Murata Kozue 村田梢

Researcher Number	80884329
Other IDs	https://orcid.org/0000-0002-6841-1493
Affiliation (Current)	2026: 京都大学, 医学研究科, 特定講師
Affiliation (based on the past Project Information) *help	2022 – 2025: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 研究員 2020 – 2024: 京都大学, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 55030:Cardiovascular surgery-related / 0905:Surgery of the organs maintaining homeostasis and related fields Except Principal Investigator Basic Section 55030:Cardiovascular surgery-related
Keywords	Principal Investigator オルガノイド / iPS細胞 / 心臓 / 成熟化 / 微小重力 / 創薬研究 / Organ-on-a-chip / HMD / 心毒性 / 組織 … More / 心筋細胞 / 脂質代謝 / 脂肪酸 / マイクロ心臓組織 … More Except Principal Investigator iPS細胞 / 心臓再生医療 / 創薬研究 / 拡張型心筋症 / 疾患再現 / ドラッグデリバリーシステム / マイクロRNA / 心臓オルガノイド Less

拡張型心筋症患者由来iPS細胞を用いた三次元マイクロ心臓組織の開発と応用
- Principal Investigator
  
  松尾武彦
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Kyoto University
Development of a Novel Cardiac Regenerative Therapy Using Human iPS Cell-Derived Cardiac Microtissues
- Principal Investigator
  
  Masumoto Hidetoshi
- Project Period (FY)
  2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Institute of Physical and Chemical Research
Establishment of a protocol for maturation of human iPS cell-derived 3D cardiac microtissue using a microgravityPrincipal Investigator
- Principal Investigator
  
  村田梢
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Institute of Physical and Chemical Research
心臓血管外科領域におけるiPS細胞技術を用いた新規遺伝子治療ベクターの開発
- Principal Investigator
  
  池田義
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Kyoto University
ヒトiPS細胞由来人工心臓組織における成熟化プロセスの理解と制御法の確立
- Principal Investigator
  
  長田裕明
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Kyoto University
Development of a cardiotoxicity evaluation system using a Heart-on-a-Chip Microdevice with aligned fiber device.Principal Investigator
- Principal Investigator
  
  Murata Kozue
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Institute of Physical and Chemical Research
  Kyoto University
Investigation of maturation mechanism of iPS cell-derived cardiac micro tissue by metabolic switch.Principal Investigator
- Principal Investigator
  
  Murata Kozue
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0905:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Kyoto University

All 2025 2024 2023 2022 2021 2020

All Journal Article Presentation Book

[Book] Animal Models and Experimental Research in Medicine2022
- Author(s)
  Osada H, Murata K, Masumoto H
- Total Pages
  206
- Publisher
  IntechOpen
- ISBN
  9781803566542
- Data Source
  KAKENHI-PROJECT-23K24420
[Book] Animal Models and Experimental Research in Medicine2022
- Author(s)
  Osada H, Murata K, Masumoto H
- Total Pages
  206
- Publisher
  IntechOpen
- ISBN
  9781071614846
- Data Source
  KAKENHI-PROJECT-22K08934
[Journal Article] Retention of locally injected human iPS cell-derived cardiomyocytes into the myocardium using hydrolyzed gelatin2025
- Author(s)
  Iida Jun、Kotani Kazuki、Murata Kozue、Hakamada Keisuke、Maihemuti Wusiman、Mandai Yoshinobu、Hiraoka Yosuke、Minatoya Kenji、Masumoto Hidetoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 15 Issue: 1 Pages: 4635-4635
- DOI
  10.1038/s41598-025-87885-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24420, KAKENHI-PROJECT-22K08956, KAKENHI-PROJECT-23K08232, KAKENHI-PROJECT-24K11991
[Journal Article] Simultaneous electro-dynamic stimulation accelerates maturation of engineered cardiac tissues generated by human iPS cells2024
- Author(s)
  Maihemuti Wusiman、Murata Kozue、Abulaiti Mosha、Minatoya Kenji、Masumoto Hidetoshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 733 Pages: 150605-150605
- DOI
  10.1016/j.bbrc.2024.150605
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24420, KAKENHI-PROJECT-22K08956, KAKENHI-PROJECT-23K08232, KAKENHI-PROJECT-24K11991
[Journal Article] miR-124-3p downregulates EGR1 to suppress ischemia-hypoxia reperfusion injury in human iPS cell-derived cardiomyocytes2024
- Author(s)
  Yang Qiaoke、Murata Kozue、Ikeda Tadashi、Minatoya Kenji、Masumoto Hidetoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 14811-14811
- DOI
  10.1038/s41598-024-65373-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24420, KAKENHI-PROJECT-22K08934, KAKENHI-PROJECT-22K08956, KAKENHI-PROJECT-23K08232, KAKENHI-PROJECT-24K11991
[Journal Article] Predicted risk of heart failure pandemic due to persistent SARS-CoV-2 infection using a three-dimensional cardiac model2024
- Author(s)
  Murata Kozue、Makino Akiko、Tomonaga Keizo、Masumoto Hidetoshi
- Journal Title
  
