Xiang Huihui 項慧慧

… Alternative Names

Huihui Xiang 項慧慧

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Researcher Number	80869793
Other IDs
Affiliation (Current)	2026: 東京科学大学, 総合研究院, 助教
Affiliation (based on the past Project Information) *help	2026: 東京科学大学, 総合研究院, 助教 2024: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所がん分子病態学部, 任期付研究員 2022 – 2023: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所がん分子病態学部, 特任研究員 2020 – 2021: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所, 技師・研究員
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related / Basic Section 55040:Respiratory surgery-related / Basic Section 55020:Digestive surgery-related
Keywords	Principal Investigator 腫瘍微小環境 / キヌレニンナーぜ / 肺がん進行 / キヌレニナーゼ / 肺がん / 消化器外科学関連 / アルギニン / アルギナーゼ1 / キラーT細胞 / 樹状細胞 … More / アルギナーゼ / 肝転移 / 転移性肝がん / 大腸がん Less

関節リウマチにおける代謝変容の意義の解明と新規治療法の開発Principal Investigator
- Principal Investigator
  
  項慧慧
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Institute of Science Tokyo
Elucidation of the mechanism of lung cancer progression through kynureninase and its application in therapyPrincipal Investigator
- Principal Investigator
  
  XIANG HUIHUI
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Kanagawa Cancer Center Research Institute
Activation of arginase-1-mediated arginine metabolism regulates metastatic colonization of colon cancer cellsPrincipal Investigator
- Principal Investigator
  
  Huihui Xiang
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kanagawa Cancer Center Research Institute

All 2025 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] アミノ酸代謝基盤に基づく肺腺がん患者の層別化2025
- Author(s)
  項慧慧, 宮城洋平
- Journal Title
  
  Precision Medicine
  
  Volume: 34（10） Pages: 58-64
- Data Source
  KAKENHI-PROJECT-22K16585
[Journal Article] Prognostic Significance of Plasma Neutrophil Extracellular Trap Levels in Patients with Non-Small Cell Lung Cancer Treated with Immune Checkpoint Inhibitors2024
- Author(s)
  S. Horaguchi, Y. Nakahara, Y. Igarashi, T. Kouro, F. Wei, K. Murotani, S. Udagawa, N. Higashijima, N. Matsuo, S. Murakami, T. Kato, T. Kondo, H. Xiang, R. Kasajima, H. Himuro, K. Tsuji, Y. Mano, M. Komahashi, Y. Miyagi, H. Saito, K. Azuma, S. Uehara, T. Sasada
- Journal Title
  
  Biomedicines
  
  Volume: 12 Issue: 8 Pages: 1831-1831
- DOI
  10.3390/biomedicines12081831
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08724, KAKENHI-PROJECT-22K16585
[Journal Article] Multi-omics analysis-based clinical and functional significance of a novel prognostic and immunotherapeutic gene signature derived from amino acid metabolism pathways in lung adenocarcinoma2024
- Author(s)
  Xiang Huihui、Kasajima Rika、Azuma Koichi、Tagami Tomoyuki、Hagiwara Asami、Nakahara Yoshiro、Saito Haruhiro、Igarashi Yuka、Wei Feifei、Ban Tatsuma、Yoshihara Mitsuyo、Nakamura Yoshiyasu、Sato Shinya、Koizume Shiro、Tamura Tomohiko、Sasada Tetsuro、Miyagi Yohei
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 15 Pages: 1361992-1361992
- DOI
  10.3389/fimmu.2024.1361992
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08724, KAKENHI-PROJECT-22K16585, KAKENHI-PROJECT-24K12523
[Journal Article] IFN-γ-STAT1-mediated NK2R expression is involved in the induction of antitumor effector CD8+ T cells in vivo2023
- Author(s)
  Shen Weidong, Wang Xiangdong, Xiang Huihui, Shichi Shunsuke, Nakamoto Hiroki, Kimura Saori, Sugiyama Ko, Taketomi Akinobu, Kitamura Hidemitsu
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 5 Pages: 1816-1829
- DOI
  10.1111/cas.15738
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07017, KAKENHI-PROJECT-22K16585
[Journal Article] Arginase-1 inhibition reduces migration ability and metastatic colonization of colon cancer cells2023
- Author(s)
  Wang Xiangdong、Xiang Huihui、Toyoshima Yujiro、Shen Weidong、Shichi Shunsuke、Nakamoto Hiroki、Kimura Saori、Sugiyama Ko、Homma Shigenori、Miyagi Yohei、Taketomi Akinobu、Kitamura Hidemitsu
- Journal Title
  
