NAKAJIN Shizuo 中陳静男

… Alternative Names

中陳静男ナカジンシズオ

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Researcher Number	90101576
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2009 – 2010: Hoshi University, 薬学部, 教授 2008: Hoshi University, 星薬科大学・薬学部, 教授 2004 – 2007: 星薬科大学, 薬学部, 教授 2001: Hoshi University, Faculty of pharmaceutical sciences, Professor, 薬学部, 教授 2000: 星薬科大学, 薬学部, 助教授 1988: 星薬科大学, 薬学部, 助教授 1986: 星薬大, 薬学部, 助教授
Review Section/Research Field	Principal Investigator Environmental pharmacy / Biological pharmacy / Environmental pharmacy
Keywords	Principal Investigator 環境化学物質 / 精巣 / Enzyme / Phthalate esters / Estrogen / Gene / Environment / 酵素 / フタル酸エステル / エストロゲン … More / 遺伝子 / 環境 / Endocrine / Steroid / Sex-hormone / Environmental chemicals / 内分泌 / ステロイド / 性ホルモン / environmental chemical / cell culture / steroidgenesis / endocrine disruptors / steroid hormone / adrenal carcinoma cell / human / ステロイドホルモン産生 / 有機スズ化合物 / steroidogenesis / 細胞培養 / 内分泌かく乱化学物質 / ステロイドホルモン / 副腎 / ヒト / 内分泌機能 / 20β-HSD / 酵素科学的性質 / 20β-ヒドロキシステロイド脱水素酵素 / 卵胞ホルモン / チトクロームP-450 / アロマターゼ / ミクロソーム / ヒト胎盤 / アイソザイム / 分子多様性 / 11β-HSD / 精子形成 / ライディッヒ細胞 / テストステロン / ストレス Less

Molecular diversity of 11β-HSDs involved in a protection mechanism from the stress-mediated suppression of testosterone productionPrincipal Investigator
- Principal Investigator
  
  NAKAJIN Shizuo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Hoshi University
Effect of Phthalate Esters on the Expression of Aromatase and Its Action MechanismPrincipal Investigator
- Principal Investigator
  
  NAKAJIN Shizuo
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Hoshi University
Basic investigation on influence of environmental chemicals on Sex-steroid hormone secretionPrincipal Investigator
- Principal Investigator
  
  NAKAJIN Shizuo
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Hoshi University School of Pharmacy and Pharmaceutical Sciences
Effect of environmental chemicals on steroidogenesis in human adrenal carcinoma cellPrincipal Investigator
- Principal Investigator
  
  NAKAJIN Shizuo
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Hoshi University
精巣20β-ヒドロキシステロイド脱水素酵素の諸性質と内分泌機能への関与Principal Investigator
- Principal Investigator
  
  中陳静男
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hoshi University
純化されたヒト胎盤アロマターゼの酵素化学的性質Principal Investigator
- Principal Investigator
  
  中陳静男
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hoshi University

All 2010 2008 2007 2006 2005 2004

All Journal Article Presentation

[Journal Article] Sequence and expression of 11β-hydroxysteroid dehydrogenase type 1 cDNA cloned from pig testis2010
- Author(s)
  Ohno S., Ohta M., Honda Y., Nakajin S.
- Journal Title
  
  Mol. Cell. Biochem. 338
  
  Pages: 149-156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590125
[Journal Article] Quantitative determination and tissue distribution of human 11β-hydroxysteroid dehydrogenase, hexose-6-phosphate dehydrogenase, glucose-6-phosphate transporter, glucocorticoid receptor and mineralocorticoid receptor mRNAs, Horm.2010
- Author(s)
  S.Ohno, M.Ohta, S.Nakajin
- Journal Title
  
  Mol.Biol.Clin.Invest. 2(1)
  
  Pages: 219-226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590125
[Journal Article] Quantitative determination and tissue distribution of human 11β-hydroxysteroid dehydrogenase, hexose-6-phosphate dehydrogenase, glucose-6-phosphate transporter, glucocorticoid receptor and mineral ocorticoid receptor mRNAs2010
- Author(s)
  S.Ohno, M.Ohta, S.Nakajin
- Journal Title
  
  Horm.Mol.Biol.Clin.Invest.
  
