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HAYASHI Toshiharu  林 俊春

ORCIDConnect your ORCID iD *help
… Alternative Names

林 俊春  ハヤシ トシハル

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Researcher Number 90111484
Other IDs
Affiliation (based on the past Project Information) *help 2009 – 2011: Yamaguchi University, 農学部, 教授
1998 – 2007: 山口大学, 農学部, 教授
1995 – 1996: Yamaguchi University, Faculty of Agriculture, Professor, 農学部, 教授
1994: 山口大学, 農学部, 助教授
1990: 山口大学, 農学部, 助教授
1986 – 1988: 東京大学, 農学部, 助手
Review Section/Research Field
Principal Investigator
Applied veterinary science / Basic veterinary science/Basic zootechnical science / Applied veterinary science / Basic veterinary science/Basic zootechnical science / Clinical veterinary science
Except Principal Investigator
Applied veterinary science / 基礎獣医学 / Basic veterinary science/Basic zootechnical science
Keywords
Principal Investigator
Th2 / Th1 / 自己免疫疾患 / ループス / 遺伝子治療 / 環境因子 / レオウイルス2型 / CD4^+CD25^+T cell / Gene therapy / Insulitis … More / 膵島炎 / レオウイルス / 自己寛容 / 喘息 / 全身性エリテマトーデス / 遅発型 / 乳酸脱水素酵素ウイルス / アレルギー / インスリン依存型糖尿病 / autoimmune diseases / tolerance / lupus / diabetes / 治療 / 接着分子 / ウイルス / CpGモチーフ / CD4^+D25^+T細胞 / 糖尿病 / Autoimmune diabetes / Reovirus type-2 / アレルギー性気管支炎 / ラミニン / 唾液腺炎 / 自己免疫 / レオウイルスー2型 / DNAワクチン / IL-12 / IL-18 / IL-4 / インターフェロンーガンマ / 自己免疫性糖尿病 / gene / reovirus / cloning / Th1 cell / epizootiology / Ibaraki virus / equine herpes virus / lactic dehydrogenase virus / IFN-Υ / 膵島細胞破壊 / マウスモデル / 遺伝子 / クローニング / Th1細胞 / 疫学 / イバラキウイルス / 馬ヘルペスウイルス / SLE / Streptozotocin / Autoimmune disease / type 2 reovirus / LFA-I / ICAM-I / IDDM / 血管内皮細胞 / LDV / 2型レオウイルス / LFA-1 / I型糖尿病 / ICAM-1 / ストレプトゾトシン / β細胞 / メカニズム / 概念 / 好酸球性血管炎 / 腸 / インターフェロンγ / Niche / 病理発生 / アレルギー性喘息 / モデル / シェーグレン症候群 / 1型糖尿病 / Th2バランス / 抗原提示 / 自然食品 / 気管支炎 / 病態 / Th2反応 / 皮膚炎 / 遅発型反応 / 即時型反応 / 鼻炎 / ヒドロキシルラジカル / Dimethylthiourea / 膵島細胞傷害 / マウス / 耐糖能異常 … More
Except Principal Investigator
FIP / CPI-17 / IL-1β / 犬 / Canine filariasis / Cat / Dod / Animals / 発生率 / フィラリヤ / 腎炎 / 犬フィラリア症 / 猫 / 家畜 / macrophage / gastrointestinal motility / Inflammatory Bowel Disease / ミオシンフォスファターゼ / ミオシンリン酸化 / 収縮 / サイトカイン / 1L-1β / プロテアーゼ受容体2 / マクロファージ / 消化管運動 / 潰瘍性大腸炎 / sialyl lewis X antigen / E-selecin / bovine leukemia / glycan chain / L-selectin / monoclonal antibody / α1-acid glycoprotein / シアソルルイスX抗原 / シアリルルイスX抗原 / E-セレクチン / 牛白血病 / 糖鎖 / L-セレクチン / モノクローナル抗体 / α1酸性糖蛋白 / JOINT / NASAL,PARANASAL AND ORAL CAVITY / BRAIN AND SPINAL CORD / DOG / COW AND HORSE / SYSTEMATIC TREE FOR DIAGNOSTIC IMAGING / PERMANENT MAGNETIC TYPE MRI / VETERINARY DIAGNOSTIC IMAGING / 放射線学的評価 / 運動器疾患 / 胸腹部疾患 / 神経疾患 / 診断システム / 画像診断 / 獣医学 / 鼻腔、副鼻腔、口腔 / 関節 / 鼻腔・副鼻腔・口腔 / 脳・脊髄 / 牛・馬 / 体系的画像診断システム / 永久磁石型MRI / 獣医画像診断 / 腸炎 / 肝炎 / Tyzzer病 / スナネズミ / CD8 / CD4 / インターロイキン4 / インターロイキン2 / 豚リンパ球 / エンドトキシン / インタ-ロイキン / 乳酸脱水素酵素ウイルス / マウス / マクロファ-ジ Less
  • Research Projects

