YAMASHITA Junkoh 山下純宏

Researcher Number	90026948
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2003 – 2004: 金沢大学, 医学系研究科, 教授 2001 – 2002: 金沢大学, 大学院・医学系研究科, 教授 2001: 金沢大学, 医学系研究科, 教授 1993 – 2000: 金沢大学, 医学部, 教授 1988 – 1990: 金沢大学, 医学部, 教授 1986 – 1987: 京都大学, 医学部, 助教授 1986: 京都大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Cerebral neurosurgery / Cerebral neurosurgery Except Principal Investigator Cerebral neurosurgery
Keywords	Principal Investigator glioma / MMP / retrovirus vector / 神経膠芽腫 / invasion / anti-gene strategy / triple stranded DNA / testican / 浸潤 / ADAMTS … More / TP53 / Apaf-1 / Testican / extracellular matrix / matrix metalloproteinase / glioma invasion / glioblastoma / integrin / ets-1 / Caspase-3 / MIP-1alpha / MCAF / adenovirus vector / chemokine / retrovirusvector / EGFR / 脳腫瘍 / aggrecanase / Brain neoplasms / Immunotherapy / Major histocompatibility complex / Gytotoxic T lymphocytes / Retroviral vector / Gene transfer / Interferon gamma / 養子免疫療法 / MHC classI / マウス神経芽細胞腫 / IFNーγ遺伝子 / 養子免疫 / 腫瘍免疫 / マウス神経系腫瘍 / IFN-γ遺伝子 / 遺伝子操作 / Crk 1 / Ets transcription factor / 12q22-23 LOH / peripheral nerve tumor / microarray / Ets-1 / TP53 mutation / deep-Seated gliobiastoma / LOH 1p,19q / microcatheter fence-post / brevican / ADAMTS-5 / γ-catenin / cyclin D1 / INI1 / hSNF5 / RT / AT / Crk I / ECM / 湿潤 / 細胞外マトリックス / dissemination / TIMP / 神経膠芽種 / 転写因子 / 髄腔内播種 / apoptosis, / PARP / CPP32 / アポトーシス / Fas / カスパーゼ3 / apoptosis / 悪性神経膠腫 / EGF / env / chimera / specificity / MIP-1 alpha / c-erb B gene / SP-1 / anti-genestrategy / triplestrandedDNA / DNA triplex, antigene, EGFR,Sp-1, human glioma, human squamous cell carcinoma, retrovirus vector, gene therapy / Sp-1 / 三重鎖DNA / 遺伝子療法 / レトロウイルスベクター / 扁平上皮癌 / グリオーマ / 癌遺伝子 / 上皮成長因子受容体 / アンチジーン / 三重鎖DNA, / latency / age / dipole moment / visual evoked magnetic field / ocular dominance / not invasive study / dominant hemisphere / MEG / visual function / 腫瘍特異抗原 / 悪性神経膠芽腫瘍 / 頚部リンパ節 / 細胞障害性Tリンパ球 / 免疫治療 / 樹状細胞 / proteoglycan … More Except Principal Investigator IL2 / グリオーマ / 腫瘍抗原 / キラーT細胞 / 脳腫瘍 / 徐放性抗癌剤 / ポリ乳酸 / オキシセルロース / シスプラチン / アドリアマイシン / 免疫組織化学 / ウエスタンブロッティング / クモ膜絨毛 / 髄膜腫 / カドヘリン Less

脳誘発磁界測定による視野認知機能の新規評価法の開発Principal Investigator
- Principal Investigator
  
  賀戸久, 山下純宏
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kanazawa Institute of Technology
  Kanazawa University
Analysis of transcription factors and of crosstalk between proteinase and extracellular matrix that are related to invasive process of glioblastomaPrincipal Investigator
- Principal Investigator
  
  WATANABE Takuya, 山下純宏
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, Kanazawa
悪性神経膠腫由来の浸潤細胞障害性T細胞が認識する脳腫瘍特異的抗原ペプチドの同定Principal Investigator
- Principal Investigator
  
  山下純宏
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kanazawa University
The analysis of transcription factor and ECM degradation enzyme associated with invasion of glioblastomaPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Junkoh
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kanazawa University
脳に特異的なマトリックスメタロプロテアーゼ遺伝子の単離Principal Investigator
- Principal Investigator
  