  Volume: 2 Pages: 219-226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590125
[Journal Article] Sequence and expression of 11β-hydroxysteroid dehydrogenase type 1 cDNA cloned from pig testis2010
- Author(s)
  S.Ohno, M.Ohta, Y.Honda, S.Nakajin
- Journal Title
  
  Mol.Cell.Biochem. 338(1-2)
  
  Pages: 149-156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590125
[Journal Article] Leydig cells from neonatal pig testis abundantly express 11β-hydroxysteroid dehydrogenase (11β-HSD) type 2 and effectively inactivate cortisol to cortisone2008
- Author(s)
  Y.Honda, S.Ohno, S.Nakajin
- Journal Title
  
  J.Steroid Biochem.Molec.Biol. 108(1-2)
  
  Pages: 91-101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590125
[Journal Article] Leydig cells from neonatal pig testis abundantly express 11β-hydroxysteroid dehydrogenase (11β-HSD) type 2 and effectively inactivate cortisol to cortisone2008
- Author(s)
  Y. Honda, S. Ohno, S. Nakajin
- Journal Title
  
  J. Steroid Biochem. Mol. Biol. 108
  
  Pages: 91-108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590125
[Journal Article] Mono-(2-ethylhexyl)phthalate(MEHP)induces nuclear receptor 4A subfamily in NCI-H295R cells:A possible mechanism of aromatase suppression by MEHP2007
- Author(s)
  M.Noda, S.Ohno, S.Nakajin
- Journal Title
  
  Mol.Cell.Endocrinol. 274
  
  Pages: 8-18
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590121
[Journal Article] Mono-(2-ethylhexyl) phthalate(MEHP) induces nuclear receptor 4A subfamily in NCI-H295R cells : A possible mechanism of aromatase suppression by MEHP2007
- Author(s)
  M. Noda, S. Ohno, S. Nakajin
- Journal Title
  
  Mol. Cell. Endocrinol. 274
  
  Pages: 8-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590121
[Journal Article] Mono-(2-ethylhexyl)phthalate(MEHP)induces nuclear receptor 4A subfamily in NCI-H295R cells:A possible mechanism of aromatase suppression by MEHP2007
- Author(s)
  M.Noda, S.Ohno, S.Nakajin
- Journal Title
  
  Mol.Cell.Endocrinol 188
  
  Pages: 8-18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590121
[Journal Article] Effect of epidermal growth factor and prostagrandin on the expression of aromatase (CYP19) in human adrenocortical carcinoma cell line NCI-H295R cells2006
- Author(s)
  M.Watanabe, M.Noda, S.Nakajin
- Journal Title
  
  J.Endocrinol. 188(1)
  
  Pages: 59-68
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590095
[Journal Article] Effect of epidermal growth factor and prostagrandin on the expression of aromatase(CYP19) in human adrenocortical carcinoma cell line NCI-H295R cells2006
- Author(s)
  M. Watanabe, M. Noda, S. Nakajin
- Journal Title
  
  J. Endocrinol. 188
  
  Pages: 59-68
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590121
[Journal Article] Effect of epidermal growth factor and prostagrandin on the expression of aromatase (CYP19) in human adrenocortical carcinoma cell line NCI-H295R cells2006
- Author(s)
  M Watanabe, M.Noda, S.Nakajin
- Journal Title
  
  J.Endocrinol. 188(1)
  
  Pages: 59-68
- Data Source
  KAKENHI-PROJECT-16590095
[Journal Article] Effect of epidermal growth factor and prostagrandin on the expression of aromatase(CYP19)in human adrenocortical carcinoma cell line NCI-H295R cells2006
- Author(s)
  M Watanabe, M.Noda S.Nakajin
- Journal Title
  
  J.Endocrinol. 188
  
  Pages: 59-68
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590121
[Journal Article] Effect of epidermal growth factor and prostagrandin on the expression of aromatase(CYP19)in human adrenocortical carcinoma cell line NCI-H295R cells2006
- Author(s)
  M.Watanabe, M.Noda, S.Nakajin
- Journal Title
  
