Nakamura Yoshihide 中村吉秀

Researcher Number	80933481
Other IDs
Affiliation (Current)	2026: 山口大学, 医学部附属病院, 助教
Affiliation (based on the past Project Information) *help	2024: 山口大学, 医学部附属病院, 助教 2023: 山口大学, 医学部, 助教(特命) 2022: 山口大学, 医学部附属病院, 診療助教(4日/週)
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Basic Section 52010:General internal medicine-related Except Principal Investigator Basic Section 53020:Cardiology-related
Keywords	Principal Investigator リアノジン受容体 / ドキソルビシン心筋症 / カルシウム / 肺動脈性肺高血圧症 / 肺高血圧症 / dantrolene / pulmonary hypertension / calmodulin / ryanodine receptor / ダントロレン / カルモジュリン / 肺高血圧 … More Except Principal Investigator … More 不整脈 / カルシウムハンドリング / ダントロレン / 心室頻拍 / 心不全 / リアノジン受容体 Less

Development of RyR2-targetting therapy for heart failure and arrhythmia
- Principal Investigator
  
  小林茂樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamaguchi University
ダントロレン短期併用によるドキソルビシン心筋症の革新的予防法Principal Investigator
- Principal Investigator
  
  中村吉秀
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamaguchi University
Development of a new treatment for pulmonary hypertension by controlling calmodulinPrincipal Investigator
- Principal Investigator
  
  Nakamura Yoshihide
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Yamaguchi University

All 2025 2024 2023 2022

All Journal Article Presentation

[Journal Article] Concomitant Administration of Dantrolene is Sufficient to Protect Against Doxorubicin-Induced Cardiomyopathy2025
- Author(s)
  Nakamura Yoshihide、Yamamoto Takeshi、Kobayashi Shigeki、Suetomi Takeshi、Uchinoumi Hitoshi、Oda Tetsuro、Sano Motoaki、Yano Masafumi
- Journal Title
  
  JACC: CardioOncology
  
  Volume: 7 Issue: 1 Pages: 38-52
- DOI
  10.1016/j.jaccao.2024.10.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-23K27597, KAKENHI-PROJECT-22K08156, KAKENHI-PROJECT-23K07477, KAKENHI-PROJECT-24K11217, KAKENHI-PROJECT-24K19034
[Journal Article] Structural instability of ryanodine receptor 2 causes endoplasmic reticulum (ER) dysfunction as well as sarcoplasmic reticulum (SR) dysfunction2025
- Author(s)
  Uchinoumi Hitoshi、Nakamura Yoshihide、Suetomi Takeshi、Nawata Takashi、Fujinaka Masafumi、Kobayashi Shigeki、Yamamoto Takeshi、Yano Masafumi、Sano Motoaki
- Journal Title
  
  Journal of Cardiology
  
  Volume: - Issue: 6 Pages: 1-8
- DOI
  10.1016/j.jjcc.2025.02.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-23K27597, KAKENHI-PROJECT-22K08156, KAKENHI-PROJECT-24K11217, KAKENHI-PROJECT-24K11412, KAKENHI-PROJECT-23K14444
[Journal Article] Role of type 2 ryanodine receptor stabilisation in autoimmune cell modulation2024
- Author(s)
  Nawata Takashi、Honda Takeshi、Sakamoto Akihiko、Uchinoumi Hitoshi、Suetomi Takeshi、Nakamura Yoshihide、Tsuji Shunya、Sakai Hiroki、Kobayashi Shigeki、Yamamoto Takeshi、Asagiri Masataka、Sano Motoaki、Yano Masafumi
- Journal Title
  
