KURODA Yoshihiro 黒田義弘

Researcher Number	90093236
Other IDs
Affiliation (based on the past Project Information) *help	2016: 姫路獨協大学, 薬学部, 特別教授 2010 – 2015: 姫路獨協大学, 薬学部, 教授 2007: Himeji Dokkyo University, Faculty of Pharmaceutical Sciences, Professor 2006: 京都大学, 薬学研究科, 助教授 1997 – 2004: 京都大学, 薬学研究科, 助教授 … More 1999: 京都大学, 大学院・薬学研究科, 助教授 1987 – 1988: 京都大学, 薬学部, 助手 1986: 京大, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Physical pharmacy / Physical pharmacy / Biological pharmacy Except Principal Investigator Physical pharmacy / Periodontal dentistry / Periodontology
Keywords	Principal Investigator EGFR / オリゴペプチド / oligopeptide / 局所麻酔薬 / ジブカイン / CDスペクトル / KIFMK / KIYEK / NYQQN / EGFR, IGF1R, 阻害ペプチド … More / 細胞膜透過性 / チロシンキナーゼ / IGF1R / 阻害ペプチド / ATP非競合的作用機序 / 細胞増殖 / 細胞毒性 / カスパーゼ3活性 / ナトリウムチャンネル / 不活性化ゲート / ペプチド / 相互作用 / NMRスペクトル / ミセル / フォスファチジルセリン / リポソーム / Sodium channel / Inactivation gate / Peptide / Local anesthetics / Dibucaine / Interaction / NMR spectrum / CD spectrum / アルツハイマー病 / プリオン病 / パーキンソン病 / αヘリックス / βシート / アミロイド線維 / Altzheimer disease / Prion disease / Parkinson's disease / α helix / β sheet / amyloid / CD spectra / 局所麻酔剤 / リドカイン / インスリン受容体 / リン酸化抑制 / 脱リン酸化 / local anesthetics / lidocaine / insulin receptor / suppression of phosphorylation / dephosphorylation / 上皮増殖因子受容体 / 自己リン酸化 / ATP非競合阻害剤 / ドッキングシミュレーション / 疑似基質 / 阻害剤 / 擬似基質 / epidermal growth factor receptor / autophosphorylation / ATP-non・competitive inhibitor / docking simulation / psuedosubstrate / テトラカイン / 二次元NMR / 核オーバーハウザー効果 / リン脂質 / ベシクル / ウィンドウ関数 / サインベル関数 / フォスファチジルコリン / 膜の運動性 / 関数処理 / Two-dimensional NMR / Window Function / Nuclear Overhauser Effect / Lipid Bilayer Vesicles / Spin Diffusion / Local Anesthetic / Tetracaine … More Except Principal Investigator 歯肉上皮細胞 / 歯周病 / apo A-1 / EGFR / 歯肉線維芽細胞 / CCL17 / CCL22 / ＢＡＦＦ / ＡＰＲＩＬ / IL-22 / 細胞内侵入細菌 / ＩＬ－２２ / P.gingivalis / 歯周病細菌 / 抗菌ペプチド / 糖タンパク質糖鎖 / 薬物・タンパク結合解析 / 糖鎖ミクロ不均一性 / 高速先端分析法 / 電子スプレー型飛行時間質量分析 / Naチャンネル蛋白 / プリオン蛋白 / glycochain / plasma protein binding / microheterogeneity / high-performance frontal analysis / ESI-T0F-MS / sodium channel inactivation gate peptide / prion protein / capillary electrophoresis / 表面プラズモン共鳴 / 生体超分子集合体 / 高次微細構造 / 高性能先端分析法 / 低密度リポタンパク質 / アミロイド / モンテカルロ計算 / 表面ブラズモン共鳴 / apoA-1 / 表面プラスモン共鳴 / 低密度血漿リポタンパク質 / 脂質2分子層 / 血漿アポリポタンパク質 / レセプター / アルツハイマー / シミュレーション / SPR / Biosuper molecular Assembly / Highly fine structure / high performance fromtall Analysis / low density lipo-protein / any loid / Monte Carlo-cal Less

Effect of IL-22 on immune response against periodontal bacteria
- Principal Investigator
  
