Sakurai Masayuki 櫻井雅之

Researcher Number	80809236
Other IDs	https://orcid.org/0000-0002-6920-1746
Affiliation (Current)	2026: 東京理科大学, 研究推進機構生命医科学研究所, 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 東京理科大学, 研究推進機構生命医科学研究所, 准教授 2018 – 2020: 東京理科大学, 研究推進機構生命医科学研究所, 講師
Review Section/Research Field	Principal Investigator Basic Section 43010:Molecular biology-related / 0701:Biology at molecular to cellular levels, and related fields Except Principal Investigator Medium-sized Section 62:Applied informatics and related fields
Keywords	Principal Investigator R-loop / アデノシン脱アミノ化 / RNA編集 / ADAR / ノヴァエピヌクレオーム / RNA:DNAハイブリッド鎖 / エピトランスクリプトーム / イノシン / ゲノム編集 / イノシン化部位標識技術 … More / A-to-I-DNA編集 / DNA編集 / イノシン化部位標識単離技術ICLAMP / ゲノム動態制御 / アデノシン脱アミノ化酵素ADAR / A-to-I DNA編集 / 細胞周期制御 / ゲノム安定性 / タンパク質リン酸化 / ICLAMP法 / セントロメア / ADAR1 / A-to-I RNA編集 / 塩基脱アミノ化 / 転写制御 / DNA損傷 / イノシン化 / 核酸創薬 / 核酸修飾 / ゲノムDNA編集 / 塩基修飾 / RNA editing / DNA 編集 / A-to-I エディティング … More Except Principal Investigator 転写 / RNA分解 / ノンコーディングRNA / RNA Less

RNAリインカネーション
- Principal Investigator
  
  浜田道昭
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 62:Applied informatics and related fields
- Research Institution
  Waseda University
Genomic DNA deamination editing mechanism regulated by RNA in humanPrincipal Investigator
- Principal Investigator
  
  Sakurai Masayuki
- Project Period (FY)
  2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Tokyo University of Science
Molecular mechanisms of mammalian endogenous RNA-dependent DNA base modification and disease pathogenesis due to dysregulationPrincipal Investigator
- Principal Investigator
  
  Sakurai Masayuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Tokyo University of Science
ゲノム&RNA編集酵素ADAR1が司るR-loop制御によるゲノム安定性維持機構Principal Investigator
- Principal Investigator
  
  櫻井雅之
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0701:Biology at molecular to cellular levels, and related fields
- Research Institution
  Tokyo University of Science

All 2025 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Book Patent

[Book] 東京理科大学　科学教養誌月刊「理大　科学フォーラム」「RNA・DNA編集によるゲノム安定性制御」2022
- Author(s)
  櫻井雅之
- Total Pages
  5
- Publisher
  東京理科大学
- Data Source
  KAKENHI-PROJECT-23K23812
[Book] 月刊「細胞」2021
- Author(s)
  櫻井雅之, 久保田真依, 市橋瑛斗, 岡田俊平, 中野美世子
- Total Pages
  4
- Publisher
  ニューサイエンス社
- Data Source
  KAKENHI-PROJECT-19H03159
[Book] 理大　科学フォーラム2021
- Author(s)
  櫻井雅之
- Total Pages
  4
- Publisher
  東京理科大学　科学教養誌
- Data Source
  KAKENHI-PROJECT-19H03159
[Book] BIO Clinica2021
- Author(s)
  櫻井雅之, 久保田真依, 中野美世子, 岡田俊平
- Total Pages
  4
- Publisher
  ニューサイエンス社
- Data Source
  KAKENHI-PROJECT-19H03159
[Book] A-to-I RNA 塩基編集による疾患と対策技術2020
- Author(s)
  櫻井雅之, 岡田俊平
- Total Pages
  4
- Publisher
  ニューサイエンス社 MSD メディカルサイエンスダイジェスト
- Data Source
  KAKENHI-PROJECT-19H03159
[Book] 分子生物学と遺伝子の研究2019
- Author(s)
  櫻井雅之、岡田俊平
- Total Pages
  6
- Publisher
  東京理科大学科学フォーラムサイエンスへの招待
- Data Source
  KAKENHI-PROJECT-19H03159
[Book] もう一つの遺伝子 ”編集” - 哺乳動物が備える核酸塩基の編集機構」2019
- Author(s)
  櫻井雅之
- Total Pages
  2
- Publisher
  ニューサイエンス社 MSD メディカル・サイエンス・ダイジェスト
- Data Source
  KAKENHI-PROJECT-19H03159
[Book] 実験医学2018
- Author(s)
  4.櫻井雅之, 長谷川拓巳, 中山宏紀
- Total Pages
  5
- Publisher
  羊土社
- ISBN
  9784758125147
- Data Source
  KAKENHI-PROJECT-18H06054
[Journal Article] Advances in Detection Methods for A‐to‐I <scp>RNA</scp> Editing2025
- Author(s)
  Yang Yuxi、Sakurai Masayuki
- Journal Title
  
