Sobue Akira 祖父江顕

Researcher Number	80823343
Affiliation (Current)	2022: 名古屋大学, 環境医学研究所, 特任助教
Affiliation (based on the past Project Information) *help	2018 – 2021: 名古屋大学, 環境医学研究所, 特任助教
Review Section/Research Field	Principal Investigator 0801:Pharmaceutical sciences and related fields / Basic Section 51030:Pathophysiologic neuroscience-related Except Principal Investigator Medium-sized Section 52:General internal medicine and related fields
Keywords	Principal Investigator アルツハイマー病 / グリア細胞 / 神経炎症 / ミクログリア / モデルマウス / SOCS3 / APP-KIマウス / ADモデルマウス Except Principal Investigator 筋萎縮性側索硬化症 / 神経変性疾患 / 構造生物学

グリア細胞を標的としたアルツハイマー病の新規治療候補分子探索とその機能解析Principal Investigator
- Principal Investigator
  
  祖父江顕
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Nagoya University
タンパク質の構造生物学に基づいた筋萎縮性側索硬化症の分子病態解明と治療法開発
- Principal Investigator
  
  山中宏二
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Nagoya University
Elucidating mechanisms of microglial activity in Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  Sobue Akira
- Project Period (FY)
  2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0801:Pharmaceutical sciences and related fields
- Research Institution
  Nagoya University

All 2022 2021 2020 2019 2018

All Journal Article Presentation Book

[Book] アルツハイマー病におけるTREM2と脳内各種細胞の関連について2020
- Author(s)
  祖父江　顕
- Total Pages
  1
- Publisher
  日本薬学会
- Data Source
  KAKENHI-PROJECT-20K16488
[Book] 神経変性疾患におけるミクログリア. 特徴と治療標的としての展望.2020
- Author(s)
  祖父江　顕、山中宏二
- Total Pages
  4
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-20K16488
[Book] 実験医学　疾患を制御するマクロファージの多様性2018
- Author(s)
  祖父江顕、遠藤史人、山中宏二
- Total Pages
  6
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-19K21221
[Journal Article] Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease2021
- Author(s)
  Sobue A, Kimine O, Hara Y, Endo F, Mizoguchi H, Watanabe S, Murayama S, Saito T, Saido T. C., Sahara N, Higuchi M, Ogi T, Yamanaka K.
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 9 Pages: 1-1
- DOI
  10.1186/s40478-020-01099-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-19K21811, KAKENHI-PROJECT-20K16488, KAKENHI-PUBLICLY-19H05017, KAKENHI-PUBLICLY-19H05437, KAKENHI-PROJECT-19H03532, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-17H04986
[Journal Article] Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons.2021
- Author(s)
  Hada K, Wulaer B, Nagai T, Itoh N, Sawahata M, Sobue A, Mizoguchi H, Mori D, Kushima I, Nabeshima T, Ozaki N, Yamada K.
- Journal Title
  
  Mol. Brain
  
  Volume: 14(1) Pages: 21-21
- DOI
  10.1186/s13041-021-00735-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21811, KAKENHI-PROJECT-20K16488, KAKENHI-PUBLICLY-19H05017, KAKENHI-PROJECT-19H03532, KAKENHI-PROJECT-20H03428, KAKENHI-PROJECT-20K07082
[Journal Article] Share Analysis of Reelin signaling and neurodevelopmental trajectory in primary cultured cortical neurons with RELN deletion identified in schizophrenia.2021
- Author(s)
  Tsuneura Yumi、Sawahata Masahito、Itoh Norimichi、Miyajima Ryoya、Mori Daisuke、Kohno Takao、Hattori Mitsuharu、Sobue Akira、Nagai Taku、Mizoguchi Hiroyuki、Nabeshima Toshitaka、Ozaki Norio、Yamada Kiyofumi
- Journal Title
  
  Neurochem Int
  
  Volume: 144 Pages: 104954-104954
- DOI
  10.1016/j.neuint.2020.104954
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07051, KAKENHI-PROJECT-19K21811, KAKENHI-PROJECT-20K16488, KAKENHI-PUBLICLY-19H05017, KAKENHI-PROJECT-19H03532, KAKENHI-PROJECT-20H03428, KAKENHI-PROJECT-17H04252, KAKENHI-PROJECT-20H03384, KAKENHI-PROJECT-19K07384, KAKENHI-PROJECT-21K19342
[Journal Article] Novel reporters of mitochondria‐associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis2021
- Author(s)
  Sakai Shohei、Watanabe Seiji、Komine Okiru、Sobue Akira、Yamanaka Koji
- Journal Title
  
