Ito Takumi 伊藤匠

… Alternative Names

Itoh Takumi 伊藤匠

Takumi Itoh 伊藤匠

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Researcher Number	80811835
Other IDs
Affiliation (Current)	2026: 順天堂大学, 大学院医学研究科, 特任助教
Affiliation (based on the past Project Information) *help	2026: 順天堂大学, 大学院医学研究科, 特任助教 2022 – 2024: 順天堂大学, 大学院医学研究科, 特任助教 2021: 順天堂大学, 大学院医学研究科, 博士研究員 2018 – 2019: 順天堂大学, 医学(系)研究科(研究院), 博士研究員
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 49010:Pathological biochemistry-related / Basic Section 55010:General surgery and pediatric surgery-related / 0901:Oncology and related fields Except Principal Investigator Basic Section 49030:Experimental pathology-related
Keywords	Principal Investigator IL-26 / 薬剤耐性 / 腫瘍免疫 / 癌微小環境 / 炎症性サイトカイン / Th17 / 炎症 / 免疫チェックポイント / 免疫回避 / 癌免疫 … More / EGFR-TKI / トリプルネガティブ乳癌 / 乳癌 / 上皮間葉転換 / 癌転移 / 悪性黒色腫 … More Except Principal Investigator 核酸 / 抗体療法 / 炎症性腸疾患 / 慢性炎症 / IL-26 Less

癌のエピジェネティクスに作用するIL-26を標的とした癌免疫療法の開発Principal Investigator
- Principal Investigator
  
  伊藤匠
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Juntendo University
Molecular understanding of an innovative therapy for chronic inflammatory diseases targeting human Th17 cytokine IL-26
- Principal Investigator
  
  森本幾夫
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Juntendo University
癌免疫のCOLD化に対するIL-26標的治療法の確立Principal Investigator
- Principal Investigator
  
  伊藤匠
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Juntendo University
IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance in triple-negative breast cancer cellsPrincipal Investigator
- Principal Investigator
  
  Itoh Takumi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Juntendo University
Development of novel IL-26 targeted therapeutic approaches for cancer metastasisPrincipal Investigator
- Principal Investigator
  
  Takumi Itoh
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  Juntendo University

All 2025 2024 2022 2021 2019 2018

All Journal Article Presentation Patent

[Journal Article] An abnormal increase in CD26(-)CD28(-) cytotoxic effector CD4 and CD8 T cell populations in patients with systemic lupus erythematosus2025
- Author(s)
  Hatano Ryo、Nakamura Hayato、Yamamoto Ayako、Otsuka Haruna、Itoh Takumi、Hosokawa Nao、Yu Jinghui、Ranjbar Sedigheh、Hasegawa Yuta、Sato Tsutomu、Dang Nam H、Ohnuma Kei、Morimoto Shinji、Sekigawa Iwao、Ishii Tomonori、Morimoto Chikao
- Journal Title
  
  International Immunology
  
  Volume: 37 Issue: 3 Pages: 153-172
- DOI
  10.1093/intimm/dxae062
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27395, KAKENHI-PROJECT-23K06501, KAKENHI-PROJECT-24K18383
[Journal Article] Functional Roles of CD26/DPP4 in Bleomycin-Induced Pulmonary Hypertension Associated with Interstitial Lung Disease2024
- Author(s)
  Okaya Tadasu、Kawasaki Takeshi、Sato Shun、Koyanagi Yu、Tatsumi Koichiro、Hatano Ryo、Ohnuma Kei、Morimoto Chikao、Kasuya Yoshitoshi、Hasegawa Yoshinori、Ohara Osamu、Suzuki Takuji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 2 Pages: 748-748
- DOI
  10.3390/ijms25020748
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16163, KAKENHI-PROJECT-23K06501, KAKENHI-PROJECT-23K27395, KAKENHI-PROJECT-23K24337
[Journal Article] Transcriptome Analysis of Fibroblasts in Hypoxia-Induced Vascular Remodeling: Functional Roles of CD26/DPP42024
- Author(s)
  Suzuki Yuri、Kawasaki Takeshi、Tatsumi Koichiro、Okaya Tadasu、Sato Shun、Shimada Ayako、Misawa Tomoko、Hatano Ryo、Morimoto Chikao、Kasuya Yoshitoshi、Hasegawa Yoshinori、Ohara Osamu、Suzuki Takuji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 23 Pages: 12599-12599
- DOI
  10.3390/ijms252312599
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24337, KAKENHI-PROJECT-23K27395, KAKENHI-PROJECT-23K06501, KAKENHI-PROJECT-22K16163
[Journal Article] Humanized anti-IL-26 monoclonal antibody as a novel targeted therapy for chronic graft-versus-host disease2022
- Author(s)
  Hatano Ryo、Itoh Takumi、Otsuka Haruna、Saeki Harumi、Yamamoto Ayako、Song Dan、Shirakawa Yuki、Iyama Satoshi、Sato Tsutomu、Iwao Noriaki、Harada Norihiro、Aune Thomas M.、Dang Nam H.、Kaneko Yutaro、Yamada Taketo、Morimoto Chikao、Ohnuma Kei
- Journal Title
  
