Okagawa Tomohiro 岡川朋弘

Researcher Number	80829036
Other IDs
Affiliation (Current)	2025: 株式会社ファスマック, 事業開発部, 研究員(移行) 2025: 北海道大学, 獣医学研究院, 特任助教
Affiliation (based on the past Project Information) *help	2019 – 2024: 北海道大学, 獣医学研究院, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 42020:Veterinary medical science-related Except Principal Investigator Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Basic Section 42010:Animal production science-related
Keywords	Principal Investigator 牛伝染性リンパ腫 / 腫瘍化機序 / BLV / ゲノム / 挿入部位 / プロウイルス / 宿主遺伝子 / 発症機序 / ドライバー遺伝子 / キメラ転写産物 … More / 免疫抑制 / 免疫活性化 / 新規制御法 / T細胞 / 免疫抑制受容体 / 牛白血病 … More Except Principal Investigator ウシ / 慢性感染症 / マダニ / プロスタグランジンE2 / 免疫チェックポイント / 免疫疲弊化 / 免疫抑制 / 海外悪性伝染病 / 免疫撹乱因子 / 家畜悪性伝染病 / レトロウイルスベクター / 牛伝染性リンパ腫 / マウス / 牛フォーミーウイルス / 牛 / 非病原性ウイルス / ワクチン / フォーミーウイルス / BLV / 免疫破綻 / 家畜悪性感染症 Less

Elucidation of the mechanism of tumorigenesis in bovine leukemia by comprehensive genomic analysis of proviral integration sitesPrincipal Investigator
- Principal Investigator
  
  岡川朋弘
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Hokkaido University
Development of novel control strategy for livestock malignant infectious diseases targeting immune disruptors
- Principal Investigator
  
  今内覚
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Hokkaido University
Mechanism of tumorigenesis in bovine leukemia initiated by chimeric transcripts of BLV-host genesPrincipal Investigator
- Principal Investigator
  
  Okagawa Tomohiro
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Hokkaido University
Establishment of Animal Formy Viral Vectors and Development of a Vaccine for Bovine Leukemia Virus
- Principal Investigator
  
  目堅博久
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  University of Miyazaki
Development of immunotherapy targeting immunoinhibitory receptors for control of bovine leukemia virus infectionPrincipal Investigator
- Principal Investigator
  
  Okagawa Tomohiro
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Hokkaido University
Analysis of the molecular mechanism for immunosuppression in malignant infectious diseases of livestock and the development of a novel control method
- Principal Investigator
  
  KONNAI SATORU
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Hokkaido University

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Combined Immune Checkpoint Blockade Enhances Antiviral Immunity against Bovine Leukemia Virus.2023
- Author(s)
  Nakamura H, Konnai S, Okagawa T, Maekawa N, Sajiki Y, Watari K, Kamitani K, Saito M, Kato Y, Suzuki Y, Murata S, Ohashi K.
- Journal Title
  
  J Virol.
  
  Volume: 97(1) Issue: 1
- DOI
  10.1128/jvi.01430-22
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19232, KAKENHI-PROJECT-20K21357, KAKENHI-PROJECT-19KK0172, KAKENHI-PROJECT-23K23768
[Journal Article] In vitro evaluation of Lactiplantibacillus plantarum HOKKAIDO strain, effective lactic acid bacteria for calf diarrhea2023
- Author(s)
  Ikehata M, Konnai S, Okagawa T, Abe K, Honma M, Kitamura T, Maekawa N, Suzuki Y, Murata S, Ohashi K.
- Journal Title
  
  Front Vet Sci.
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0172
[Journal Article] ピックアップ新技術：牛のリンパ腫発症を予測するがん検診技術を開発. リスク高い牛の優先淘汰2023
- Author(s)
  今内覚, 岡川朋弘
- Journal Title
  
  DAIRYMAN
  
  Volume: 73(2) Pages: 64-66
- Data Source
  KAKENHI-PROJECT-19KK0172
[Journal Article] Enhancement of Vaccine-Induced T-Cell Responses by PD-L1 Blockade in Calves2023
- Author(s)
  Okagawa T, Konnai S, Nakamura H, Ganbaatar O, Sajiki Y, Watari K, Noda H, Honma M, Kato Y, Suzuki Y, Maekawa N, Murata S, Ohashi K.
- Journal Title
  
  Vaccines (Basel)
  
  Volume: 11(3) Issue: 3 Pages: 559-559
- DOI
  10.3390/vaccines11030559
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19232, KAKENHI-PROJECT-20K21357, KAKENHI-PROJECT-19KK0172, KAKENHI-PROJECT-23K23768
[Journal Article] Characterization of SpsQ from Staphylococcus pseudintermedius as an affinity chromatography ligand for canine therapeutic antibodies2023
- Author(s)
  Takeuchi H, Nakajima C, Konnai S, Maekawa N, Okagawa T, Usui M, Tamura Y, Suzuki Y, Murata S, Ohashi K.
- Journal Title
  