  WIREs RNA
  
  Volume: 16 Issue: 2
- DOI
  10.1002/wrna.70014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K23812
[Journal Article] ICLAMP: a novel technique to explore adenosine deamination via inosine chemical labeling and affinity molecular purification2024
- Author(s)
  Yang Yuxi、Nakayama Koki、Okada Shunpei、Sato Kazuki、Wada Takeshi、Sakaguchi Yuriko、Murayama Ayaka、Suzuki Tsutomu、Sakurai Masayuki
- Journal Title
  
  FEBS Letters
  
  Volume: in press Issue: 9 Pages: 1080-1093
- DOI
  10.1002/1873-3468.14854
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05272, KAKENHI-PROJECT-23K23812
[Journal Article] ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16INK4a levels2022
- Author(s)
  Hao Xue、Shiromoto Yusuke、Sakurai Masayuki、Towers Martina、Zhang Qiang、Wu Shuai、Havas Aaron、Wang Lu、Berger Shelley、Adams Peter D.、Tian Bin、Nishikura Kazuko、Kossenkov Andrew V.、Liu Pingyu、Zhang Rugang
- Journal Title
  
  Nature Cell Biology
  
  Volume: 24 Issue: 8 Pages: 1202-1210
- DOI
  10.1038/s41556-022-00959-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20655, KAKENHI-PROJECT-23K23812
[Journal Article] Adenosine-to-inosine RNA editing in neurological development and disease2021
- Author(s)
  Yuxi Yang、Shunpei Okada、Masayuki Sakurai
- Journal Title
  
  RNA Biology
  
  Volume: 6 Issue: 7 Pages: 1-15
- DOI
  10.1080/15476286.2020.1867797
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16037, KAKENHI-PROJECT-19H03159
[Journal Article] ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells2021
- Author(s)
  Shiromoto Yusuke、Sakurai Masayuki、Minakuchi Moeko、Ariyoshi Kentaro、Nishikura Kazuko
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1
- DOI
  10.1038/s41467-021-21921-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12354, KAKENHI-PROJECT-19H03159
[Journal Article] Discovering A-to-I RNA Editing Through Chemical Methodology “ICE-seq”2020
- Author(s)
  Sakurai, M., Okada, S., Ueda, H., and Yang, Y.
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 2181 Pages: 113-148
- DOI
  10.1007/978-1-0716-0787-9_8
- ISBN
  9781071607862, 9781071607879
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16037, KAKENHI-PROJECT-23K21431, KAKENHI-PROJECT-19H03159
[Journal Article] Processing of Alu small RNAs by DICER/ADAR1 complexes and their RNAi targets2020
- Author(s)
  Shiromoto Yusuke、Sakurai Masayuki、Qu Helen、Kossenkov Andrew V.、Nishikura Kazuko
- Journal Title
  
  RNA
  
  Volume: 26 Issue: 12 Pages: 1801-1814
- DOI
  10.1261/rna.076745.120
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03159
[Journal Article] Discovering RNA editing by chemical methods2019
- Author(s)
  Sakurai, M.*(Corresponding Author), Okada, S., Ueda, H.
- Journal Title
  