  iScience
  
  Volume: 27 Issue: 1 Pages: 108641-108641
- DOI
  10.1016/j.isci.2023.108641
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08934, KAKENHI-PROJECT-22K08956, KAKENHI-PROJECT-23K08232, KAKENHI-PROJECT-21K07053, KAKENHI-PROJECT-23K24420
[Journal Article] A novel approach for the endothelialization of xenogeneic decellularized vascular tissues by human cells utilizing surface modification and dynamic culture2022
- Author(s)
  Ho Wen-Jin、Kobayashi Mako、Murata Kozue、Hashimoto Yoshihide、Izumi Kenji、Kimura Tsuyoshi、Kanemitsu Hideo、Yamazaki Kazuhiro、Ikeda Tadashi、Minatoya Kenji、Kishida Akio、Masumoto Hidetoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 22294-22294
- DOI
  10.1038/s41598-022-26792-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08918, KAKENHI-PROJECT-22K08934, KAKENHI-PROJECT-22K08956, KAKENHI-PROJECT-21H04954, KAKENHI-PROJECT-20H03764, KAKENHI-PROJECT-20K09125, KAKENHI-PROJECT-23K24420
[Journal Article] Systems for the Functional Evaluation of Human Heart Tissues Derived from Pluripotent Stem Cells2022
- Author(s)
  Murata Kozue、Masumoto Hidetoshi
- Journal Title
  
  Stem Cells
  
  Volume: In press Issue: 6 Pages: 537-545
- DOI
  10.1093/stmcls/sxac022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09241, KAKENHI-PROJECT-19K09242, KAKENHI-PROJECT-19K09281, KAKENHI-PROJECT-20K22949, KAKENHI-PROJECT-20K09125, KAKENHI-PROJECT-20K09147, KAKENHI-PROJECT-21K08861, KAKENHI-PROJECT-19KK0219, KAKENHI-PROJECT-22K08918, KAKENHI-PROJECT-22K08934, KAKENHI-PROJECT-22K08956, KAKENHI-PROJECT-20H03764, KAKENHI-PROJECT-23K24420
[Journal Article] Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function2020
- Author(s)
  Abulaiti Mosha、Yalikun Yaxiaer、Murata Kozue、Sato Asako、Sami Mustafa M.、Sasaki Yuko、Fujiwara Yasue、Minatoya Kenji、Shiba Yuji、Tanaka Yo、Masumoto Hidetoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 19201-19201
- DOI
  10.1038/s41598-020-76062-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09241, KAKENHI-PROJECT-19K09242, KAKENHI-PROJECT-19K09281, KAKENHI-PROJECT-20K09125, KAKENHI-PROJECT-20K09147, KAKENHI-PROJECT-20K22949, KAKENHI-PROJECT-19KK0219, KAKENHI-PROJECT-18H02887, KAKENHI-PROJECT-20H02596, KAKENHI-PROJECT-20H03764
[Journal Article] Strategies for immune regulation in iPS cell-based cardiac regenerative medicine2020
- Author(s)
  Murata Kozue、Ikegawa Masaya、Minatoya Kenji、Masumoto Hidetoshi
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 40 Issue: 1 Pages: 36-36
- DOI
  10.1186/s41232-020-00145-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09241, KAKENHI-PROJECT-19K09242, KAKENHI-PROJECT-19K09281, KAKENHI-PROJECT-20K09125, KAKENHI-PROJECT-20K09147, KAKENHI-PROJECT-20K22949, KAKENHI-PROJECT-19KK0219, KAKENHI-PROJECT-18H02887, KAKENHI-PROJECT-20H03764, KAKENHI-PROJECT-20H02932
[Presentation] Simultaneous Electro-Dynamic Stimulation Accelerates Maturation of Engineered Cardiac Tissue from Human Induced Pluripotent Stem Cells2024
- Author(s)
  Maihemuti W, Murata K, Abulaiti M, Masumoto H
- Organizer
  AHA Scientific Sessions 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24420
[Presentation] 配向性ファイバーデバイスを用いた改良型ハートオンチップ型マイクロデバイスによる心毒性評価系の開発2024
- Author(s)
  村田梢、アブラティモシャ、長垣良和、加藤謙介、升本英利
- Organizer
  第23回日本再生医療学会
- Data Source
  KAKENHI-PROJECT-21K08861
[Presentation] Transplantation of vascularized cardiac microtissue derived from human iPS cells improves impaired electrical conduction capacity in a porcine myocardial injury model2024
- Author(s)
  Kuroda Y, Iida J, Murata K, Kobiki J, Minatoya K, Masumoto H
- Organizer
  AHA Scientific Sessions 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24420
[Presentation] Transplantation of vascularized cardiac microtissue derived from human iPS cells improves impaired electrical conduction capacity in a porcine myocardial injury model2024
- Author(s)
  Kuroda Y, Iida J, Murata K, Kobiki J, Minatoya K, Masumoto H
- Organizer
  AHA Scientific Sessions 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K08232
[Presentation] Simultaneous Electro-Dynamic Stimulation Accelerates Maturation of Engineered Cardiac Tissue from Human Induced Pluripotent Stem Cells2024
- Author(s)
  Maihemuti W, Murata K, Abulaiti M, Masumoto H
- Organizer
  AHA Scientific Sessions 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K08232
[Presentation] Development of a cardiotoxicity evaluation system using a Heart-on-a-Chip Microdevice with aligned fiber device2024
- Author(s)
  Kozue Murata, Mosha Abulaiti, Yoshikazu Nagakaki, Kensuke Kato, Hidetoshi Masumoto
- Organizer
  ESC Congress 2024 London
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08861
[Presentation] Suppression Of Ischemia-hypoxia Reperfusion Injury In Human Ips Cell-derived Cardiomyocytes Through Downregulation Of Egr1 Mediated By Mir-124-3p2023
- Author(s)
  Yang Q, Murata K, Ikeda T, Minatoya K, Masumoto H
- Organizer
  American Heart Association Scientific Sessions 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08934
[Presentation] ハートオンチップ型マイクロデバイスを用いた抗悪性腫瘍剤における高感度心毒性評価系の開発2023
- Author(s)
  升本英利, 村田梢, アブラティ・モシャ
- Organizer
  第6回日本腫瘍循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24420
[Presentation] Myocardial Restoration and Functional Recovery Through Transplantation of Vascularized Cardiac Microtissues Derived from Human Induced Pluripotent Stem Cells in a Rat Model of Myocardial Infarction2023
- Author(s)
  Hakamada K, Murata K, Minatoya K, Masumoto H
- Organizer
  American Heart Association Scientific Sessions 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24420
[Presentation] Suppression Of Ischemia-hypoxia Reperfusion Injury In Human Ips Cell-derived Cardiomyocytes Through Downregulation Of Egr1 Mediated By Mir-124-3p2023
- Author(s)
  Yang Q, Murata K, Ikeda T, Minatoya K, Masumoto H
- Organizer
  American Heart Association Scientific Sessions 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24420
[Presentation] Suppression Of Ischemia-hypoxia Reperfusion Injury In Human Ips Cell-derived Cardiomyocytes Through Downregulation Of Egr1 Mediated By Mir-124-3p2023
- Author(s)
  Yang Q, Murata K, Ikeda T, Minatoya K, Masumoto H
- Organizer
  American Heart Association Scientific Sessions 2023
- Data Source
  KAKENHI-PROJECT-23K08232
[Presentation] ハートオンチップ型マイクロデバイスを用いた抗悪性腫瘍剤における高感度心毒性評価系の開発2023
- Author(s)
  升本英利, 村田梢, アブラティ・モシャ
- Organizer
  第6回日本腫瘍循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08934
[Presentation] ハートオンチップ型マイクロデバイスを用いた抗悪性腫瘍剤における高感度心毒性評価系の開発2023
- Author(s)
  升本英利, 村田梢, アブラティ・モシャ
- Organizer
  第6回日本腫瘍循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-23K08232
[Presentation] ヒト心臓組織機能評価のためのヒトiPS細胞を用いたハートオンチップ型マイクロデバイスの開発2021
- Author(s)
  村田梢, Mosha Abulaiti , 佐藤麻子, 佐々木裕子, 柴祐司, 田中陽 , 升本英利
- Organizer
  第20回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-20K22949