  Cancer&Metabolism
  
  Volume: 11 Issue: 1 Pages: 1-1
- DOI
  10.1186/s40170-022-00301-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16585
[Journal Article] IFN‐α/β‐mediated NK2R expression is related to the malignancy of colon cancer cells2022
- Author(s)
  Xiang Huihui、Toyoshima Yujiro、Shen Weidong、Wang Xiangdong、Okada Naoki、Kii Shuhei、Sugiyama Ko、Nagato Toshihiro、Kobayashi Hiroya、Ikeo Kazuho、Hashimoto Shinichi、Tanino Mishie、Taketomi Akinobu、Kitamura Hidemitsu
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 8 Pages: 2513-2525
- DOI
  10.1111/cas.15397
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16585
[Journal Article] Clinical significance of plasma-free amino acids and tryptophan metabolites in patients with non-small cell lung cancer receiving PD-1 inhibitor: a pilot cohort study for developing a prognostic multivariate model2022
- Author(s)
  Azuma Koichi#、Xiang Huihui#、Tagami Tomoyuki、Kasajima Rika、Kato Yumiko、Karakawa Sachise、Kikuchi Shinya、Imaizumi Akira、Matsuo Norikazu、Ishii Hidenobu、Tokito Takaaki、Kawahara Akihiko、Murotani Kenta、Sasada Tetsuro、Miyagi Yohei、Hoshino Tomoaki (# Contributed equally)
- Journal Title
  
  Journal for ImmunoTherapy of Cancer
  
  Volume: 10 Issue: 5 Pages: e004420-e004420
- DOI
  10.1136/jitc-2021-004420
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16585, KAKENHI-PROJECT-21H02995
[Presentation] 末梢血単核細胞における遺伝子発現ががん免疫チェックポイント阻害剤治療法の予後に与る影響2024
- Author(s)
  項慧慧、東公一、笠島理加、笹田哲朗、宮城洋平
- Organizer
  第28回日本がん免疫学会総会第37回日本バイオセラピィ学会学術集会総会
- Data Source
  KAKENHI-PROJECT-22K16585
[Presentation] Implication of kynureninase expression in lung adenocarcinoma cells for progression of the tumor2024
- Author(s)
  Huihui Xiang, Rika Kasajima, Tetsuro Sasada, Yohei Miyagi
- Organizer
  第83回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K16585
[Presentation] Further study on a novel signature based on tumor-specific amino acid metabolism genes associated with OS prognosis2023
- Author(s)
  Huihui Xiang, Rika Kasajima, Tetsuro Sasada, Yohei Miyagi
- Organizer
  The 82th Annual meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-22K16585
[Presentation] Transcriptomic profiling identifies an amino acid metabolism-related prognostic gene signature in lung adenocarcinoma patients2023
- Author(s)
  Huihui Xiang, Rika Kasajima, Hiroyuki Ito, Tomoyuki Yokose, Takashi Oshima, Tetsuro Sasada, Yohei Miyagi.
- Organizer
  American Association for Cancer Research Annual Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16585
[Presentation] キヌレニナーゼの肺がん組織における発現動態の解析2023
- Author(s)
  項慧慧, 笠島理加, 笹田哲朗, 宮城洋平.
- Organizer
  第40 回分子病理学研究会クラークシンポジウム
- Data Source
  KAKENHI-PROJECT-22K16585
[Presentation] アルギナーゼ1を介したアルギニン代謝の活性化は大腸がんの肝転移巣形成と抗腫瘍免疫を制御する2022
- Author(s)
  北村秀光, 王向東, 項慧慧, 豊島雄二郎, 沈輝棟, 志智俊介, 中本裕紀, 木村沙織, 杉山昂, 本間重紀, 宮城洋平, 武冨紹信
- Organizer
  第26回日本がん免疫学会
- Data Source
  KAKENHI-PROJECT-22K16585
[Presentation] A novel prognostic gene signature of amino acid metabolism pathways under lung adenocarcinoma tumor immune microenvironment2022
- Author(s)
  Huihui Xiang, Rika Kasajima, Tetsuro Sasada, Yohei Miyagi
- Organizer
  第51回日本免疫学会学術総会
- Data Source
  KAKENHI-PROJECT-22K16585
[Presentation] Multi-omics analysis of a novel prognostic gene signature linked to amino acid metabolism pathway in lung adenocarcinoma2022
- Author(s)
  Huihui Xiang, Rika Kasajima, Tetsuro Sasada, Yohei Miyagi
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K16585
[Presentation] アルギナーゼ1を介したアルギニン代謝の活性化は大腸がんの肝転移巣形成と抗腫瘍免疫を制御する2022
- Author(s)
  北村秀光、王向東、項慧慧、豊島雄二郎、沈輝棟、志智俊介、中本裕紀、木村沙織、杉山昂、本間重紀、宮城洋平、武冨紹信
- Organizer
  第25回日本がん免疫学会
- Data Source
  KAKENHI-PROJECT-20K17635
[Presentation] アルギナーゼ1の発現とアルギニン代謝の活性化は、がんの悪性化と抗腫瘍免疫の抑制に関連する2021
- Author(s)
  北村秀光、王向東、項慧慧、豊島雄二郎、沈輝棟、杉山昂、志智俊介、木村沙織、本間重紀、武冨紹信.
- Organizer
  第25回日本がん免疫学会
- Data Source
  KAKENHI-PROJECT-20K17635
[Presentation] A novel prognostic gene signature of amino acid metabolism in lung adenocarcinoma2021
- Author(s)
  Huihui Xiang, Rika Kasajima, Tetsuro Sasada, Yohei Miyagi.
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K17635
[Presentation] Arginine metabolism in the tumor-bearing state is related to the metastatic colonization of cancer cells2021
- Author(s)
  Xiangdong Wang, Huihui Xiang, Yujiro Toyoshima, Shunsuke Shichi, Ko Sugiyama, Shen Weidong, Saori Kimura, Shigenori Homma, Akinobu Taketomi, Hidemitsu Kitamura.
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K17635
[Presentation] Blockade of arginase-1 reduces metastatic colonization of colon cancer cells in tumor-bearing host2020
- Author(s)
  Xiangdong Wang, Huihui Xiang, Yujiro Toyoshima, Ko Sugiyama, Shunsuke Shichi, Shen Weidong, Shigenori Homma, Akinobu Taketomi, Hidemitsu Kitamura
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K17635
[Presentation] 尿素回路・オルニチン代謝関連酵素であるアルギナーゼ1遺伝子の発現は大腸がんの転移巣形成と関連する2020
- Author(s)
  王向東, 項慧慧, 豊島雄二郎, 杉山昂, 志智俊介, 沈輝棟, 本間重紀, 武冨紹信, 北村秀光
- Organizer
  第24回日本がん免疫学会
- Data Source
  KAKENHI-PROJECT-20K17635