  PLOS ONE
  
  Volume: 18 Issue: 1 Pages: e0281171-e0281171
- DOI
  10.1371/journal.pone.0281171
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21357, KAKENHI-PROJECT-19KK0172, KAKENHI-PROJECT-23K23768
[Journal Article] Chimeric provirus of bovine leukemia virus/ SMAD family member 3 in cattle with enzootic bovine leukosis2023
- Author(s)
  Nao N, Okagawa T, Nojiri N, Konnai S, Shimakura H, Tominaga M, Yoshida-Frihata H, Nishiyama E, Matsudaira T, Maekawa N, Murata S, Muramatsu M, Ohashi K, Saito M.
- Journal Title
  
  Archi Virol.
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0172
[Journal Article] 講座: 牛伝染性リンパ腫診断の新技術・早期発症予測診断法RAISINGとは2023
- Author(s)
  今内覚, 岡川朋弘
- Journal Title
  
  家畜診療.
  
  Volume: 印刷中
- Data Source
  KAKENHI-PROJECT-19KK0172
[Journal Article] 牛伝染性リンパ腫の現状から最後の砦：発症予測法について2023
- Author(s)
  今内覚, 岡川朋弘
- Journal Title
  
  臨床獣医
  
  Volume: 2 Pages: 46-31
- Data Source
  KAKENHI-PROJECT-19KK0172
[Journal Article] 成果紹介：ウシ伝染性リンパ腫の早期発症診断による経済損失提言の実現2023
- Author(s)
  今内覚, 岡川朋弘
- Journal Title
  
  JATAFFジャーナル
  
  Volume: 印刷中
- Data Source
  KAKENHI-PROJECT-19KK0172
[Journal Article] Enhancement of interleukin-2 production by bovine peripheral blood mononuclear cells treated with the combination of anti-programmed death-ligand 1 and cytotoxic T lymphocyte antigen 4 chimeric monoclonal antibodies2022
- Author(s)
  WATARI Kei、KONNAI Satoru、OKAGAWA Tomohiro、MAEKAWA Naoya、SAJIKI Yamato、KATO Yukinari、SUZUKI Yasuhiko、MURATA Shiro、OHASHI Kazuhiko
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 84 Issue: 1 Pages: 6-15
- DOI
  10.1292/jvms.21-0552
- NAID
  130008139952
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19J21826, KAKENHI-PROJECT-20K21357, KAKENHI-PROJECT-19KK0172
[Journal Article] Prostaglandin E2-Induced Immune Suppression via Cytotoxic T-Lymphocyte Antigen 4 in Paratuberculosis2022
- Author(s)
  Sajiki Y, Konnai S, Watari K, Okagawa T, Tanaka A, Kawaji S, Nagata R, Maekawa N, Suzuki Y, Kato Y, Murata S, Mori Y, Ohashi K.
- Journal Title
  
  Infection and Immunity
  
  Volume: 90 Issue: 10
- DOI
  10.1128/iai.00210-22
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21357, KAKENHI-PROJECT-19KK0172, KAKENHI-PROJECT-23K23768
[Journal Article] Diagnosis and Early Prediction of Lymphoma Using High-Throughput Clonality Analysis of Bovine Leukemia Virus-Infected Cells2022
- Author(s)
  Okagawa T, Shimakura H, Konnai S, Saito M, Matsudaira T, Nao N, Yamada S, Murakami K, Maekawa N, Murata S, Ohashi K.
- Journal Title
  
  Microbiol Spectr.
  
  Volume: 10(6) Issue: 6
- DOI
  10.1128/spectrum.02595-22
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19232, KAKENHI-PROJECT-20K21357, KAKENHI-PROJECT-19KK0172, KAKENHI-PROJECT-23K23768
[Journal Article] Suppressive effects of Ixodes persulcatus sialostatin L2 against Borrelia miyamotoi-stimulated immunity2022
- Author(s)
  Sajiki Y, Konnai S, Okagawa T, Maekawa N, Isezaki M, Yamada S, Ito T, Sato K, Kawabata H, Logullo C, da Silva Vaz Jr I, Murata S, Ohashi K.
- Journal Title
  
  Ticks and Tick-borne Diseases
  
  Volume: 13 Issue: 4 Pages: 101963-101963
- DOI
  10.1016/j.ttbdis.2022.101963
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21357, KAKENHI-PROJECT-19KK0172, KAKENHI-PROJECT-23K23768
[Journal Article] Estradiol-induced immune suppression via prostaglandin E2 during parturition in bovine leukemia virus-infected cattle2022
- Author(s)
  Sajiki Yamato、Konnai Satoru、Okagawa Tomohiro、Maekawa Naoya、Goto Shinya、Kohara Junko、Nitanai Atsushi、Takahashi Hirofumi、Kubota Kentaro、Takeda Hiroshi、Murata Shiro、Ohashi Kazuhiko
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 3 Pages: 1-13
- DOI
  10.1371/journal.pone.0263660
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19J21826, KAKENHI-PROJECT-20K21357, KAKENHI-PROJECT-19KK0172
[Journal Article] Cross-species reactivity of antibodies against Ixodes persulcatus ferritin 2 to Rhipicephalus microplus2021
- Author(s)
  Xavier AM, Konnai S, Parizi FP, Githaka WN, Isezaki M, Goto S, Fujisawa S, Yamada S, Okagawa T, Maekawa N, Logullo C, Silva Vaz J r I, Murata S, Ohashi K.
- Journal Title
  
  Jpn J Vet Res.
  
