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TOGA Hirohisa  栂 博久

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… Alternative Names

栂 博久  トガ ヒロヒサ

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Researcher Number 90142554
Other IDs
External Links
Affiliation (Current) 2025: 金沢医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2004 – 2011: 金沢医科大学, 医学部, 教授
1995 – 2002: 金沢医科大学, 医学部, 助教授
Review Section/Research Field
Principal Investigator
Respiratory organ internal medicine / Respiratory organ internal medicine
Except Principal Investigator
Respiratory organ internal medicine / Radiation science / Respiratory organ internal medicine
Keywords
Principal Investigator
RT-PCR / ventilator-induced lung injury / 気管支肺胞洗浄 / cytokine-induced neutrophil chemoattractant-1 / broncho-alveolar lavage / pulmonary alveolar epithelial cell / Fas ligand / Fas / 肺胞上皮細胞 / western blotting … More / inducible nitric oxide synthase / in situ hybridization / dexamethasone / 活性窒素酸化物 / エンドトキシン / 免疫組織染色 / II型肺胞上皮細胞 / 肺胞上皮損傷 / active nitrogen oxide / cell stretch / 誘導型NO合成酵素 / ventilator-induced lung / 細胞伸展 / pressure load / alveolar type II cells / neutrophil / neutralizing antibody / CXC chemokine / CINC-1 / VILI / 圧負荷 / 好中球 / 中和抗体 / CXCケモカイン / cytokine / T lymphocyte / apoptosis / pulmonary alveolar epithelial injury / acute respiratory distress syndrome / Western blotting / Fas Ligand / サイトカイン / Tリンパ球 / アポトーシス / 急性呼吸窮迫症候群 / immuno-histological stain / endotoxin / acute lung injury / 酵素抗体法 / 肺微小血管圧 / 肺高血圧 / 一酸化窒素 / 成人呼吸窮迫症候群 / ウェスタンブロット / ウエスタンブロット / 誘導型一酸化窒素合成酵素 / 急性肺傷害 / reverse transferase-polymerase chain reaction / NF-κB / DNA ladder / toll-like receptor / 呼吸器病学 … More
Except Principal Investigator
hypoxia / hypoxia inducible factor / DNA microarray / glucose transporter / FDG PET / 肺サーファクタント / 肺胞II型上皮細胞 / molecular targeting therapy / angiogenesis / lung adenocarcinoma / hypoxia induced factor / 抗CD105抗体 / 抗CD31抗体 / 新生血管 / Real-time RT PCR / mRNA / angiopoietin / VEGF / 肺癌 / 分子標的治療 / Hypoxia / Hypoxia inducible factor / 血管新生 / 肺腺癌 / brefeldin A / lamellar body / intracellular transport / alveolar type II cell / lung surfactant / 層状封入体 / ブレフェルジンA / 細胞内輸送 / Alveolar fluid clearance / Lung surfactant / Interleukin-1 beta / Inflammatory cytokines / Alveolar type II cell / Lung injury / 活性酸素 / サイトカイン受容体 / 肺線維定 / 肺組織障害 / IL-1B / II型肺胞上皮細胞 / Matrix metallo proteinase / アポトーシス / NO / サイトカイン / 肺線維症 / 肺気腫 / 肺水分調節 / IL-1β / 炎症性サイトカイン / 肺組織傷害 / 肺小動脈 / 牛 / Rho-kinase / 低酸素 / 右心カテーテル法 / 肺高血圧症 / エンドセリン / Rhoキナーゼ / high-altitude pulmonary hypertension(HAPH) / ウシ / ヤク / 高地適応動物 Less
  • Research Projects

    (9 results)
  • Research Products

    (39 results)
  • Co-Researchers

    (15 People)
  •  Characteristics of pulmonary circulation in high-altitude active animals-Biomolecular study focusing on the central role of Rho-kinase

    • Principal Investigator
      ISHIZAKI Takeshi
    • Project Period (FY)
      2008 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      University of Fukui
  •  Role of toll-like receptors in alveolar epithelial injury induced by cell deformation.Principal Investigator

    • Principal Investigator
      TOGA Hirohisa
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Kanazawa Medical University
  •  Role of active nitrogen oxide in cell stretch-induced pulmonary alveolar injury.Principal Investigator