  American Journal of Transplantation
  
  Volume: 22 Issue: 12 Pages: 2804-2820
- DOI
  10.1111/ajt.17178
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19387, KAKENHI-PROJECT-21K16389, KAKENHI-PROJECT-22K15400, KAKENHI-PROJECT-20K07683
[Journal Article] Effector memory CD4+T cells in mesenteric lymph nodes mediate bone loss in food-allergic enteropathy model mice, creating IL-4 dominance2021
- Author(s)
  Ono-Ohmachi Aiko、Udagawa Nobuyuki、Nakamichi Yuko、Koide Masanori、Nakajima-Adachi Haruyo
- Journal Title
  
  Mucosal Immunology
  
  Volume: 14 Issue: 6 Pages: 1335-1346
- DOI
  10.1038/s41385-021-00434-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22729, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-20H03471, KAKENHI-PROJECT-20H03872, KAKENHI-PROJECT-21H02394, KAKENHI-PROJECT-19K22728, KAKENHI-PROJECT-20K21689, KAKENHI-PROJECT-21K16389, KAKENHI-PROJECT-19KK0234, KAKENHI-PROJECT-23K21488, KAKENHI-PROJECT-21K18229, KAKENHI-PROJECT-18K19265
[Journal Article] IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells2021
- Author(s)
  Itoh Takumi、Hatano Ryo、Horimoto Yoshiya、Yamada Taketo、Song Dan、Otsuka Haruna、Shirakawa Yuki、Mastuoka Shuji、Iwao Noriaki、Aune Thomas M.、Dang Nam H.、Kaneko Yutaro、Okumura Ko、Morimoto Chikao、Ohnuma Kei
- Journal Title
  
  Cell Death and Disease
  
  Volume: 12 Issue: 6 Pages: 520-520
- DOI
  10.1038/s41419-021-03787-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03519, KAKENHI-PROJECT-20H03471, KAKENHI-PROJECT-20K07683, KAKENHI-PROJECT-21K16389
[Journal Article] Biological effects of IL-26 on T cell-mediated skin inflammation, including psoriasis.2019
- Author(s)
  Itoh T, Hatano R, Komiya E, Otsuka H, Narita Y, Aune TM, Dang NH, Matsuoka S, Naito H, Tominaga M, Takamori K, Morimoto C, Ohnuma K.
- Journal Title
  
  J Invest Dermatol
  
  Volume: 139 Issue: 4 Pages: 878-889
- DOI
  10.1016/j.jid.2018.09.037
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10008, KAKENHI-PROJECT-17K16353, KAKENHI-PROJECT-16H05345, KAKENHI-PROJECT-19K21278, KAKENHI-PROJECT-18H02782, KAKENHI-PROJECT-18K07396
[Journal Article] Characterization of novel anti-IL-26 neutralizing monoclonal antibodies for the treatment of inflammatory diseases including psoriasis.2019
- Author(s)
  Hatano R, Itoh T, Otsuka H, Okamoto S, Komiya E, Iwata S, Aune TM, Dang NH, Kuwahara-Arai K, Ohnuma K, Morimoto C.
- Journal Title
  
  mabs.
  