  The FASEB Journal
  
  Volume: 35
- DOI
  10.1096/fj.202100137r
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04986, KAKENHI-PROJECT-20K16488, KAKENHI-PROJECT-19KK0214
[Journal Article] Generation and analysis of novel Reln‐ deleted mouse model corresponding to exonic Reln deletion in schizophrenia2020
- Author(s)
  Masahito Sawahata, Daisuke Mori, Yuko Arioka, Hisako Kubo, Itaru Kushima, Kanako Kitagawa, Akira Sobue, Emiko Shishido, Mariko Sekiguchi, Akiko Kodama, Ryosuke Ikeda, Branko Aleksic, Hiroki Kimura, Kanako Ishizuka, Taku Nagai, Kozo Kaibuchi, Toshitaka Nabeshima, Kiyofumi Yamada, Norio Ozaki
- Journal Title
  
  Psychiatry Clin Neurosci
  
  Volume: 1 Pages: 1-10
- DOI
  10.1111/pcn.12993
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07384, KAKENHI-PROJECT-19K08072, KAKENHI-PROJECT-18K19511, KAKENHI-PROJECT-17H02220, KAKENHI-PROJECT-17H04031, KAKENHI-PROJECT-17H04252, KAKENHI-PROJECT-17H05090, KAKENHI-PROJECT-18K15513, KAKENHI-PROJECT-19K21221, KAKENHI-PROJECT-20K07082, KAKENHI-PROJECT-20K16625, KAKENHI-PROJECT-18H04040
[Journal Article] ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration2020
- Author(s)
  Watanabe Seiji、Oiwa Kotaro、Murata Yuri、Komine Okiru、Sobue Akira、Endo Fumito、Takahashi Eiki、Yamanaka Koji
- Journal Title
  
  Molecular Brain
  
  Volume: 13 Pages: 8-8
- DOI
  10.1186/s13041-020-0550-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0214, KAKENHI-PUBLICLY-18H04860, KAKENHI-PROJECT-18H02740, KAKENHI-PROJECT-17H04986, KAKENHI-PROJECT-19K21221
[Journal Article] Overexpression of astroglial major histocompatibility complex class I in the medial prefrontal cortex impairs visual discrimination learning in mice2020
- Author(s)
  Wulaer Bolati、Hada Kazuhiro、Sobue Akira、Itoh Norimichi、Nabeshima Toshitaka、Nagai Taku、Yamada Kiyofumi
- Journal Title
  
  Mol Brain
  
  Volume: 13 Pages: 170-170
- DOI
  10.1186/s13041-020-00710-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16488, KAKENHI-PROJECT-20H03428, KAKENHI-PROJECT-17H04252
[Journal Article] Aggresome formation and liquid?liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 432020
- Author(s)
  Watanabe Seiji、Inami Hidekazu、Oiwa Kotaro、Murata Yuri、Sakai Shohei、Komine Okiru、Sobue Akira、Iguchi Yohei、Katsuno Masahisa、Yamanaka Koji
- Journal Title
  
  Cell Death & Disease
  
  Volume: 11 Pages: 909-909
- DOI
  10.1038/s41419-020-03116-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16488, KAKENHI-PROJECT-19KK0214, KAKENHI-PROJECT-20H03589, KAKENHI-PROJECT-18H02740, KAKENHI-PROJECT-17H04986
[Journal Article] ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk.2020
- Author(s)
  Sekiguchi M, Sobue A, Kushima I, et al.
- Journal Title
  
  Transl Psychiatry.
  
  Volume: 10 Pages: 1-15
- DOI
  10.1038/s41398-020-00917-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08072, KAKENHI-PROJECT-20K07082, KAKENHI-PROJECT-20K07965, KAKENHI-PROJECT-20K21832, KAKENHI-PROJECT-18K14816, KAKENHI-PROJECT-20K16488, KAKENHI-PROJECT-20K16625, KAKENHI-PROJECT-19H05467, KAKENHI-PUBLICLY-19H05210, KAKENHI-PUBLICLY-20H04841, KAKENHI-PROJECT-18H04040, KAKENHI-PROJECT-20H03611, KAKENHI-PROJECT-20H04281, KAKENHI-PROJECT-17K07383, KAKENHI-PROJECT-18K15512, KAKENHI-PROJECT-19K16111, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-17H04252, KAKENHI-PROJECT-18KT0022
[Journal Article] Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair.2020
- Author(s)
  Nakazawa Y, Hara Y, Oka Y, Komine O, van den Heuvel D, Guo C, Daigaku Y, Isono M, He Y, Shimada M, Kato K, Jia N, Hashimoto S, Kotani Y, Miyoshi Y, Tanaka M, Sobue A, Mitsutake N, Suganami T, Masuda A, Ohno K, Nakada S, Mashimo T, Yamanaka K, Luijsterburg MS, Ogi T
- Journal Title
  