  Advances in Rheumatology
  
  Volume: 64 Issue: 1 Pages: 1-2
- DOI
  10.1186/s42358-024-00426-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-23K27597, KAKENHI-PROJECT-23K07477, KAKENHI-PROJECT-24K11217, KAKENHI-PROJECT-23K14444
[Journal Article] RyR2-targeting therapy prevents left ventricular remodeling and ventricular tachycardia in post-infarction heart failure2023
- Author(s)
  Fujii Shohei、Kobayashi Shigeki、Chang Yaowei、Nawata Junya、Yoshitomi Ryosuke、Tanaka Shinji、Kohno Michiaki、Nakamura Yoshihide、Ishiguchi Hironori、Suetomi Takeshi、Uchinoumi Hitoshi、Oda Tetsuro、Okuda Shinichi、Okamura Takayuki、Yamamoto Takeshi、Yano Masafumi
- Journal Title
  
  Journal of Molecular and Cellular Cardiology
  
  Volume: 178 Pages: 36-50
- DOI
  10.1016/j.yjmcc.2023.03.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-20K17119, KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-22K15686, KAKENHI-PROJECT-23K27597
[Journal Article] Stabilizing cardiac ryanodine receptor with dantrolene treatment prevents left ventricular remodeling in pressure-overloaded heart failure mice2023
- Author(s)
  Yano Yasutake、Kobayashi Shigeki、Uchida Tomoyuki、Chang Yaowei、Nawata Junya、Fujii Shohei、Nakamura Yoshihide、Suetomi Takeshi、Uchinoumi Hitoshi、Oda Tetsuro、Yamamoto Takeshi、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 642 Pages: 175-184
- DOI
  10.1016/j.bbrc.2022.12.063
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-22K15686, KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-20K17119
[Journal Article] Herpud1 modulates hypertrophic signals independently of calmodulin nuclear translocation in rat myocardium-derived H9C2 cells2023
- Author(s)
  Fujioka Riko、Yamamoto Takeshi、Maruta Akihiro、Nakamura Yoshihide、Tominaga Naoomi、Inamitsu Masako、Oda Tetsuro、Kobayashi Shigeki、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 652 Pages: 61-67
- DOI
  10.1016/j.bbrc.2023.02.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-22K15686, KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-21K08128
[Journal Article] Dantrolene improves left ventricular diastolic property in mineralcorticoid-salt-induced hypertensive rats2023
- Author(s)
  Nawata Junya、Yamamoto Takeshi、Tanaka Shinji、Yano Yasutake、Uchida Tomoyuki、Fujii Shohei、Nakamura Yoshihide、Suetomi Takeshi、Uchinoumi Hitoshi、Oda Tetsuro、Kobayashi Shigeki、Yano Masafumi
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 34 Pages: 101449-101449
- DOI
  10.1016/j.bbrep.2023.101449
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-22K15686, KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-20K17119, KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-23K27597
[Journal Article] Dantrolene reduces platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell proliferation and neointimal formation following vascular injury in mice2022
- Author(s)
  Sakai Chihiro、Mikawa Mei、Yamamoto Takeshi、Uchida Tomoyuki、Nakamura Yoshihide、Akase Hideaki、Suetomi Takeshi、Tominaga Naoomi、Inamitsu Masako、Oda Tetsuro、Okamura Takayuki、Kobayashi Shigeki、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 623 Pages: 51-58
- DOI
  10.1016/j.bbrc.2022.07.038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-22K15686, KAKENHI-PROJECT-20K17119
[Journal Article] Endoplasmic reticulum stress promotes nuclear translocation of calmodulin, which activates phenotypic switching of vascular smooth muscle cells2022
- Author(s)
  Uchida Tomoyuki、Oda Tetsuro、Yamamoto Takeshi、Inamitsu Masako、Sakai Chihiro、Uchinoumi Hitoshi、Suetomi Takeshi、Nakamura Yoshihide、Okamoto Yoko、Tateda Satomi、Fujii Shohei、Tanaka Shinji、Nawata Junya、Okamura Takayuki、Kobayashi Shigeki、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 628 Pages: 155-162
- DOI
  10.1016/j.bbrc.2022.08.069
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-22K15686, KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-20K17119