    (14 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (19 People)
  •  Destruction of niche and target-cells in autoimmune diseases by effector cells and moleculesPrincipal Investigator

    • Principal Investigator
      HAYASHI Toshiharu
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Basic veterinary science/Basic zootechnical science
    • Research Institution
      Yamaguchi University
  •  アレルギー性疾患の効果相における傷害臓器の決定に関する分子メカニズムPrincipal Investigator

    • Principal Investigator
      林 俊春
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Clinical veterinary science
    • Research Institution
      Yamaguchi University
  •  Mechanisms and treatments of autoimmune diseases by Th1/Th2 unbalancePrincipal Investigator

    • Principal Investigator
      HAYASHI Toshiharu
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied veterinary science
    • Research Institution
      Yamaguchi University
  •  Involvement of inflammatory cells on the dysmotility of gastrointestinal smooth muscles in experimental colitis model animals.

    • Principal Investigator
      SATO Koichi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Basic veterinary science/Basic zootechnical science
    • Research Institution
      Yamaguchi University
  •  Gene therapy for autoimmune diabetes by DNA vaccinePrincipal Investigator

    • Principal Investigator
      HAYASHI Toshiharu
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied veterinary science
    • Research Institution
      Yamaguchi University
  •  ANALYSIS OF GLYCAN CHAIN AND BINDING AFFINITY TO ADHESION MOLECULES ON ACUTE PHASE GLYCOPROTEIN IN BOVINE LEUKEMIA

    • Principal Investigator
      IWATA Hiroyuki
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied veterinary science
    • Research Institution
      YAMAGUCHI UNIVERSITY
  •  Studies on pathogenesis, prevention and treatment of serious diseases.Principal Investigator

    • Principal Investigator
      HAYASHI Toshiharu
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied veterinary science
    • Research Institution
      Yamaguchi University
  •  レオウイルス誘導糖尿病発症におけるNOおよびO_2由来派生分子と膵島傷害との関連Principal Investigator

    • Principal Investigator
      林 俊春
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Basic veterinary science/Basic zootechnical science
    • Research Institution
      Yamaguchi University
  •  サイトカインおよび細胞間接着分子発現による豚リンパ球の機能解析

    • Principal Investigator
      IWATA Hiroyuki
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied veterinary science
    • Research Institution
      Yamaguchi University
  •  DEVELOPMENT OF VETERINARY DIAGNOSTIC IMAGING TECHNIQUES WITH PERMANENT MAGNETIC TYPE MRI

    • Principal Investigator
      TAKEUCHI Akira
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Applied veterinary science
    • Research Institution
      IWATE UNIVERSITY
      Yamaguchi University
  •  Relations between development of insulitis and expression of adhesion molecules in multiple low-dose streptozotocin-treated mice.Principal Investigator

    • Principal Investigator
      HAYASHI Toshiharu
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Basic veterinary science/Basic zootechnical science
    • Research Institution
      Yamaguchi University
  •  乳酸脱水素酵素ウイルス感染マウスの免疫系とくにマクロファ-ジ機能の解析

    • Principal Investigator
      山本 春弥
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      基礎獣医学
    • Research Institution
      Yamaguchi University
  •  スナネズミにおけるTyzzer病の病理発生に関する研究

    • Principal Investigator
      藤原 公策
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      基礎獣医学
    • Research Institution
      The University of Tokyo
  •  Studies on Pathogenesis of Nephritis on Domestic Animals

    • Principal Investigator
      TAKAHASHI Reiji
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      基礎獣医学
    • Research Institution
      Azabu University
      The University of Tokyo

All 2012 2011 2010 2008 2007 2006 2005 2003

All Journal Article Book

  • [Book] Molecular mechanisms in allergic rhinitis : modulation by microbes, In : Advances in Medicine and Biology2012

    • Author(s)
      Hayashi T.
    • Data Source
      KAKENHI-PROJECT-21580362
  • [Book] In : Handbook of Type1 Diabetes Mellitus2010

    • Author(s)
      Hayashi T.
    • Publisher
      Environmental factors and concepts in the induction of type 1 diabetes
    • Data Source
      KAKENHI-PROJECT-21580362
  • [Book] Environmental factors and concepts in the induction of type 1 diabetes2010