  Volume: 11 Issue: 8 Pages: 1428-1442
- DOI
  10.1080/19420862.2019.1654305
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16353, KAKENHI-PROJECT-17K10008, KAKENHI-PROJECT-19K21278
[Journal Article] Stromal fibroblasts induce metastatic tumor cell clusters via epithelial-mesenchymal plasticity.2019
- Author(s)
  Matsumura Y, Ito Y, Mezawa Y, Sulidan K, Daigo Y, Hiraga T, Mogushi K, Wali N, Suzuki H, Itoh T, Miyagi Y, Yokose T, Shimizu S, Takano A, Terao Y, Saeki H, Ozawa M, Abe M, Takeda S, Okumura K, Habu S, Hino O, Takeda K, Hamada M, Orimo A.
- Journal Title
  
  Life Sci Alliance
  
  Volume: 2(4):e201900425. Issue: 4 Pages: 1-24
- DOI
  10.26508/lsa.201900425
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10652, KAKENHI-PROJECT-18K06198, KAKENHI-PROJECT-18K07207, KAKENHI-PROJECT-18K08798, KAKENHI-PROJECT-19K07884, KAKENHI-PROJECT-18K19656, KAKENHI-PROJECT-18H02695, KAKENHI-PROJECT-19H03559, KAKENHI-PROJECT-18K19483, KAKENHI-PROJECT-19K21278, KAKENHI-PROJECT-16H05879, KAKENHI-PROJECT-16H06277
[Journal Article] Development of novel monoclonal antibodies with specific binding affinity for denatured human CD26 in formalin-fixed paraffin-embedded and decalcified specimens2019
- Author(s)
  Hatano R, Yamada T, Madokoro H, Otsuka H, Komiya E, Itoh T, Narita Y, Iwata S, Yamazaki H, Matsuoka S, Dang NH, Morimoto C
- Journal Title
  
  PLoS ONE
  
  Volume: 14 Issue: 6 Pages: e0218330-e0218330
- DOI
  10.1371/journal.pone.0218330
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22542, KAKENHI-PROJECT-17K16353, KAKENHI-PROJECT-18H02782, KAKENHI-PROJECT-19H03519, KAKENHI-PROJECT-17K10008, KAKENHI-PROJECT-19K21278
[Patent] インターロイキン-26阻害薬を用いたがん治療2025
- Inventor(s)
  森本幾夫, 波多野良, 伊藤匠, 大沼圭, 金子有太郎
- Industrial Property Rights Holder
  ワイズ・エー・シー株式会社、学校法人順天堂
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2025-007248
- Filing Date
  2025
- Data Source
  KAKENHI-PROJECT-23K27395
[Presentation] 胸膜中皮腫に対するヒト化CD26抗体とPD-1抗体との新規併用療法の開発2024
- Author(s)
  波多野良, 伊藤匠, 山田健人, 大沼圭, 青江啓介, 藤本伸一, 岸本卓巳, 金子有太郎, 森本幾夫
- Organizer
  第5回日本石綿・中皮腫学会
- Data Source
  KAKENHI-PROJECT-23K27395
[Presentation] IL-26 facilitates cartilage destruction and infiltration of inflammatory cells into synovium in a collagen induced arthritis model.2022
- Author(s)
  Shirakawa Y, Hatano R, Itoh T, Otsuka H, Okumura K, Morimoto C.
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K16389
[Presentation] がん免疫における多機能性サイトカインの役割2022
- Author(s)
  伊藤匠
- Organizer
  第19回日本免疫治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K16389
[Presentation] Anti-interleukin-26 therapy for the control of chronic inflammation in GVHD.2021
- Author(s)
  Ryo Hatano, Haruna Otsuka, Takumi Itoh, Harumi Saeki, Ayako Yamamoto, Yuki Shirakawa, Satoshi Iyama, Noriaki Iwao, Tsutomu Sato, Taketo Yamada, Chikao Morimoto, Kei Ohnuma
- Organizer
  第83回日本血液学会
- Data Source
  KAKENHI-PROJECT-21K16389
[Presentation] Possible role for CD26/DPPIV in regulating mechanical itch (Alloknesis)2019
- Author(s)
  古宮栄利子, 波多野良, 伊藤匠, 大塚春奈, 鎌田弥生, 本田耕太郎, 外山扇雅, カタリナサギタモニアガ, 大沼圭, 冨永光俊, 森本幾夫, 高森建二
- Organizer
  28th European Academy of Dermatology and Venereology (EADV) Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21278
[Presentation] 加齢皮膚で誘発される機械的かゆみ調節機構の解明2019
- Author(s)
  古宮栄利子,冨永光俊, 波多野良, 伊藤匠, 大塚春奈, 本田耕太郎, 外山扇雅, 鎌田弥生, 大沼圭, 森本幾夫, 高森建二
- Organizer
  第15回加齢皮膚医学研究会
- Data Source
  KAKENHI-PROJECT-19K21278
[Presentation] Possible regulation of mechanical itch by CD26/DPPIV2019
- Author(s)
  古宮栄利子, 波多野良, 伊藤匠, 大塚春奈, 鎌田弥生, 本田耕太郎, 外山扇雅, カタリナサギタモニアガ, 大沼圭, 冨永光俊, 森本幾夫, 高森建二
- Organizer
  10th World Congress on Itch (WCI)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21278
[Presentation] CD26/DPPIV regulates mechanical itch by enzymatic degradation of mu-opioid receptor ligands2019
- Author(s)
  古宮栄利子, 波多野良, 伊藤匠, 大塚春奈, 大沼圭, 冨永光俊, 森本幾夫, 高森建二
- Organizer
  24th World Congress of Dermatology (WCD)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21278
[Presentation] CD26/ dipeptidyl-peptidase IVは機械的かゆみの抑制因子である2019
- Author(s)
  古宮栄利子, 波多野良, 冨永光俊, 伊藤匠, 鎌田弥生, 本田耕太郎, 外山扇雅, カタリナサギタモニアガ, 大沼圭, 森本幾夫, 高森建二
- Organizer
  日本病態プロテアーゼ学会
- Data Source
  KAKENHI-PROJECT-19K21278
[Presentation] 機械的かゆみの調節メカニズムの解明2018
- Author(s)
  古宮栄利子, 波多野良, 大塚春奈, 伊藤匠, 松田浩則, 須賀康, 大沼圭, 冨永光俊, 森本幾夫, 髙森建二
- Organizer
  第82回日本皮膚科学会東京支部
- Data Source
  KAKENHI-PROJECT-19K21278