[Presentation] Add-on Therapy with Dantrolene, a RyR2 Stabilizer, Terminates Ventricular Tachycardia Storm refractory to Intravenous Amiodarone in Heart Failure2024
- Author(s)
  Junya Nawata, Shigeki Kobayashi, Maho Ishikawa, Yuki Nakata, Kaori Murakawa, Yusuke Nakashima, Masahiro Hisaoka, Tetsuya Matsuyama, Yoshihide Nakamura, Ayumi Omuro, Masakazu Fukuda, Takeshi Suetomi, Yosuke Miyazaki,Tatsuhiro Fujimura, Mamoru Mochizuki, Motoaki Sano
- Organizer
  American Heart Association 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K11217
[Presentation] Two Cases of ATTR Type Cardiac Amyloidosis Diagnosed with Endomyocardial Biopsies2024
- Author(s)
  藤田美穂、小林茂樹、石川真帆、中嶋佑輔、中村吉秀、福田昌和、末冨　建、宮崎要介、藤村達大、内海仁志、望月　守、小田哲郎、岡村誉之
- Organizer
  The 88th Annual Scientific Meeting of the Japanese Circulation Society
- Data Source
  KAKENHI-PROJECT-22K15686
[Presentation] ダントロレン短期間併用はドキソルビシン心筋症の革新的予防法となりうる2024
- Author(s)
  中村　吉秀、小林　茂樹、山本　健、矢野　雅文、佐野　元昭
- Organizer
  第10回日本心筋症研究会
- Data Source
  KAKENHI-PROJECT-24K19034
[Presentation] Concomitant administration of dantrolene is sufficient to protect against doxorubicin-induced cardiomyopathy2024
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Shigeki Kobayashi, Takeshi Suetomi, Hitoshi Uchinoumi, Tetsuro Oda, Masafumi Yano
- Organizer
  CVMW2024
- Data Source
  KAKENHI-PROJECT-24K11217
[Presentation] Concomitant administration of dantrolene is sufficient to protect against doxorubicin-induced cardiomyopathy2024
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Shigeki Kobayashi, Takeshi Suetomi, Hitoshi Uchinoumi, Tetsuro Oda, Masafumi Yano
- Organizer
  Basic Cardiovascular Sciences Scientific Sessions　2024
- Data Source
  KAKENHI-PROJECT-24K19034
[Presentation] Concomitant administration of dantrolene is sufficient to protect against doxorubicin-induced cardiomyopathy2024
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Shigeki Kobayashi, Takeshi Suetomi, Hitoshi Uchinoumi, Tetsuro Oda, Masafumi Yano
- Organizer
  BCVS2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K11217
[Presentation] Role of serial evaluation of myocardial inflammatory activity and oxidative stress in determining the therapeutic efficacy of immunosuppression and clinical outcome in patients with cardiac sarcoidosis2024
- Author(s)
  Yusuke Nakashima Shigeki Kobayashi Maho Ishikawa, Junya Nawata, Yoshihide Nakamura,Tatsuhiro Fujimura, Motoaki Sano
- Organizer
  American Heart Association 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K11217
[Presentation] Stabilization of RyR2 with Dantrolene Treatment Ameliorates Left Ventricular Remodeling and Ventricular Tachycardia After Myocardial Infarction2024
- Author(s)
  Shohei Fujii, Takeshi Suetomi, Shigeki Kobayashi, Yoshihide Nakamura, Hitoshi Uchinoumi, Takeshi Yamamoto, Masafumi Yano, Motoaki Sano
- Organizer
  BCVS2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K11217
[Presentation] たこつぼ心筋症患者における内因性カテコラミンと心筋内酸化ストレスの関係に関する検討2023
- Author(s)
  石川真帆、小林茂樹、中嶋佑輔、松山哲也、中村吉秀、南野巧真、尾崎功治、石口博智、小田聖子、福田昌和、末冨　建、宮崎要介、藤村達大、内海仁志、望月　守、小田哲郎、岡村誉之、矢野雅文
- Organizer
  第122回日本循環器学会中国四国合同地方会
- Data Source
  KAKENHI-PROJECT-22K15686
[Presentation] リアノジン受容体安定化治療が心筋梗塞後の左室リモデリングや心室頻拍を抑制する2023
- Author(s)
  藤井翔平、小林茂樹、矢野泰健、内田智之、常　耀偉、縄田純也、中村吉秀、末冨　建、内海仁志、小田哲郎、岡村誉之、山本　健、矢野雅文
- Organizer
  第9回日本心筋症研究会
- Data Source
  KAKENHI-PROJECT-22K15686
[Presentation] 心筋型リアノジン受容体 4 量体構造の安定化は心筋梗塞後の予後を改善する2023
- Author(s)
  藤井翔平、小林茂樹、矢野泰健、内田智之、常　耀偉、中村吉秀、末冨　建、内海仁志、小田哲郎、岡村誉之、山本　健、矢野雅文
- Organizer
  第122回日本循環器学会中国四国合同地方会
- Data Source
  KAKENHI-PROJECT-22K15686
[Presentation] 当院における ATTR 型心アミロイドーシスにおける予後予測因子の検討2023
- Author(s)
  藤田美穂、小林茂樹、石川真帆、中嶋佑輔、中村吉秀、小室あゆみ、石口博智、福田昌和、末冨　建、宮崎要介、内海仁志、望月　守、小田哲郎、岡村誉之、矢野雅文
- Organizer
  第122回日本循環器学会中国四国合同地方会
- Data Source
  KAKENHI-PROJECT-22K15686