  山下純宏
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kanazawa University
The analysis of invasion associated gene in glioblastomaPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Junkoh
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kanazawa University
Analysis of cell death inducing gene in human malignant gliomasPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Junkoh
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kanazawa University
Inhibition of Gene Expression from the Human c-erb B Gene Promoter by a Retroviral Vector Expressing Anti-gene RNAPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Junkoh
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  KANAZAWA UNIVERSITY
Development of chemokine-expressing retrovirus vector system in malignant gliomasPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Junkoh
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  KANAZAWA UNIVERSITY
INHIBITION OF TRANSCRIPTION OF THE HUMAN EGFR GENE IN GLIOMA BY SITE-SPECIFIC OLIGONUCLEOTIDES DESIGNED TO FORM DNA TRIPLE HELICESPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Junkoh
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kanazawa University
脳腫瘍における細胞間接着因子(カドヘリン)の研究
- Principal Investigator
  
  山嶋哲盛
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kanazawa University
Adoptive Immunotherapy for Malignant Brain Tumors Using Killer T Lymphocytes Enhanced by Interferon Gamma Gene TransferPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Junkoh
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kanazawa University
  Kyoto University
悪性脳腫瘍の手術時における留置用徐放性抗癌剤の開発
- Principal Investigator
  
  堀了平
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
ヒト腫瘍細胞特異的キラーT細胞の誘導とその応用
- Principal Investigator
  
  難波雄二郎
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University

All 2005 2004 2003

All Journal Article Book

[Book] Brain Tumor Surgery-new strategy based on biological behavior of brain tumors-2005
- Author(s)
  Yamashita J (Editor)
- Publisher
  Published by Medica shuppan [Osaka, Japan]
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390431
[Book] 脳腫瘍の外科-Biological behaviorにのっとった新しい治療戦略-2005
- Author(s)
  山下純宏(編)
- Total Pages
  338
- Publisher
  メディカ出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390431
[Journal Article] Cyclin D1 is overexpressed in atypical teratoid/rhabdoid tumor with hSNF5/INI1 genes inactivation.2005
- Author(s)
  Fujisawa H, Misaki K, Takabatake Y, Hasegawa M, Yamashita J
- Journal Title
  
  J Neurooncol 73
  
  Pages: 117-124
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390431
[Journal Article] Therapeutic strategy of oligodendroglioma based on LOH 1p and 19q.2005
- Author(s)
  Fujisawa H, Miyashita K, Tachibana O, Hasegawa M, Yamashita J
- Journal Title
  
  Brain Tumor Surgery[Japanese]
  
  Pages: 142-149
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390431
[Journal Article] Human glioblastomas overexpress ADAMTS-5 that degrades brevican2005
- Author(s)
  Nakada M, Miyamori H, Kita D, Takahashi T, Yamashita J, Sato H, Miura R, Yamaguchi Y, Okada Y
- Journal Title
  
  Acta Neuropathol (Berl) 110
  
  Pages: 239-246
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390431
[Journal Article] Correlation of gamma-catenin expression with good prognosis in medulloblastomas.2005
- Author(s)
  Misaki K, Marukawa K, Hayashi Y, Fukusato T, Minamoto T, Hasegawa M, Yamashita J, Fujisawa H
- Journal Title
  
  J Neurosurg 102
  
  Pages: 197-206
- Data Source
  KAKENHI-PROJECT-15390431
[Journal Article] Cyclin D1 is overexpressed in atypical teratoid/rhabdoid tumor with hSNF5/INI1 gene inactivation.2005
- Author(s)
  Fujisawa H, Misaki K, Takabatake Y, Hasegawa M, Yamashita J
- Journal Title
  
  J Neurooncol 73
  
  Pages: 117-124
- Data Source
  KAKENHI-PROJECT-15390431
[Journal Article] Correlation of gamma-catenin expression with good prognosis in medulloblastomas.2005
- Author(s)
  Misaki K, Marukawa K, Hayashi Y, Fukusato T, Minamoto T, Hasegawa M,. Yamashita J, Fujisawa H
- Journal Title
  
