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ISHI Kunio  石井 邦雄

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… Alternative Names

ISHII Kunio  石井 邦雄

石井 邦雄  イシイ クニオ

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Researcher Number 90137993
Affiliation (Current) 2025: 北里大学, 薬学部, 名誉教授
Affiliation (based on the past Project Information) *help 2016 – 2018: 横浜薬科大学, 薬学部, 教授
2009 – 2014: Kitasato University, 薬学部, 教授
2005 – 2006: 北里大学, 薬学部, 教授
1997 – 2001: Department of Pharmacology, Faculty of Pharmaceutical Sciences, University of Sh, 薬学部, 教授
1997: 北里大学, 薬学部, 助教授(教授) … More
1996: 静岡県立大学, 助教授
1992 – 1996: 静岡県立大学, 薬学部, 助教授
1986: 慶応義塾大学, 医学部, 助手
1986: 慶應義塾大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Biological pharmacy / Biological pharmacy / General pharmacology / Medical pharmacy
Except Principal Investigator
Biological pharmacy / 医薬分子機能学 / General pharmacology
Keywords
Principal Investigator
糖尿病 / 微小循環 / 網膜 / 薬理学 / rat / 眼底カメラ / 血管径 / 網膜細動静脈 / ラット / fura 2 … More / 網膜循環 / 血管生物学 / 血液 / 心血管 / 神経-グリア-血管連関 / 神経‐グリア‐血管連関 / 神経細胞 / アストロサイト / 内皮細胞 / 血管 / グリア細胞 / 神経 / β-adrenergic receptors / drug responsiveness / fundus camera / hypertension / diabetes mellitus / retinal venule / retinal arteriole / 血管拡張薬 / 高血圧 / 血管収縮薬 / β-アドレナリン受容体 / アドレナリンβ受容体 / 薬物反応性 / 高血圧症 / 網膜細静脈 / 網膜細動脈 / micro circulation / cerebral blood vessel / ibudilast / CaィイD12+ィエD1 antagonists / diameter / digital funduscope / retinal blood vessel / 中枢血管 / Ca^<2+>拮抗薬 / デジタル・マイクロスコープ / 網膜中心静脈 / 網膜中心動脈 / 脳血管 / 脳循環改善薬 / カルシウム拮抗薬 / デジタルマイクロスコープ / development / mambrane potential / cyclic GMP / L-arginine / nitric oxide(NO) / Ca^<2+> concentration / pancreatic B cell / 加齢 / 細胞内遊離カルシウム・イオン濃度 / fura2 / 発達 / 膜電位 / cGMP / L-Arginine / 一酸化窒素(NO) / 細胞内遊離カルシウムイオン濃度 / 膵ランゲルハンス氏島B細胞 / hypertensive response / hypotensive response / metabolism / lung / cholinesterase / acetylcholine / phenylephrine / ネオスチグミン / アンギオテンシンII / ムスカリン様受容体 / alpha受容体 / 代謝 / 昇圧 / 降圧反応 / 肺 / コリンエステラーゼ / アセチルコリン / フェニレフリン / β アドレナリン受容体 / 一酸化窒素 / 血管内皮 / 動的光散乱 / 水晶体 / 白内障 … More
Except Principal Investigator
筋原性収縮 / 血管 / バイオメカニクス / myogenic contraction / stretch / tyrosine kinase / 物理受容・応答 / 血管収縮 / ストレッチ / 物理受容 / 脳・冠動脈 / Ca^<2+>チャネル / プロテインキナーゼC / ニューロペプチドY / セロトニン / pressure / hemodynamics / cardiovascular system / protein tyosyl phosphorylation / tyrosine kinase inhibitor / biomechanics / mechano-transduction / 接着班キナーゼ活性 / 細胞内情報伝達 / チロシンキナーゼ阻害薬 / 循環系 / 細胞シグナリング / 実験治療学 / チロシンリン酸化酵素 / 血行力学刺激 / 循環 / cellar signal transduction / adhesion molecule / protein tyrosyl phosphorylation / vascular tissue / mechano-reception / intracellular signaling / herbimycin A / tyrphostin 23 / genistein / tyrosine kinase inhbitor / myogenic tone / cerebral artery / 細胞情報伝達 / 接着因子 / チロシンリン酸化 / チロシンキナーゼ / Ca^<2+> Signaling / Phopspholipase C / Vascontraction / Mechanical Receptor / Stretch Activation / Stretch / Biomechanics / Cerebral and Coronary Artery / モノクロタリン肺高血圧 / アーテリオグラフ / 筋原性収縮反応 / 圧負荷 / 物理情報 / カルシウムシグナリング / フォスフォリパーゼC / 伸展刺激 / HL-60細胞 / ホルボールエステル / 合成ジアシルグリセロール / C-キナーゼ / 腫瘍プロモーション / 細胞内遊離【Ca^(2+)】濃度,【Ca^(2+)】取り込み,脱感作,C-キナーゼ,副腎髄質クロマフィン細胞. / ホスホリパーゼC / イノシトール3リン酸 / カルシウムイオン / ストレッチ反応 / 複合刺激 / ミオシン軽鎖リン酸化 / カルシウム感受性 / エンドセリン / 急速伸展刺激 / エンドセリン-1 / イヌ脳動脈 / ブタ冠動脈 Less
  • Research Projects

