Orimo Takashi 折茂貴是

Researcher Number	80843036
Affiliation (Current)	2023: 和歌山県立医科大学, 医学部, 特別研究員
Affiliation (based on the past Project Information) *help	2019 – 2021: 和歌山県立医科大学, 医学部, 特別研究員
Review Section/Research Field	Principal Investigator 0803:Pathology, infection/immunology, and related fields / Basic Section 49070:Immunology-related
Keywords	Principal Investigator 小胞体ストレス応答 / コレラ毒素 / 小胞体ストレス / 免疫アジュバント / マクロファージ / プロテアソーム / 免疫不全 / リンパ球 / 樹状細胞 / 好中球 … More / 単球 / T細胞 / 自己炎症性疾患 / 抗体産生細胞 / B細胞 / 炎症 / 遺伝子変異 / 自然免疫 Less

Roles of immunoproteasome in immune cellsPrincipal Investigator
- Principal Investigator
  
  Orimo Takashi
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Wakayama Medical University
Elucidation of the physiological roles of unfolded protein responses in immune responsesPrincipal Investigator
- Principal Investigator
  
  Orimo Takashi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0803:Pathology, infection/immunology, and related fields
- Research Institution
  Wakayama Medical University

All 2021 2020 2019

All Journal Article Presentation

[Journal Article] Augmentation of Stimulator of Interferon Genes-Induced Type I Interferon Production in COPA Syndrome.2021
- Author(s)
  Kato Takashi、Yamamoto Masaki、Honda Yoshitaka、Orimo Takashi、Sasaki Izumi、Murakami Kohei、Hemmi Hiroaki、Fukuda‐Ohta Yuri、Isono Kyoichi、Takayama Saki、Nakamura Hidenori、Otsuki Yoshiro、Miyamoto Toshiaki、Takita Junko、Yasumi Takahiro、Nishikomori Ryuta、Matsubayashi Tadashi、Izawa Kazushi、Kaisho Tsuneyasu
- Journal Title
  
  Arthritis & Rheumatology
  
  Volume: in press Pages: 2105-2115
- DOI
  10.1002/art.41790
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H04813, KAKENHI-PROJECT-18K16096, KAKENHI-PROJECT-19K07628, KAKENHI-PROJECT-19K08299, KAKENHI-PROJECT-20K16289, KAKENHI-PROJECT-20H00528, KAKENHI-PROJECT-20H03505, KAKENHI-PROJECT-21J22615, KAKENHI-PROJECT-21K06956, KAKENHI-PROJECT-21K09216, KAKENHI-PROJECT-21K19384, KAKENHI-PROJECT-21K19405
[Journal Article] Anticancer Effects of Chemokine-Directed Antigen Delivery to a Cross-Presenting Dendritic Cell Subset With Immune Checkpoint Blockade2020
- Author(s)
  Mizumoto Y, Hemmi H, Katsuda M, Miyazawa M, Kitahata Y, Miyamoto A, Nakamori M, Ojima T, Matsuda K, Nakamura M, Hayata K, Fukuda-Ohta Y, Sugiyama M, Ohta T, Orimo T, Okura S, Sasaki I, Tamada K, Yamaue H, Kaisho T.
- Journal Title
  
  British Journal of Cancer.
  
  Volume: 122 Pages: 1185-1192
- DOI
  10.1038/s41416-020-0757-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07071, KAKENHI-PROJECT-19K09183, KAKENHI-PROJECT-18K16096, KAKENHI-PUBLICLY-19H04813, KAKENHI-PROJECT-17H04088, KAKENHI-PROJECT-17K10603, KAKENHI-PROJECT-17K10604, KAKENHI-PROJECT-17K10711, KAKENHI-PROJECT-19K07628, KAKENHI-PROJECT-20K09063, KAKENHI-PROJECT-19K18101, KAKENHI-PROJECT-20K16289, KAKENHI-PROJECT-17H01580, KAKENHI-PROJECT-19K23848
[Journal Article] Cholera toxin B induces interleukine-1β production from resident peritoneal macrophages through pyrin as well as NLRP3 inflammasome.2019
- Author(s)
  Orimo, T., I. Sasaki, H. Hemmi, T. Ozasa, Y. Fukuda-Ohta, T. Ohta, M. Morinaka, M. Kitauchi, T. Yamaguchi, Y. Sato, T. Tanaka, K. Hoshino, K. I. Katayama, S. Fukuda, K. Miyake, M. Yamamoto, T. Satoh, K. Furukawa, E. Kuroda, K. J. Ishii, K. Takeda, and T. Kaisho.
- Journal Title
  
