Fukasawa Takemichi 深澤毅倫

Researcher Number	80884056
Affiliation (Current)	2023: 東京大学, 医学部附属病院, 特任講師
Affiliation (based on the past Project Information) *help	2020 – 2022: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator 0903:Organ-based internal medicine and related fields / Basic Section 53050:Dermatology-related
Keywords	Principal Investigator 自己反応性B細胞 / 全身性強皮症 / 医工連携 / サイトカイン / T細胞 / microfluidics / 単一細胞解析 / B細胞 / affinity / 新規治療

Single-cell analysis of autoantigen-reactive B cells in systemic sclerosis and development of novel therapeutic targetsPrincipal Investigator
- Principal Investigator
  
  深澤毅倫
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  The University of Tokyo
Analysis of the effect of cytokine production by autoantigen-reactive B cells in systemic sclerosis on other immune systems.Principal Investigator
- Principal Investigator
  
  Fukasawa Takemichi
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0903:Organ-based internal medicine and related fields
- Research Institution
  The University of Tokyo

All 2022 2021

All Journal Article Presentation Book

[Book] 「臨床と研究」2022
- Author(s)
  深澤毅倫、吉崎歩、佐藤伸一
- Total Pages
  5
- Publisher
  大道学館出版部
- Data Source
  KAKENHI-PROJECT-20K22925
[Book] 皮膚科　膠原病　皮疹から全身を診る2021
- Author(s)
  深澤毅倫
- Total Pages
  5
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-20K22925
[Journal Article] Predictors of rituximab effect on modified Rodnan skin score in systemic sclerosis: a machine-learning analysis of the DesiReS trial2022
- Author(s)
  Ebata Satoshi、Oba Koji、Kashiwabara Kosuke、Ueda Keiko、Uemura Yukari、Watadani Takeyuki、Fukasawa Takemichi、Miura Shunsuke、Yoshizaki-Ogawa Asako、Yoshihide Asano、Yoshizaki Ayumi、Sato Shinichi
- Journal Title
  
  Rheumatology
  
  Volume: 5 Pages: 5-5
- DOI
  10.1093/rheumatology/keac023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22925
[Journal Article] Decrease in MAP3Ks expression enhances the cell death caused by hyperthermia.2022
- Author(s)
  Enomoto Atsushi、Fukasawa Takemichi、Terunuma Hiroshi、Nakagawa Keiichi、Yoshizaki Ayumi、Sato Shinichi、Miyagawa Kiyoshi
- Journal Title
  
  International Journal of Hyperthermia
  
  Volume: 39 Pages: 200-208
- DOI
  10.1080/02656736.2021.2024281
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22925, KAKENHI-PROJECT-20K08100
[Journal Article] Clinical Significance of Anti-U1 Ribonucleoprotein Antibody in Anti-Topoisomerase I Antibody-Positive Systemic Sclerosis Patients: A Retrospective Observational Study2021
- Author(s)
  Kazuki M Matsuda, Ayumi Yoshizaki, Hirohito Kotani, Ai Kuzumi, Maiko Fukayama, Takemichi Fukasawa, Satoshi Ebata, Asako Yoshizaki-Ogawa, Yoshihide Asano, Koji Oba, Shinichi Sato
- Journal Title
  
  Archives of Clinical and Biomedical Research
  
  Volume: 5 Pages: 76-84
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22925
[Journal Article] Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model2021
- Author(s)
  Fukasawa T, Yoshizaki A, Ebata S, Yoshizaki-Ogawa A, Asano Y, Enomoto A, Miyagawa K, Kazoe Y, Mawatari K, Kitamori T, Sato S.
- Journal Title
  
  eLife
  
  Volume: 10 Pages: 5-5
- DOI
  10.7554/elife.67209
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08787, KAKENHI-PROJECT-20K22925, KAKENHI-PROJECT-20K08100
[Journal Article] Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis.2021
- Author(s)
  Kuzumi Ai、Yoshizaki Ayumi、Matsuda Kazuki M.、Kotani Hirohito、Norimatsu Yuta、Fukayama Maiko、Ebata Satoshi、Fukasawa Takemichi、Yoshizaki-Ogawa Asako、Asano Yoshihide、Morikawa Kyojiro、Kazoe Yutaka、Mawatari Kazuma、Kitamori Takehiko、Sato Shinichi
- Journal Title
  
  Nat Commun.
  