  Volume: 69(1) Pages: 57-65
- NAID
  120006994840
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0172
[Journal Article] 発酵哺乳飼料による子牛の腸炎防御効果の直接証明2021
- Author(s)
  今内覚, 岡川朋弘
- Journal Title
  
  JATAFFジャーナル
  
  Volume: 9(10) Pages: 21-26
- Data Source
  KAKENHI-PROJECT-19KK0172
[Journal Article] 牛伝染性リンパ腫の病態発生機序解析を基盤とする新制御法の試み2021
- Author(s)
  今内覚, 岡川朋弘, 前川直也, 村田史郎, 大橋和彦
- Journal Title
  
  家畜衛生学雑誌
  
  Volume: 47(3) Pages: 147-150
- Data Source
  KAKENHI-PROJECT-19KK0172
[Journal Article] Tick saliva-induced programmed death-1 and PD-ligand 1 and its related host immunosuppression2021
- Author(s)
  Sajiki, Y., Konnai, S., Ikenaka, Y., Gulay, K. C. M., Kobayashi, A. Parizi, L. F., Joo, B. C., Watari, K., Fujisawa, S., Okagawa, T., Maekawa, N., Logullo, C.,da Silva Vaz, I.,Murata, S., Ohashi, K.
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 1063-1063
- DOI
  10.1038/s41598-020-80251-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21357, KAKENHI-PROJECT-19KK0172, KAKENHI-PROJECT-18H02332, KAKENHI-PROJECT-19J21826
[Journal Article] Direct evidence of the preventive effect of milk replacer?based probiotic feeding in calves against severe diarrhea2021
- Author(s)
  Kayasaki, F., Okagawa, T., Konnai, S., Kohara, J., Sajiki, Y., Watari, K., Ganbaatar, O., Goto, S., Nakamura, H., Shimakura, H., Minato, E., Kobayashi, A., Kubota, M., Terasaki, N., Takeda, A., Noda, H., Honma, M., Maekawa, N., Murata, S., Ohashi, K.
- Journal Title
  
  Veterinary Microbiology
  
  Volume: 254 Pages: 108976-108976
- DOI
  10.1016/j.vetmic.2020.108976
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21357, KAKENHI-PROJECT-19KK0172, KAKENHI-PROJECT-18H02332, KAKENHI-PROJECT-19J21826
[Journal Article] Intrauterine infection with Mycobacterium avium subsp. paratuberculosis in pregnant cattle diagnosed with Johne’s disease2021
- Author(s)
  Taniguchi Y, Konnai S, Sakakibara S, Yamamoto A, Okagawa T, Maekawa N, Murata S, Ohashi K.
- Journal Title
  
  Jpn J Vet Res.
  
  Volume: 69(1) Pages: 51-55
- NAID
  120006994839
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19KK0172
[Journal Article] Prostaglandin-related immune suppression in cattle2021
- Author(s)
  Sajiki Y.、Konnai S.、Ikenaka Y.、Okagawa T.、Maekawa N.、Logullo C.、da Silva Vaz I.、Murata S.、Ohashi K.
- Journal Title
  
  Veterinary Immunology and Immunopathology
  
  Volume: 236 Pages: 110238-110238
- DOI
  10.1016/j.vetimm.2021.110238
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K15993, KAKENHI-PROJECT-19J21826, KAKENHI-PROJECT-20K21357, KAKENHI-PROJECT-19KK0172
[Journal Article] プロバイオティクスで子牛を下痢から守る～高品質で安全な発酵代用乳～2021
- Author(s)
  岡川朋弘, 今内覚
- Journal Title
  
  MPアグロジャーナル
  
  Volume: 45(7) Pages: 34-37
- NAID
  40022636371
- Data Source
  KAKENHI-PROJECT-19KK0172
[Journal Article] The enhancement of Th1 immune response by anti-PD-L1 antibody in cattle infected with <i>Mycobacterium avium</i> subsp. <i>paratuberculosis</i>2021
- Author(s)
  Sajiki, Y., Konnai, S., Nagata, R., Kawaji, S., Nakamura, H., Fujisawa, S., Okagawa, T., Mawkawa, N., Kato, Y., Suzuki, Y., Murata, S., Mori, Y., Ohashi, K.
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 83 Issue: 2 Pages: 162-166
- DOI
  10.1292/jvms.20-0590
- NAID
  130007990713
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21357, KAKENHI-PROJECT-19KK0172, KAKENHI-PROJECT-18H02332, KAKENHI-PROJECT-19J21826, KAKENHI-PROJECT-19K15993
[Journal Article] Prostaglandin-related immune suppression in cattle2021
- Author(s)
  Sajiki Y, Konnai S, Ikenaka Y, Okagawa T, Maekawa N, Logullo C, da Silva Vaz Jr I, Murata S, Ohashi K.
- Journal Title
  
  Vet Immunol Immunopath.
  
