(unregistrated) (unregistrated) 深野顕人

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Fukano Kento 深野顕人

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Researcher Number	80848531
Other IDs
Affiliation (Current)	2023: 国立研究開発法人国立国際医療研究センター, 臨床研究センター, 産学連携推進部上級研究員
Affiliation (based on the past Project Information) *help	2021 – 2022: 国立研究開発法人国立国際医療研究センター, 臨床研究センター, 産学連携推進部上級研究員 2019 – 2020: 国立感染症研究所, ウイルス第二部, 研究員
Review Section/Research Field	Principal Investigator 0803:Pathology, infection/immunology, and related fields / Basic Section 49060:Virology-related
Keywords	Principal Investigator B型肝炎ウイルス / HBV / 内在化 / NTCP / 多量体 / EGFR / 侵入 / 感染 / 多量体化 / 肝細胞がん / ゲノム挿入 / インテグレーション

B型肝炎ウイルスゲノム挿入の新規検出法を利用したメカニズム解析Principal Investigator
- Principal Investigator
  
  深野顕人
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  National Center for Global Health and Medicine
Mechanistic analysis of hepatitis B virus internalization focusing on NTCP oligomerizationPrincipal Investigator
- Principal Investigator
  
  Fukano Kento
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0803:Pathology, infection/immunology, and related fields
- Research Institution
  National Center for Global Health and Medicine
  National Institute of Infectious Diseases

All 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro2022
- Author(s)
  Gad Sameh A.、Sugiyama Masaya、Tsuge Masataka、Wakae Kosho、Fukano Kento、Oshima Mizuki、Sureau Camille、Watanabe Noriyuki、Kato Takanobu、Murayama Asako、Li Yingfang、Shoji Ikuo、Shimotohno Kunitada、Chayama Kazuaki、Muramatsu Masamichi、Wakita Takaji、Nozaki Tomoyoshi、Aly Hussein H.
- Journal Title
  
  PLOS Pathogens
  
  Volume: 18 Pages: 1-26
- DOI
  10.1371/journal.ppat.1009983
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07586, KAKENHI-PROJECT-19K23855, KAKENHI-PROJECT-21K08006
[Journal Article] Identification of natural compounds extracted from crude drugs as novel inhibitors of hepatitis C virus.2021
- Author(s)
  Zheng Xin、Guo Rui、Liu Qingbo、Wakae Kousho、Watanabe Noriyuki、Fukano Kento、Que Lusheng、Li Yingfang、Aly Hussein H.、Watashi Koichi、Suzuki Ryosuke、Murayama Asako、Kato Takanobu、Aizaki Hideki、Wakita Takaji、Huang Xiaoxiao、Yan Yi、Song Shao-Jiang、Muramatsu Masamichi
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 567 Pages: 1-8
- DOI
  10.1016/j.bbrc.2021.06.022
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07586, KAKENHI-PROJECT-19K23855, KAKENHI-PROJECT-20K08369, KAKENHI-PROJECT-21K07974
[Journal Article] NTCP oligomerization occurs downstream of the NTCP-EGFR interaction during hepatitis B virus internalization.2021
- Author(s)
  Fukano Kento、Oshima Mizuki、Tsukuda Senko、Aizaki Hideki、Ohki Mio、Park Sam-Yong、Wakita Takaji、Wakae Kousho、Watashi Koichi、Muramatsu Masamichi
- Journal Title
  
  J Virol.
  
  Volume: 95 Pages: 1-12
- DOI
  10.1128/jvi.00938-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07583, KAKENHI-PROJECT-19K23855, KAKENHI-PROJECT-21K07974
[Journal Article] MCPIP1 reduces HBV-RNA by targeting its epsilon structure.2020
- Author(s)
  Li Y, Que L, Fukano K, Koura M, Kitamura K, Zheng X, Kato T, Aly HH, Watashi K, Tsukuda S, Aizaki H, Watanabe N, Sato Y, Suzuki T, Suzuki HI, Hosomichi K, Kurachi M, Wakae K, Muramatsu M.
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 20763-20763
- DOI
  10.1038/s41598-020-77166-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07476, KAKENHI-PROJECT-19K07583, KAKENHI-PROJECT-19K07586, KAKENHI-PROJECT-20K08380, KAKENHI-PROJECT-20K21705, KAKENHI-PROJECT-19K23855, KAKENHI-PUBLICLY-19H05344, KAKENHI-PROJECT-19K24694
[Journal Article] B型肝炎ウイルスの感染機序と創薬2020
- Author(s)
  深野顕人、渡士幸一
- Journal Title
  
  FARUAW
  
  Volume: 56 Issue: 12 Pages: 1079-1083
- DOI
  10.14894/faruawpsj.56.12_1079
- NAID
  130007948621
- ISSN
  0014-8601, 2189-7026
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K23855
[Journal Article] EBV‐LMP1 induces APOBEC3s and mitochondrial DNA hypermutation in nasopharyngeal cancer2020
- Author(s)
  Wakae K, Kondo S, Pham HT, Wakisaka N, Que L, Li Y, Zheng X, Fukano K, Kitamura K, Watashi K, Aizaki H, Ueno T, Moriyama-Kita M, Ishikawa K, Nakanishi Y, Endo K, Muramatsu M, Yoshizaki T.
- Journal Title
  