1. 森本幾夫 (30119028)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 波多野良 (30638789)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 大沼圭 (10396872)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. MOGUSHI Kaoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 小出雅則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 川崎剛

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 山田健人

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
8. 山田幸司

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 古宮栄利子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 鈴木拓児

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ito Takumi 伊藤 匠

Itoh Takumi 伊藤 匠

Takumi Itoh 伊藤 匠

Research Projects

Research Products

Co-Researchers

癌のエピジェネティクスに作用するIL-26を標的とした癌免疫療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular understanding of an innovative therapy for chronic inflammatory diseases targeting human Th17 cytokine IL-26

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

癌免疫のCOLD化に対するIL-26標的治療法の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance in triple-negative breast cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel IL-26 targeted therapeutic approaches for cancer metastasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] An abnormal increase in CD26(-)CD28(-) cytotoxic effector CD4 and CD8 T cell populations in patients with systemic lupus erythematosus2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functional Roles of CD26/DPP4 in Bleomycin-Induced Pulmonary Hypertension Associated with Interstitial Lung Disease2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcriptome Analysis of Fibroblasts in Hypoxia-Induced Vascular Remodeling: Functional Roles of CD26/DPP42024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Humanized anti-IL-26 monoclonal antibody as a novel targeted therapy for chronic graft-versus-host disease2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effector memory CD4+T cells in mesenteric lymph nodes mediate bone loss in food-allergic enteropathy model mice, creating IL-4 dominance2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biological effects of IL-26 on T cell-mediated skin inflammation, including psoriasis.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of novel anti-IL-26 neutralizing monoclonal antibodies for the treatment of inflammatory diseases including psoriasis.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stromal fibroblasts induce metastatic tumor cell clusters via epithelial-mesenchymal plasticity.2019

Author(s)

Journal Title

DOI

Ito Takumi 伊藤匠

Itoh Takumi 伊藤匠

Takumi Itoh 伊藤匠