  Int Immunol
  
  Volume: 印刷中 Pages: 657-668
- DOI
  10.1093/intimm/dxz004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07071, KAKENHI-PUBLICLY-17H05799, KAKENHI-PROJECT-17H04088, KAKENHI-PROJECT-17K19568, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K07628, KAKENHI-PROJECT-19K22518, KAKENHI-PROJECT-18K16096, KAKENHI-PROJECT-19K23848, KAKENHI-PUBLICLY-19H04813, KAKENHI-PROJECT-17K19616
[Presentation] 自己炎症性疾患COPA症候群モデルマウスにおけるI型IFN症発症の分子基盤2021
- Author(s)
  加藤喬、折茂貴是、大田（福田）有里、西山奈央子、中井千尋、佐々木泉、村上康平、邊見弘明、本田吉孝、井澤和司、大月寛郎、松林正、西小森隆太、改正恒康
- Organizer
  第28回日本免疫毒性学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16289
[Presentation] Analysis of innate immune cells in proteasome subunit mutant mice2021
- Author(s)
  H. Hemmi, T. Orimo, I. Sasaki, T. Kato, Y. Fukuda-Ohta, N. Kinjo, H. Ohnishi, N. Kanzawa, T. Kaisho
- Organizer
  IEIIS2021: 16th Meeting of the International Endotoxin and Innate Immunity Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16289
[Presentation] An endoplasmic reticulum stress sensor IRE1α is involved in cholera toxin-induced interleukin-1β production from tissue resident macrophages2021
- Author(s)
  I. Sasaki, Y. Fukuda-Ohta, N. Wakaki-Nishiyama, C. Nakai, S. Morita, D. Okuzaki, M. Kaku, K. Sawase, T. Kato, T. Orimo, K. Furukawa, T. Kaisho
- Organizer
  第28回日本免疫毒性学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16289
[Presentation] 自然免疫応答における小胞体ストレスセンサーIRE1αの機能的意義2021
- Author(s)
  澤瀬幹太、加藤喬、折茂貴是、大田（福田）有里、西山奈央子、中井千尋、佐々木泉、改正恒康
- Organizer
  第89回和歌山医学会総会
- Data Source
  KAKENHI-PROJECT-20K16289
[Presentation] Interstitial Lung Disease and abnormal STING activation in COPA V242G heterozygous variant mice2021
- Author(s)
  T. Kato, T. Orimo, Y. Fukuda-Ohta, N. Wakaki-Nishiyama, C. Nakai, I. Sasaki, K. Murakami, H. Hemmi, Y. Honda, K. Izawa, Y. Otsuki, T. Matsubayashi, R. Nishikomori, T. Kaisho
- Organizer
  IEIIS2021: 16th Meeting of the International Endotoxin and Innate Immunity Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16289
[Presentation] Chemokine-medicated delivery of cancer peptide vaccine to a dendritic cell subset with high crosspresentation activity2021
- Author(s)
  Y. Mizumoto, H. Hemmi, M. Katsuda, Y. Fukuda-Ohta, T. Orimo, I. Sasaki, K. Tamada, H. Yamaue, T. Kaisho
- Organizer
  The 27th International Symposium on Molecular Cell Biology of Macrophage (MMCB 2020+1).
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16289
[Presentation] 自己炎症性疾患COPA症候群変異マウスにおけるSTINGシグナルの活性化2021
- Author(s)
  加藤喬、折茂貴是、大田（福田）有里、西山奈央子、中井千尋、張江伊水、田中日向子、佐々木泉、村上康平、邊見弘明、本田吉孝、井澤和司、西小森隆太、改正恒康
- Organizer
  第85回日本インターフェロン・サイトカイン学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16289
[Presentation] Hyperactivation of STING-induced type I interferon pathway in dendritic cells from novel mice model for an autoinflammatory disease, COPA syndrome2021
- Author(s)
  T. Kato, T. Orimo, Y. Fukuda-Ohta, I. Sasaki, H. Hemmi, Y. Honda, K. Izawa, R. Nishikomori, T. Kaisho