  Volume: in press
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0172
[Journal Article] 子牛下痢症対策のアップデート：子牛下痢症への発酵代用乳の適応2021
- Author(s)
  岡川朋弘, 今内覚
- Journal Title
  
  臨床獣医
  
  Volume: 9 Pages: 34-38
- Data Source
  KAKENHI-PROJECT-19KK0172
[Journal Article] A TLR7 agonist activates bovine Th1 response and exerts antiviral activity against bovine leukemia virus2021
- Author(s)
  Sajiki, Y., Konnai, S., Okagawa, T., Maekawa, N., Nakamura, H., Kato, Y., Suzuki, Y., Murata, S., Ohashi, K.
- Journal Title
  
  Developmental & Comparative Immunology
  
  Volume: 114 Pages: 103847-103847
- DOI
  10.1016/j.dci.2020.103847
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21357, KAKENHI-PROJECT-19KK0172, KAKENHI-PROJECT-18H02332, KAKENHI-PROJECT-19J21826, KAKENHI-PROJECT-19K15993
[Journal Article] Programmed death‐ligand 1 expression in swine chronic infections and enhancement of interleukin‐2 production via programmed death‐1/programmed death‐ligand 1 blockade2021
- Author(s)
  Ganbaatar, O., Konnai, S., Okagawa, T., Nojima, Y., Maekawa, N., Ichikawa, Y., Kobayashi, A., Shibahara, T., Yanagawa, Y., Higuchi, H., Kato, Y., Suzuki, Y., Murata, S., Ohashi, K.
- Journal Title
  
  Immunity, Inflammation and Disease
  
  Volume: 9 Issue: 4 Pages: 1573-1583
- DOI
  10.1002/iid3.510
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21357, KAKENHI-PROJECT-19KK0172
[Journal Article] Molecular Epidemiology and Whole-Genome Analysis of Bovine Foamy Virus in Japan2021
- Author(s)
  Mekata Hirohisa、Okagawa Tomohiro、Konnai Satoru、Miyazawa Takayuki
- Journal Title
  
  Viruses
  
  Volume: 13 Issue: 6 Pages: 1017-1017
- DOI
  10.3390/v13061017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03150, KAKENHI-PROJECT-19KK0172
[Journal Article] Identification and functional analysis of ferritin 2 from the Taiga tick Ixodes persulcatus Schulze2020
- Author(s)
  Githaka, N. W., Konnai, S., Isezaki, M., Goto, S., Xavier, M. A., Fujisawa, S., Yamada, S., Okagawa, T., Maekawa, N., Logullo, C., da Silva Vaz, I., Murata, S., Ohashi, K. 4.巻 11
- Journal Title
  
  Ticks and Tick-borne Diseases
  
  Volume: 11 Issue: 6 Pages: 101547-101547
- DOI
  10.1016/j.ttbdis.2020.101547
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21357, KAKENHI-PROJECT-19KK0172, KAKENHI-PROJECT-18H02332
[Journal Article] The Suppression of Th1 Response by Inducing TGF-β1 From Regulatory T Cells in Bovine Mycoplasmosis2020
- Author(s)
  Sajiki Yamato、Konnai Satoru、Goto Shinya、Okagawa Tomohiro、Ohira Kosuke、Shimakura Honami、Maekawa Naoya、Gondaira Satoshi、Higuchi Hidetoshi、Tajima Motoshi、Hirano Yuki、Kohara Junko、Murata Shiro、Ohashi Kazuhiko
- Journal Title
  
  Frontiers in Veterinary Science
  
  Volume: 7 Pages: 2564-2569
- DOI
  10.3389/fvets.2020.609443
- NAID
  120007193553
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06425, KAKENHI-PROJECT-20K21357, KAKENHI-PROJECT-19KK0172, KAKENHI-PROJECT-18H02332, KAKENHI-PROJECT-19J21826, KAKENHI-PROJECT-19K15993
[Journal Article] Clinical efficacy of the combined treatment of anti-PD-L1 rat-bovine chimeric antibody with a COX-2 inhibitor in calves infected with Mycoplasma bovis2020
- Author(s)
  Goto S, Konnai S, Hirano Y, Kohara J, Okagawa T, Maekawa N, Sajiki Y, Watari K, Minato E, Kobayashi A, Gondaira S, Higuchi H, Koiwa M, Tajima M, Taguchi E, Ishida M, Uemura R, Yamada S, Kaneko M, Kato Y, Yamamoto K, Toda M, Suzuki Y, Murata S, Ohashi K.
- Journal Title
  
  Jpn J Vet Res.
  