  Cancer Medicine
  
  Volume: 20 Pages: 7663-7671
- DOI
  10.1002/cam4.3357
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18246, KAKENHI-PROJECT-19K23855, KAKENHI-PROJECT-17H01590, KAKENHI-PROJECT-17H04343
[Journal Article] Non-nucleoside hepatitis B virus polymerase inhibitors identified by an in vitro polymerase elongation assay2020
- Author(s)
  Nakajima Shogo、Watashi Koichi、Fukano Kento、Tsukuda Senko、Wakae Kousho、Aizaki Hideki、Muramatsu Masamichi、Wakita Takaji、Toyoda Tetsuya
- Journal Title
  
  J Gastroenterol
  
  Volume: 55 Pages: 441-452
- DOI
  10.1007/s00535-019-01643-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K23855, KAKENHI-PROJECT-19K07583, KAKENHI-PROJECT-17H04085
[Presentation] 感染受容体NTCPの多量体化が導くB型肝炎ウイルス細胞内侵入機構の解明2022
- Author(s)
  深野顕人、九十田千子、大嶋美月、大木規央、朴三用、若江亨祥、相崎英樹、脇田隆字、渡士幸一、村松正道
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K23855
[Presentation] 新規作用機序によりB型肝炎ウイルス感染を阻害する酸化ステロール合成誘導体の同定2022
- Author(s)
  大嶋美月、深野顕人、岩本将士、Frank Stappenbeck、Feng Wang、鄭シン、山崎雅子、若江亨祥、相崎英樹、倉持幸司、村松正道、脇田隆字、Farhad Parhami、渡士幸一
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K23855
[Presentation] MCPIP1 reduces HBV-RNA by targeting its epsilon structure2021
- Author(s)
  Li Y, Que L, Fukano K, Koura M, Kitamura K, Wakae K, Muramatsu M
- Organizer
  2021 International HBV Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23855
[Presentation] B型肝炎ウイルスpreS2領域に対する抗体はウイルス感染を抑制する2021
- Author(s)
  矢藤慶悟、深野顕人、松田麻未、田中智久、森石恆司、西辻裕紀、下遠野邦忠、田村浩二、加藤孝宣、村松正道、鈴木亮介
- Organizer
  第68回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-19K23855
[Presentation] NTCP oligomerization is initiated downstream of the NTCP-EGFR interaction during HBV internalization2021
- Author(s)
  Fukano K, Oshima M, Tsukuda S, Aizaki H, Ohki M, Park SY, Wakita T, Wakae K, Watashi K, Muramatsu M
- Organizer
  2021 International HBV Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23855
[Presentation] アメントフラボンのB型肝炎ウイルス感染阻害活性について2021
- Author(s)
  靱千恵、Puguh Indrasetiawan、深野顕人、村松正道、堀田博、亀岡正典
- Organizer
  第68回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-19K23855
[Presentation] The kinesin KIF4 is essential to promote HBV/HDV entry through the regulation of surface localization of NTCP, and is a possible target for anti-HBV/HDV therapy2021
- Author(s)
  Gad SA, Wakae K, Fukano K, Kato T, Shoji I, Shimotohno K, Chayama K, Muramatsu M, Wakita T, Nozaki T, Aly HH
- Organizer
  第68回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-19K23855
[Presentation] SLC10A1/NTCP多量体形成が制御するB型肝炎ウイルス細胞内侵入機構の解析2021
- Author(s)
  深野顕人、大嶋美月、九十田千子、相崎英樹、大木規央、朴三用、脇田隆字、若江亨祥、渡士幸一、村松正道
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K23855
[Presentation] Kinesin KIF4 is a key regulator for surface localization of NTCP, and HBV/HDV infection2021
- Author(s)
  Gad SA, Sugiyama M, Tsuge M, Wakae K, Fukano K, Watanabe N, Kato T, Murayama A, Li Y, Shoji I, Shimotohno K, Chayama K, Muramatsu M, Wakita T, Nozaki T, Aly HH
- Organizer
  2021 International HBV Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23855
[Presentation] Identification of an oxysterol derivative that inhibits HBV infection by interrupting NTCP oligomerization2021
- Author(s)
  Oshima M, Fukano K, Iwamoto M, Stappenbeck F, Wang F, Zheng X, Yamasaki M, Wakae K, Aizaki H, Kuramochi K, Muramatsu M, Wakita T, Parhami F, Watashi K
- Organizer
  第68回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-19K23855
[Presentation] A biflavonoid amentoflavone inhibits hepatitis B virus infection2021
- Author(s)
  Aoki-Utsubo C, Indrasetiawan P, Fukano K, Muramatsu M, Hotta H, Kameoka M
- Organizer
  The 11th JSP・CSP・KSP Joint Symposium on Pharmacognosy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23855
[Presentation] Functional relevance between NTCP oligomerization and EGFR during hepatitis B virus internalization2021
- Author(s)
  Fukano K, Oshima M, Tsukuda S, Aizaki H, Ohki M, Park SY, Wakita T, Wakae K, Watashi K, Muramatsu M
- Organizer
  第68回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-19K23855
[Presentation] B型肝炎ウイルス内在化機構における感染受容体多量体化の関与2020
- Author(s)
  深野顕人、九十田千子、大嶋美月、大木規央、朴三用、若江亨祥、相崎英樹、脇田隆字、渡士幸一、村松正道
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K23855
[Presentation] MCPIP1はエプシロン構造を介してB型肝炎ウイルスRNAを分解する2020
- Author(s)
  李瑩芳、闕路晟、深野顕人、小浦美樹、喜多村晃一、倉知慎、若江亨祥、村松正道
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K23855
[Presentation] Identification of a novel inhibitor for hepatitis B virus internalization targeting viral receptor oligomerization2020
- Author(s)
  Fukano K, Tsukuda S, Oshima M, Ohki M, Park SY, Wakae K, Aizaki H, Wakita T, Watashi K, Muramatsu M
- Organizer
  Virtual PSWC2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23855
[Presentation] NTCP oligomerization involved in hepatitis B virus internalization2019
- Author(s)
  Fukano K, Tsukuda S, Oshima M, Ohki M, Park SY, Wakae K, Aizaki H, Wakita T, Muramatsu M, Watashi K
- Organizer
  2019 International HBV Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23855
[Presentation] NTCP多量体化によるB型肝炎ウイルス内在化制御機構2019
- Author(s)
  深野顕人、九十田千子、大嶋美月、大木規央、朴三用、若江亨祥、相崎英樹、脇田隆字、村松正道、渡士幸一
- Organizer
  第67回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-19K23855
[Presentation] 酸化コレステロールによるHBV内在化阻害とその機構の解析2019
- Author(s)
  大嶋美月、深野顕人、岩本将士、若江亨祥、相崎英樹、村松正道、脇田隆字、渡士幸一
- Organizer
  第16回ウイルス学キャンプin湯河原
- Data Source
  KAKENHI-PROJECT-19K23855
[Presentation] Interference with NTCP oligomerization impairs the HBV internalization2019
- Author(s)
  Fukano K, Tsukuda S, Oshima M, Suzuki R, Aizaki H, Ohki M, Park SY, Muramatsu M, Wakita T, Sureau C, Ogasawara Y, Watashi K
- Organizer
  7th JAPAN-TAIWAN-KOREA HBV Research Symposium 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23855

