Kiyoshi、Susa Koichiro、Ando Fumiaki、Sohara Eisei、Rai Tatemitsu、Uchida Shinichi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 517 Pages: 364-368

    • DOI

      10.1016/j.bbrc.2019.07.086

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15970, KAKENHI-PROJECT-18K15995
  • [Journal Article] Tolvaptan activates the Nrf2/HO-1 antioxidant pathway through PERK phosphorylation2019

    • Author(s)
      Fujiki Tamami、Ando Fumiaki、Murakami Kana、Isobe Kiyoshi、Mori Takayasu、Susa Koichiro、Nomura Naohiro、Sohara Eisei、Rai Tatemitsu、Uchida Shinichi
    • Journal Title

      Scientific Reports

      Volume: 9 Pages: 9245-9245

    • DOI

      10.1038/s41598-019-45539-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K16501, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15970
  • [Journal Article] Decreased KLHL3 expression is involved in the pathogenesis of pseudohypoaldosteronism type II caused by cullin 3 mutation in vivo.2018

    • Author(s)
      Yoshida S, Araki Y, Mori T, Sasaki E, Kasagi Y, Isobe K, Susa K, Inoue Y, Bomont P, Okado T, Rai T, Uchida S, Sohara E
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 22 Pages: 1251-1257

    • DOI

      10.1007/s10157-018-1593-z

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15970, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-16K09642
  • [Journal Article] Metformin increases urinary sodium excretion by reducing phosphorylation of the sodium-chloride cotransporter2018

    • Author(s)
      Hashimoto Hiroko、Nomura Naohiro、Shoda Wakana、Isobe Kiyoshi、Kikuchi Hiroaki、Yamamoto Kouhei、Fujimaru Takuya、Ando Fumiaki、Mori Takayasu、Okado Tomokazu、Rai Tatemitsu、Uchida Shinichi、Sohara Eisei
    • Journal Title

      Metabolism

      Volume: 85 Pages: 23-31

    • DOI

      10.1016/j.metabol.2018.02.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09642, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16K15467, KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15970, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-16H05314
  • 1.  SOHARA Eisei
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 8 results
  • 2.  内田 信一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 6 results
  • 3.  野村 尚弘
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 4.  頼 建光
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 8 results
  • 5.  南嶋 洋司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  藤井 晋也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 7.  田頭 秀章
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  正田 若菜
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  安藤 史顕
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  萬代 新太郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  橋本 博子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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