Saito Masafumi 齋藤雅史

… Alternative Names

Masafumi Saito 齋藤雅史

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Researcher Number	80826321
Other IDs
Affiliation (Current)	2025: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 免疫・微生物学, 助教
Affiliation (based on the past Project Information) *help	2023: 帝京大学, 医学部, 助教 2023: 帝京大学, 基礎医学, 助教 2021 – 2023: 神戸大学, 医学研究科, 助教 2020: 神戸大学, 医学研究科, 特命助教 2019: 神戸大学, 医学研究科, 学術研究員
Review Section/Research Field	Principal Investigator Basic Section 55060:Emergency medicine-related Except Principal Investigator Basic Section 55020:Digestive surgery-related
Keywords	Principal Investigator 敗血症 / T細胞 / 精神障害 / 敗血症性脳症 / 神経新生 / IL-4 / CD4+T細胞 / ミクログリア / うつ / 不安様行動 … More / 脳内炎症 / 制御性T細胞 / リンパ球活性化因子 / 高齢者敗血症 / Interleukin-15 / リンパ球 / 長期予後 / 免疫抑制 / IL-15 / 高齢者 … More Except Principal Investigator 空間的解析 / NKT細胞 / 免疫療法 / レジデントメモリーT細胞 / 肝転移 / 大腸癌 / 術前化学放射線療法 / イメージサイトメトリー / 細胞間相互作用 / CD8+T細胞 / レジデントメモリーCD8+T細胞 (TRM) / 化学放射線療法 / 直腸癌 / レジデントメモリーCD8＋T細胞 / RNA解析 / 空間的情報 / 組織滞在型メモリーCD8+T細胞 / 人工知能イメージサイトメトリー / 免疫チェックポイント阻害剤 / 術前化学療法 / 食道癌 Less

Spatial Analysis of Rectal Cancer after Preoperative Chemoradiotherapy to Explore Predictors of Treatment Response
- Principal Investigator
  
  山下公大
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kobe University
Establishment of novel precision immunotherapy for liver metastases of colorectal cancer
- Principal Investigator
  
  裏川直樹
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kobe University
Therapeutic strategies for sepsis-associated mental disorders focusing on T cells and neurogenesis in the brain.Principal Investigator
- Principal Investigator
  
  齋藤雅史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Teikyo University
Development of new preoperative therapy for esophageal cancer based on the dynamics of tumor-infiltrating lymphocytes
- Principal Investigator
  
  押切太郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Ehime University
  Kobe University
Elucidation of pathogenesis of septic encephalopathy and associated psychiatric disorders and therapeutic strategies focusing on regulatory T cellsPrincipal Investigator
- Principal Investigator
  
  Saito Masafumi
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Kobe University
Long-term immune evaluation and novel therapeutic strategy using lymphocyte activating factor in elderly with sepsisPrincipal Investigator
- Principal Investigator
  
  Masafumi Saito
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Kobe University

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Brain T cell ameliorates mental disorders in the mouse model of post-sepsis syndrome2022
- Author(s)
  Saito Masafumi、Fujinami Yoshihisa、Ono Yuko、Yamashita Kimihiro、Inoue Shigeaki、Kotani Joji
- Journal Title
  
  The Japanese Journal of SURGICAL METABOLISM and NUTRITION
  
  Volume: 56 Issue: 4 Pages: 155-159
- DOI
  10.11638/jssmn.56.4_155
- ISSN
  0389-5564, 2187-5154
- Year and Date
  2022-08-15
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K16572
[Journal Article] Does Sepsis-Associated Encephalopathy Begin and End with T Cells?2021
- Author(s)
  Masafumi Saito
- Journal Title
  
  Journal of Mucosal Immunology Research
  
  Volume: 3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K16572
[Journal Article] IL-15 Improves Aging-Induced Persistent T Cell Exhaustion in Mouse Models of Repeated Sepsis2020
- Author(s)
  Saito Masafumi、Inoue Shigeaki、Yamashita Kimihiro、Kakeji Yoshihiro、Fukumoto Takumi、Kotani Joji
- Journal Title
  