    (16 results)
  • Research Products

    (80 results)
  • Co-Researchers

    (13 People)
  •  Mechanisms of neuronal-glial-vascular interactions in the retina and the development of novel strategies for treating retinal diseasesPrincipal Investigator

    • Principal Investigator
      ISHII Kunio
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Yokohama College of Pharmacy
  •  Elucidation of mechanisms for regulating retinal circulation and identification of target molecule for novel preventive and/or therapeutic drugs for retinopathyPrincipal Investigator

    • Principal Investigator
      ISHII Kunio
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Kitasato University
  •  Elucidation of the molecular basis attributed to onset of abnormal retinal hemodynamics and strategy of novel prevention drugs for retinopathyPrincipal Investigator

    • Principal Investigator
      ISHII Kunio
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Kitasato University
  •  動的光散乱法を中心とした糖尿病性白内障進展過程の解析と予防薬/治療薬開発への応用Principal Investigator

    • Principal Investigator
      石井 邦雄
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      Kitasato University
  •  Development of high-resolution digital fundus camera for small animals and application of it to studies on analysis of responsiveness of retinal blood vesselsPrincipal Investigator

    • Principal Investigator
      ISHII Kunio
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Kitasato University
  •  Studies on responsiveness of rat retial blood vessels with a newly developed digital funduscope system for small animalsPrincipal Investigator

    • Principal Investigator
      ISHII Kunio
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Kitasato University
  •  Development of the modulator drug specifically targeting biomechanical reaction in the circulatory system and the application for experimental therapeutics.

    • Principal Investigator
      NAKAYAMA Koichi
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      医薬分子機能学
    • Research Institution
      University of Shizuoka
  •  Studies on changes in the pancreatic B cell function during development and aging assessed by computer-aided fluorescent microscopyPrincipal Investigator

    • Principal Investigator
      ISHI Kunio
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Kitasato University
      University of Shizuoka
  •  Specific role of tyrosine kinase in the vascular contraction produced by stretch.

    • Principal Investigator
      NAKAYAMA Koichi
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Department of Pharmacology, Faculty of Pharmaceutical Sciences, University of Shizuoka
  •  脈管系におけるバイオメカニクス反応と薬物による制御

    • Principal Investigator
      中山 貢一
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      University of Shizuoka
  •  血管〓縮関与推定因子の複合刺激による相乗的血管収縮機能発現とその細胞内機序

    • Principal Investigator
      中山 貢一
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      University of Shizuoka
  •  Reguratory mechanism of hypotensive responses to muscarinic cholinergic stimulation through the adrenergic receptor system.Principal Investigator

    • Principal Investigator
      ISHII Kunio
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      University of Shizuoka
  •  血管攣縮関与推定因子の複合刺激による相乗的血管収縮機能発現とその細胞内機序

    • Principal Investigator
      NAKAYAMA Koichi
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      University of Shizuoka
  •  Sutudy of vascular reactions in response to hemodynamic factors assessed by stretch activation

    • Principal Investigator
      NAKAYAMA Koichi
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Uuniversity of Shizuoka
  •  副腎クロマフィン細胞における受容体刺激に伴うカルシウムイオン流入の急速脱感作機構

