SHINKAI Hiroshi 新海浤

… Alternative Names

新海宏シンカイヒロシ

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Researcher Number	90030957
Other IDs
Affiliation (based on the past Project Information) *help	2001 – 2004: 千葉大学, 大学院・医学研究院, 教授 1995 – 2000: Chiba University School of Medicine, Professor, 医学部, 教授 1998: 千葉大学, 医学部・皮膚科, 教授 1991 – 1992: 大分医科大学, 医学部, 助教授 1986 – 1989: 大分医科大学, 医学部, 助教授 1986: 大分医大, 医学部, 助教授
Review Section/Research Field	Principal Investigator Dermatology / Dermatology Except Principal Investigator Dermatology
Keywords	Principal Investigator デコリン / デルマトポンチン / Ehlers-Danlos / エーラス・ダンロス / 強皮症 / プロテオグリカン / コラーゲン / Collagen / デルマタン硫酸プロテオグリカン / 創傷治癒 … More / SLRP / Dermatopontin / Decorin / デルマタン硫酸 / p38MAPK / 皮膚線維化 / コラーゲン線維 / HPLC / Proteodermatan sulfate / Hydroxylysine / Hydroxyproline / プロコラーゲン / ダンロス症候群 / エーラス / 高速液体クロマトグラフィ- / アミノ酸配列 / 二次元電気泳動 / 骨形成不全症 / 高速液体クロマト / プロテオデルマタン硫酸 / エ-ラスダンロス症候群 / ハイドロオキンリジン / ハイドロオキンプロリン / コラ-ゲン / reverse-phase HPLC Proteoglycan / Hereditary connective tissue disease / エーラス・ダンロス症候群 / コンドロイチン硫酸プロテオグリカン / 逆層高速液体クロマトグラフィー / 遺伝性結合織疾患 / fibrillogenesis / dermatopontin / decorin / proteoglycans / collagen / IL-4 / 線維化 / Wound healing / collagen fibril / gene targeting / 遺伝子操作 / Cytokines / バイグリカン / リン酸化 / MAPK / 情報伝達 / サイトカイン / skin fibrosis. / systemic sclerosis ; / hypertrophic scar / interleukin-4 / TGF-beta / 肥厚性瘢痕 / インターロイキン 4 / TGF-β / Fibrosis / 45kD protein / Extracellular matrix / 45KD蛋白質 / 細胞外マトリックス / ECM / 22Kタンパク質 … More Except Principal Investigator transcription / 転写 / I型コラーゲン / コラゲナーゼ / type I collagen / 皮膚線維症 / cutis laxa / コラーゲン / type III collagen / fibrotic skin diseases / Ehlers-Danlos症候群 / ColF1 / III型コラーゲン / 遺伝子発現 / TNF-α / Erythromycin analog / Co1F1 / 転写因子 / マクロライド誘導体 / 遺伝子発見 / マクロライド透導体 / Cutis laxa / acrogeria / α_2(I)コラーゲン / COlF1 / TGF beta receptor / TGF beta / Pur beta / Pur alpha / promoter gene / COLF1 / TGFβレセプター / TGFβ / Purβ / Purα / TGF βレセプター / TGF β / Pur β / Pur α / プロモーター遺伝子 / glycosaminoglycans / actinic keratosis / matrix metalloproteinase / extracellular matrix / skin cancer / ムコ多糖 / 日光角化症 / マトリックスメタロプロテアーゼ / 細胞外マトリックス / 皮膚悪性腫瘍 / collagenase / type Vl collagen / TNF-alpha / fibrosis / type l collagen / DNA結合因子 / 遺伝子 / α_1(I)コラーゲン / VI型コラーゲン / TNF‐α / cutis Laxa / VT型コラーゲン / 線維症 / ヒスチジノアラニン / リジルオキシターゼ / 軟骨プロテオグリカン / 單クローン抗体 / 骨形成不全症 / エーラス・ダンロス症候群 / リジルオキシダーゼ / 軟骨肉腫 / 代謝異常單クローン抗体 / 骨形成 / ダンロス症候群 / エーラス / HSP47 / 強皮症 / DNA配列 / 分子生物学 / 一次構造 / 水疱性類天疱瘡抗原 / ペプチドマップ / 類天疱瘡抗原 / 水疱症 / 水疱性類天疱瘡 Less

Collagen fibrillogenesisPrincipal Investigator
- Principal Investigator
  
  SHINKAI Hiroshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Chiba University
Analysis of transcriptional control mechanism for the expression of type I collagen and related gene in fibrotic skin disorders
- Principal Investigator
  
  HATAMOCHI Atsushi
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Dokkyo University School of Medicine
  Chiba University
COLLAGEN FIBRILLOGENESISPrincipal Investigator
- Principal Investigator
  
  SHINKAI Hiroshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  CHIBA UNIVERSITY
COLLAGEN FIBRILLOGENESISPrincipal Investigator
- Principal Investigator
  