  Shock
  
  Volume: 53 Issue: 2 Pages: 228-235
- DOI
  10.1097/shk.0000000000001352
- NAID
  120007002629
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18323
[Journal Article] IL-15 improves aging-induced persistent T cell exhaustion in mouse models of repeated sepsis.2020
- Author(s)
  Masafumi Saito, Shigeaki Inoue, Kimihiro Yamashita, Yoshihiro Kakeji, Takumi Fukumoto, and Joji Kotani
- Journal Title
  
  SHOCK
  
  Volume: 53 Pages: 228-235
- NAID
  120007002629
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18323
[Presentation] 頸部リンパ節を除去した敗血症マウスでは、脳へのT細胞の浸潤が抑制され、敗血症に伴う精神障害の回復が遅れる2023
- Author(s)
  齋藤雅史、大野雄康、中西信人、山下公大、小谷穣治
- Organizer
  第28回エンドトキシン・自然免疫研究会
- Data Source
  KAKENHI-PROJECT-23K08459
[Presentation] 敗血症に伴う精神障害の回復にはCD4+T細胞が重要である2023
- Author(s)
  齋藤雅史、大野雄康、山下公大、関恒慶、千原典夫、小谷穣治
- Organizer
  第35回日本神経免疫学会
- Data Source
  KAKENHI-PROJECT-23K08459
[Presentation] CD4+ T細胞を欠失させた敗血症マウスでは、ミクログリアの活性化と敗血症性脳症が遷延し、不安様行動の回復が遅れる2022
- Author(s)
  齋藤雅史、大野雄康、山下公大、小谷穣治
- Organizer
  第27回日本エンドトキシン・自然免疫研究会
- Data Source
  KAKENHI-PROJECT-21K16572
[Presentation] 敗血症誘導後の脳内に増加したIL-17産生γδT細胞は、いかにマウスの不安様行動を増悪させるのか？2022
- Author(s)
  齋藤雅史、森山直紀、大野雄康、山下公大、小谷穣治
- Organizer
  第27回日本エンドトキシン・自然免疫研究会
- Data Source
  KAKENHI-PROJECT-21K16572
[Presentation] Cervical lymph node-derived Treg attenuates anxiety-like behavior in the septic mice via alleviation of encephalopathy2022
- Author(s)
  Masafumi Saito, Yuko Ono, Kimihiro Yamashita, Joji Kotani
- Organizer
  Cell symposia: Neuro-immune Axis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16572
[Presentation] Cervical lymph node-derived CXCR3+ regulatory T cells alleviate anxiety-like behavior via attenuation of sepsis-associated encephalopathy in the septic mouse model2022
- Author(s)
  Masafumi Saito, Yuko Ono, Kyosuke Agawa, Kimihiro Yamashita, Joji Kotani
- Organizer
  第51回日本免疫学会
- Data Source
  KAKENHI-PROJECT-21K16572
[Presentation] CX3CR1high macrophage and Treg in the brain may help to improve anxiety-like behavior in septic mice2021
- Author(s)
  齋藤雅史
- Organizer
  International Endotoxin and Innate Immunity Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16572
[Presentation] 敗血症モデルマウスにおいて、脳内に浸潤したT細胞は敗血症性脳症とそれに伴う不安様行動の回復を促進する2021
- Author(s)
  齋藤雅史
- Organizer
  外科代謝栄養学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K16572
[Presentation] 敗血症マウスの脳内に浸潤したT細胞は、敗血症性脳症を抑制し、精神障害の回復を促進する2021
- Author(s)
  齋藤雅史
- Organizer
  第35回日本shock学会
- Data Source
  KAKENHI-PROJECT-21K16572
[Presentation] 高齢マウス反復性敗血症モデルにおいて IL-15は遷延するT細胞疲弊を長期間改善する2019
- Author(s)
  齋藤雅史、井上茂亮、安藤維洋、山田勇、前田裕二、小谷穣治
- Organizer
  日本集中治療学会
- Data Source
  KAKENHI-PROJECT-19K18323
[Presentation] 高齢マウス反復感染モデルにおける長期的な疲弊の機序解明とIL-15の効果2019
- Author(s)
  齋藤雅史、井上茂亮、藤岡一路、小谷穣治
- Organizer
  日本Shock学会
- Data Source
  KAKENHI-PROJECT-19K18323
[Presentation] IL-15は、高齢マウス敗血症のT細胞疲弊とマクロファージ機能を改善し、長期予後を改善する2019
- Author(s)
  齋藤雅史、井上茂亮、山田勇、安藤維洋、山下公大、掛地吉弘、福本巧、小谷穣治
- Organizer
  日本外科代謝栄養学会
- Data Source
  KAKENHI-PROJECT-19K18323
[Presentation] Interleukin-15 improves aging-induced persistent T cell exhaustion in mouse models of repeated sepsis2019
- Author(s)
  Masafumi Saito, Shigeaki Inoue, Joji Kotani
- Organizer
  American shock society
- Data Source
  KAKENHI-PROJECT-19K18323