  J Neurosurg 102
  
  Pages: 197-206
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390431
[Journal Article] Catheter guided brain tumor surgery (fence-post catheter technique) using navigation system, especially on supratentorial intra-axial tumors.2005
- Author(s)
  Kita D.Hasegawa M, Yamashita J
- Journal Title
  
  Brain Tumor Surgery[Japanese]
  
  Pages: 307-313
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390431
[Journal Article] テント上脳実質内腫瘍手術におけるnavigation system下fence-post catheter法の有用性2005
- Author(s)
  喜多大輔, 長谷川光広, 山下純宏
- Journal Title
  
  脳腫瘍の外科-Biological beheviorにのっとった新しい治療戦略-
  
  Pages: 307-313
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390431
[Journal Article] テント上脳実質内腫瘍手術におけるnavigation system下fence-post catheter法の有用性2005
- Author(s)
  喜多大輔, 長谷川光広, 山下純宏
- Journal Title
  
  脳腫瘍の外科-Biological behaviorにのっとった新しい治療戦略-
  
  Pages: 307-313
- Data Source
  KAKENHI-PROJECT-15390431
[Journal Article] LOH 1p,19qに基づいたoligodendroglial tumorの治療戦略2005
- Author(s)
  藤沢弘範, 宮下勝吉, 立花修, 長谷川光広, 山下純宏
- Journal Title
  
  脳腫瘍の外科-Biological behaviorにのっとった新しい治療戦略-
  
  Pages: 142-149
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390431
[Journal Article] Human glioblastomas overexpress ADAMTS-5 that degrades brevican.2005
- Author(s)
  Nakada M, Miyamori H, Kita D, Takahashi T, Yamashita J, Sato H, Miura R, Yamaguchi Y, Okada Y
- Journal Title
  
  Acta Neuropathol (Berl) 110
  
  Pages: 239-246
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390431
[Journal Article] Correlation of gamma-catenin expression with good prognosis in medulloblastomas2005
- Author(s)
  Misaki K, Marukawa K, Hayashi Y, Fukusato T, Minamoto T, Hasegawa M, Yamashita J, Fujisawa H
- Journal Title
  
  J Neurosurg 102
  
  Pages: 197-206
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390431
[Journal Article] Cyclin D1 is overexpressed in atypical teratoid/rhabdoid tumor with hSNF5/INI1 gene inactivation2005
- Author(s)
  Fujisawa H, Misaki K, Takabatake Y, Hasegawa M, Yamashita J
- Journal Title
  
  J Neurooncol 73
  
  Pages: 117-124
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390431
[Journal Article] Surgical pathology of spinal schwannoma : has the nerve of its origin been preserved or already degenerated during tumor growth?2005
- Author(s)
  Hasegawa M, Fujisawa H, Hayashi Y, Tachibana O, Kida S, Yamashita J
- Journal Title
  
  Clin Neuropathol 24
  
  Pages: 19-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390431
[Journal Article] Molecular genetic analysis of deep-seated glioblastomas2004
- Author(s)
  Hayashi Y, Yamashita J, Watanabe T
- Journal Title
  
  Cancer Genet Cytogenet 153
  
  Pages: 64-68
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390431
[Journal Article] Autologous amnion graft for repair of myelomeningocele : technical note and clinical implication.2004
- Author(s)
  Hasegawa M, Fujisawa H, Hayashi Y, Yamashita J
- Journal Title
  
  J Clin Neurosci 11
  
  Pages: 408-411
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390431
[Journal Article] Autologous amnion graft for repair of myelomeningocele : technical note and clinical implication2004
- Author(s)
  Hasegawa M, Fujisawa H, Hayashi Y, Yamashita J
- Journal Title
  
  J Clin Neurosci 11
  
  Pages: 408-411
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390431
[Journal Article] Molecular analysis of the rhabdoid predisposition syndrome in a child : a novel germline hSNF5/INI1 mutation and absence of c-myc amplification2003
- Author(s)
  Fujisawa, H., Takabatake, Y., Fukusato, T., Tachibana, O., Tsuchiya, Y., Yamashita, J
- Journal Title
  
  J Neurooncol 63
  
  Pages: 257-262
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390431
[Journal Article] Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins.2003
- Author(s)
  Nakada M, Miyamori H, Yamashita J, Sato H
- Journal Title
  