  Kato-kogoe Nahoko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontology
- Research Institution
  Osaka Medical College
  Hyogo College of Medicine
The effect of EGF receptor pathway on cytokine production in gingival fibroblasts
- Principal Investigator
  
  KOGOE Nahoko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Himeji Dokkyo University
The inhibitory potency of peptides derived from autophosphorylation sites of receptor tyrosine kinase in a non-ATP-competitive mechanism on tumor cells.Principal Investigator
- Principal Investigator
  
  KURODA Yoshihiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Himeji Dokkyo University
Studies on inhibitors for epidermal growth factor receptor based on oligopeptides which imitated pseudosubstratesPrincipal Investigator
- Principal Investigator
  
  KURODA Yoshihiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Himeji Dokkyo University
  Kyoto University
Mechanisms of suppression of insulin signaling by Na channel blockersPrincipal Investigator
- Principal Investigator
  
  KURODA Yoshihiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  KYOTO UNIVERSITY
Structural investigations for developing the rapeutics of Altzheimer, prion, and Parkinson's diseasePrincipal Investigator
- Principal Investigator
  
  KURODA Yoshihiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  KYOTO UNIVERSITY
医薬品化学領域における生体超分子集合体の高次微細構造と機能に関する研究
- Principal Investigator
  
  TAGA Tooru
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  KYOTO UNIVERSITY
Development of fine micro analytical method of drug recognition function of sugar chains
- Principal Investigator
  
  NAKAGAWA Terumichi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Physical pharmacy
- Research Institution
  KYOTO UNIVERSITY
Structural investiga tions for developing therapeutics of functional disorders due to the sodium channelPrincipal Investigator
- Principal Investigator
  
  KURODA Yoshihiro
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  KYOTO UNIVERSITY
Two-dimensional nuclear magnetic resonance spectroscopic studies on the interactions between membranes and drugsPrincipal Investigator
- Principal Investigator
  
  KURODA Yoshihiro
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto University

All 2015 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Suppressive effect of membrane-permeable peptides derived from autophosphorylation sites of the IGF-1 receptor on breast cancer cells.2015
- Author(s)
  Kuroda Y, Kato-Kogoe N, Tasaki E, Yuasa-Sunagawa M, Yamanegi K, Nakasyo K, Nakase I, Futaki S, Tohyama Y, Hirose M
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 765 Pages: 24-33
- DOI
  10.1016/j.ejphar.2015.08.004
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460405, KAKENHI-PROJECT-26463151
[Journal Article] Oligopeptides derived from autophosphorylation sites of EGF receptor suppress EGF-stimulated responses in human lung carcinoma A549 cells.2013
- Author(s)
  Kuroda Y, Kato-Kogoe N, Tasaki E, Murata E, Ueda K, Abe M, Miyamoto K, Nakase I, Futaki S, Tohyama Y, Hirose M.
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 5 Pages: 87-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590076
[Journal Article] Oligopeptides derived from autophosphorylation sites of EGF receptor suppress EGF-stimulated responses in human lung carcinoma A549 cells2013
- Author(s)
  Kuroda Y, Kato-Kogoe N, Tasaki E, Murata M, Ueda K, Abe M, Miyamoto K, Nakase I, Futaki S, Tohyama Y, Hirose M
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 698 Pages: 87-94
- DOI
  10.1016/j.ejphar.2012.10.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390297, KAKENHI-PROJECT-22590076, KAKENHI-PROJECT-23590374, KAKENHI-PROJECT-23593077, KAKENHI-PROJECT-23700588, KAKENHI-PROJECT-23790129
[Journal Article] Effects of TrkA inhibitory peptide on cancer-induced pain in a mouse melanoma model.2012
- Author(s)
  Tabata M, Murata E, Ueda K, Kato-Kogoe N, Kuroda Y, Hirose M.
- Journal Title
  
  J Anesth.
  