- Organizer
  第50回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20K16289
[Presentation] コレラ毒素による炎症性サイトカインIL-6産生誘導機構の解明2021
- Author(s)
  賀来美嘉、加藤喬、折茂貴是、大田（福田）有里、西山奈央子、中井千尋、佐々木泉、改正恒康
- Organizer
  第89回和歌山医学会総会
- Data Source
  KAKENHI-PROJECT-20K16289
[Presentation] Critical roles of IRE1α in cholera toxin-induced interleukin-1β production from resident peritoneal macrophages2021
- Author(s)
  I. Sasaki, Y. Fukuda-Ohta, N. Wakaki-Nishiyama, C. Nakai, S. Morita, D. Okuzaki, M. Kaku, K. Sawase, A. Yamamoto, T. Kato, T. Orimo, K. Furukawa, T. Kaisho
- Organizer
  IEIIS2021: 16th Meeting of the International Endotoxin and Innate Immunity Society (26tth Japanese Endotoxin and innate Immunity Society)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16289
[Presentation] An endoplasmic reticulum stress sensor IRE1α is involved in cholera toxin-induced interleukin-1β production from resident peritoneal macrophages.2021
- Author(s)
  I. Sasaki, Y. Fukuda-Ohta, S. Morita, D. Okuzaki, T. Kato, T. Orimo, K. Furukawa, T. Kaisho
- Organizer
  第50回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20K16289
[Presentation] COPA症候群の新規モデルマウスにおけるSTINGの活性化とT細胞の異常. Activation of STING and T cell abnormalities in a novel mouse model of COPA syndrome.2021
- Author(s)
  加藤喬、折茂貴是、大田(福田)有里、西山奈央子、中井千尋、佐々木泉、村上康平、邊見弘明、本田吉孝、井澤和司、八角高裕、大月寛郎、松林正、西小森隆太、改正恒康
- Organizer
  第5回日本免疫不全・自己炎症学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K16289
[Presentation] Impaired monocyte and dendritic cell development in mice carrying a mutation identified from the proteasome-associated autoinflammation and immunodeficiency disease patient2021
- Author(s)
  H. Hemmi, T. Orimo, Naoko Nishiyama, T. Kato, T. Ozasa, I. Sasaki, H. Ohnishi, N. Kinjo, N. Kanzawa, T. Kaisho
- Organizer
  The 27th International Symposium on Molecular Cell Biology of Macrophage (MMCB 2020+1)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16289
[Presentation] Impaired development of myeloid cells in proteasome subunit mutant mice2021
- Author(s)
  H. Hemmi, T. Orimo, I. Sasaki, T. Kato, Y. Fukuda-Ohta, N. Kinjo, H. Ohnishi, N. Kanazawa, T. Kaisho
- Organizer
  第50回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20K16289
[Presentation] Th1-skewing colitis in mutant mice with homozygous missense mutation of DNA ligase IV2021
- Author(s)
  S. Tamura, Y. Yamashita, T. Orimo, S. Iwabuchi, I. Sasaki, H. Hemmi, S. Hashimoto, T. Sonoki, T. Kaisho
- Organizer
  The 27th International Symposium on Molecular Cell Biology of Macrophage (MMCB 2020+1)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16289
[Presentation] 遺伝子改変マウスを用いたCOPA症候群の病態解明2021
- Author(s)
  加藤喬、川野果歩、折茂貴是、大田（福田）有里、西山奈央子、中井千尋、佐々木泉、改正恒康
- Organizer
  第89回和歌山医学会総会
- Data Source
  KAKENHI-PROJECT-20K16289
[Presentation] The roles of unfold protein responses in cholera toxinB-induced interleukin-1β production.2020
- Author(s)
  佐々木泉、折茂貴是、張江伊水、滝沢優子、古川綱一、改正恒康
- Organizer