  Methods Mol. Biol.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H06054
[Patent] A Novel Technique to Explore Adenosine Deamination via Inosine Chemical Labeling and Affinity Molecular Purification2024
- Inventor(s)
  Sakurai, M. et al.
- Industrial Property Rights Holder
  Sakurai, M. et al.
- Industrial Property Rights Type
  特許
- Filing Date
  2024
- Overseas
- Data Source
  KAKENHI-PROJECT-23K23812
[Patent] イノシン塩基の標識方法、イノシン塩基の検出方法、核酸の配列決定方法、イノシン塩基を含む核酸の濃縮方法、イノシン塩基標識剤、及びキット2023
- Inventor(s)
  櫻井雅之, 楊雨溪, 中山宏紀, 岡田俊平, 和田猛, 佐藤一樹
- Industrial Property Rights Holder
  学校法人東京理科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-175606
- Filing Date
  2023
- Acquisition Date
  2023
- Data Source
  KAKENHI-PROJECT-23K23812
[Presentation] Adenosine-to-inosine base editing by ADAR; new features for DNA regulation via R-loop structure.2024
- Author(s)
  Sakurai, M., Yang, Y., Kubota, M., Ichihashi, E.
- Organizer
  The 25th Annual Meeting of the RNA Society of Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23812
[Presentation] ICLAMP: a novel technique to explore adenosine deamination via inosine chemical labeling and affinity molecular purification.2024
- Author(s)
  Sakurai, M., Yang, Y., Nakayama, N., Okada, S., Sakaguchi, Y., Murayama, A., Suzuki, T., Sato, K., Wada, T.
- Organizer
  XXV International Round Table on Nucleosides, Nucleotides and Nucleic Acids （IRT2024）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23812
[Presentation] Identify the effect of R-loop on transcriptional regulatory mechanisms.2024
- Author(s)
  Yanoshita, R., Ichihashi, E., Kubota, M., Zeng, C., Hamada, M., Sakurai, M.
- Organizer
  The 25th Annual Meeting of the RNA Society of Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23812
[Presentation] ICLAMP: a novel technique to explore adenosine deamination via inosine chemical labeling and affinity molecular purification.2024
- Author(s)
  Yang, Y., Nakayama, N., Okada, S., Sato, K., Wada, T., Sakaguchi, Y., Murayama, A., Suzuki, T., Sakurai, M.
- Organizer
  The 25th Annual Meeting of the RNA Society of Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23812
[Presentation] Adenosine-to-inosine base editing by ADAR; new features for DNA regulation.2023
- Author(s)
  Sakurai, M., Yang, Y., Kubota, M., Ichihashi, E., Nishikura, K., Shiromoto, Y., Minakuchi, M.
- Organizer
  第24回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-23K23812
[Presentation] アデノシン脱アミノ化によるRNA:DNA鎖を介したDNA動態制御2023
- Author(s)
  櫻井雅之
- Organizer
  第9回がんと代謝研究会
- Data Source
  KAKENHI-PROJECT-23K23812
[Presentation] アデノシン脱アミノ化編集酵素によるDNA編集とその動態制御2023
- Author(s)
  櫻井雅之
- Organizer
  日本核酸医薬学会「生物セッション第6回サテライトシンポジウム」　―RNA が制御する多様な生命機能―
- Data Source
  KAKENHI-PROJECT-23K23812
[Presentation] Development of a new technique to isolate inosine-containing molecules from intracellular nucleic acid.2023
- Author(s)
  Yang, Y., Nakayama, K., Okada, S., Sato, K. Wada, T., Sakurai, M.
- Organizer
  第24回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-23K23812
[Presentation] The short isoform of ADAR1 contributes to cell maintenance in DNA repair and mitosis regulation.2023
- Author(s)
  Kubota, M., Nishikura, K., Shiromoto, Y., Sakurai, M.
- Organizer
  第24回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-23K23812
[Presentation] Development of a new technique to isolate inosine-containing molecules from intracellular nucleic acid2022
- Author(s)
  Yang, Y., Nakayama, K., Okada, S., Sato, K., Wada, T., Sakurai, M.
- Organizer
  The 49th International Symposium on Nucleic Acids Chemistry 2022 / The 6th Annual Meeting of Japan Society of Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23812
[Presentation] Identify the effect of R-loop on transcriptional regulatory mechanisms2022
- Author(s)
  Ichihashi, E., Kubota, M., Zeng, C., Hamada, M., Nisikura, K., Siromoto, Y., Sakurai, M.
- Organizer
  The 49th International Symposium on Nucleic Acids Chemistry 2022 / The 6th Annual Meeting of Japan Society of Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23812
[Presentation] Identify the effect of R-loop on transcriptional regulatory mechanisms2022
- Author(s)
  Ichihashi, E., Kubota, M., Zeng, C., Hamada, M., Nisikura, K., Siromoto, Y., Sakurai, M.
- Organizer
  The 23rd Annual Meeting of the RNA Society of Japan
- Data Source
  KAKENHI-PROJECT-23K23812
[Presentation] Development of a new technique to isolate inosine-containing molecules from intracellular nucleic acid2022
- Author(s)
  Yang, Y., Nakayama, K., Okada, S., Sato, K., Wada, T., Sakurai, M.
- Organizer
  The 23rd Annual Meeting of the RNA Society of Japan
- Data Source
  KAKENHI-PROJECT-23K23812
[Presentation] Regulatory Mechanism of Mitosis by RNA: DNA Strand Binding of RNA Editing Enzymes2022
- Author(s)
  Kubota, M., Nishikura, K., Shiromoto, Y., Sakurai, M.
- Organizer
  The 23rd Annual Meeting of the RNA Society of Japan
- Data Source
  KAKENHI-PROJECT-23K23812
[Presentation] New function of Adenosine Deaminase acting on RNA~ A-to-I RNA & DNA editing2022
- Author(s)
  Sakurai, M.
- Organizer
  The 45th Annual Meeting of the Molecular Biology Society of Japan.
- Data Source
  KAKENHI-PROJECT-23K23812
[Presentation] Regulatory Mechanism of Mitosis by RNA: DNA Strand Binding of RNA Editing Enzymes2022
- Author(s)
  Kubota, M., Nishikura, K., Shiromoto, Y., Sakurai, M
- Organizer
  The 49th International Symposium on Nucleic Acids Chemistry 2022 / The 6th Annual Meeting of Japan Society of Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23812
[Presentation] ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells2020
- Author(s)
  Shiromoto, Y., Sakurai, M., Mizugushi,M., Ariyoshi,K., and Nishikura, K.
- Organizer
  VIRTUAL KEYSTONESYMPOSIA RNA Editing and Modifications: From Biology to Therapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03159
[Presentation] RNA reincarnation2020
- Author(s)
  Sakurai, M
- Organizer
  The 43rd Annual Meeting of the Molecular Biology Society of Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03159
[Presentation] RNA編集酵素ADAR1によるR-loop形成抑制とGenome Stability維持機構2019
- Author(s)
  Yusuke Shirotmo, Masayuki Sakurai, Moeko Mizuguchi, Kentaro Ariyosi, Kazuk Nisikura.
- Organizer
  第42回日本分子生物学会年会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03159
[Presentation] Regulation of Genome Stability by ADAR RNA Editing Enzymes2019
- Author(s)
  Nishikura, K, Sakurai, M., Shiromoto, Y., Ariyoshi, K., Kossenkov, A.V., Wickramasinghe, J., Showe, L.C.
- Organizer
  2019 Gordon Research Conference, RNA editing
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H06054
[Presentation] Technology to identify 5th nucleic acids base INOSINE in transcriptome2019
- Author(s)
  Sakurai, M.
- Organizer
  BIO JAPAN 2019
- Data Source
  KAKENHI-PROJECT-19H03159
[Presentation] RNA adenosine deaminase regulates embryogenesis and cancer metastasis.2018
- Author(s)
  Sakurai, M., Gumireddy, K., Li, A., Kossenkov, A.V., Yan, J., Li, Y., Xu, H., Wang, J., Zhang, PJ., Zhang, L., Showe, L., Nishikura, K., and Huang, Q.
- Organizer
  The 2nd International Innovation Dialogue on Genome Engineering Animal Models and Biomedical Research Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H06054
[Presentation] ADAR1 controls apoptosis of stressed cells by inhibitin Staufen-mediated mRNA decay.2018
- Author(s)
  Sakurai, M., Shiromoto, Y., Ota, H., Song, C., Kossenkov, A.V., Wickramasinghe, J., Showe, L.C., Skordalakes, E., Tao, H.Y., Speicher, D.W., and Nishikura, K.
- Organizer
  The 20th RNA meeting. 第20回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-18H06054