  Volume: 68(2) Pages: 77-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19KK0172
[Journal Article] 牛白血病の病態発生機序解析を基盤とする新制御法の試み2020
- Author(s)
  今内覚, 岡川朋弘, 前川直也, 村田史郎, 大橋和彦
- Journal Title
  
  畜産技術
  
  Volume: 784 Pages: 36-40
- Data Source
  KAKENHI-PROJECT-19K15993
[Journal Article] Immunosuppressive Effects of Sialostatins L and L2 Isolated from the Taiga Tick Ixodes persulcatus Schulze2020
- Author(s)
  Sajiki Y, Konnai S, Ochi A, Okagawa T, Githaka N, Isezaki M, Yamada S, Ito T, Ando S, Kawabata H, Da Silva Vaz Jr I, Logullo C, Maekawa N, Murata S, Ohashi K.
- Journal Title
  
  Ticks Tick born Dis.
  
  Volume: 11(2) Issue: 2 Pages: 101332-101332
- DOI
  10.1016/j.ttbdis.2019.101332
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0172, KAKENHI-PROJECT-19J21826, KAKENHI-PROJECT-20K21357, KAKENHI-PROJECT-18H02332
[Journal Article] PD-L1 expression in equine malignant melanoma and functional effects of PD-L1 blockade2020
- Author(s)
  Ganbaatar, O., Konnai, S. Okagawa, T., Nojima, Y., Maekawa, N., Minato, E., Kobayashi, A., Ando, R., Sasaki, N., Miyakoshi, D., Ichii, O., Kato, Y., Suzuki, Y., Murata, S., Ohashi, K.
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 11 Pages: e0234218-e0234218
- DOI
  10.1371/journal.pone.0234218
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21357, KAKENHI-PROJECT-19KK0172, KAKENHI-PROJECT-18H02332, KAKENHI-PROJECT-19H03114
[Journal Article] 動物用抗体医薬品の開発および臨床研究2020
- Author(s)
  今内覚、岡川朋弘、前川直也、中島千絵、鈴木定彦、山本啓一、戸田幹洋、村田史郎、大橋和彦
- Journal Title
  
  日本動物用医薬品協会会報
  
  Volume: 67(2) Pages: 1-10
- NAID
  40022176977
- Data Source
  KAKENHI-PROJECT-19KK0172
[Journal Article] Clinical efficacy of the combined treatment of anti-PD-L1 rat-bovine chimeric antibody with a COX-2 inhibitor in calves infected with Mycoplasma bovis2020
- Author(s)
  Goto S, Konnai S, Hirano Y, Kohara J, Okagawa T, Maekawa N, Sajiki Y, Watari K, Minato E, Kobayashi A, Gondaira S, Higuchi H, Koiwa M, Tajima M, Taguchi E, Uemura R, Yamada S, Kaneko MK, Kato Y, Yamamoto K, Toda M, Suzuki Y, Murata S, Ohashi K
- Journal Title
  
  Japanese Journal of Veterinary Research
  
  Volume: 68 Issue: 2 Pages: 77-90
- DOI
  10.14943/jjvr.68.2.77
- NAID
  120006863178
- ISSN
  0047-1917
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K15993
[Journal Article] Enhanced Immunotherapeutic Efficacy of Anti?PD-L1 Antibody in Combination with an EP4 Antagonist2020
- Author(s)
  Sajiki Yamato、Konnai Satoru、Cai Zimeng、Takada Kensuke、Okagawa Tomohiro、Maekawa Naoya、Fujisawa Sotaro、Kato Yukinari、Suzuki Yasuhiko、Murata Shiro、Ohashi Kazuhiko
- Journal Title
  
  ImmunoHorizons
  
  Volume: 4 Issue: 12 Pages: 837-850
- DOI
  10.4049/immunohorizons.2000089
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21356, KAKENHI-PROJECT-20K21357, KAKENHI-PROJECT-19KK0172, KAKENHI-PROJECT-17H03928, KAKENHI-PROJECT-18H02332, KAKENHI-PROJECT-19H03114, KAKENHI-PROJECT-19J21826, KAKENHI-PROJECT-19K15993
[Journal Article] Upregulation of PD-L1 Expression by Prostaglandin E2 and the Enhancement of IFN-γ by Anti-PD-L1 Antibody Combined With a COX-2 Inhibitor in Mycoplasma bovis Infection2020
- Author(s)
  Goto Shinya、Konnai Satoru、Hirano Yuki、Kohara Junko、Okagawa Tomohiro、Maekawa Naoya、Sajiki Yamato、Watari Kei、Minato Erina、Kobayashi Atsuhi、et al.
- Journal Title
  