    • Principal Investigator
      加藤 隆一
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Keio University
  •  腫瘍プロモーターTPAの作用機序に関する研究

    • Principal Investigator
      山本 慧
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Keio University

All 2017 2015 2014 2013 2012 2011 2010 2009 2007 2006 2005 Other

All Journal Article Presentation Patent Other

  • [Journal Article] Effect of Long-Term Treatment of L-Ornithine on Visual Function and Retinal Histology in the Rats2015

    • Author(s)
      Sakamoto K, Mori A, Nakahara T, Morita M, Ishii K.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 38 Issue: 1 Pages: 139-143

    • DOI

      10.1248/bpb.b14-00491

    • NAID

      130004872232

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24590122, KAKENHI-PROJECT-24590329
  • [Journal Article] Mechanisms underlying dysfunction of retinal blood vessels in diabetic rats2015

    • Author(s)
      Mori A, Sakamoto K, Nakahara T, Ishii K.
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 145 Issue: 2 Pages: 70-73

    • DOI

      10.1254/fpj.145.70

    • NAID

      130004827720

    • ISSN
      0015-5691, 1347-8397
    • Language
      Japanese
    • Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24590122, KAKENHI-PROJECT-24790261
  • [Journal Article] Preventive Effects of Rapamycin on Inflammation and Capillary Degeneration in a Rat Model of NMDA-Induced Retinal Injury2015

    • Author(s)
      Aoki Y, Nakahara T, Asano D, Ushikubo H, Mori A, Sakamoto K, Ishii K.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 38 Issue: 2 Pages: 321-324

    • DOI

      10.1248/bpb.b14-00631

    • NAID

      130004872255

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24590122, KAKENHI-PROJECT-24590329, KAKENHI-PROJECT-26460103
  • [Journal Article] Anti-angiogenic Effects of Mammalian Target of Rapamycin Inhibitors in a Mouse Model of Oxygen-Induced Retinopathy2014

    • Author(s)
      Yagasaki R, Nakahara T, Ushikubo H, Mori A, Sakamoto K, Ishii K.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 37 Issue: 11 Pages: 1838-1842

    • DOI

      10.1248/bpb.b14-00487

    • NAID

      130004703901

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24590122, KAKENHI-PROJECT-24590329, KAKENHI-PUBLICLY-25122712
  • [Journal Article] Treatment of Newborn Mice with Inhibitors of Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Induces Abnormal Retinal Vascular Patterning2014

    • Author(s)
      Morita A, Nakahara T, Ushikubo H, Mori A, Sakamoto K, Ishii K.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 37 Issue: 12 Pages: 1986-1989

    • DOI

      10.1248/bpb.b14-00540

    • NAID

      130004703916

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24590122, KAKENHI-PROJECT-24590329, KAKENHI-PUBLICLY-25122712, KAKENHI-PROJECT-26460103
  • [Journal Article] Elucidation of Dysfunctional Mechanisms of Retinal Circulation in the Rat Models of Glaucoma and Exploration of Novel Therapeutic Drugs2013

    • Author(s)
      Mori A, Nakahara T, Kurauchi Y, Sakamoto K, Ishii K.
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 133 Issue: 12 Pages: 1343-1350

    • DOI

      10.1248/yakushi.13-00228-2

    • NAID

      130003382289

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2013-12-01
    • Language
      Japanese
    • Data Source
      KAKENHI-PROJECT-24590122, KAKENHI-PROJECT-24790261
  • [Journal Article] BMS-191011, an opener of large-conductance Ca^<2+>-activated potassium channels, dilates rat retinal arterioles in vivo.2011

    • Author(s)
      Mori A, Suzuki S, Sakamoto K, Nakahara T, Ishii K.
    • Journal Title

      Biol Pharm Bull.