  SHINKAI Hiroshi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  CHIBA UNIVERSITY
強皮症患者のコラーゲン沈着へのHSP47の関与
- Principal Investigator
  
  UTANI Atsushi
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Chiba University
Analysis of transcriptional control mechanism for the expression of type I collagen gene in fibrotic skin disorders
- Principal Investigator
  
  HATAMOCHI Atsushi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Chiba University
Analysis of Fibrillogenesis for Inactivation of TGF-beta by DecorinPrincipal Investigator
- Principal Investigator
  
  SHINKAI Hiroshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Chiba University School of Medicine
コラーゲン線維化におけるデルマトポンチン(新しい細胞外マトリックス成分)の機能Principal Investigator
- Principal Investigator
  
  新海浤
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Chiba University
The expression of extracellular matrix-related genes in skin cancers
- Principal Investigator
  
  TSUKIFUJI Reiko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Chiba University
Transcriptional control mechanism for the expression of type I collagen gene in fibrotic skin disorders and related diseases
- Principal Investigator
  
  HATAMOCHI Atsushi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Chiba University
コラーゲン線維形成における新しい細胞外マトリックスタンパク質の機能と性状Principal Investigator
- Principal Investigator
  
  新海浤
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Chiba University
Transcriptional control mechanism for the expression of alpha1 (1) collagen gene in fibrotic skin disorders
- Principal Investigator
  
  HATAMOCHI Atsushi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Chiba University
  Kawasaki Medical School
新しい水疱性類天疱瘡抗原の分子構造
- Principal Investigator
  
  藤原作平
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  大分医科大学
Isolation of novel extracellualr matrix component and its function related with tissue fragilityPrincipal Investigator
- Principal Investigator
  
  SHINKAI Hiroshi
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Oita Medical University
水疱性類天疱瘡(BP)抗原の発現機構-cDNAクロ-ニングとin situハイブリダイゼイション-
- Principal Investigator
  
  FUJIWARA Sakuhei
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  大分医科大学
コラーゲン代謝異常の病因・病態解析
- Principal Investigator
  
  永井裕
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  The University of Tokyo
Developments of the diagnostic methods in heritable connective tissue diseases on the enzymatic and cDNAs levelsPrincipal Investigator
- Principal Investigator
  
  SHINKAI Hiroshi
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Dermatology
- Research Institution
  Medical College of Oita
コラーゲン代謝異常の病因・病態解析
- Principal Investigator
  
  永井裕
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Tokyo Medical and Dental University
Studies on the microheterogenities of proteoglycans and collagen in the fibrous tissuesPrincipal Investigator
- Principal Investigator
  
  SHINKAI Hiroshi
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Meiidical College of Oita

All 2004 2003 2002

All Journal Article

[Journal Article] Rare Autosomal Recessive Cardiac Valvular Form of Ehlers-Danlos Syndrome Results from Mutations in the COL1A2 Gene That Activate the Nonsense-Mediated RNA Decay Pathway.2004
- Author(s)
  U.Schwarze, R-I.Hata, V.A.McKusick, H.Shinkai, H.E.Hoyme, R.E.Pyeritz, P.H.Byers
- Journal Title
  
  Am J Hum.Genet 74
  
  Pages: 917-930
- Data Source
  KAKENHI-PROJECT-15591168
[Journal Article] Matrix Metalloproteinase 9 Expression is Coordinately Modulated by the KRE-M9 and 12-O-Tetradecanoyl-Phorbol-13-Acetate Responsive Elements2004
- Author(s)
  Kobayashi T, Kishimoto J, Hattori S, Wachi H, Shinkai H, Burgeson R.E.
- Journal Title
  
  J Invest Dermatol 122
  
  Pages: 278-285
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591168
[Journal Article] Rare Autosomal Recessive Cardiac Valvular From of Ehlers-Danols Syndrome Results from Mutations in the COL1A2 Gene That Activate the Nonsense-Mediated RNA Decay Pathway.2004
- Author(s)
  U.Schwarze, R-I.Hata, V.A.McKusick, H.Shinkai, H.E.Hoyme, R.E.Pyeritz, P.H.Byers
- Journal Title
  
  Am J Hum.Genet 74
  
  Pages: 917-930
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591168
[Journal Article] Localization of laminin a4 chain in the skin and identification of a heparin-dependent cell adhesion site within the laminin a4 chain C-terminal LG4 module2004
- Author(s)
  H.Matsuura, Y.Momota, K.Murata, H.Matsushima, N.Suzuki, M.Nomizu, H.Shinkai, A.Utani
- Journal Title
  
  J Invest Dermatol 122
  
  Pages: 614-620
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591168
[Journal Article] Rare Autosomal Recessive Cardiac Valvular Form of Ehlers-Danlos Syndrome Results from Mutations in the COL1A2 Gene That Activate the Nonsense-Mediated RNA Decay Pathway.2004
- Author(s)
  U.Schwarze, R-I.Hata, V.A.McKusick, H.Shinkai, H.E.Hoyme, R.E.Pyeritz, P.M.Byers
- Journal Title
  