  Cell
  
  Volume: 19 Pages: 1228-1244
- DOI
  10.1016/j.cell.2020.02.010
- NAID
  120006871293
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06058, KAKENHI-PROJECT-18K08508, KAKENHI-PROJECT-18K11639, KAKENHI-PROJECT-18K19585, KAKENHI-PROJECT-19K22802, KAKENHI-PROJECT-18KK0307, KAKENHI-PROJECT-17H00783, KAKENHI-PROJECT-18H03974, KAKENHI-PROJECT-17H01877, KAKENHI-PROJECT-18H03372, KAKENHI-PROJECT-16H06151, KAKENHI-PROJECT-17K12821, KAKENHI-PROJECT-19K21221
[Journal Article] Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer’s disease2020
- Author(s)
  Saifullah MAB, Komine O, Dong Y, Fukumoto K, Sobue A, Endo F, Saito T, Saido TC, Yamanaka K, Mizoguchi H.
- Journal Title
  
  Molecular Brain
  
  Volume: 13(1) Pages: 147-147
- DOI
  10.1186/s13041-020-00690-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21811, KAKENHI-PROJECT-20K16488, KAKENHI-PUBLICLY-19H05017, KAKENHI-PROJECT-19H03532
[Presentation] 早期アルツハイマー病理脳におけるグリア細胞関連遺伝子発現解析と治療標的探索2022
- Author(s)
  祖父江顕
- Organizer
  令和3年度コホート・生体試料支援プラットホーム若手支援研究成果発表会
- Data Source
  KAKENHI-PROJECT-20K16488
[Presentation] ミクログリアのカンナビノイド受容体2型を介したアルツハイマー病における神経炎症調節機構について2021
- Author(s)
  祖父江顕、小峯　起、遠藤史人、村山繁雄、斉藤貴志、西道隆臣、山中宏二
- Organizer
  第139回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-20K16488
[Presentation] Downregulation of homeostatic microglial genes is correlated with progression of Alzheimer's disease in mice2021
- Author(s)
  Sobue A, Komine O, Hara Y, Endo F, Mizoguchi H, Watanabe S, Murayama S, Saito T, Saido TC, Sahara N, Higuchi M, Ogi T, Yamanaka K.
- Organizer
  第44回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-20K16488
[Presentation] Microglial cannabinoid receptor type II as a therapeutic target for Alzheimer’s disease2021
- Author(s)
  Sobue A, Komine O, Endo F, Murayama S, Saito T, Saido T, Yamanaka K
- Organizer
  第25回グリア研究会
- Data Source
  KAKENHI-PROJECT-20K16488
[Presentation] Dimethyl Fumarate ameliorates neuroinflammation in App knock-in mouse though activation of Nrf2 pathway2021
- Author(s)
  Wang T, Sobue A, Komine O, Saito T, Saido T, Yamanaka K
- Organizer
  第44回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-20K16488
[Presentation] アルツハイマー病モデルにおけるアンドロゲン受容体を介した神経炎症調節機構2021
- Author(s)
  前川華澄、祖父江顕、小峯　起、斉藤貴志、西道隆臣、山中宏二
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16488
[Presentation] アルツハイマー病の病態進行に伴いミクログリアの生理機能が低下する2021
- Author(s)
  祖父江　顕、小峯　起、原　雄一郎、遠藤史人、溝口博之、渡邊征爾、村山繁雄、斉藤貴志,、西道隆臣、佐原成彦、樋口真人、荻　朋男、山中宏二
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16488
[Presentation] アルツハイマー病モデルマウスにおける末梢免疫システムの役割2021
- Author(s)
  小峯　起、祖父江顕、齋藤貴志、山中宏二
- Organizer
  第44回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-20K16488
[Presentation] アルツハイマー病モデルマウスにおけるミクログリア発現アンドロゲン受容体を介したテストステロンの神経炎症の制御2021
- Author(s)
  前川華澄、祖父江顕、小峯　起、斉藤貴志、西道隆臣、山中宏二
- Organizer
  第44回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-20K16488
[Presentation] E40K変異イヌSOD1タンパク質の種特異的凝集に重要なアミノ酸残基の同定.2021
- Author(s)
  橋本　慶、渡邊征爾、小峯起、祖父江顕、神志那弘明、山中宏二.
- Organizer
  第94回日本生化学大会
- Data Source
  KAKENHI-PROJECT-19KK0214
[Presentation] Effect of Dimethyl Fumarate on the neuroinflammation in App Knock-in mouse2020
- Author(s)
  Wang Ting, Akira Sobue, Okiru Komine, Takashi Saito, Takaomi Saido, Koji Yamanaka
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16488
[Presentation] Multimerization of TDP-43 plays a key role in determination of its subcellular localization.2020
- Author(s)
  大岩康太郎、渡邊征爾、祖父江　顕、小峯　起、勝野雅央、山中宏二.
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19KK0214
[Presentation] Cannabinoid receptor type II in microglia as a therapeutic target for Alzheimer's disease2020
- Author(s)
  Akira Sobue, Okiru Komine, Fumito Endo, Shigeo Murayama, Takashi Saito, Takaomi C Saido, Koji Yamanaka
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-20K16488
[Presentation] アルツハイマー病モデルにおける神経炎症に対する全身炎症が与える影響の検討2020
- Author(s)
  下川梨津子、小峯　起、伊藤綾香、祖父江顕、斉藤貴志、西道隆臣、菅波孝祥、山中宏二
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16488
[Presentation] ADにおけるミクログリアのカンナビノイド受容体2型を介した神経炎症調節機構について2020
- Author(s)
  祖父江顕、小峯起、遠藤史人、村山繁雄、斉藤貴志、西道隆臣、山中宏二
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16488
[Presentation] TDP-43の多量体化が、その細胞内局在の決定に重要である2019
- Author(s)
  大岩康太郎、渡邊征爾、祖父江　顕、小峯起、勝野雅央、山中宏二
- Organizer
  第42回日本神経科学大会第62回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19K21221
[Presentation] Touchscreen-based tests detect cognitive impairment at an early stage in APP knock-in mice model2019
- Author(s)
  Saifulah Md. Ali Bin, Komine O, Sobue A, Yamanaka K, Mizoguchi H
- Organizer
  6th Congress of Asian College of Neuropsychopharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21221
[Presentation] アルツハイマー病患者とAppNL-G-F マウスにおける神経炎症関連遺伝子解析2019
- Author(s)
  祖父江　顕、小峯　起、遠藤史人、村山繁雄、斉藤貴志、西道隆臣、山中宏二
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K21221
[Presentation] Behavioral characterization of APP knock-in mice model in touchscreen-based tests aiming early detection of Alzheimer's disease2019
- Author(s)
  Saifullah MD. Ali Bin、小峯　起、祖父江　顕、山中宏二、溝口博之
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K21221
[Presentation] アルツハイマー病患者脳とAPP- KIマウス由来ミクログリアにおける遺伝子発現解析2019
- Author(s)
  祖父江　顕、小峯　起、遠藤史人、村山繁雄、斉藤貴志、西道隆臣、山中宏二
- Organizer
  第42回日本神経科学大会第62回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19K21221
[Presentation] タッチスクリーン式学習試験法はアルツハイマー病モデル動物の早期の認知機能障害を検出できる2019
- Author(s)
  溝口博之、小峯　起、Md. Ali Bin Saifullah1、祖父江　顕、遠藤史人、山中宏二
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K21221
[Presentation] 早期アルツハイマー病理を呈する患者脳における神経炎症関連遺伝子発現解析2018
- Author(s)
  祖父江顕、遠藤史人、小峯　起、村山繁雄、山中宏二
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K21221