      Volume: 34 Pages: 150-152

    • NAID

      130000402279

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Journal Article] Role of ss_3-adrenoceptors in regulation of retinal vascular tone in rats2011

    • Author(s)
      Mori A, Nakahara T, Sakamoto K, Ishii K
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol

      Volume: 384 Pages: 603-608

    • URL

      http://dx.doi.org/10.1007/s00210-011-0682-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Journal Article] BMS-191011, an opener of large-conductance Ca^<2+>-activated potassium channels, dilates rat retinal arterioles in vivo2011

    • Author(s)
      Mori A, Suzuki S, Sakamoto K, Nakahara T, Ishii K
    • Journal Title

      Biol Pharm Bull

      Volume: 34 Pages: 150-152

    • NAID

      130000402279

    • URL

      http://dx.doi.org/10.1248/bpb.34.150

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Journal Article] Vasodilation of retinal arterioles induced by activation of BK_<Ca> channels is attenuated in diabetic rats2011

    • Author(s)
      Mori A, Suzuki S, Sakamoto K, Nakahara T, Ishii K
    • Journal Title

      Eur J Pharmacol

      Volume: 669 Pages: 94-99

    • URL

      http://dx.doi.org/10.1016/j.ejphar.2011.07.042

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Journal Article] Role of calcium-activated potassium channels in acetylcholine-induced vasodilation of rat retinal arterioles in vivo.2011

    • Author(s)
      Mori A, Suzuki S, Sakamoto K, Nakahara T, Ishii K.
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol.

      Volume: 383 Pages: 27-34

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Journal Article] Role of calcium-activated potassium channels in acetylcholine-induced vasodilation of rat retinal arterioles in vivo2011

    • Author(s)
      Mori A, Suzuki S, Sakamoto K, Nakahara T, Ishii K
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol

      Volume: 383 Pages: 27-34

    • URL

      http://dx.doi.org/10.1007/s00210-010-0570-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Journal Article] Noradrenaline contracts rat retinal arterioles via stimulation ofα_<1A-> andα_<1D-> adrenoceptors2011

    • Author(s)
      Mori A, Hanada M, Sakamoto K, Nakahara T, Ishii K
    • Journal Title

      Eur J Pharmacol

      Volume: 673 Pages: 65-69

    • URL

      http://dx.doi.org/10.1016/j.ejphar.2011.10.012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Journal Article] Drugs for improving retinal circulation : current status and future perspectives2010

    • Author(s)
      Nakahara T, Mori A, Sakamoto K, Ishii K
    • Journal Title

      日本薬理学雑誌

      Volume: 135(4) Pages: 146-148

    • NAID

      10029416613

    • URL

      http://dx.doi.org/10.1254/fpj.135.146

    • Data Source
      KAKENHI-PROJECT-21590102
  • [Journal Article] Hyperglycemia impairs acetylcholine-induced vasodilation of retinal arterioles through polyol pathway-independent mechanisms in rats.2010

    • Author(s)
      Mori A, Saigo O, Sakamoto K, Nakahara T, Ishii K.
    • Journal Title

      J Pharmacol Sci. 112(3)

      Pages: 336-342

    • NAID

      10027744548

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Journal Article] Pharmacological evidence for the presence of functional ss_3-adrenoceptors in rat retinal blood vessels2010

    • Author(s)
      Mori A, Miwa T, Sakamoto K, Nakahara T, Ishii K
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol

      Volume: 382 Pages: 119-126

    • URL

      http://dx.doi.org/10.1007/s00210-010-0526-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Journal Article] Hyperglycemia impairs acetylcholine-induced vasodilation of retinal arterioles through polyol pathway-independent mechanisms in rats2010

    • Author(s)
      Mori A, Saigo O, Sakamoto K, Nakahara T, Ishii K
    • Journal Title

      J Pharmacol Sci

      Volume: 112 Pages: 336-342

    • NAID

      10027744548

    • URL

      http://dx.doi.org/10.1254/jphs.09312FP

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Journal Article] Drugs for improving retinal circulation : current status and future perspectives.2010

    • Author(s)
      Nakahara T, Mori A, Sakamoto K, Ishii K.
    • Journal Title

      日本薬理学雑誌

      Volume: 135 Pages: 146-148

    • NAID

      10029416613

    • Data Source
      KAKENHI-PROJECT-21590102
  • [Journal Article] Pharmacological evidence for the presence of functional β_3-adrenoceptors in ratretinal blood vessels.2010

    • Author(s)
      Mori A, Miwa T, Sakamoto K, Nakahara T, Ishii K.
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol.