    • Principal Investigator
      SATOGA Hirohi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      KANAZAWA MEDICAL UNIVERSITY
  •  EVALUATION OF GENE EXPRESSION RELATED MOLECULAR TARGETING THERAPY OF LUNG CANCER USING FDG PET

    • Principal Investigator
      HIGASHI Kotaro
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Kanazawa Medical University
  •  Role of CXC chemokines in pulmonary alveolar injury under mechanical stressPrincipal Investigator

    • Principal Investigator
      TOGA Hirohisa
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      KANAZAWA MEDICAL UNIVERCITY
  •  Pulmonary alveolar epithelium protects the lung through apoptosis of T lymphocytesPrincipal Investigator

    • Principal Investigator
      TOGA Hirohisa
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Kanazawa Medical University
  •  Signal transduction of lung surfactant synthesis, transport, and secretion in alveolar type II cell

    • Principal Investigator
      OSANAI Kazuhiro
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Kanazawa Medical University
  •  INTERACTIONS BETWEEN ALVEOLAR TYPE II CELL AND CYTOKINES IN THE LUNG INJURY

    • Principal Investigator
      TAKAHASHI Keiji
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      KANAZAWA MEDICAL UNIVERSITY
  •  Role of nitric oxide in lung injury.Principal Investigator

    • Principal Investigator
      TOGA Hirohisa
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Kanazawa Medical University

All 2009 2008 2007 2006 2005 2004 2003 2002 2001

All Journal Article Presentation

  • [Journal Article] A mutation in Rab38 small GTPase causes abnormal lung surfactant homeostasis and aberrant alveolar structure in mice.2008

    • Author(s)
      Osanai K, Oikawa R, Higuchi J, Kobayashi M, Tsuchihara K, Iguchi M, Huang J, Toga H, Voelker DR
    • Journal Title

      Am J Pathol 173

      Pages: 1265-1274

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590920
  • [Journal Article] Lung carcinoma: diffusion-weighted MR imaging - preliminary evaluation with apparent diffusion coefficient.2007

    • Author(s)
      Matoba M, Tonami H, Kondou T, Yokota H, Higashi K, Toga H, Sakuma T
    • Journal Title

      Radiology 243

      Pages: 570-577

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590920
  • [Journal Article] Fluorodeoxy- glucose uptake correlates with the growth pattern of small peripheral pulmonary adenocarcinoma.2006

    • Author(s)
      Sagawa M, Toga H et al.
    • Journal Title

      Surg Today 36

      Pages: 230-234

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590768
  • [Journal Article] Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine.2006

    • Author(s)
      Sakuma T, Toga et al.
    • Journal Title

      Crit Care Med 34

      Pages: 676-681

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590768
  • [Journal Article] Denopamine stimulates alveolar fluid clearance via cystic fibrosis transmembrane conductance regulator in rat lungs.2006

    • Author(s)
      Gu XG, Toga H, et al.
    • Journal Title

      Respirology 11

      Pages: 566-571

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590768
  • [Journal Article] Microvessel density : Correlation with ^<18>F-FDG uptake and prognostic impact in lung adenocarcinomas.2006

    • Author(s)
      Guo JF, Toga H et al.
    • Journal Title

      J Nucl Med 47

      Pages: 419-425

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590768
  • [Journal Article] Pulmonary surfactant transport in alveolar type II cells.2006

    • Author(s)
      Osanai K, Toga H et al.
    • Journal Title

      Respirology 11

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590768
  • [Journal Article] Pulmonary surfactant transport in alveolar type II cells.2006

    • Author(s)
      Osanai K, Toga H, et al.
    • Journal Title

      Respirology 11

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590768
  • [Journal Article] Denopamine stimulates alveolar fluid clearance via cystic fibrosis transmembrane conductance regulator in rat lungs.2006

    • Author(s)
      Gu XG, Toga H et al.
    • Journal Title

      Respirology 11

      Pages: 566-571

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590768
  • [Journal Article] Fluorodeoxy-glucose uptake correlates with the growth pattern of small peripheral pulmonary adenocarcinoma.2006

    • Author(s)
      Sagawa M, Toga H, et al.
    • Journal Title

      Surg Today 36

      Pages: 230-234

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590768
  • [Journal Article] Microvessel density : Correlation with 18F-FDG uptake and prognostic impact in lung adenocarcinomas.2006