1. 掛地吉弘 (80284488)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 山下公大 (80535427)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 高村史記 (90528564)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 藤田貢 (40609997)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 押切太郎 (30771498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 裏川直樹 (20647763)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Saito Masafumi 齋藤 雅史

Masafumi Saito 齋藤 雅史

Research Projects

Research Products

Co-Researchers

Spatial Analysis of Rectal Cancer after Preoperative Chemoradiotherapy to Explore Predictors of Treatment Response

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of novel precision immunotherapy for liver metastases of colorectal cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Therapeutic strategies for sepsis-associated mental disorders focusing on T cells and neurogenesis in the brain.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new preoperative therapy for esophageal cancer based on the dynamics of tumor-infiltrating lymphocytes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of pathogenesis of septic encephalopathy and associated psychiatric disorders and therapeutic strategies focusing on regulatory T cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Long-term immune evaluation and novel therapeutic strategy using lymphocyte activating factor in elderly with sepsisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Brain T cell ameliorates mental disorders in the mouse model of post-sepsis syndrome2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Does Sepsis-Associated Encephalopathy Begin and End with T Cells?2021

Author(s)

Journal Title

Data Source

[Journal Article] IL-15 Improves Aging-Induced Persistent T Cell Exhaustion in Mouse Models of Repeated Sepsis2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] IL-15 improves aging-induced persistent T cell exhaustion in mouse models of repeated sepsis.2020

Author(s)

Journal Title

NAID

Data Source

[Presentation] 頸部リンパ節を除去した敗血症マウスでは、脳へのT細胞の浸潤が抑制され、敗血症に伴う精神障害の回復が遅れる2023

Author(s)

Organizer

Data Source

[Presentation] 敗血症に伴う精神障害の回復にはCD4+T細胞が重要である2023

Author(s)

Organizer

Data Source

[Presentation] CD4+ T細胞を欠失させた敗血症マウスでは、 ミクログリアの活性化と敗血症性脳症が遷延し、 不安様行動の回復が遅れる2022

Author(s)

Organizer

Data Source

[Presentation] 敗血症誘導後の脳内に増加したIL-17産生γδT細胞は、 いかにマウスの不安様行動を増悪させるのか？2022

Author(s)

Organizer

Data Source

Saito Masafumi 齋藤雅史

Masafumi Saito 齋藤雅史

[Presentation] CD4+ T細胞を欠失させた敗血症マウスでは、ミクログリアの活性化と敗血症性脳症が遷延し、不安様行動の回復が遅れる2022

[Presentation] 敗血症誘導後の脳内に増加したIL-17産生γδT細胞は、いかにマウスの不安様行動を増悪させるのか？2022

[Presentation] 敗血症モデルマウスにおいて、脳内に浸潤したT細胞は敗血症性脳症とそれに伴う不安様行動の回復を促進する2021

[Presentation] IL-15は、高齢マウス敗血症のT細胞疲弊とマクロファージ機能を改善し、長期予後を改善する2019