1. 浜田道昭 (00596538)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 秋光信佳 (40294962)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 岡田俊平

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 有吉健太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 鈴木勉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 城本悠助

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakurai Masayuki 櫻井 雅之

Research Projects

Research Products

Co-Researchers

RNAリインカネーション

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Genomic DNA deamination editing mechanism regulated by RNA in humanPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms of mammalian endogenous RNA-dependent DNA base modification and disease pathogenesis due to dysregulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ゲノム&RNA編集酵素ADAR1が司るR-loop制御によるゲノム安定性維持機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 東京理科大学 科学教養誌 月刊「理大 科学フォーラム」「RNA・DNA編集によるゲノム安定性制御」2022

Author(s)

Total Pages

Publisher

Data Source

[Book] 月刊「細胞」2021

Author(s)

Total Pages

Publisher

Data Source

[Book] 理大 科学フォーラム2021

Author(s)

Total Pages

Publisher

Data Source

[Book] BIO Clinica2021

Author(s)

Total Pages

Publisher

Data Source

[Book] A-to-I RNA 塩基編集による疾患と対策技術2020

Author(s)

Total Pages

Publisher

Data Source

[Book] 分子生物学と遺伝子の研究2019

Author(s)

Total Pages

Publisher

Data Source

[Book] もう一つの遺伝子 ”編集” - 哺乳動物が備える核酸塩基の編集機構」2019

Author(s)

Total Pages

Publisher

Data Source

[Book] 実験医学2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Advances in Detection Methods for A‐to‐I <scp>RNA</scp> Editing2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ICLAMP: a novel technique to explore adenosine deamination via inosine chemical labeling and affinity molecular purification2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16INK4a levels2022

Sakurai Masayuki 櫻井雅之

[Book] 東京理科大学　科学教養誌月刊「理大　科学フォーラム」「RNA・DNA編集によるゲノム安定性制御」2022

[Book] 理大　科学フォーラム2021