  Frontiers in Veterinary Science
  
  Volume: 7 Pages: 12-12
- DOI
  10.3389/fvets.2020.00012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-19KK0172, KAKENHI-PROJECT-18H02332, KAKENHI-PROJECT-18J13237, KAKENHI-PROJECT-19J21826, KAKENHI-PROJECT-19K06425, KAKENHI-PROJECT-20K21357, KAKENHI-PROJECT-19K15993
[Journal Article] Clinical efficacy of the combined treatment of anti-PD-L1 rat-bovine chimeric antibody with a COX-2 inhibitor in calves infected with Mycoplasma bovis2020
- Author(s)
  Goto S, Konnai S, Hirano Y, Kohara J, Okagawa T, Maekawa N, Sajiki Y, Watari K, Minato E, Kobayashi A, Gondaira S, Higuchi H, Koiwa M, Tajima M, Taguchi E, Ishida M, Uemura R, Yamada S, Kaneko M, Kato Y, Yamamoto K, Toda M, Suzuki Y, Murata S, Ohashi K.
- Journal Title
  
  Jpn. J. Vet. Res
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19KK0172
[Journal Article] 牛白血病の病態発生機序解析を基盤とする新制御法の試み2020
- Author(s)
  今内覚, 岡川朋弘, 前川直也, 村田史郎, 大橋和彦
- Journal Title
  
  畜産技術
  
  Volume: 784) Pages: 36-40
- Data Source
  KAKENHI-PROJECT-19KK0172
[Journal Article] Immune inhibitory function of bovine CTLA-4 and the effects of its blockade in IFN-γ production2019
- Author(s)
  Watari K, Konnai S, Maekawa N, Okagawa T, Suzuki Y, Murata S, Ohashi K.
- Journal Title
  
  BMC Vet Res.
  
  Volume: 15(1) Issue: 1 Pages: 380-380
- DOI
  10.1186/s12917-019-2082-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0172, KAKENHI-PROJECT-18H02332, KAKENHI-PROJECT-19H03114
[Journal Article] ダニ研究の最前線とダニ媒介性感染症制御の可能性を探る: 病原体伝播に関わるマダニ因子～マダニ唾液中の免疫抑制因子～2019
- Author(s)
  今内覚、岡川朋弘、前川直也、村田史郎、大橋和彦
- Journal Title
  
  Med. Entomol. Zool.
  
  Volume: 70(4) Pages: 189-197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19KK0172
[Journal Article] ウシマイコプラズマ感染症における免疫疲弊化2019
- Author(s)
  今内覚、後藤伸也、岡川朋弘、前川直也、村田史郎、大橋和彦
- Journal Title
  
