Onodera Kazunari 小野寺一成

Researcher Number	80895772
Affiliation (Current)	2025: 愛知医科大学, 加齢医科学研究所, 助教
Affiliation (based on the past Project Information) *help	2022 – 2025: 愛知医科大学, 加齢医科学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related Except Principal Investigator Basic Section 52020:Neurology-related
Keywords	Principal Investigator 運動ニューロン / iPS細胞 / 球脊髄性筋萎縮症 / 変異アンドロゲン受容体凝集体 / 転写制御 / 早期病態 / 骨格筋 Except Principal Investigator 疾患iPS細胞 / 神経筋接合部 / 運動ニューロン疾患 … More / 疾患特異的iPS細胞 / 骨格筋 / 球脊髄性筋萎縮症 / 運動ニューロン / iPS細胞 / 筋萎縮性側索硬化症 Less

Elucidation of the molecular pathology underlying the neurodegeneration caused by factors derived from the muscle
- Principal Investigator
  
  岡田洋平
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Aichi Medical University
転写制御異常から迫る球脊髄性筋萎縮症の病態解明Principal Investigator
- Principal Investigator
  
  小野寺一成
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Aichi Medical University
Establishment of efficient pathological analysis and drug discovery platform for amyotrophic lateral sclerosis using disease specific iPSCs
- Principal Investigator
  
  道勇学
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Aichi Medical University
患者神経細胞で高発現する早期病態因子に着目した球脊髄性筋萎縮症の病態解析Principal Investigator
- Principal Investigator
  
  小野寺一成
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Aichi Medical University
Pathophysiological analysis of motor neuron diseases targeting neuromuscular junction using disease specific iPSCs
- Principal Investigator
  
  岡田洋平
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Aichi Medical University

All 2023 2022

All Journal Article Presentation

[Journal Article] Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis2023
- Author(s)
  Oiwa Kotaro、Watanabe Seiji、Onodera Kazunari、Iguchi Yohei、Kinoshita Yukako、Komine Okiru、Sobue Akira、Okada Yohei、Katsuno Masahisa、Yamanaka Koji
- Journal Title
  
  Science Advances
  
  Volume: 9 Issue: 31
- DOI
  10.1126/sciadv.adf6895
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15739, KAKENHI-PROJECT-23K14687, KAKENHI-PROJECT-19KK0214, KAKENHI-PROJECT-21K07471, KAKENHI-PROJECT-23K06826, KAKENHI-PROJECT-23K06955, KAKENHI-PROJECT-23K06975, KAKENHI-PROJECT-18K07539, KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-22K19506, KAKENHI-PROJECT-20K16488, KAKENHI-PROJECT-22H00467, KAKENHI-PROJECT-23K24249
[Journal Article] iPS細胞を用いた神経疾患研究2023
- Author(s)
  岡田洋平、伊藤卓治、小野寺一成
- Journal Title
  
  日本臨床検査医学会誌
  
  Volume: 71 Pages: 704-710
- Data Source
  KAKENHI-PROJECT-23K24249
[Journal Article] iPS細胞を用いた神経疾患研究2023
- Author(s)
  岡田洋平、伊藤卓治、小野寺一成
- Journal Title
  
  日本臨床検査医学会誌
  
  Volume: 71 Pages: 704-710
- Data Source
  KAKENHI-PROJECT-23K06975
[Journal Article] Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients2023
- Author(s)
  Nakamura R, Tohnai G, Nakatochi M,… Onodera K, Ito T, Okada Y, Okano H, Sobue G
- Journal Title
  
  Journal of Neurology, Neurosurgery & Psychiatry
  
  Volume: 94 Issue: 10 Pages: 816-824
- DOI
  10.1136/jnnp-2022-330851
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15739, KAKENHI-PROJECT-19K06523, KAKENHI-PROJECT-19K07973, KAKENHI-PROJECT-21K07471, KAKENHI-PROJECT-22K07359, KAKENHI-PROJECT-22K07509, KAKENHI-PROJECT-23K06955, KAKENHI-PROJECT-23K06975, KAKENHI-PROJECT-18K07539, KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-23K24249
[Journal Article] iPS細胞を用いた神経疾患研究2023
- Author(s)
  岡田洋平、伊藤卓治、小野寺一成
- Journal Title
  