  J. Endocrinol. 188(1)
  
  Pages: 59-68
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590095
[Journal Article] Tributyltin chloride suppresses the P450cl7 transcription involved in testosterone production induced by gonadotropin stimulation in cultured pig Leydig cells2005
- Author(s)
  Y.Nakajima, G.Sato, S.0hno, S.Nakajin
- Journal Title
  
  Environmental Toxicol. Pharmacol. 20
  
  Pages: 11-17
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590095
[Journal Article] Triphenyltin and Tributyltin inhibit pig testicular 17β-hydroxysteroid dehydrogenase activity and suppress testicular testosterone biosynthesis2005
- Author(s)
  S.Ohno, Y.Nakajima, S.Nakajin
- Journal Title
  
  Steroids 70
  
  Pages: 645-651
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590095
[Journal Article] Tributyltin chloride suppresses Hie P450c17 transcription involved in testosterone production induced by gonadotropin stimulation in cultured pig Leydig cells2005
- Author(s)
  Y.Nakajima, G.Sato, S.Ohno, S.Nakajin
- Journal Title
  
  Environmental Toxicol.Pharmacol. 20
  
  Pages: 11-17
- Data Source
  KAKENHI-PROJECT-16590095
[Journal Article] Tributyltin chloride suppresses the P450cl7 transcription involved in testosterone production induced by gonadotropin stimulation in cultured pig Leydig cells2005
- Author(s)
  Y.Nakajima, G.Sato, S.Ohno, S.Nakajin
- Journal Title
  
  Environmental Toxicol.Pahrmacol. 20
  
  Pages: 11-17
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590095
[Journal Article] Forskolin up-regulates the aromatase (CYP19) activity and gene transcript in the human adrenocortical carcinoma cell line H295R2004
- Author(s)
  M.Watanabe, S.Nakajin
- Journal Title
  
  J.Endocrinol. 180(1)
  
  Pages: 125-133
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590095
[Journal Article] 性ホルモン産生に及ぼす内分泌撹乱化学物質の影響2004
- Author(s)
  中陳静男, 大野修司
- Journal Title
  
  FOOD INGREDIENTS JOURNAL OF JAPAN 2009,(8)
  
  Pages: 638-647
- NAID
  40006391334
- Data Source
  KAKENHI-PROJECT-16590095
[Journal Article] 性ホルモン産生に及ぼす内分泌撹乱化学物質の影響2004
- Author(s)
  中陳静男, 大野修司
- Journal Title
  
  FFIジャーナル 2009(8)
  
  Pages: 638-647
- NAID
  40006391334
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590095
[Journal Article] Effect of endocrine disruptors on sex-hormone production2004
- Author(s)
  S.Nakajin, S.Ohno
- Journal Title
  
  Foods Food Ingredients J.Jpn. 209(8)
  
  Pages: 638-647
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590095
[Journal Article] Forskolin up-regulates the aromatase(CYP19)activity and gene transcript in the human adrenocortical carcinoma cell line H295R2004
- Author(s)
  M.Watanabe, S.Nakajin
- Journal Title
  