1. 小林茂樹 (90397993)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
2. 矢野雅文

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
3. 山本健

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
4. 小田哲郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results

Nakamura Yoshihide 中村 吉秀

Research Projects

Research Products

Co-Researchers

Development of RyR2-targetting therapy for heart failure and arrhythmia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ダントロレン短期併用によるドキソルビシン心筋症の革新的予防法Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a new treatment for pulmonary hypertension by controlling calmodulinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Concomitant Administration of Dantrolene is Sufficient to Protect Against Doxorubicin-Induced Cardiomyopathy2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural instability of ryanodine receptor 2 causes endoplasmic reticulum (ER) dysfunction as well as sarcoplasmic reticulum (SR) dysfunction2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of type 2 ryanodine receptor stabilisation in autoimmune cell modulation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RyR2-targeting therapy prevents left ventricular remodeling and ventricular tachycardia in post-infarction heart failure2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stabilizing cardiac ryanodine receptor with dantrolene treatment prevents left ventricular remodeling in pressure-overloaded heart failure mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Herpud1 modulates hypertrophic signals independently of calmodulin nuclear translocation in rat myocardium-derived H9C2 cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dantrolene improves left ventricular diastolic property in mineralcorticoid-salt-induced hypertensive rats2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dantrolene reduces platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell proliferation and neointimal formation following vascular injury in mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Endoplasmic reticulum stress promotes nuclear translocation of calmodulin, which activates phenotypic switching of vascular smooth muscle cells2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] Add-on Therapy with Dantrolene, a RyR2 Stabilizer, Terminates Ventricular Tachycardia Storm refractory to Intravenous Amiodarone in Heart Failure2024

Author(s)

Organizer

Data Source

[Presentation] Two Cases of ATTR Type Cardiac Amyloidosis Diagnosed with Endomyocardial Biopsies2024

Author(s)

Organizer

Data Source

[Presentation] ダントロレン短期間併用はドキソルビシン心筋症の革新的予防法となりうる2024

Author(s)

Organizer

Data Source

[Presentation] Concomitant administration of dantrolene is sufficient to protect against doxorubicin-induced cardiomyopathy2024

Nakamura Yoshihide 中村吉秀