Honma Sota 本間颯太

Researcher Number	80980953
Other IDs
Affiliation (Current)	2026: 慶應義塾大学, 薬学部(芝共立), 助教 2026: 北里大学, 大村智記念研究所, 特任助教 2026: 北里大学, 感染制御科学府, 特任助教
Affiliation (based on the past Project Information) *help	2023 – 2025: 北里大学, 感染制御科学府, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related / 0602:Agricultural and environmental biology and related fields
Keywords	Principal Investigator 遺伝子発現制御 / 生物活性物質 / LaeA / メチルトランスフェラーゼ / 糸状菌 / 植物免疫 / 植物 / スクリーニング / 植物免疫系 / 植物抵抗性誘導剤 … More / 細菌感染評価系 / 一酸化窒素 / 大村天然化合物ライブラリー / 活性窒素種 / 天然物 / 植物抵抗生誘導剤 Less

Establishment of a method for secondary metabolic awakening of fungi using LaeA and analysis of the natural products.Principal Investigator
- Principal Investigator
  
  本間颯太
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Kitasato University
Search for novel plant immune-priming compounds by simple screening system using nitric oxidePrincipal Investigator
- Principal Investigator
  
  Honma Sota
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0602:Agricultural and environmental biology and related fields
- Research Institution
  Kitasato University

All 2025 2024

All Journal Article Presentation

[Journal Article] laeA Gene Introduction Strategy Enabling the Construction of a Prolific Fungal Secondary Metabolite Library2025
- Author(s)
 Kimishima Aoi、Honma Sota、Kato Satoshi、Honsho Masako、Kojima Hiroki、Tokiwa Toshiyuki、Sugawara Akihiro、Nonaka Kenichi、Araki Yasuko、Takahashi Tadashi、Ito Kotaro、Asami Yukihiro
- Journal Title
 
 Journal of Natural Products
 
 Volume: 88 Issue: 3 Pages: 682-687
- DOI
 10.1021/acs.jnatprod.4c01317
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-23K19296
[Journal Article] Re-discovery of MS-347a as a fungicide candidate through a new drug discovery platform with a multidrug-sensitive Saccharomyces cerevisiae screening system and the introduction of a global secondary metabolism regulator, laeA gene2024
- Author(s)
 Honma Sota、Kimishima Aoi、Kimishima Atsushi、Honsho Masako、Kojima Hiroki、Tokiwa Toshiyuki、Nishitomi Atsuka、Kato Satoshi、Kondo Naozumi、Araki Yasuko、Takahashi Tadashi、Chinen Takumi、Usui Takeo、Fuji Shin-ichi、Ito Kotaro、Asami Yukihiro
- Journal Title
 
 Bioscience, Biotechnology, and Biochemistry
 
 Volume: 88 Issue: 7 Pages: 824-829
- DOI
 10.1093/bbb/zbae050
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-22K06526, KAKENHI-PROJECT-23K19296
[Journal Article] Discovery of an anti-malarial compound, burnettiene A, with a multidrug-sensitive Saccharomyces cerevisiae screening system based on mitochondrial function inhibitory activity2024
- Author(s)
  Kimishima A, Nishitomi A, Tsuruoka I, Sakai K, Hokari R, Honsho M, Honma S, Ono Y, Kondo N, Tsutsumi H, Kikuchi Y, Tokiwa T, Kojima H, Higo M, Nonaka K, Inahashi Y, Iwatsuki M, Fuji SI, Jang JP, Jang JH, Chinen T, Usui T, Asami Y.
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 88 Issue: 10 Pages: 1212-1216
- DOI
  10.1093/bbb/zbae098
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K19296
[Journal Article] PurA is the main target of aurodox, a type III secretion system inhibitor2024
- Author(s)
  Watanabe Yoshihiro、Haneda Takeshi、Kimishima Aoi、Kuwae Asaomi、Suga Takuya、Suzuki Takahiro、Iwabuchi Yoshiharu、Honsho Masako、Honma Sota、Iwatsuki Masato、Matsui Hidehito、Hanaki Hideaki、Kanoh Naoki、Abe Akio、Asami Yukihiro、?mura Satoshi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 121 Issue: 17
- DOI
  10.1073/pnas.2322363121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06531, KAKENHI-PROJECT-23K19296, KAKENHI-PROJECT-23K27307
[Journal Article] The isolation of sclerotinin A as an anti-malarial compound by utilization of a global secondary metabolism regulator, laeA gene2024
- Author(s)
  Sota Honma, Aoi Kimishima, Satoshi Kato, Akari Horiuchi, Rei Hokari, Masako Honsho, Hiroki Kojima, Toshiyuki Tokiwa, Akihiro Sugawara, Masato Iwatsuki, Yasuko Araki, Tadashi Takahashi, Takumi Chinen, Takeo Usui, Kotaro Ito, Yukihiro Asami
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 113 Pages: 129947-129947
- DOI
  10.1016/j.bmcl.2024.129947
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K19296
[Journal Article] Isolation of microorganisms from the feces of Kitasato Yakumo beef cattle as bioactive natural product producers2024
- Author(s)
  Aoi Kimishima, Atsuka Nishitomi, Naozumi Kondo, Sota Honma, Masako Honsho, Sota Ngami, Serino Maruyama, Kazuki Taguchi, Hidehito Matsui, Hideaki Hanaki, Takumi Chinen, Takeo Usui, Hideki Ogasawara, Yukihiro Asami
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 88 Issue: 10 Pages: 1242-1246
- DOI
  10.1093/bbb/zbae103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K19296
[Journal Article] Colistin Potentiates the Anti-bacterial Activity of 5-O-Mycaminosyltylonolide for Some Gram-Negative Bacteria2024
- Author(s)
 Aoi Kimishima, Hidehito Matsui, Yukiko Takarabe, Masako Honsho, Paul Wasuwanich, Sota Honma, Junsei Terai, Hideaki Hanaki, Yukihiro Asami
- Journal Title
 