      Volume: 382 Pages: 119-126

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Journal Article] Intravenously administered vasodilatory prostaglandins increase retinal and choroidal blood flow in rats.2007

    • Author(s)
      Mori A, Saito M, Sakamoto K, Nakahara T, Ishii K
    • Journal Title

      Journal of Pharmacological Sciences 103(1)

      Pages: 103-112

    • NAID

      10024312187

    • Data Source
      KAKENHI-PROJECT-17659048
  • [Journal Article] Establishment of a precise methods for evaluating rat cataract by using two types pf digital camera systems that are equipped with a non-reflecting illuminator or a slit lamp.2007

    • Author(s)
      Ueo M, Saito M, Takenaka M, Saigo O, Nakatani H, Hayashi K, Nakahara T, Sakamoto K, Ishii K
    • Journal Title

      Journal of Pharmacological Sciences 103 (Suppl. I)

      Pages: 270-270

    • Data Source
      KAKENHI-PROJECT-17659048
  • [Journal Article] Stimulation of EP_2 receptor dilates retinal blood vessels and increses fundus blood flow in rats.2007

    • Author(s)
      Mori A, Saito M, Sakamoto K, Narita M, Nakahara T, Ishii K
    • Journal Title

      Journal of Pharmacological Sciences 103(Suppl. I)

      Pages: 248-248

    • Data Source
      KAKENHI-PROJECT-17659048
  • [Journal Article] Attenuation of nitric oxide- and prostaglandin-independent vasodilation of retinal arterioles induced by acetylcholine in streptozotocin-treated rats.2007

    • Author(s)
      Nakazawa T, Kaneko Y, Mori A, Saito M, Sakamoto K, Nakahara T, Ishii K
    • Journal Title

      Vascular Pharmacology 46(3)

      Pages: 153-159

    • Data Source
      KAKENHI-PROJECT-17659048
  • [Journal Article] Modulation of cell cycle reduces neuronal cell death observed after ischemia-reperfusion in the rat retina.2006

    • Author(s)
      Ohki K, Saito M, Nakahara T, Sakamoto K, Ishii K.
    • Journal Title

      Journal of Pharmaceutical Sciences 100(suppl.I)

      Pages: 259-259

    • Data Source
      KAKENHI-PROJECT-17659048
  • [Journal Article] Inducible nitric oxide synthase inhibitors abolished histological protection by late ischemic preconditioning in rat retina.2006

    • Author(s)
      Sakamoto K.他6名(7番目の著者:Ishii K.)
    • Journal Title

      Experimental Eye Research 82(3)(In press)

    • Data Source
      KAKENHI-PROJECT-17659048
  • [Journal Article] Vasodilator effects of adrenomedullin on retinal arterioles in streptozotocin-induced diabetic rats.2006

    • Author(s)
      Kaneko Y, Saito M, Mori A, Sakamoto K, Nakahara T, Ishii K
    • Journal Title

      Journal of Ocular Pharmacology 22(5)

      Pages: 317-322

    • Data Source
      KAKENHI-PROJECT-17659048
  • [Journal Article] Cilnidipine reduces neuronal cell death induced by intravitreous injection of NMDA in the rat retina.2006

    • Author(s)
      Kawakami T, Saito M, Nakahara T, Sakamoto K, Ishii K.
    • Journal Title

      Journal of Pharmaceutical Sciences 100(suppl.I)

      Pages: 150-150

    • Data Source
      KAKENHI-PROJECT-17659048
  • [Journal Article] Differential mechanisms of bradykinin-induced vasodilation in retinal and peripheral blood vessels of rats.2006

    • Author(s)
      Kojima N, Saito M, Mori A, Nakahara T, Sakamoto K., Ishii K.
    • Journal Title

      Journal of Pharmaceutical Sciences 100(suppl.I)

      Pages: 67-67

    • Data Source
      KAKENHI-PROJECT-17659048
  • [Journal Article] Disappearance of glibenclamide-induced hypoglycemia in wistar-kyoto rats.2006

    • Author(s)
      Sakamoto K.他8名(9番目の著者:Ishii K.)
    • Journal Title

      Biological and Pharmaceutical Bulletin 29(3)

      Pages: 574-576

    • NAID

      110005602148

    • Data Source
      KAKENHI-PROJECT-17659048
  • [Journal Article] Involvement of the βγ subunits of G proteins in the cAMP response induced by stimulation of the histamine H_1 receptor.2005