  Cancer Res 63
  
  Pages: 3364-3369
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390431
[Journal Article] The role of matrix metalloproteinases in glioma invasion2003
- Author(s)
  Nakada M, Okada Y, Yamashita J.
- Journal Title
  
  Front Biosci 8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390431
[Journal Article] Oxidized galectin-1 stimulates the migration of Schwann cells from both proximal and distal stumps of transected nerves and promotes axonal regeneration after peripheral nerve injury2003
- Author(s)
  Fukaya K, Hasegawa M, Mashitani T, Kadoya T, Horie H, Hayashi Y, Fujisawa H, Tachibana O, Kida S, Yamashita J
- Journal Title
  
  J Neuropathol Exp Neurol 62
  
  Pages: 162-172
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390431
[Journal Article] CrkI adapter protein modulates cell migration and invasion in glioblastoma.2003
- Author(s)
  Takino T, Nakada M, Miyamori H, Yamashita J, Yamada KM, Sato H
- Journal Title
  
  Cancer Res 63
  
  Pages: 2335-2337
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390431
[Journal Article] Oxidized galectin-1 stimulates the migration of Schwann cells from both proximal and distal stumps of transected nerves and promotes axonal regeneration after peripheral nerve injury.2003
- Author(s)
  Fukaya K, Hasegawa M, Mashitani T, Kadoya T, Horie H, Hayashi Y, Fujisawa H, Tachibana O, Kida, S, Yamashita J
- Journal Title
  
  J Neuropathol Exp Neurol 62
  
  Pages: 162-172
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390431
[Journal Article] Frequent LOH at chromosome 12q22-23 and Apaf-1 inactivation in glioblastoma.2003
- Author(s)
  Watanabe T, Hirota Y, Arakawa Y, Fujisawa H, Tachibana O, Hasegawa M, Yamashita J, Hayashi Y
- Journal Title
  
  Brain Pathol 13
  
  Pages: 431-439
- NAID
  110000140479
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390431

1. YAMAGUCHI Kazuo (00019879)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. TACHIBANA Osamu (40211362)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. WATANABE Takuya (90399775)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 賀戸久 (60278091)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. NAKADA Mitsutoshi (20334774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. YAMASAKI Toshiki (50201835)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 山嶋哲盛 (60135077)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 中条達也 (00303298)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 中尾眞二 (70217660)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 岡本禎一 (40324074)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 藤沢弘範 (40283113)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 長谷川光広 (70218460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 堀了平 (40001036)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 岩川精吾 (50168548)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 乾賢一 (70034030)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 奥村勝彦 (60025707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 難波雄二郎 (50027322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 花岡正男 (30027304)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 喜多大輔 (10377385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
20. 徳力康彦 (90155523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. AMANUMA Hiroshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YAMASHITA Junkoh 山下 純宏

Research Projects

Research Products

Co-Researchers

脳誘発磁界測定による視野認知機能の新規評価法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of transcription factors and of crosstalk between proteinase and extracellular matrix that are related to invasive process of glioblastomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

悪性神経膠腫由来の浸潤細胞障害性T細胞が認識する脳腫瘍特異的抗原ペプチドの同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The analysis of transcription factor and ECM degradation enzyme associated with invasion of glioblastomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

脳に特異的なマトリックスメタロプロテアーゼ遺伝子の単離Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The analysis of invasion associated gene in glioblastomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of cell death inducing gene in human malignant gliomasPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Inhibition of Gene Expression from the Human c-erb B Gene Promoter by a Retroviral Vector Expressing Anti-gene RNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of chemokine-expressing retrovirus vector system in malignant gliomasPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

INHIBITION OF TRANSCRIPTION OF THE HUMAN EGFR GENE IN GLIOMA BY SITE-SPECIFIC OLIGONUCLEOTIDES DESIGNED TO FORM DNA TRIPLE HELICESPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

脳腫瘍における細胞間接着因子(カドヘリン)の研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Adoptive Immunotherapy for Malignant Brain Tumors Using Killer T Lymphocytes Enhanced by Interferon Gamma Gene TransferPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

悪性脳腫瘍の手術時における留置用徐放性抗癌剤の開発

Principal Investigator

Project Period (FY)

Research Category

YAMASHITA Junkoh 山下純宏