 BPB Reports
 
 Volume: 7 Issue: 5 Pages: 157-159
- DOI
 10.1248/bpbreports.7.5_157
- ISSN
 2434-432X
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-23K19296
[Journal Article] Synthesis and biological evaluation of burnettiene A derivatives enabling discovery of novel fungicide candidates2024
- Author(s)
  Aoi Kimishima, Atsuka Nishitomi, Iori Tsuruoka, Masako Honsho, Sota Negami, Sota Honma, Paul Wasuwanich, Katsuyuki Sakai, Toshiyuki Tokiwa, Hiroki Kojima, Kenichi Nonaka, Shin-ichi Fuji, Takumi Chinen, Takeo Usui, Yukihiro Asami
- Journal Title
  
  Journal of Pesticide Science
  
  Volume: 49 Issue: 3 Pages: 159-167
- DOI
  10.1584/jpestics.D24-014
- ISSN
  1348-589X, 1349-0923
- Year and Date
  2024-08-20
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K19296
[Journal Article] Synthesis and biological evaluation of MS-347a derivatives against plant pathogenic fungi based on a strategy of laeA gene introduction2024
- Author(s)
 Kimishima Aoi、Honma Sota、Kimishima Atsushi、Nishitomi Atsuka、Honsho Masako、Wasuwanich Paul、Kojima Hiroki、Tokiwa Toshiyuki、Sugawara Akihiro、Araki Yasuko、Takahashi Tadashi、Chinen Takumi、Usui Takeo、Fuji Shin-ichi、Ito Kotaro、Asami Yukihiro
- Journal Title
 