    • Author(s)
      Maruko T.他6名(7番目の著者:Ishii K.)
    • Journal Title

      Naunyn-Schmiedebergs Archives of Pharmacology 372(2)

      Pages: 153-159

    • Data Source
      KAKENHI-PROJECT-17659048
  • [Patent] 特許権2007

    • Inventor(s)
      石井邦雄 他
    • Industrial Property Rights Holder
      北里学園
    • Industrial Property Number
      2007-032923
    • Filing Date
      2007-02-15
    • Data Source
      KAKENHI-PROJECT-17659048
  • [Presentation] ラット網膜においてオピオイド μ 受容体刺激は神経由来の NO 産生を介して血管を拡張させる2017

    • Author(s)
      染谷英理子,森 麻美,坂本謙司,石井邦雄,中原 努
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎新聞文化ホール(長崎県長崎市)
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-16K08554
  • [Presentation] Mechanisms underlying dysfunction of retinal blood vessels in diabetes rats.2014

    • Author(s)
      Asami Mori, Kenji Sakamoto, Tsutomu Nakahara, Kunio Ishii
    • Organizer
      第 87 回日本薬理学会年会
    • Place of Presentation
      宮城県仙台市(仙台国際センター)
    • Data Source
      KAKENHI-PROJECT-24590122
  • [Presentation] ラット網膜血管における gap junction を介した拡張機序の解明2014

    • Author(s)
      森 麻美,滑川 諒,坂本 謙司,中原 努,石井 邦雄
    • Organizer
      第 130 回日本薬理学会関東部会
    • Place of Presentation
      星薬科大学 百年記念館(東京都品川区)
    • Year and Date
      2014-07-05
    • Data Source
      KAKENHI-PROJECT-24590122
  • [Presentation] Probucol ameliorates dydfunction of retinal circulation in diabetes rats.2014

    • Author(s)
      Kentaro Higashi, Asami Mori, Kenji Sakamoto, Tsutomu Nakahara, Kunio Ishii
    • Organizer
      第 87 回日本薬理学会年会
    • Place of Presentation
      宮城県仙台市(仙台国際センター)
    • Data Source
      KAKENHI-PROJECT-24590122
  • [Presentation] NO は電位依存性カリウムチャネルを介してラット網膜血管を拡張させる2014

    • Author(s)
      森 麻美,滑川 諒,坂本 謙司,中原 努,石井 邦雄
    • Organizer
      日本薬学会第 134 年会
    • Place of Presentation
      熊本県熊本市(熊本市総合体育館)
    • Data Source
      KAKENHI-PROJECT-24590122
  • [Presentation] NO による網膜血管拡張反応における PGI2 の役割2013

    • Author(s)
      滑川 諒,森 麻美,坂本 謙司,中原 努,石井 邦雄
    • Organizer
      第 128 回日本薬理学会関東部会
    • Place of Presentation
      東京都新宿区(早稲田大学国際会議場)
    • Data Source
      KAKENHI-PROJECT-24590122
  • [Presentation] L-Citrulline ameliorates dysfunction of retinal circulation in diabetic rats2012

    • Author(s)
      Takei T, Mori A, Morita M, Nakagawa S, Sakamoto K, Nakahara T, Ishii K
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      (京都)日本薬理学会
    • Year and Date
      2012-03-14
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Presentation] L-Citrulline dilates retinal blood vessels in rats2012

    • Author(s)
      Mori A, Takei T, Morita M, Nakagawa S, Sakamoto K, Nakahara T, Ishii K
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      (京都)日本薬理学会
    • Year and Date
      2012-03-15
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Presentation] NMDA誘発緑内障モデルにおける網膜血管反応性の変化2011

    • Author(s)
      森麻美、花田真幸、坂本謙司、中原努、石井邦雄
    • Organizer
      第124回日本薬理学会関東部会
    • Year and Date
      2011-06-04
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Presentation] EDHFはBK_<Ca>チャネルを介してラット網膜血管を拡張させる2011

    • Author(s)
      森麻美, 鈴木佐知, 坂本謙司, 中原努, 石井邦雄
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2011
    • Place of Presentation
      東京
    • Year and Date
      2011-08-31
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Presentation] NMDA誘発緑内障モデルにおける網膜血管反応性の変化2011