  第27回日本免疫毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19K23848
[Presentation] 自然免疫応答における小胞体ストレスセンサー IRE1αの機能的意義2020
- Author(s)
  三並桃花、石田エヴァ如月、加藤喬、折茂貴是、大田（福田）有里、西山奈央子、中井千尋、佐々木泉、改正恒康
- Organizer
  第88回和歌山医学会総会
- Data Source
  KAKENHI-PROJECT-19K23848
[Presentation] 遺伝性炎症性疾患COPA症候群のモデルマウスの樹立とその解析2020
- Author(s)
  張江伊水、滝沢優子、加藤喬、折茂貴是、大田（福田）有里、西山奈央子、中井千尋、佐々木泉、改正恒康
- Organizer
  第88回和歌山医学会総会
- Data Source
  KAKENHI-PROJECT-19K23848
[Presentation] The roles of unfold protein responses in cholera toxinB-induced interleukin-1β production.2020
- Author(s)
  佐々木泉、折茂貴是、張江伊水、滝沢優子、古川綱一、改正恒康
- Organizer
  第27回日本免疫毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-20K16289
[Presentation] 遺伝性炎症性疾患COPA症候群の分子基盤の解明2020
- Author(s)
  田中日尚子、林茉里、加藤喬、折茂貴是、大田（福田）有里、西山奈央子、中井千尋、佐々木泉、改正恒康
- Organizer
  第88回和歌山医学会総会
- Data Source
  KAKENHI-PROJECT-19K23848
[Presentation] 遺伝性炎症性疾患COPA症候群のモデルマウスの樹立とその解析2020
- Author(s)
  張江伊水、滝沢優子、加藤喬、折茂貴是、大田（福田）有里、西山奈央子、中井千尋、佐々木泉、改正恒康
- Organizer
  第88回和歌山医学会総会
- Data Source
  KAKENHI-PROJECT-20K16289
[Presentation] 遺伝性炎症性疾患COPA症候群の分子基盤の解明2020
- Author(s)
  田中日尚子、林茉里、加藤喬、折茂貴是、大田（福田）有里、西山奈央子、中井千尋、佐々木泉、改正恒康
- Organizer
  第88回和歌山医学会総会
- Data Source
  KAKENHI-PROJECT-20K16289
[Presentation] 自然免疫応答における小胞体ストレスセンサー IRE1αの機能的意義2020
- Author(s)
  三並桃花、石田エヴァ如月、加藤喬、折茂貴是、大田（福田）有里、西山奈央子、中井千尋、佐々木泉、改正恒康
- Organizer
  第88回和歌山医学会総会
- Data Source
  KAKENHI-PROJECT-20K16289
[Presentation] Roles of endoplasmic reticulum stress in cholera toxinB-induced interleukine-1β production from resident peritoneal macrophages.2019
- Author(s)
  I. Sasaki, S. Morita, D. Okuzaki, T. Orimo, H. Hemmi, K. Furukawa, T. Kaisho.
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K23848
[Presentation] Lig4遺伝子改変マウスを用いた腸管免疫寛容破綻の病態解明2019
- Author(s)
  田村志宣、山下友佑、折茂貴是、大田（福田）有里、小笹俊哉、中嶋一貴、金澤伸雄、邊見弘明、大島孝一、改正恒康、園木孝志
- Organizer
  第47回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-19K23848
[Presentation] Cholera toxin B can induce interleukine-1beta production from resident peritoneal macrophages in synergy with lipopolysaccharides.2019
- Author(s)
  I. Sasaki, T. Orimo, H. Hemmi, K. Furukawa, T. Kaisho.
- Organizer
  第18回あわじ感染と免疫国際フォーラム (The 18th Awaji International Forum on Infection and Immunity)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23848
[Presentation] コレラ毒素Bサブユニットによる炎症性サイトカインIL-1β産生誘導機構2019
- Author(s)
  佐々木泉、折茂貴是、邊見弘明、土屋慧馬、井上正一、熊谷直光、古川鋼一、改正恒康
- Organizer
  第26回日本免疫毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19K23848
[Presentation] Impaired development of myeloid cells in mice carrying a patient-derived proteasome subunit mutation.2019
- Author(s)
  邊見弘明、折茂貴是、佐々木泉、加藤喬、大田(福田)有里、金城紀子、濱田聡、木下晃、吉浦孝一郎、大西秀典、金澤伸雄、改正恒康
- Organizer
  第3回日本免疫不全・自己炎症学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K23848
[Presentation] コレラ毒素Bサブユニットは細胞内病原体センサーNLRP3とPyrinを介して炎症性サイトカインIL-1βの産生を誘導する2019
- Author(s)
  佐々木泉、折茂貴是、邊見弘明、古川鋼一、改正恒康
- Organizer
  第29回日本樹状細胞研究会
- Data Source
  KAKENHI-PROJECT-19K23848