 Journal of Pesticide Science
 
 Volume: 49 Issue: 4 Pages: 224-231
- DOI
 10.1584/jpestics.D24-035
- ISSN
 1348-589X, 1349-0923
- Year and Date
 2024-11-20
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-22K06526, KAKENHI-PROJECT-23K19296
[Presentation] 北里八雲牛糞便からの微生物の分離とその応用2025
- Author(s)
  君嶋葵, 西冨あつか, 近藤直純, 本間颯太, 照屋悠介, 谷和樹, 本庄雅子, 根上颯太, 丸山世莉乃, 田口和樹, 松井秀仁, 花木秀明, 知念拓実, 臼井健郎, 石井貴広, 小笠原英毅, 浅見行弘
- Organizer
  日本農芸化学会2025年度大会
- Data Source
  KAKENHI-PROJECT-23K19296
[Presentation] 糸状菌由来生物活性物質探索におけるlaeA導入戦略の有用性2025
- Author(s)
  加藤聡, 君嶋葵, 本間颯太, 本庄雅子, 小島裕貴, 常盤俊之, 菅原章公, 野中健一, 荒木康子, 高橋理, 伊藤考太郎, 浅見行弘
- Organizer
  日本農芸化学会2025年度大会
- Data Source
  KAKENHI-PROJECT-23K19296
[Presentation] laeA遺伝子導入によるsclerotinin Aの単離とその生物活性について2025
- Author(s)
  本間颯太, 君嶋葵, 加藤聡, 堀内紅里, 穂苅玲, 本庄雅子, 小島裕貴, 常盤俊之, 菅原章公, 岩月正人, 荒木康子, 高橋理, 知念拓実, 臼井健郎, 伊藤考太郎, 浅見行弘
- Organizer
  日本農芸化学会2025年度大会
- Data Source
  KAKENHI-PROJECT-23K19296
[Presentation] 薬剤超感受性出芽酵母とlaeA導入を基盤とした新規薬剤探索プラットホームからの抗真菌化合物の再発見2024
- Author(s)
  本間颯太, 君嶋葵, 君嶋敦, 本庄雅子, 小島裕貴, 常盤俊之, 西冨あつか, 加藤聡, 近藤直純, 藤晋一, 知念拓実, 荒木康子, 高橋理, 臼井健郎, 伊藤考太郎, 浅見行弘
- Organizer
  第34回新薬創製談話会
- Data Source
  KAKENHI-PROJECT-23K19296
[Presentation] III 型分泌装置阻害剤aurodox の標的分子の同定2024
- Author(s)
  渡邊善洋, 羽田健, 君嶋葵, 桑江朝臣, 須賀拓弥, 鈴木貴大, 岩渕好治, 本庄雅子, 本間颯太, 岩月正人, 松井秀仁, 花木秀明, 叶直樹, 阿部章夫, 浅見行弘, 大村智
- Organizer
  第66回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-23K19296
[Presentation] 薬剤超感受性出芽酵母とlaeA導入を基盤とした新規薬剤探索プラットホームからの抗真菌化合物MS-347aの再発見2024
- Author(s)
  本間颯太, 君嶋葵, 君嶋敦, 本庄雅子, 小島裕貴, 常盤俊之, 西冨あつか, 加藤聡, 近藤直純, 藤晋一, 知念拓実, 荒木康子, 高橋理, 臼井健郎, 伊藤考太郎, 浅見行弘
- Organizer
  第66回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-23K19296

1. 君嶋敦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 桑江朝臣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Honma Sota 本間 颯太

Research Projects

Research Products

Co-Researchers

Establishment of a method for secondary metabolic awakening of fungi using LaeA and analysis of the natural products.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for novel plant immune-priming compounds by simple screening system using nitric oxidePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] <i>laeA</i> Gene Introduction Strategy Enabling the Construction of a Prolific Fungal Secondary Metabolite Library2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Re-discovery of MS-347a as a fungicide candidate through a new drug discovery platform with a multidrug-sensitive <i>Saccharomyces cerevisiae</i> screening system and the introduction of a global secondary metabolism regulator, <i>laeA</i> gene2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discovery of an anti-malarial compound, burnettiene A, with a multidrug-sensitive Saccharomyces cerevisiae screening system based on mitochondrial function inhibitory activity2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PurA is the main target of aurodox, a type III secretion system inhibitor2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The isolation of sclerotinin A as an anti-malarial compound by utilization of a global secondary metabolism regulator, laeA gene2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Isolation of microorganisms from the feces of Kitasato Yakumo beef cattle as bioactive natural product producers2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Colistin Potentiates the Anti-bacterial Activity of 5-<i>O</i>-Mycaminosyltylonolide for Some Gram-Negative Bacteria2024

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Synthesis and biological evaluation of burnettiene A derivatives enabling discovery of novel fungicide candidates2024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Synthesis and biological evaluation of MS-347a derivatives against plant pathogenic fungi based on a strategy of <i>laeA</i> gene introduction2024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Presentation] 北里八雲牛糞便からの微生物の分離とその応用2025

Author(s)

Organizer

Data Source

[Presentation] 糸状菌由来生物活性物質探索におけるlaeA導入戦略の有用性2025

Author(s)

Organizer

Data Source

[Presentation] laeA遺伝子導入によるsclerotinin Aの単離とその生物活性について2025

Author(s)

Organizer

Honma Sota 本間颯太

[Presentation] 薬剤超感受性出芽酵母とlaeA導入を基盤とした新規薬剤探索プラットホームからの抗真菌化合物の再発見2024

[Presentation] 薬剤超感受性出芽酵母とlaeA導入を基盤とした新規薬剤探索プラットホームからの抗真菌化合物MS-347aの再発見2024