  Am J Hum.Genet 74
  
  Pages: 917-930
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591168
[Journal Article] Matrix Metalloproteinase 9 Expression is Coordinately Modulated by the KRE-M9 and 12-O-Tetradecanoyl-Phorbol-13-Acetate Responsive Elements2004
- Author(s)
  Kobayashi T, KishimotoJ, HattoriS, Wachi H, Shinkai H, Burgeson R.E.
- Journal Title
  
  J Invest Dermatol 122
  
  Pages: 278-285
- Data Source
  KAKENHI-PROJECT-15591168
[Journal Article] A unique point mutation in the NSDHL gene in a Japanese patient with CHILD syndrome.2003
- Author(s)
  Murata K, Shinkai H, Ishikiriyama S, Yamazaki M, Fukuzumi Y, Hatamochi A.
- Journal Title
  
  J Dermatol Sci. 33(1)
  
  Pages: 67-69
- NAID
  50000330899
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570799
[Journal Article] Matrix metalloproteinase-2 and -9 are secreted from human fibroblasts2003
- Author(s)
  Kobayashi T, Hattori S, Shinkai H.
- Journal Title
  
  Acta Derm Venereol. 83
  
  Pages: 105-107
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591168
[Journal Article] Matrix metalloproteinases-2 and -9 aresecreted from human fibroblasts2003
- Author(s)
  Kobayashi T, Hattori S, Shinkai H.
- Journal Title
  
  Acta Derm Venereol. 83
  
  Pages: 105-107
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591168
[Journal Article] Increased procollagen alpha 1 (I) mRNA expression of dermal fibroblasts on melorheostosis.2003
- Author(s)
  Endo H, Katsumi A, Kuroda K, Utani A, Moriya H, Shinkai H
- Journal Title
  
  Br J Dermatol. 148
  
  Pages: 799-803
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591168
[Journal Article] Laminin alpha 3 LG4 module induces matrix metalloproteinase-1 (MMP-1) through MAPK signaling2003
- Author(s)
  Utani A, Momota Y, Endo H, Kasuya Y, Beck K, Suzuki N, Nomizu M, Shinkai H.
- Journal Title
  
  J Biol Chem. 278
  
  Pages: 34483-34490
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591168
[Journal Article] Laminin alpha 3 LG4 module induces matrix metalloproteinase-1(MMP-1) through MAPK signaling2003
- Author(s)
  Utani A, Momota Y, Endo H, Kasuya Y, Beck K, Suzuki N, Nomizu M, Shinkai H.
- Journal Title
  
  J Biol Chem. 278
  
  Pages: 34483-34490
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591168
[Journal Article] Ehlers-Danlos syndrome type IV with few extrathoracic findings : a newly recognized point mutation in the COL3A1 gene.2002
- Author(s)
  Watanabe A, Kawabata Y, Okada O, Tanabe N, Kimura H, Hatamochi A, Shinkai H, Sakai N, Shimada T, Hiroshima K, Kuriyama T.
- Journal Title
  
  Eur Respir J. 19(1)
  
  Pages: 195-198
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570799

1. HATAMOCHI Atsushi (90172923)

# of Collaborated Projects: 9 results

# of Collaborated Products: 2 results
2. KURODA Kei (90225300)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
3. ENDO Hideji (50282489)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
4. FUJIWARA Sakuhei (90181411)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
5. TSUKIFUJI Reiko (70218048)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
6. UTANI Atsushi (10292707)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
7. KATAGIRI Kazumoto (00204420)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 坂井靖夫 (50272315)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. HONDA Tomohito (80173665)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. MATSUNAGA Etsuji (00145400)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 永井裕 (90013812)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 早川太郎 (80064822)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 鈴木旺 (50022504)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. 藤本大三郎 (40004288)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. 藤田拓男 (30009964)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. YAMAZAKI Soji (80008333)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. SATO Madoka (90364538)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. SAKAI Tsukasa (80215590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. 長橋美江 (40258231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 愛甲隆昭 (30258230)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 渡辺圭介 (80268606)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 植木宏明 (30069017)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 鎌田憲明 (00334186)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 中村康博 (80323418)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SHINKAI Hiroshi 新海 浤

新海 宏 シンカイ ヒロシ

Research Projects

Research Products

Co-Researchers

Collagen fibrillogenesisPrincipal Investigator

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COLLAGEN FIBRILLOGENESISPrincipal Investigator

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COLLAGEN FIBRILLOGENESISPrincipal Investigator

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Analysis of Fibrillogenesis for Inactivation of TGF-beta by DecorinPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

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コラーゲン線維化におけるデルマトポンチン(新しい細胞外マトリックス成分)の機能Principal Investigator

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コラーゲン線維形成における新しい細胞外マトリックスタンパク質の機能と性状Principal Investigator

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Principal Investigator

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Isolation of novel extracellualr matrix component and its function related with tissue fragilityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

SHINKAI Hiroshi 新海浤

新海宏シンカイヒロシ