1. IZAWA Kazushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. TAKEDA Naoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. TANAKA Tetsu

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# of Collaborated Products: 1 results
4. KATAYAMA Norihiro

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# of Collaborated Products: 1 results
5. KATSUDA Masahiro

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# of Collaborated Products: 1 results
6. MIYAZAWA Motoki

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# of Collaborated Products: 1 results
7. NAKAMORI Mikihito

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# of Collaborated Products: 1 results
8. NAKAMURA Masaki

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# of Collaborated Products: 1 results
9. OJIMA Toshiyasu

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10. 改正恒康

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# of Collaborated Products: 3 results
11. 福田有里

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# of Collaborated Products: 3 results
12. 佐々木泉

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# of Collaborated Products: 3 results
13. 西小森隆太

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# of Collaborated Products: 1 results
14. 滝田順子

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15. 邊見弘明

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16. 村上康平

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17. 古川鋼一

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18. 古川圭子

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19. 山上裕機

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20. 北畑裕司

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21. 水本有紀

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# of Collaborated Products: 1 results

Orimo Takashi 折茂 貴是

Research Projects

Research Products

Co-Researchers

Roles of immunoproteasome in immune cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the physiological roles of unfolded protein responses in immune responsesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Augmentation of Stimulator of Interferon Genes-Induced Type I Interferon Production in COPA Syndrome.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anticancer Effects of Chemokine-Directed Antigen Delivery to a Cross-Presenting Dendritic Cell Subset With Immune Checkpoint Blockade2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cholera toxin B induces interleukine-1β production from resident peritoneal macrophages through pyrin as well as NLRP3 inflammasome.2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] 自己炎症性疾患COPA症候群モデルマウスにおけるI型IFN症発症の分子基盤2021

Author(s)

Organizer

Data Source

[Presentation] Analysis of innate immune cells in proteasome subunit mutant mice2021

Author(s)

Organizer

Data Source

[Presentation] An endoplasmic reticulum stress sensor IRE1α is involved in cholera toxin-induced interleukin-1β production from tissue resident macrophages2021

Author(s)

Organizer

Data Source

[Presentation] 自然免疫応答における小胞体ストレスセンサーIRE1αの機能的意義2021

Author(s)

Organizer

Data Source

[Presentation] Interstitial Lung Disease and abnormal STING activation in COPA V242G heterozygous variant mice2021

Author(s)

Organizer

Data Source

[Presentation] Chemokine-medicated delivery of cancer peptide vaccine to a dendritic cell subset with high crosspresentation activity2021

Author(s)

Organizer

Data Source

[Presentation] 自己炎症性疾患COPA症候群変異マウスにおけるSTINGシグナルの活性化2021

Author(s)

Organizer

Data Source

[Presentation] Hyperactivation of STING-induced type I interferon pathway in dendritic cells from novel mice model for an autoinflammatory disease, COPA syndrome2021

Author(s)

Organizer

Data Source

[Presentation] コレラ毒素による炎症性サイトカインIL-6産生誘導機構の解明2021

Author(s)

Organizer

Data Source

[Presentation] Critical roles of IRE1α in cholera toxin-induced interleukin-1β production from resident peritoneal macrophages2021

Author(s)

Organizer

Data Source

[Presentation] An endoplasmic reticulum stress sensor IRE1α is involved in cholera toxin-induced interleukin-1β production from resident peritoneal macrophages.2021

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[Presentation] COPA症候群の新規モデルマウスにおけるSTINGの活性化とT細胞の異常. Activation of STING and T cell abnormalities in a novel mouse model of COPA syndrome.2021

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[Presentation] Impaired monocyte and dendritic cell development in mice carrying a mutation identified from the proteasome-associated autoinflammation and immunodeficiency disease patient2021

Orimo Takashi 折茂貴是