  J. Endocrinol. 180(1)
  
  Pages: 125-133
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590095
[Presentation] ブタ11β-HSD type 1 cDNAの新規配列とその発現2010
- Author(s)
  大田正規、本田容子、大野修司、中陳静男
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20590125
[Presentation] ブタ11β-HSD type 1 cDNAの新規配列とその発現2010
- Author(s)
  大田正規、本田容子、大野修司、中陳静男
- Organizer
  日本薬学会大130年会
- Place of Presentation
  桃太郎アリーナ(岡山)
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-20590125
[Presentation] EGFによるヒト副腎腫瘍由来細胞株のアロマターゼ発現誘導への核内レセプターNR4A関与の可能性2007
- Author(s)
  野田万理子、中陳静男
- Organizer
  第51回日本薬学会関東支部学会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590121
[Presentation] EGFによるヒト副腎腫瘍由来細胞株のアロマターゼ発現誘導への核内レセプターNR4A関与の可能性2007
- Author(s)
  野田万理子、中陳静男
- Organizer
  第51回日本薬学会関東支部学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18590121
[Presentation] Contribution of nuclear receptor 4A on the expression of aromatase by EGF in human adrenocortical carcinoma cell line2007
- Author(s)
  M. Noda, S. Nakajin
- Organizer
  Annual Meeting of The Pharmaceutical Society of Japan, Kanto Branch
- Place of Presentation
  Tokyo, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590121
[Presentation] Possible new action mechanism of aromatase suppressin by MEHP exposure in NCI-H295R cells2006
- Author(s)
  M. Noda, S. Ohno, S. Nakajin
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
- Place of Presentation
  Kyoto, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590121
[Presentation] Possible new action mechanism of aromatase suppression by MEHP exposure in NCI-H295R cells2006
- Author(s)
  M.Noda, S.Ohno, S.Nakajin
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
- Place of Presentation
  Kyoto,Japan
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590121

1. OHNO Shuji (20233223)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results

NAKAJIN Shizuo 中陳 静男

中陳 静男 ナカジン シズオ

Research Projects

Research Products

Co-Researchers

Molecular diversity of 11β-HSDs involved in a protection mechanism from the stress-mediated suppression of testosterone productionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of Phthalate Esters on the Expression of Aromatase and Its Action MechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic investigation on influence of environmental chemicals on Sex-steroid hormone secretionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of environmental chemicals on steroidogenesis in human adrenal carcinoma cellPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

精巣20β-ヒドロキシステロイド脱水素酵素の諸性質と内分泌機能への関与Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

純化されたヒト胎盤アロマターゼの酵素化学的性質Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Sequence and expression of 11β-hydroxysteroid dehydrogenase type 1 cDNA cloned from pig testis2010

Author(s)

Journal Title

Data Source

[Journal Article] Quantitative determination and tissue distribution of human 11β-hydroxysteroid dehydrogenase, hexose-6-phosphate dehydrogenase, glucose-6-phosphate transporter, glucocorticoid receptor and mineralocorticoid receptor mRNAs, Horm.2010

Author(s)

Journal Title

Data Source

[Journal Article] Quantitative determination and tissue distribution of human 11β-hydroxysteroid dehydrogenase, hexose-6-phosphate dehydrogenase, glucose-6-phosphate transporter, glucocorticoid receptor and mineral ocorticoid receptor mRNAs2010

Author(s)

Journal Title

Data Source

[Journal Article] Sequence and expression of 11β-hydroxysteroid dehydrogenase type 1 cDNA cloned from pig testis2010

Author(s)

Journal Title

Data Source

[Journal Article] Leydig cells from neonatal pig testis abundantly express 11β-hydroxysteroid dehydrogenase (11β-HSD) type 2 and effectively inactivate cortisol to cortisone2008

Author(s)

Journal Title

Data Source

[Journal Article] Leydig cells from neonatal pig testis abundantly express 11β-hydroxysteroid dehydrogenase (11β-HSD) type 2 and effectively inactivate cortisol to cortisone2008

Author(s)

Journal Title

Data Source

[Journal Article] Mono-(2-ethylhexyl)phthalate(MEHP)induces nuclear receptor 4A subfamily in NCI-H295R cells:A possible mechanism of aromatase suppression by MEHP2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Mono-(2-ethylhexyl) phthalate(MEHP) induces nuclear receptor 4A subfamily in NCI-H295R cells : A possible mechanism of aromatase suppression by MEHP2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Mono-(2-ethylhexyl)phthalate(MEHP)induces nuclear receptor 4A subfamily in NCI-H295R cells:A possible mechanism of aromatase suppression by MEHP2007

Author(s)

Journal Title

Data Source

[Journal Article] Effect of epidermal growth factor and prostagrandin on the expression of aromatase (CYP19) in human adrenocortical carcinoma cell line NCI-H295R cells2006

NAKAJIN Shizuo 中陳静男

中陳静男ナカジンシズオ