1. 北村秀光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 武冨紹信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 魏菲菲

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 笹田哲朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Xiang Huihui 項 慧慧

Huihui Xiang 項 慧慧

Research Projects

Research Products

Co-Researchers

関節リウマチにおける代謝変容の意義の解明と新規治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of lung cancer progression through kynureninase and its application in therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Activation of arginase-1-mediated arginine metabolism regulates metastatic colonization of colon cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] アミノ酸代謝基盤に基づく肺腺がん患者の層別化2025

Author(s)

Journal Title

Data Source

[Journal Article] Prognostic Significance of Plasma Neutrophil Extracellular Trap Levels in Patients with Non-Small Cell Lung Cancer Treated with Immune Checkpoint Inhibitors2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multi-omics analysis-based clinical and functional significance of a novel prognostic and immunotherapeutic gene signature derived from amino acid metabolism pathways in lung adenocarcinoma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IFN-γ-STAT1-mediated NK2R expression is involved in the induction of antitumor effector CD8+ T cells in vivo2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Arginase-1 inhibition reduces migration ability and metastatic colonization of colon cancer cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IFN‐α/β‐mediated NK2R expression is related to the malignancy of colon cancer cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical significance of plasma-free amino acids and tryptophan metabolites in patients with non-small cell lung cancer receiving PD-1 inhibitor: a pilot cohort study for developing a prognostic multivariate model2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] 末梢血単核細胞における遺伝子発現ががん免疫チェックポイント阻害剤治療法の予後 に与る影響2024

Author(s)

Organizer

Data Source

[Presentation] Implication of kynureninase expression in lung adenocarcinoma cells for progression of the tumor2024

Author(s)

Organizer

Data Source

[Presentation] Further study on a novel signature based on tumor-specific amino acid metabolism genes associated with OS prognosis2023

Author(s)

Organizer

Data Source

[Presentation] Transcriptomic profiling identifies an amino acid metabolism-related prognostic gene signature in lung adenocarcinoma patients2023

Author(s)

Organizer

Data Source

[Presentation] キヌレニナーゼの肺がん組織における発現動態の解析2023

Author(s)

Organizer

Data Source

[Presentation] アルギナーゼ1を介したアルギニン代謝の活性化は大腸がんの肝転移巣形成と抗腫瘍免疫を制御する2022

Author(s)

Organizer

Xiang Huihui 項慧慧

Huihui Xiang 項慧慧

[Presentation] 末梢血単核細胞における遺伝子発現ががん免疫チェックポイント阻害剤治療法の予後に与る影響2024