  Volume: in press
- NAID
  10031070301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23593077
[Presentation] IGF-1Rの自己リン酸化部位由来ペプチドがMCF-7ヒト乳がん細胞に及ぼす影響2013
- Author(s)
  黒田義弘,小越菜保子,田崎絵美,中瀬生彦,二木史朗,通山由美,廣瀬宗孝
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2013-09-11
- Data Source
  KAKENHI-PROJECT-23593077
[Presentation] 細胞透過性オリゴペプチドによるA549ヒト肺線がん細胞に体する細胞増殖抑制、細胞毒性、及びアポトーシスへの影響2011
- Author(s)
  黒田義弘、村田恵理、上田康陽、田崎絵美、小越菜保子、阿部峰大、宮本和英、中瀬生彦、二木史朗、通山由美、廣瀬宗孝
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-22590076
[Presentation] EGFRの自己リン酸化部位由来ペプチドのA549ヒト肺腺がん細胞における効果2011
- Author(s)
  黒田義弘,村田恵理,上田康陽,田崎絵美,小越菜保子,阿部峰大,宮本和英,中瀬生彦,二木史朗,通山由美,廣瀬宗孝
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-23593077
[Presentation] 細胞透過性オリゴペプチドによるA549ヒト肺腺がん細胞に対する細胞増殖抑制、細胞毒性、及びアポトーシスへの影響2011
- Author(s)
  黒田義弘
- Organizer
  日本薬学会第131年会
- Place of Presentation
  ツインメッセ静岡(静岡市)
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-22590076
[Presentation] EGFRの自己リン酸化部位由来ペプチドの A549ヒト肺腺がん細胞における効果2011
- Author(s)
  黒田義弘，村田恵理，上田康陽，田崎絵美，小越菜保子，阿部峰大，宮本和英，中瀬生彦，二木史朗，通山由美，廣瀬宗孝
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館(京都)
- Data Source
  KAKENHI-PROJECT-23593077
[Presentation] EGFRの自己リン酸化部位由来ペプチドのA549ヒト肺腺がん細胞における効果2011
- Author(s)
  黒田義弘
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館(京都)
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22590076
[Presentation] EGFRの自己リン酸化部位由来ペプチドのA549ヒト肺腺がん細胞における効果.2011
- Author(s)
  黒田義弘、村田恵理、上田康陽、田崎絵美、小越菜保子、阿部峰大、宮本和英、中瀬生彦、二木史朗、通山由美、廣瀬宗孝
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22590076
[Presentation] IGF-1Rの自己リン酸化部位由来ペプチドがMCF-7ヒト乳がん細胞に及ぼす影響
- Author(s)
  黒田義弘
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23593077

1. KOGOE Nahoko (60509115)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. NAKAGAWA Terumichi (70025708)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. OHYAMA Hideki (90280685)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. SHIBUKAWA Akimasa (30170913)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TAGA Tooru (00025694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. HONDA Tetsuro (00025719)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MATSUMOTO Osamu (10231599)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 中山真彰 (10579105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 山根木康嗣 (00434944)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 山田直子 (10319858)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 通山由美

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 廣瀬宗孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 宮本和英

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 中瀬生彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KURODA Yoshihiro 黒田 義弘

Research Projects

Research Products

Co-Researchers

Effect of IL-22 on immune response against periodontal bacteria

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effect of EGF receptor pathway on cytokine production in gingival fibroblasts

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The inhibitory potency of peptides derived from autophosphorylation sites of receptor tyrosine kinase in a non-ATP-competitive mechanism on tumor cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on inhibitors for epidermal growth factor receptor based on oligopeptides which imitated pseudosubstratesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of suppression of insulin signaling by Na channel blockersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural investigations for developing the rapeutics of Altzheimer, prion, and Parkinson's diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

医薬品化学領域における生体超分子集合体の高次微細構造と機能に関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of fine micro analytical method of drug recognition function of sugar chains

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural investiga tions for developing therapeutics of functional disorders due to the sodium channelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Two-dimensional nuclear magnetic resonance spectroscopic studies on the interactions between membranes and drugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Suppressive effect of membrane-permeable peptides derived from autophosphorylation sites of the IGF-1 receptor on breast cancer cells.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oligopeptides derived from autophosphorylation sites of EGF receptor suppress EGF-stimulated responses in human lung carcinoma A549 cells.2013

Author(s)

Journal Title

Data Source

[Journal Article] Oligopeptides derived from autophosphorylation sites of EGF receptor suppress EGF-stimulated responses in human lung carcinoma A549 cells2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of TrkA inhibitory peptide on cancer-induced pain in a mouse melanoma model.2012

Author(s)

KURODA Yoshihiro 黒田義弘