Hiyoshi Takumi 日吉巧

Researcher Number	80911437
Other IDs
Affiliation (based on the past Project Information) *help	2022 – 2023: 新潟大学, 医歯学系, 助教 2021: 新潟大学, 医歯学系, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 57030:Conservative dentistry-related / 0907:Oral science and related fields Except Principal Investigator Medium-sized Section 57:Oral science and related fields
Keywords	Principal Investigator 歯周炎マウスモデル / エラスターゼ / 好中球 / 歯周炎 / 骨代謝 / 歯周炎マウス / プロテオーム解析 / 歯周炎重症化 / 細胞接着分子 / ヒト歯肉上皮細胞 / 好中球エラスターゼ / 歯肉上皮バリア / エラスターゼ阻害剤 … More Except Principal Investigator … More 口腔粘膜修復 / 骨再生能 / 幹細胞 / 老化ニッチ / 骨免疫 / 骨代謝 / 骨再生 / 老化幹細胞ニッチ / 老化細胞 / 口腔老化 Less

Understanding oral aging mechanisms by focusing on the oral stem cell niche
- Principal Investigator
  
  前川知樹
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Niigata University
プロテオーム解析法を用いたエラスターゼによる歯周炎重症化メカニズムの網羅的解析Principal Investigator
- Principal Investigator
  
  日吉巧
- Project Period (FY)
  2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Niigata University
Exploration of the Mechanisms Underlying the Exacerbation of Periodontitis Targeting ElastasePrincipal Investigator
- Principal Investigator
  
  Hiyoshi Takumi
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0907:Oral science and related fields
- Research Institution
  Niigata University

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] A novel macrolide?Del-1 axis to regenerate bone in old age2024
- Author(s)
  Sirisereephap Kridtapat、Tamura Hikaru、Lim Jong-Hyung、Surboyo Meircurius Dwi Condro、Isono Toshihito、Hiyoshi Takumi、Rosenkranz Andrea L.、Sato-Yamada Yurie、Domon Hisanori et al.
- Journal Title
  
  iScience
  
  Volume: 27 Issue: 2 Pages: 108798-108798
- DOI
  10.1016/j.isci.2024.108798
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18355, KAKENHI-PROJECT-23KK0160, KAKENHI-PROJECT-22K06535, KAKENHI-PROJECT-22KJ1445, KAKENHI-PROJECT-23K24517, KAKENHI-PROJECT-23K24525
[Journal Article] The Pneumococcal Protein SufC Binds to Host Plasminogen and Promotes Its Conversion into Plasmin2023
- Author(s)
  Yasui Yoshihito、Hirayama Satoru、Hiyoshi Takumi、Isono Toshihito、Domon Hisanori、Maekawa Tomoki、Tabeta Koichi、Terao Yutaka
- Journal Title
  
  Microorganisms
  
  Volume: 11 Issue: 12 Pages: 2969-2969
- DOI
  10.3390/microorganisms11122969
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18355, KAKENHI-PROJECT-23KK0160, KAKENHI-PROJECT-22K09923, KAKENHI-PROJECT-22KJ1445, KAKENHI-PROJECT-23K24525
[Journal Article] Degradation of EGFR on lung epithelial cells by neutrophil elastase contributes to the aggravation of pneumococcal pneumonia2023
- Author(s)
  Isono Toshihito、Hirayama Satoru、Domon Hisanori、Maekawa Tomoki、Tamura Hikaru、Hiyoshi Takumi、Sirisereephap Kridtapat、Takenaka Shoji、Noiri Yuichiro、Terao Yutaka
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 6 Pages: 104760-104760
- DOI
  10.1016/j.jbc.2023.104760
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18355, KAKENHI-PROJECT-23KK0160, KAKENHI-PROJECT-22K09923, KAKENHI-PROJECT-22KJ1445, KAKENHI-PROJECT-23K24525
[Journal Article] Neutrophil elastase aggravates periodontitis by disrupting gingival epithelial barrier via cleaving cell adhesion molecules2022
- Author(s)
  Hiyoshi T., Domon H., Maekawa T., Tamura H., Isono T., Hirayama S., Sasagawa K., Takizawa F., Tabeta K., Terao Y.
- Journal Title
  
  Scientific Reports
  
  Volume: 12(1) Issue: 1 Pages: 8159-8159
- DOI
  10.1038/s41598-022-12358-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KJ1445, KAKENHI-PROJECT-20K09903, KAKENHI-PROJECT-21K21058, KAKENHI-PROJECT-23K24525
[Presentation] 好中球エラスターゼによる歯周炎重症化機序と新規治療法の探索2022
- Author(s)
  日吉　巧
- Organizer
  第４回オーラルサイエンス研究会
- Data Source
  KAKENHI-PROJECT-21K21058
[Presentation] 好中球エラスターゼによる歯周炎重症化機序と新規治療法の探索2022
- Author(s)
  日吉　巧
- Organizer
  オーラルサイエンス研究会
- Data Source
  KAKENHI-PROJECT-22K17053
[Presentation] 好中球エラスターゼの歯肉上皮バリア傷害作用による歯周炎重症化メカニズム解析2021
- Author(s)
  日吉　巧
- Organizer
  第64回秋季歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-21K21058
[Presentation] エラスターゼの歯肉上皮バリア傷害作用を介した歯周組織破壊機序の解析2021
- Author(s)
  日吉　巧，土門久哲，前川知樹，田村　光，笹川花梨，多部田康一
- Organizer
  日本歯科保存学会2021年度秋季学術大会（第155回）
- Data Source
  KAKENHI-PROJECT-21K21058

1. 前川知樹 (50625168)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 都野隆博 (40907383)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 原実生 (60848266)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. DOMON Hisanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
5. 寺尾豊

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 平山悟

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 竹中彰治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hiyoshi Takumi 日吉 巧

Research Projects

Research Products

Co-Researchers

Understanding oral aging mechanisms by focusing on the oral stem cell niche

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

プロテオーム解析法を用いたエラスターゼによる歯周炎重症化メカニズムの網羅的解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploration of the Mechanisms Underlying the Exacerbation of Periodontitis Targeting ElastasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] A novel macrolide?Del-1 axis to regenerate bone in old age2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Pneumococcal Protein SufC Binds to Host Plasminogen and Promotes Its Conversion into Plasmin2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Degradation of EGFR on lung epithelial cells by neutrophil elastase contributes to the aggravation of pneumococcal pneumonia2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neutrophil elastase aggravates periodontitis by disrupting gingival epithelial barrier via cleaving cell adhesion molecules2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] 好中球エラスターゼによる歯周炎重症化機序と新規治療法の探索2022

Author(s)

Organizer

Data Source

[Presentation] 好中球エラスターゼによる歯周炎重症化機序と新規治療法の探索2022

Author(s)

Organizer

Data Source

[Presentation] 好中球エラスターゼの歯肉上皮バリア傷害作用による歯周炎重症化メカニズム解析2021

Author(s)

Organizer

Data Source

[Presentation] エラスターゼの歯肉上皮バリア傷害作用を介した歯周組織破壊機序の解析2021

Author(s)

Organizer

Data Source

Hiyoshi Takumi 日吉巧