1. 山中宏二 (80446533)

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2. 渡邊征爾 (70633577)

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3. DAISUKE Mori

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5. TAKAHASHI Eiki

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7. NAKAZAWA Yuka

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10. 齊藤祐子

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17. 尾崎紀夫

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27. 木村大樹

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28. 佐久間哲史

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29. 増田章男

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30. 田中都

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31. 荻朋男

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32. 嶋田繭子

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33. 岡泰由

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34. 光武範吏

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35. 大野欽司

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36. 真下知士

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37. 大学保一

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38. 磯野真由

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Sobue Akira 祖父江 顕

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グリア細胞を標的としたアルツハイマー病の新規治療候補分子探索とその機能解析Principal Investigator

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タンパク質の構造生物学に基づいた筋萎縮性側索硬化症の分子病態解明と治療法開発

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Elucidating mechanisms of microglial activity in Alzheimer's diseasePrincipal Investigator

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[Book] アルツハイマー病におけるTREM2と脳内各種細胞の関連について2020

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[Book] 神経変性疾患におけるミクログリア. 特徴と治療標的としての展望.2020

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[Book] 実験医学 疾患を制御するマクロファージの多様性2018

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[Journal Article] Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease2021

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[Journal Article] Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons.2021

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[Journal Article] Share Analysis of Reelin signaling and neurodevelopmental trajectory in primary cultured cortical neurons with RELN deletion identified in schizophrenia.2021

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[Journal Article] Novel reporters of mitochondria‐associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis2021

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[Journal Article] Generation and analysis of novel Reln‐ deleted mouse model corresponding to exonic Reln deletion in schizophrenia2020

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[Journal Article] ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration2020

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[Journal Article] Overexpression of astroglial major histocompatibility complex class I in the medial prefrontal cortex impairs visual discrimination learning in mice2020

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[Journal Article] Aggresome formation and liquid?liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 432020

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[Journal Article] ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk.2020

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Sobue Akira 祖父江顕

[Book] 実験医学　疾患を制御するマクロファージの多様性2018