    • Author(s)
      Toshiharu Hayashi
    • Total Pages
      46
    • Publisher
      Nova Science Publisheres, Inc.
    • Data Source
      KAKENHI-PROJECT-21580362
  • [Journal Article] Destruction of salivary and lacrimal glands by T1 polarized reaction in a model of secondary Sjogren' s Syndrome in lupus-prone female NZB_xNZWF_1 mice.2011

    • Author(s)
      Hayashi T, Shimoyama N, Mizuno T.
    • Journal Title

      Inflammation

      Volume: (In press) Issue: 2 Pages: 638-646

    • DOI

      10.1007/s10753-011-9356-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21580362, KAKENHI-PROJECT-23380186
  • [Journal Article] Dysfunction of lacrimal and salivary glands in Sjogren' s syndrome : non-immunologic injury in pre-inflammatory phase and mouse2011

    • Author(s)
      Hayashi T.
    • Journal Title

      J Biomed Biotech

      Volume: 2011 Issue: 1

    • DOI

      10.1155/2011/407031

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21580362
  • [Journal Article] Eosinophilic venulitis of intestine in a mouse model of late allergic rhinitis2011

    • Author(s)
      Linh BK, Hayashi T, Nakasima T, T. Horii Y.
    • Journal Title

      Inflammation

      Volume: 34 Pages: 499-508

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21580362
  • [Journal Article] Immunopathogenesis of distant manifestation in effector phase after a local airway allergy2011

    • Author(s)
      Hayashi T.
    • Journal Title

      Research Trends

      Volume: 12 Pages: 67-76

    • Data Source
      KAKENHI-PROJECT-21580362
  • [Journal Article] Eosinophilic venulitis in the small intestines in a mouse model of late asthma2010

    • Author(s)
      Linh, B.K., Hayashi, T., Nakasima, T., T.Horiii
    • Journal Title

      Inflammation

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21580362
  • [Journal Article] Therapeutic strategies for SLE involving cytokines : mechanism-oriented therapies especially IFN-γ targeting gene therapy2010

    • Author(s)
      Hayashi, T.
    • Journal Title

      J.Biomed.Biotech.

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21580362
  • [Journal Article] Therapeutic strategies for SLE involving cytokines : mechanism-oriented therapies especially IFN-γtargeting gene therapy2010

    • Author(s)
      Hayashi T.
    • Journal Title

      J Biomed Biotech

      Volume: 2010 Pages: 1-19

    • DOI

      10.1155/2010/461641

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21580362
  • [Journal Article] Acute urticaria-like lesions in allergen-unexposed cutaneous tissues in a mouse model of late allergic rhinitis.2008

    • Author(s)
      Hayashi T, et. al.
    • Journal Title

      Int. J. Exp. Path. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17658142
  • [Journal Article] Systemic administration of olygodeoxynucleotides with CpG motifs at Priming phase reduces local Th2 response and late allergic rhinitis.2008

    • Author(s)
      Hayashi T, et. al.
    • Journal Title

      Inflammation 31

      Pages: 47-56

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17658142
  • [Journal Article] Reduction of late allergic eosinopbilic rbinitis by kurozu moromi powder in BALB/c mice.2007

    • Author(s)
      Hayashi T, et. al.
    • Journal Title

      Food Sci. Tech. Res. 13

      Pages: 385-390

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17658142
  • [Journal Article] Amelioration of late asthmatic bronchial-bronchiolar lesions in BALB/c mice by kurozu moromi powder2006

    • Author(s)
      Hayashi T et al.
    • Journal Title

      Food and Agricultural Immunology 17(1-4)

      Pages: 139-148

    • Data Source
      KAKENHI-PROJECT-17658142
  • [Journal Article] Elimination of CD4^+CD25^+ T cells breaks down reovirus type 2-triggered and CpG ODN-induced prolonged mild autoimmune insulitis in DBA/1 mice.2006

    • Author(s)
      Hayashi T., Hasegawa K., Sasaki Y.
    • Journal Title

      Scand.J.Immunol. 63(2)

      Pages: 116-124

    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] Elimination of CD4^+CD25^+T cell enhances Reo-2-triggered and CpG oligodeoxynucleotides-induced prolonged autoimmune insulitis in DBA/1J mice.2006

    • Author(s)
      Hayashi, T., Hasegawa, K., Sasaki, Y., Onodera, T.
    • Journal Title

      Scand.J.Immunol. 163

      Pages: 116-124

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] Elimination of CD4+CD25+T cell accelerate the development of glomerulonephritis during the preactive phae in lupus-prone female NZBxNZWF_1.mice.2005

    • Author(s)
      Hayashi T, Hasegawa K, Adachi C
    • Journal Title

      Int.J.Exp.Path. 86

      Pages: 289-296

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] Elimination of CD4^+CD25^+ T cell accelerates the development of glomerulonephritis during the preactive phase in autoimmune-prone female NZBxNZWF_1 mice.2005