  日本臨床検査医学会誌
  
  Volume: 71 Pages: 704-710
- Data Source
  KAKENHI-PROJECT-22K15739
[Journal Article] Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling2023
- Author(s)
  Rashid Muhammad Irfanur、Ito Takuji、Miya Fuyuki、Shimojo Daisuke、Arimoto Kanae、Onodera Kazunari、Okada Rina、Nagashima Takunori、Yamamoto Kazuki、Khatun Zohora、Shimul Rayhanul Islam、Niwa Jun-ichi、Katsuno Masahisa、Sobue Gen、Okano Hideyuki、Sakurai Hidetoshi、Shimizu Kazunori、Doyu Manabu、Okada Yohei
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 8146-8146
- DOI
  10.1038/s41598-023-34445-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15739, KAKENHI-PROJECT-22KJ2982, KAKENHI-PROJECT-21K07471, KAKENHI-PROJECT-23K06955, KAKENHI-PROJECT-23K06975, KAKENHI-PROJECT-18K07539, KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-20K16611, KAKENHI-PROJECT-23H00420, KAKENHI-PROJECT-23K24249
[Presentation] EXPLORATION OF PATHOGENIC MOLECULES IN MOTOR NEURON DISEASE USING THE HUMAN IPSC-DERIVED NEUROMUSCULAR MODEL2023
- Author(s)
  Ito T, Rashid MI, Onodera K, Okada R, Shimojo D, Tanaka S, Katsuno M, Sobue G, Doyu M, Okano H, Okada Y
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K15739
[Presentation] A novel reporter, TDP-DiLuc, detects TDP-43 monomerization preceding TDP-43 pathology2023
- Author(s)
  大岩康太郎, 渡邊征爾, 小野寺一成, 井口洋平, 岡田洋平, 勝野雅央, 山中宏二
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K15739
[Presentation] Exploration of pathogenic molecules in motor neuron disease using the human ipsc-derived neuromuscular model2023
- Author(s)
  Ito T, Rashid MI, Onodera K, Okada R, Shimojo D, Tanaka S, Katsuno M, Sobue G, Doyu M, Okano H, Okada Y
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K06975
[Presentation] Establishment of a more efficient disease model for ALS using feeder-free disease specific iPSCs.2023
- Author(s)
  Khatun Z, Onodera K, Yamaguchi S, Okada R, Ito T, Rashid MI, Inoue H, Aoki M, Okano H, Doyu M, Okada Y,
- Organizer
  第22回再生医療学会総会
- Data Source
  KAKENHI-PROJECT-22K15739
[Presentation] Elucidating early pathophysiology of spinal-bulbar muscular atrophy using disease-specific iPSCs2023
- Author(s)
  小野寺一成, 下門大祐, 石原康晴, 太田明伸, 宮冬樹, Rashid Muhammad Irfanur, 伊藤卓治, 岡田梨奈, 細川好孝, 道勇学, 祖父江元, 勝野雅央, 岡野栄之, 岡田洋平
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-23K06975
[Presentation] Establishment of a more efficient disease model for ALS using feeder-free disease specific iPSCs2023
- Author(s)
  Khatun Z, Onodera K, Yamaguchi S, Okada R, Ito T, Rashid MI, Inoue H, Aoki M, Okano H, Doyu M, Okada Y
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K24249
[Presentation] Exploration of pathogenic molecules in motor neuron disease using the human ipsc-derived neuromuscular model2023
- Author(s)
  Ito T, Rashid MI, Onodera K, Okada R, Shimojo D, Tanaka S, Katsuno M, Sobue G, Doyu M, Okano H, Okada Y
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K24249
[Presentation] Elucidating early pathophysiology of spinal-bulbar muscular atrophy using disease-specific iPSCs2023
- Author(s)
  小野寺一成, 下門大祐, 石原康晴, 太田明伸, 宮冬樹, Rashid Muhammad Irfanur, 伊藤卓治, 岡田梨奈, 細川好孝, 道勇学, 祖父江元, 勝野雅央,岡野栄之,岡田洋平
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K15739
[Presentation] Establishment of a more efficient disease model for ALS using feeder-free disease specific iPSCs2023
- Author(s)
  Khatun Z, Onodera K, Yamaguchi S, Okada R, Ito T, Rashid MI, Inoue H, Aoki M, Okano H, Doyu M, Okada Y
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K06975
[Presentation] Elucidating early pathophysiology of spinal-bulbar muscular atrophy using disease-specific iPSCs2023
- Author(s)
  小野寺一成, 下門大祐, 石原康晴, 太田明伸, 宮冬樹, Rashid Muhammad Irfanur, 伊藤卓治, 岡田梨奈, 細川好孝, 道勇学, 祖父江元, 勝野雅央, 岡野栄之, 岡田洋平
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-23K24249
[Presentation] Establishment of a more efficient disease model for ALS using feeder-free disease specific iPSCs2023
- Author(s)
  Khatun Z, Onodera K, Yamaguchi S, Okada R, Ito T, Rashid MI, Inoue H, Aoki M, Okano H, Doyu M, Okada Y
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K15739