  Volume: 12 Pages: 5-5
- DOI
  10.1038/s41467-021-26099-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22925, KAKENHI-PROJECT-21H02939
[Journal Article] Cutaneous Sarcoidosis as a Predictor of Cardiac Sarcoidosis2021
- Author(s)
  Yuta Norimatsu, Ayumi Yoshizaki, Yuki Ohno, Yuka Mizuno, Haruka Watanabe, Hirohito Kotani, Kazuki M Matsuda, Maiko Fukayama, Ai Kuzumi, Satoshi Ebata, Takemichi Fukasawa, Asako Yoshizaki-Ogawa, Shinichi Sato
- Journal Title
  
  Archives of Clinical and Biomedical Research
  
  Volume: 5 Pages: 368-375
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22925
[Journal Article] Development of a prediction model of treatment response in patients with cutaneous arteritis: Insights from a cohort of 33 patients2021
- Author(s)
  Matsuda Kazuki Mitsuru、Yoshizaki Ayumi、Kotani Hirohito、Kuzumi Ai、Fukayama Maiko、Ebata Satoshi、Fukasawa Takemichi、Yoshizaki‐Ogawa Asako、Sato Shinichi
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 5 Pages: 5-5
- DOI
  10.1111/1346-8138.15868
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22925
[Journal Article] Expert-Level Distinction of Systemic Sclerosis from Hand Photographs Using Deep Convolutional Neural Networks2021
- Author(s)
  Norimatsu Yuta、Yoshizaki Ayumi、Kabeya Yoshinori、Fukasawa Takemichi、Omatsu Jun、Fukayama Maiko、Kuzumi Ai、Ebata Satoshi、Yoshizaki-Ogawa Asako、Asano Yoshihide、Ichimura Haruka、Yonezawa Sho、Nakano Hiroki、Sato Shinichi
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 141 Pages: 2536-2539
- DOI
  10.1016/j.jid.2021.03.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22925
[Journal Article] Increased Red Blood Cell Distribution Width in the First Year after Diagnosis Predicts Worsening of Systemic Sclerosis-Associated Interstitial Lung Disease at 5 Years: A Pilot Study2021
- Author(s)
  Ebata Satoshi、Yoshizaki Ayumi、Fukasawa Takemichi、Yoshizaki-Ogawa Asako、Asano Yoshihide、Kashiwabara Kosuke、Oba Koji、Sato Shinichi
- Journal Title
  
  Diagnostics
  
  Volume: 11 Pages: 2274-2274
- DOI
  10.3390/diagnostics11122274
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22925
[Journal Article] Serum heat shock protein 27 levels in patients with systemic sclerosis: a possible biomarker of skin sclerosis2021
- Author(s)
  Matsuda K.M.、Yoshizaki A.、Kotani H.、Norimatsu Y.、Kuzumi A.、Fukayama M.、Fukasawa T.、Ebata S.、Yoshizaki‐Ogawa A.、Asano Y.、Oba K.、Sato S.
- Journal Title
  
  Journal of the European Academy of Dermatology and Venereology
  
  Volume: 35 Pages: 250-250
- DOI
  10.1111/jdv.16885
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22925
[Journal Article] Safety and efficacy of rituximab in systemic sclerosis (DESIRES): a double-blind, investigator-initiated, randomised, placebo-controlled trial.2021
- Author(s)
  Ebata, S., Yoshizaki, A., Oba, K., Kashiwabara, K., Ueda, K., Uemura, Y., Watadani, T., Fukasawa, T., Miura, S., Yoshizaki-Ogawa, A., Asano, Y., Okiyama, N., Kodera, M., Hasegawa, M., & Sato, S.
- Journal Title
  
  Lancet Rheumatology
  
  Volume: 3 Pages: 489-497
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22925
[Journal Article] COVID-19 pandemic highlighted the importance of telemedicine in the collagen disease of systemic sclerosis2021
- Author(s)
  Y. Norimatsu, A. Yoshizaki, T. Fukasawa, S. Ebata, K. Oba, S. Sato
- Journal Title
  