1. MAKOTO KURACHI

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. KITAMURA Koichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. HOSOMICHI Kazuyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. SUZUKI Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. KONDO Satoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. ENDO Kazuhira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. アリフセインハッサン

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
8. 脇田隆字

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 相崎英樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 村松正道

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
11. 石川和也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 吉崎智一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 脇坂尚宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 渡士幸一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 柘植雅貴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

(unregistrated) (unregistrated) 深野 顕人

Fukano Kento 深野 顕人

Research Projects

Research Products

Co-Researchers

B型肝炎ウイルスゲノム挿入の新規検出法を利用したメカニズム解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanistic analysis of hepatitis B virus internalization focusing on NTCP oligomerizationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of natural compounds extracted from crude drugs as novel inhibitors of hepatitis C virus.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NTCP oligomerization occurs downstream of the NTCP-EGFR interaction during hepatitis B virus internalization.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MCPIP1 reduces HBV-RNA by targeting its epsilon structure.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] B型肝炎ウイルスの感染機序と創薬2020

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] EBV‐LMP1 induces APOBEC3s and mitochondrial DNA hypermutation in nasopharyngeal cancer2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Non-nucleoside hepatitis B virus polymerase inhibitors identified by an in vitro polymerase elongation assay2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] 感染受容体NTCPの多量体化が導くB型肝炎ウイルス細胞内侵入機構の解明2022

Author(s)

Organizer

Data Source

[Presentation] 新規作用機序によりB型肝炎ウイルス感染を阻害する酸化ステロール合成誘導体の同定2022

Author(s)

Organizer

Data Source

[Presentation] MCPIP1 reduces HBV-RNA by targeting its epsilon structure2021

Author(s)

Organizer

Data Source

[Presentation] B型肝炎ウイルスpreS2領域に対する抗体はウイルス感染を抑制する2021

Author(s)

Organizer

Data Source

[Presentation] NTCP oligomerization is initiated downstream of the NTCP-EGFR interaction during HBV internalization2021

Author(s)

Organizer

Data Source

[Presentation] アメントフラボンのB型肝炎ウイルス感染阻害活性について2021

Author(s)

Organizer

Data Source

[Presentation] The kinesin KIF4 is essential to promote HBV/HDV entry through the regulation of surface localization of NTCP, and is a possible target for anti-HBV/HDV therapy2021

(unregistrated) (unregistrated) 深野顕人

Fukano Kento 深野顕人