  日本マイコプラズマ学会雑誌
  
  Volume: 46 Pages: 31-33
- Data Source
  KAKENHI-PROJECT-19KK0172
[Presentation] クローナリティ解析による地方病性牛伝染性リンパ腫に対する発症予測法の開発2023
- Author(s)
  富永みその, 今内覚, 岡川朋弘, 神谷可菜, 齋藤麻矢, 安富一郎, 目堅博久, 前川直也, 村田史郎, 大橋和彦
- Organizer
  第166回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-23KK0124
[Presentation] Molecular characterization of immunoinhibitory factors PD-1/PD-L1 in sheep2023
- Author(s)
  Wisa Tiyamanee, Satoru Konnai, Tomohiro Okagawa, Naoya Maekawa, Shiro Murata, Kazuhiko Ohashi.
- Organizer
  第166回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-23KK0124
[Presentation] 牛伝染性リンパ腫ウイルス感染症における免疫チェックポイント因子TIM-3およびPD-L1を標的とした抗ウイルス効果の検討2023
- Author(s)
  中村隼人, 今内覚, 岡川朋弘, 前川直也, 村田史郎, 大橋和彦
- Organizer
  第166回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-23KK0124
[Presentation] 牛伝染性リンパ腫の診断と早期発症予測法の開発2023
- Author(s)
  富永みその, 今内覚, 岡川朋弘, 神谷可菜, 齋藤麻矢, 安富一郎, 目堅博久, 前川直也, 村田史郎, 大橋和彦
- Organizer
  令和5年度北海道獣医師会地区学会
- Data Source
  KAKENHI-PROJECT-23KK0124
[Presentation] In vitro evaluation of Lactiplantibacillus plantarum HOKKAIDO strain, effective lactic acid bacteria for calf diarrhea2023
- Author(s)
  Mari Ikehata, Satoru Konnai, Tomohiro Okagawa, Kentaro Abe, Misturu Honma , Toru Kitamura, Naoya Maekawa, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi
- Organizer
  The 11th Sapporo Summer Symposium for One Health
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23KK0124
[Presentation] Combined Immune Checkpoint Blockade Enhances Antiviral Immunity against Bovine Leukemia Virus2023
- Author(s)
  Hayato Nakamura, Satoru Konnai, Tomohiro Okagawa, Naoya Maekawa, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi
- Organizer
  The 11th Sapporo Summer Symposium for One Health
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23KK0124
[Presentation] Temporal analysis of programmed death-ligand 1 expression and proviral load in sheep experimentally infected with bovine leukemia virus2023
- Author(s)
  Wisa Tiyamanee, Satoru Konnai, Tomohiro Okagawa, Naoya Maekawa, Shiro Murata, Kazuhiko Ohashi
- Organizer
  The 11th Sapporo Summer Symposium for One Health
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23KK0124
[Presentation] 地方病性牛伝染性リンパ腫における牛伝染性リンパ腫ウイルス/SMAD3融合遺伝子の検出2023
- Author(s)
  直亨則, 岡川朋弘, 野尻直未, 今内覚, 嶋倉穂南, 富永みその, 吉田初佳, 西山依里, 松平崇弘, 前川直也, 村田史郎, 大橋和彦, 斎藤益満
- Organizer
  第70回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-23KK0124
[Presentation] PD-L1 blockade enhances T-cell response to vaccination in calves2023
- Author(s)
  Tomohiro Okagawa, Satoru Konnai, Naoya Maekawa, Shiro Murata, Kazuhiko Ohashi
- Organizer
  13th International Veterinary Immunology Symposium (IVIS2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23KK0124
[Presentation] From Bench to Farm: Development of Immunotherapy and Clonality Analysis Technologies for BLV Control2023
- Author(s)
  Tomohiro Okagawa, Satoru Konnai, Naoya Maekawa, Shiro Murata, Kazuhiko Ohashi
- Organizer
  The international all things bovine leukemia virus conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23KK0124
[Presentation] Identification and characterization of ovine PD-1 and PD-L12022
- Author(s)
  Tiyamanee W, Konnai S, Okagawa T, Maekawa N, Murata S, Ohashi K.
- Organizer
  The 10th Sapporo Summer Seminar for One Health
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0172
[Presentation] 牛伝染性リンパ腫ウイルス感染牛における分娩が及ぼす免疫抑制メカニズムの解析2022
- Author(s)
  富永みその, 今内覚, 佐治木大和, 岡川朋弘, 小原潤子, 似内厚之, 高橋博文, 窪田健太郎, 武田休史, 前川直也, 村田史郎, 大橋和彦
- Organizer
  令和４年度日本産業動物獣医学会（北海道）
- Data Source
  KAKENHI-PROJECT-19KK0172
[Presentation] 乳酸菌Lactobacillus plantarum HOKKAIDO株による免疫制御機序の解明2022
- Author(s)
  池端麻里, 今内覚, 岡川朋弘, 阿部健太郎, 本間満, 北村亨, 前川直也, 村田史郎, 大橋和彦
- Organizer
  第165回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-19KK0172
[Presentation] The use of recombinant spsQ from Staphylococcus pseudintermedius may improve the purification efficiency of therapeutic antibodies for dogs2022
- Author(s)
  Takeuchi H, Konnai S, Okagawa T, Maekawa N, Murata S, Ohashi K.
- Organizer
  The 10th Sapporo Summer Seminar for One Health
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0172
[Presentation] 牛伝染性リンパ腫発症母牛における子宮内感染の解析2021
- Author(s)
  嶋倉穂南、今内覚、岡川朋弘、中村隼人、神谷可菜、齋藤麻矢、前川直也、村田史郎、大橋和彦
- Organizer
  第164回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-19KK0172
[Presentation] 牛の慢性感染症に対する免疫チェックポイント阻害抗体薬の臨床研究2021
- Author(s)
  岡川朋弘
- Organizer
  第12回動物用ワクチン・バイオ医薬品研究会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19K15993
[Presentation] Expression and functional analysis of swine PD-1 /PD-L1 pathway2021
- Author(s)
  Ganbaatar O, Konnai S, Okagawa T, Nojima Y, Maekawa N, Ichikawa Y, Kobayashi A, Shibahara T, Yanagawa Y, Suzuki Y, Murata S, Ohashi K.
- Organizer
  第164回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-19KK0172
[Presentation] ウシCTLA-4ならびにPD-L1を標的とした抗体併用法による免疫増強効果の検討2021
- Author(s)
  渡　慧、今内覚、岡川朋弘、前川直也、村田史郎、鈴木定彦、大橋和彦
- Organizer
  第164回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-19KK0172
[Presentation] Enhanced production of IL-2 by combination of anti-Cytotoxic T Lymphocyte Antigen 4 chimeric antibody with Programmed Death Ligand 1 blockade2021
- Author(s)
  Watari K, Konnai S, Okagawa T, Maekawa N, Suzuki Y, Murata S, Ohashi K.
- Organizer
  The 9th Sapporo Summer Seminar for One Health
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0172
[Presentation] PD-L1 expression in swine chronic infections and enhancement of IL-2 production via PD-1/PD-L1 blockade2021
- Author(s)
  Ganbaatar O, Konnai S, Okagawa T, Maekawa N, Murata S, Ohashi K.
- Organizer
  The 9th Sapporo Summer Seminar for One Health
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0172
[Presentation] 牛白血病ウイルス感染症における免疫抑制受容体TIM-3の発現解析および機能解析2020
- Author(s)
  中村隼人、今内覚、岡川朋弘、佐治木大和、渡慧、神谷可菜、齋藤麻矢、前川直也、村田史郎、大橋和彦
- Organizer
  第163回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-19K15993
[Presentation] Functional analysis of bovine CTLA-4 in bovine leukemia virus infection2020
- Author(s)
  渡　慧、今内　覚、岡川朋弘、前川直也、村田史郎、大橋和彦
- Organizer
  リオグランデドスール連邦大学特別講演(リオグランデドスル連邦大学、ポルト・アレグレ、ブラジル)
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0172
[Presentation] Enhanced immune efficacy of anti-Cytotoxic T Lymphocyte Antigen 4 chimeric antibody by combination with Programmed Death Ligand 1 blockade2020
- Author(s)
  Watari K, Konnai S, Okagawa T, Maekawa N, Suzuki Y, Murata S, Ohashi K.
- Organizer
  Sapporo Summer Symposium for One Health 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0172
[Presentation] Immunosuppressive function of prostaglandin E2 in cattle2020
- Author(s)
  佐治木大和、今内　覚、岡川朋弘、前川直也、村田史郎、大橋和彦
- Organizer
  リオグランデドスール連邦大学特別講演(リオグランデドスル連邦大学、ポルト・アレグレ、ブラジル)
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0172
[Presentation] Characterization and functional analysis of swine PD-1 /PD-L1 pathway2020
- Author(s)
  Ganbaatar O, Konnai S, Okagawa T, Nojima Y, Maekawa N, Minato E, Kobayashi A, Ando R, Sasaki N, Miyakoshi D, Ichii O, Kato Y, Suzuki Y, Murata S, Ohashi K.
- Organizer
  Sapporo Summer Symposium for One Health 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0172