1. Masumoto Hidetoshi (70645754)

# of Collaborated Projects: 6 results

# of Collaborated Products: 23 results
2. 田中陽 (40532271)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 長田裕明 (10915432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 川東正英 (00837700)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 湊谷謙司 (20393241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. 池田義 (40281092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 朝長啓造 (10301920)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 松尾武彦 (10991200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 本田知之 (80402676)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Murata Kozue 村田 梢

Research Projects

Research Products

Co-Researchers

拡張型心筋症患者由来iPS細胞を用いた三次元マイクロ心臓組織の開発と応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a Novel Cardiac Regenerative Therapy Using Human iPS Cell-Derived Cardiac Microtissues

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of a protocol for maturation of human iPS cell-derived 3D cardiac microtissue using a microgravityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

心臓血管外科領域におけるiPS細胞技術を用いた新規遺伝子治療ベクターの開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒトiPS細胞由来人工心臓組織における成熟化プロセスの理解と制御法の確立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a cardiotoxicity evaluation system using a Heart-on-a-Chip Microdevice with aligned fiber device.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of maturation mechanism of iPS cell-derived cardiac micro tissue by metabolic switch.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] Animal Models and Experimental Research in Medicine2022

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] Animal Models and Experimental Research in Medicine2022

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Retention of locally injected human iPS cell-derived cardiomyocytes into the myocardium using hydrolyzed gelatin2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Simultaneous electro-dynamic stimulation accelerates maturation of engineered cardiac tissues generated by human iPS cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] miR-124-3p downregulates EGR1 to suppress ischemia-hypoxia reperfusion injury in human iPS cell-derived cardiomyocytes2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Predicted risk of heart failure pandemic due to persistent SARS-CoV-2 infection using a three-dimensional cardiac model2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel approach for the endothelialization of xenogeneic decellularized vascular tissues by human cells utilizing surface modification and dynamic culture2022

Author(s)

Murata Kozue 村田梢