    • Author(s)
      Hayashi, T., Hasegawa, K., Adachi, C.
    • Journal Title

      Int.J.Exp.Path. 86

      Pages: 289-296

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] ICAM-1 expression on endothelium and systemic cytokine production in cutaneous neutrophilic leucocytoclastic vasculitis in NZBxNZWF_1 mice.2005

    • Author(s)
      Hayashi, T., Hasegawa, K., Ichinohe, N.
    • Journal Title

      Histol.Histpatol. 20

      Pages: 44-52

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] Elimination of CD4^+CD25^+ T cell during preactive phase accerelates lupus in autoimmune-prone female B/WF_1 mice.2005

    • Author(s)
      Hayashi T., Hasegawa K., Adachi C.
    • Journal Title

      Int.J.Exp.Path. 86

      Pages: 289-296

    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] ICAM-1 expression on endothelium and systemic cytokine production in cutaneous neutrophilic leukocytoclastic vasculitis in NZBxNZWF1 mice.2005

    • Author(s)
      Hayashi T.
    • Journal Title

      Histol.Histopathol. 20

      Pages: 45-52

    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] Elimination of CD4+CD25+ regulatory T cells breaks down reovirus type b2-triggered and CpG ODN-induced prolonged mild autoimmune insulitis in DBA/1 mice.2005

    • Author(s)
      Hayashi T, Hasegawa K, Sasaki Y, Onodera T
    • Journal Title

      Scand.J.Immunol. 163

      Pages: 116-124

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] II-4 expressing plasmid DNA inhibits reovirus type-2-induced autoimmune insulitis in DBA/1 mice..2003

    • Author(s)
      Hayashi T, Yasutomi Y, Hasegawa K, Sasaki Y, Onodera T
    • Journal Title

      Int.J.Exp.Pathol. 18

      Pages: 1-6

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] Synthetic CpG oligodeoxynucleotides accelerate the development of lupus nephritis during preactive phase in NZBxNZWF_1 mice.2003

    • Author(s)
      Hasegawa, K., Hayashi, T.
    • Journal Title

      Lupus 12

      Pages: 1-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] Effect of antibodies to ICAM-1 and LFA-1 on cytokine mRNA expression in reo-2-triggered autoimmune insulitis in suckling DBA/1 mice.2003

    • Author(s)
      Hayashi T, Hasegawa K, Morimoto M, Onodera T
    • Journal Title

      J.Comp.Path.. 128

      Pages: 283-288

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] Synthetic CpG oligodeoxynucleotides accelerate the development of lupus nephritis durinmg preactive phase in NZBxNZWF_1mice.2003

    • Author(s)
      Hasegawa K, Hayashi T
    • Journal Title

      Lupus 12

      Pages: 1-8

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] ICAM-1 expression on endothelium and systemic cytokine production in icutaneous neutrophilic leucocytoclastic vasculitis in NZBxNZWF_1mice.2003

    • Author(s)
      Hayashi T, Hasegawa K, Ichinohe N
    • Journal Title

      Histol.Histopath. 20o5

      Pages: 44-52

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] IL-4 expressing plasmid DNA inhibits reovirus type-2-induced autoimmune insulitis in DBA/1J mice.2003

    • Author(s)
      Hayashi, T., Yasutomi, Y., Hasegawa, K., Sasaki, Y., Onodera, T.
    • Journal Title

      Int.J.Exp.Pathol. 84

      Pages: 1-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] Effect of antibodies to ICAM-1 and anti-LFA-1 on cytokine mRNA expression in reovirus type-2-triggered autoimmune insulitis in DBA/1 suckling mice.2003

    • Author(s)
      Hayashi, T., Hasegawa, K., Morimoto, M., Onodera, T.
    • Journal Title

      J.Comp.Pathol. 128

      Pages: 283-288

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15380210
  • 1.  IWATA Hiroyuki (40193750)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 2.  MORIMOTO Masahiro (30274187)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  SATO Kouichi (90205914)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  MAEDA Ken (90284273)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  TAKEUCHI Akira (90011874)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  OHNISHI Takafumi (60081593)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  TAURA Yasuho (80163153)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  NAKAMA Sanenori (90081596)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  MAKITA Takashi (90035105)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  KYUWA Shigeru (30177943)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  YASUTOMI Yasuhiro (90281724)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  NASU Tetsuyuki (70035559)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  TAKAHASHI Reiji (80011998)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  NAKAYAMA Hiroyuki (40155891)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  山本 春弥 (70210549)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  井上 誠 (80035112)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  藤原 公策 (60012689)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  後藤 直彰 (70011989)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  保富 康弘
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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