[Presentation] 疾患特異的iPS細胞を用いた球脊髄性筋萎縮症（SBMA）の早期病態解明と治療開発2023
- Author(s)
  小野寺一成、下門大祐、石原康晴、太田明伸、Muhammad Irfanur Rashid、伊藤卓治、岡田梨奈、細川好孝、道勇学、祖父江元、勝野雅央、岡野栄、岡田洋平
- Organizer
  第22回再生医療学会総会
- Data Source
  KAKENHI-PROJECT-22K15739
[Presentation] 疾患iPS細胞由来神経・筋共培養モデルを用いた運動ニューロン疾患の神経・筋病態の解明2023
- Author(s)
  伊藤卓治、RASHID Muhammad Irfanur、小野寺一成、岡田梨奈、下門大祐、田中智史、勝野雅央、祖父江元、道勇学、岡野栄之、岡田洋平
- Organizer
  第22回再生医療学会総会
- Data Source
  KAKENHI-PROJECT-22K15739
[Presentation] 疾患特異的iPS細胞を用いた球脊髄性筋萎縮症（SBMA）の早期病態解明と治療開発2022
- Author(s)
  小野寺一成、下門大祐、石原康晴、太田明伸、Muhammad Irfanur Rashid、伊藤卓治、岡田梨奈、細川好孝、道勇学、祖父江元、勝野雅央、岡野栄之、岡田洋平
- Organizer
  第22回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-23K24249
[Presentation] Establishment of a more efficient disease model for ALS using feeder-free disease specific iPSCs2022
- Author(s)
  Khatun Z, Onodera K, Yamaguchi S, Okada R, Ito T, Rashid MI, Inoue H, Aoki M, Okano H, Doyu M, Okada Y
- Organizer
  第33回日本末梢神経学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24249
[Presentation] Elucidating early pathophysiology of spinal-bulbar muscular atrophy using disease-specific iPSCs．2022
- Author(s)
  Onodera K, Shimojo D, de Araujo Herculano B, Ishihara Y, Yoda M, Ota A, Yano M, Miya F, Rashid MI, Ito T, Okada R, Tsunoda T, Hosokawa Y, Doyu M, Sobue G, Katsuno M, Okano H, Okada Y,
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K15739
[Presentation] Establishment of a more efficient disease model for ALS using feeder-free disease specific iPSCs.2022
- Author(s)
  Khatun Z, Onodera K, Yamaguchi S, Okada R, Ito T, Rashid MI, Inoue H, Aoki M, Okano H, Doyu M, Okada Y,
- Organizer
  第33回日本末梢神経学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15739
[Presentation] 疾患iPS細胞由来神経・筋共培養モデルを用いた運動ニューロン疾患の非細胞自律的神経変性を担う分子病態の解明2022
- Author(s)
  伊藤卓治、ラシッド　ムハンマド　イルファヌール、小野寺一成、岡田梨奈、下門大祐、田中智史、勝野雅央、祖父江元、道勇学、岡野栄之、岡田洋平
- Organizer
  第22回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-23K24249
[Presentation] Establishment of a more efficient disease model for ALS using feeder-free disease specific iPSCs2022
- Author(s)
  Khatun Z, Onodera K, Yamaguchi S, Okada R, Ito T, Rashid MI, Inoue H, Aoki M, Okano H, Doyu M, Okada Y
- Organizer
  第22回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-23K24249
[Presentation] Establishment of a more efficient disease model for ALS using feeder-free disease specific iPSCs2022
- Author(s)
  Khatun Z, Onodera K, Yamaguchi S, Okada R, Ito T, Rashid MI, Inoue H, Aoki M, Okano H, Doyu M, Okada Y
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K24249
[Presentation] Elucidating early pathophysiology of spinal-bulbar muscular atrophy using disease-specific iPSCs2022
- Author(s)
  小野寺一成, 下門大祐, Bruno De Araujo Herculano1, 石原康晴, 依田真由子, 太田明伸, 矢野真人, 宮冬樹, Rashid Muhammad Irfanur, 伊藤卓治, 岡田梨奈, 角田達彦, 細川好孝, 道勇学, 祖父江元, 勝野雅央,岡野栄之,岡田洋平
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-23K24249
[Presentation] 疾患iPS細胞由来神経・筋共培養モデルを用いた運動ニューロン疾患の非細胞自律的神経変性を担う分子病態の解明2022
- Author(s)
  伊藤卓治、ラシッド　ムハンマド　イルファヌール、小野寺一成、岡田梨奈、下門大祐、田中智史、勝野雅央、祖父江元、道勇学、岡野栄之、岡田洋平
- Organizer
  第33回日本末梢神経学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24249
[Presentation] Monomerization of　TDP-43 is a key determinant for inducing TDP-43 pathology in ALS2022
- Author(s)
  大岩康太郎, 渡邊征爾, 小野寺一成, 井口洋, 岡田洋平, 勝野雅央, 山中宏二
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-23K24249
[Presentation] 疾患iPS細胞由来神経・筋共培養モデルを用いた運動ニューロン疾患の非細胞自律的神経変性を担う分子病態の解明2022
- Author(s)
  伊藤卓治、RASHID Muhammad Irfanur、小野寺一成、岡田梨奈、下門大祐、田中智史、勝野雅央、祖父江元、道勇学、岡野栄之、岡田洋平
- Organizer
  第33回日本末梢神経学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15739
[Presentation] 疾患iPS細胞由来神経・筋共培養モデルを用いた運動ニューロン疾患の非細胞自律的神経変性を担う分子病態の解明2022
- Author(s)
  伊藤卓治、ラシッド　ムハンマド　イルファヌール、小野寺一成、岡田梨奈、下門大祐、田中智史、勝野雅央、祖父江元、道勇学、岡野栄之、岡田洋平
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K24249
[Presentation] Bulk differentiation of iPSCs into contractible muscles for muscular disease modeling2022
- Author(s)
  Rashid MI, Ito T, Miya F, Shimojo D, Arimoto K, Onodera K, Okada R, Nagashima T, Yamamoto K, Khatun Z, Okano H, Sakurai H, Shimizu K, Doyu M, Okada Y
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K24249