1. KONNAI SATORU (40396304)

# of Collaborated Projects: 4 results

# of Collaborated Products: 47 results
2. 前川直也 (70829035)

# of Collaborated Projects: 3 results

# of Collaborated Products: 37 results
3. 目堅博久 (90633264)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 齊藤暁 (30621792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TAKADA Kensuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 村田史郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 9 results
7. 樋口豪紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 権平智

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 小林篤史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 宮沢孝幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okagawa Tomohiro 岡川 朋弘

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanism of tumorigenesis in bovine leukemia by comprehensive genomic analysis of proviral integration sitesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel control strategy for livestock malignant infectious diseases targeting immune disruptors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of tumorigenesis in bovine leukemia initiated by chimeric transcripts of BLV-host genesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of Animal Formy Viral Vectors and Development of a Vaccine for Bovine Leukemia Virus

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of immunotherapy targeting immunoinhibitory receptors for control of bovine leukemia virus infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the molecular mechanism for immunosuppression in malignant infectious diseases of livestock and the development of a novel control method

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Combined Immune Checkpoint Blockade Enhances Antiviral Immunity against Bovine Leukemia Virus.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vitro evaluation of Lactiplantibacillus plantarum HOKKAIDO strain, effective lactic acid bacteria for calf diarrhea2023

Author(s)

Journal Title

Data Source

[Journal Article] ピックアップ新技術：牛のリンパ腫発症を予測するがん検診技術を開発. リスク高い牛の優先淘汰2023

Author(s)

Journal Title

Data Source

[Journal Article] Enhancement of Vaccine-Induced T-Cell Responses by PD-L1 Blockade in Calves2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of SpsQ from Staphylococcus pseudintermedius as an affinity chromatography ligand for canine therapeutic antibodies2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chimeric provirus of bovine leukemia virus/ SMAD family member 3 in cattle with enzootic bovine leukosis2023

Author(s)

Journal Title

Data Source

[Journal Article] 講座: 牛伝染性リンパ腫診断の新技術・早期発症予測診断法RAISINGとは2023

Author(s)

Journal Title

Data Source

[Journal Article] 牛伝染性リンパ腫の現状から最後の砦：発症予測法について2023

Author(s)

Journal Title

Data Source

[Journal Article] 成果紹介：ウシ伝染性リンパ腫の早期発症診断による経済損失提言の実現2023

Author(s)

Journal Title

Data Source

[Journal Article] Enhancement of interleukin-2 production by bovine peripheral blood mononuclear cells treated with the combination of anti-programmed death-ligand 1 and cytotoxic T lymphocyte antigen 4 chimeric monoclonal antibodies2022

Okagawa Tomohiro 岡川朋弘

[Journal Article] プロバイオティクスで子牛を下痢から守る～高品質で安全な発酵代用乳～2021