    • Author(s)
      森麻美, 花田真幸, 坂本謙司, 中原努, 石井邦雄
    • Organizer
      第124回日本薬理学会関東部会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-04
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Presentation] 新規網膜血流量測定システムの構築とそれによる網膜循環改善薬の探索2011

    • Author(s)
      森麻美、花田真幸、坂本謙司、中原努、石井邦雄
    • Organizer
      第12回Pharmaco-Hematologyシンポジウム
    • Year and Date
      2011-06-18
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Presentation] 新規網膜血流量測定システムの構築とそれによる網膜循環改善薬の探索2011

    • Author(s)
      森麻美, 花田真幸, 坂本謙司, 中原努, 石井邦雄
    • Organizer
      第12回Pharmaco-Hematologyシンポジウム
    • Place of Presentation
      富山
    • Year and Date
      2011-06-18
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Presentation] EDHFはBKCaチャネルを介してラット網膜血管を拡張させる2011

    • Author(s)
      森麻美, 鈴木佐知, 坂本謙司, 中原努, 石井邦雄
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2011
    • Place of Presentation
      (東京)日本薬学会薬理系薬学部会
    • Year and Date
      2011-08-31
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Presentation] Changes in responsiveness of the retinal blood vessels induced by intravitreal injection of NMDA in rats2011

    • Author(s)
      Hanada M, Mori A, Sakamoto K, Nakahara T, Ishii K
    • Organizer
      第84回日本薬理学会年会
    • Year and Date
      2011-03-24
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Presentation] ACh誘発EDHF様ラット網膜血管拡張反応におけるBK_<ca>チャネルの役割2010

    • Author(s)
      森麻美, 鈴木佐知, 坂本謙司, 中原努, 石井邦雄
    • Organizer
      第20回日本循環薬理学会
    • Place of Presentation
      札幌
    • Year and Date
      2010-11-11
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Presentation] NO dilates retinal arterioles through the COX-1 derived prostanoids-cAMP signaling pathway in rats in vivo2010

    • Author(s)
      Mori A, Nakahara T, Hoshino M, Sakamoto K, Ishii K
    • Organizer
      第83回日本薬理学会年会日本薬理学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-16
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Presentation] ACh誘発EDHF様ラット網膜血管拡張反応におけるBKCaチャネルの役割2010

    • Author(s)
      森麻美, 鈴木佐知, 坂本謙司, 中原努, 石井邦雄
    • Organizer
      第20回日本循環薬理学会,第38回薬物活性シンポジウム
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Presentation] 高血糖はポリオール経路非依存性機序を介してアセチルコリンによるラット網膜細動脈拡張を障害する2010

    • Author(s)
      森麻美, 西郷織江, 坂本謙司, 中原努, 石井邦雄
    • Organizer
      日本薬学会第130回年会
    • Place of Presentation
      (岡山)日本薬学会
    • Year and Date
      2010-03-30
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Presentation] NO dilates retinal arterioles through the COX-1 derived prostanoids-cAMP signaling pathway in rats in vivo.2010

    • Author(s)
      Mori A, Nakahara T, Hoshino M, Sakamoto K, Ishii K.
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-16
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Presentation] Drugs for improving retinal circulation : Current status and future2010

    • Author(s)
      Ishii K, Mori A, Sakamoto K, Nakahara T
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      (大阪)日本薬理学会
    • Year and Date
      2010-03-18
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Presentation] NO dilates rat retinal blood vessels through the COX-1-dependent prostanoids-cAMP signalling pathway in vivo2010

    • Author(s)
      Kunio Ishii, A Mori, K Sakamoto, T Nakahara
    • Organizer
      16th World Congress on Basic and Clinical Pharmacology World Pharma 2010
    • Place of Presentation
      Copenhagen, Denmark
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Presentation] 高血糖はポリオール経路非依存性機序を介してアセチルコリンによるラット網膜細動脈拡張を障害する2010

    • Author(s)
      森麻美, 西郷織江, 坂本謙司, 中原努, 石井邦雄
    • Organizer
      日本薬学会第130回年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Presentation] Drugs for improving retinal circulation : Current status and future.2010

    • Author(s)
      Ishii K, Mori A, Sakamoto Nakahara T.
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-18
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Presentation] ACh誘発ラット網膜血管拡張反応におけるK_<ca> channelの関与2009