1. 岡田洋平 (30383714)

# of Collaborated Projects: 3 results

# of Collaborated Products: 18 results
2. 伊藤卓治 (30794151)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
3. 道勇学 (90293703)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 岡田梨奈 (50881893)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 鄭羽伸 (51011895)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Onodera Kazunari 小野寺 一成

Research Projects

Research Products

Co-Researchers

Elucidation of the molecular pathology underlying the neurodegeneration caused by factors derived from the muscle

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

転写制御異常から迫る球脊髄性筋萎縮症の病態解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of efficient pathological analysis and drug discovery platform for amyotrophic lateral sclerosis using disease specific iPSCs

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

患者神経細胞で高発現する早期病態因子に着目した球脊髄性筋萎縮症の病態解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathophysiological analysis of motor neuron diseases targeting neuromuscular junction using disease specific iPSCs

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] iPS細胞を用いた神経疾患研究2023

Author(s)

Journal Title

Data Source

[Journal Article] iPS細胞を用いた神経疾患研究2023

Author(s)

Journal Title

Data Source

[Journal Article] Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] iPS細胞を用いた神経疾患研究2023

Author(s)

Journal Title

Data Source

[Journal Article] Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling2023

Author(s)

Journal Title

DOI

Data Source

[Presentation] EXPLORATION OF PATHOGENIC MOLECULES IN MOTOR NEURON DISEASE USING THE HUMAN IPSC-DERIVED NEUROMUSCULAR MODEL2023

Author(s)

Organizer

Data Source

[Presentation] A novel reporter, TDP-DiLuc, detects TDP-43 monomerization preceding TDP-43 pathology2023

Author(s)

Organizer

Data Source

[Presentation] Exploration of pathogenic molecules in motor neuron disease using the human ipsc-derived neuromuscular model2023

Author(s)

Organizer

Data Source

[Presentation] Establishment of a more efficient disease model for ALS using feeder-free disease specific iPSCs.2023

Author(s)

Organizer

Data Source

[Presentation] Elucidating early pathophysiology of spinal-bulbar muscular atrophy using disease-specific iPSCs2023

Author(s)

Organizer

Onodera Kazunari 小野寺一成

[Presentation] Monomerization of　TDP-43 is a key determinant for inducing TDP-43 pathology in ALS2022