  Clinical and Experimental Rheumatology
  
  Volume: 39 Pages: 160-160
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22925
[Journal Article] Serum Calponin 3 Levels in Patients with Systemic Sclerosis: Possible Association with Skin Sclerosis and Arthralgia2021
- Author(s)
  Kotani Hirohito、Yoshizaki Ayumi、Matsuda Kazuki M.、Norimatsu Yuta、Kuzumi Ai、Fukayama Maiko、Fukasawa Takemichi、Ebata Satoshi、Yoshizaki-Ogawa Asako、Asano Yoshihide、Oba Koji、Sato Shinichi
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 10 Pages: 280-280
- DOI
  10.3390/jcm10020280
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22925
[Journal Article] Serum TARC Levels in Patients with Systemic Sclerosis: Clinical Association with Interstitial Lung Disease2021
- Author(s)
  Kuzumi Ai、Yoshizaki Ayumi、Ebata Satoshi、Fukasawa Takemichi、Yoshizaki-Ogawa Asako、Asano Yoshihide、Oba Koji、Sato Shinichi
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 10 Pages: 660-660
- DOI
  10.3390/jcm10040660
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22925
[Journal Article] Rapid decrease of serum surfactant protein‐D levels predicts the reactivity of rituximab therapy in systemic sclerosis‐associated interstitial lung disease2021
- Author(s)
  Ebata Satoshi、Yoshizaki Ayumi、Fukasawa Takemichi、Asano Yoshihide、Oba Koji、Sato Shinichi
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 47 Pages: 796-800
- DOI
  10.1111/1346-8138.15379
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22925
[Journal Article] Percentage of residual B cells after 2 weeks of rituximab treatment predicts the improvement of systemic sclerosis‐associated interstitial lung disease2021
- Author(s)
  Ebata Satoshi、Yoshizaki Ayumi、Fukasawa Takemichi、Yoshizaki‐Ogawa Asako、Asano Yoshihide、Kashiwabara Kosuke、Oba Koji、Sato Shinichi
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 49 Pages: 179-183
- DOI
  10.1111/1346-8138.16206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22925
[Journal Article] Interleukin (IL)‐17F and IL‐17E are related to fibrosis and vasculopathy in systemic sclerosis2021
- Author(s)
  Fukayama Maiko、Yoshizaki Ayumi、Fukasawa Takemichi、Ebata Satoshi、Kuzumi Ai、Yoshizaki‐Ogawa Asako、Asano Yoshihide、Oba Koji、Sato Shinichi
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 47 Pages: 1287-1292
- DOI
  10.1111/1346-8138.15508
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22925
[Journal Article] B Cell Depletion Inhibits Fibrosis via Suppression of Profibrotic Macrophage Differentiation in a Mouse Model of Systemic Sclerosis2021
- Author(s)
  Numajiri Hiroko、Kuzumi Ai、Fukasawa Takemichi、Ebata Satoshi、Yoshizaki‐Ogawa Asako、Asano Yoshihide、Kazoe Yutaka、Mawatari Kazuma、Kitamori Takehiko、Yoshizaki Ayumi、Sato Shinichi
- Journal Title
  
  Arthritis & Rheumatology
  
  Volume: 73 Pages: 2086-2095
- DOI
  10.1002/art.41798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22925
[Presentation] Safety and Efficacy of Rituximab for Systemic Sclerosis: A Double-Blind, Parallel-Group Comparison, Investigators Initiated Confirmatory Randomized Clinical Trial (DESIRES Study)2021
- Author(s)
  Satoshi Ebata, Ayumi Yoshizaki, Koji Oba, Kosuke Kashiwabara, Keiko Ueda, Yukari Umemura, Takeyuki Watadani, Takemichi Fukasawa, Shunsuke Miura, Asako Yoshizaki-Ogawa, Yoshihide Asano, Naoko Okiyama, Masanari Kodera, Minoru Hasegawa and Shinichi Sato
- Organizer
  American college of rheumatology 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22925

1. YOSHIZAKI Ayumu

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 榎本敦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 佐藤伸一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fukasawa Takemichi 深澤 毅倫

Research Projects

Research Products

Co-Researchers

Single-cell analysis of autoantigen-reactive B cells in systemic sclerosis and development of novel therapeutic targetsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the effect of cytokine production by autoantigen-reactive B cells in systemic sclerosis on other immune systems.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 「臨床と研究」2022

Author(s)

Total Pages

Publisher

Data Source

[Book] 皮膚科 膠原病 皮疹から全身を診る2021

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Predictors of rituximab effect on modified Rodnan skin score in systemic sclerosis: a machine-learning analysis of the DesiReS trial2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Decrease in MAP3Ks expression enhances the cell death caused by hyperthermia.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical Significance of Anti-U1 Ribonucleoprotein Antibody in Anti-Topoisomerase I Antibody-Positive Systemic Sclerosis Patients: A Retrospective Observational Study2021

Author(s)

Journal Title

Data Source

[Journal Article] Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cutaneous Sarcoidosis as a Predictor of Cardiac Sarcoidosis2021

Author(s)

Journal Title

Data Source

[Journal Article] Development of a prediction model of treatment response in patients with cutaneous arteritis: Insights from a cohort of 33 patients2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expert-Level Distinction of Systemic Sclerosis from Hand Photographs Using Deep Convolutional Neural Networks2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increased Red Blood Cell Distribution Width in the First Year after Diagnosis Predicts Worsening of Systemic Sclerosis-Associated Interstitial Lung Disease at 5 Years: A Pilot Study2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Serum heat shock protein 27 levels in patients with systemic sclerosis: a possible biomarker of skin sclerosis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Safety and efficacy of rituximab in systemic sclerosis (DESIRES): a double-blind, investigator-initiated, randomised, placebo-controlled trial.2021

Author(s)

Journal Title

Data Source

[Journal Article] COVID-19 pandemic highlighted the importance of telemedicine in the collagen disease of systemic sclerosis2021

Author(s)

Fukasawa Takemichi 深澤毅倫

[Book] 皮膚科　膠原病　皮疹から全身を診る2021