    • Author(s)
      鈴木佐知, 森麻美, 中原努, 坂本謙司, 石井邦雄
    • Organizer
      第120回日本薬理学会関東部会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-11
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Presentation] 1型糖尿病モデルラットを用いた網膜循環障害発症機序の解析2009

    • Author(s)
      石井邦雄
    • Organizer
      日本薬学会関東支部第34回学術講演会日本薬学会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-07
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Presentation] 1型糖尿病モデルラットを用いた網膜循環障害発症機序の解析2009

    • Author(s)
      石井邦雄
    • Organizer
      日本薬学会関東支部第34回学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-07
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Presentation] 糖尿病モデルラットを用いた糖尿病性眼合併症の発症・進行機序の解析:ポリオール経路の意義2009

    • Author(s)
      石井邦雄、中原努、坂本謙司、森麻美
    • Organizer
      第121回日本薬理学会関東部会日本薬理学会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-10
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Presentation] 糖尿病モデルラットを用いた糖尿病性眼合併症の発症・進行機序の解析:ポリオール経路の意義2009

    • Author(s)
      石井邦雄
    • Organizer
      第121回日本薬理学会関東部会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-10
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Presentation] ACh誘発ラット網膜血管拡張反応におけるK_<Ca> channelの関与2009

    • Author(s)
      鈴木佐知, 森麻美, 中原努, 坂本謙司, 石井邦雄
    • Organizer
      第120回日本薬理学会関東部会日本薬理学会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-11
    • Data Source
      KAKENHI-PROJECT-21590102
  • [Presentation] Role of beta3-adrenoceptors in the regulatory mechanism of retinal vascular tone in rats.

    • Author(s)
      Mori A, Nakahara T, Kurauchi Y, Sakamoto K, Ishii K.
    • Organizer
      第86 回日本薬理学会年会
    • Place of Presentation
      福岡県福岡市(福岡国際会議場)
    • Data Source
      KAKENHI-PROJECT-24590122
  • [Presentation] エルカトニンのラット網膜循環に及ぼす影響

    • Author(s)
      森 麻美,須澤 弘典,坂本 謙司,中原 努,石井 邦雄
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      デザインクリエイティブセンター神戸(兵庫県神戸市)
    • Year and Date
      2015-03-26 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-24590122
  • [Presentation] 網膜循環調節機構の基礎的研究と糖尿病性眼疾患に対する新規予防治療戦略開拓の試み

    • Author(s)
      石井 邦雄
    • Organizer
      第 32 回日本眼薬理学会学術集会(招待講演)
    • Place of Presentation
      滋賀県大津市(ピアザ淡海)
    • Invited
    • Data Source
      KAKENHI-PROJECT-24590122
  • [Presentation] 4-ヒドロキシ 2-ノネナールはアドレナリン β2 受容体刺激薬によるラット網膜細動脈拡張反応を減弱させる

    • Author(s)
      森 麻美, 武井 俊明, 坂本 謙司, 中原 努, 石井 邦雄
    • Organizer
      第 88 回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-03-18 – 2015-03-20
    • Data Source
      KAKENHI-PROJECT-24590122
  • [Presentation] プロスタノイド EP2 受容体刺激薬の緑内障予防・治療薬としての可能性

    • Author(s)
      森 麻美,黒崎 航平,牛久保 裕子,坂本 謙司,中原 努,石井 邦雄
    • Organizer
      第 34 回日本眼薬理学会
    • Place of Presentation
      長谷川国際会議場(岐阜県岐阜市)
    • Year and Date
      2014-09-13 – 2014-09-14
    • Data Source
      KAKENHI-PROJECT-24590122
  • []

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  • 1.  NAKAYAMA Koichi (50112769)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 2.  NAKAHARA Tsutomu (10296519)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 52 results
  • 3.  TASNAKA Yoshio (60188349)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  MORI Asami (80453504)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 44 results
  • 5.  TANABE Yoshiyuki (10275109)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  山本 慧 (50138129)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  OBARA Kazuo (60117611)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  TAKEISHI Keiichi (90012608)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  斉藤 麻希 (40365185)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 10.  加藤 隆一 (40112685)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  中木 敏夫 (30164148)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  ASANO Toshio
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  浅井 敏雄
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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