    • Author(s)
      Guo JF, Toga H, et al.
    • Journal Title

      J Nucl Med 47

      Pages: 419-425

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590768
  • [Journal Article] Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine.2006

    • Author(s)
      Sakuma T, Toga H, et al.
    • Journal Title

      Crit Care Med 34

      Pages: 676-681

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590768
  • [Journal Article] Catecholamine clearance from alveolar spaces of rat and human lungs.2005

    • Author(s)
      Sakuma T, Toga H, et al.
    • Journal Title

      Respiration 72

      Pages: 189-196

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590768
  • [Journal Article] Catecholamine clearance from alveolar spaces of rat and human lungs.2005

    • Author(s)
      Sakuma T, Toga et al.
    • Journal Title

      Respiration 72

      Pages: 189-196

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590768
  • [Journal Article] Expression and characterization of Rab38,a new member of the Rab small G protein family.2005

    • Author(s)
      Osanai K, Toga H et al.
    • Journal Title

      Biol Chem 386

      Pages: 143-153

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590768
  • [Journal Article] Expression and characterization of Rab38, a new member of the Rab small G protein family.2005

    • Author(s)
      Osanai K, Toga H, et al.
    • Journal Title

      Biol Chem 386

      Pages: 143-153

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590768
  • [Journal Article] Role of CXC chemokines in ventilator-induced lung injury in rats.2004

    • Author(s)
      Toga H, et al.
    • Journal Title

      J Jpn Med Soc Biol Interface 35

      Pages: 9-16

    • NAID

      10013598287

    • Data Source
      KAKENHI-PROJECT-16590768
  • [Journal Article] Effects of α1-, β1-, β2-, β3-adrenergic agonists on alveolar fluid clearance in isolated rat lungs.2004

    • Author(s)
      Gu X, Toga H, et al.
    • Journal Title

      J Kanazawa Med Univ 29

      Pages: 91-96

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590768
  • [Journal Article] Malnutrition impaires alveolar fluid clearance in rat lungs.2004

    • Author(s)
      Sakuma T, Toga H, et al.
    • Journal Title

      Am J Physiol (Lung) 286

    • Data Source
      KAKENHI-PROJECT-16590768
  • [Journal Article] Role of nitric oxide in ARDS.2004

    • Author(s)
      Tobe T, Toga H.
    • Journal Title

      ARDS today.Bessatsu-Igaku no ayumi

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13670621
  • [Journal Article] Maximal inspiratory flow with nasal continuous positive airway pressure in patients with sleep- disordered breathing : relevance to the upper airway reflex.2004

    • Author(s)
      Huang J, Toga H, et al.
    • Journal Title

      Jpn J Clin Physiol 34(3)

      Pages: 169-176

    • NAID

      10013491776

    • Data Source
      KAKENHI-PROJECT-16590768
  • [Journal Article] Effects of α_1-,β_1-,β_2-,β_3-adrenergic agonists on alveolar fluid clearance in isolated rat lungs.2004

    • Author(s)
      Gu X, Toga H et al.
    • Journal Title

      J Kanazawa Med Univ 29

      Pages: 91-96

    • NAID

      110004617776

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590768
  • [Journal Article] Detection of inspiratory flow limitation with cardiogenic flow oscillation in patients with obstructive sleep apnea.2004

    • Author(s)
      Huang J, Toga H, et al.
    • Journal Title

      Jpn J Clin Physiol 34(3)

      Pages: 161-168

    • NAID

      10013491755

    • Data Source
      KAKENHI-PROJECT-16590768
  • [Journal Article] Uridine 5'-triphosphate stimulates alveolar fluid clearance in the isolated rat lungs.2004

    • Author(s)
      Sakuma T, Toga H, et al.
    • Journal Title

      J Pharmacol Sci 95

      Pages: 420-425

    • NAID

      10014165787

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590768
  • [Journal Article] Uridine 5'-triphosphate stimulates alveolar fluid clearance in the isolated rat lungs.2004

    • Author(s)
      Sakuma T, Toga H et al.
    • Journal Title

      J Pharmacol Sci 95

      Pages: 420-425

    • NAID

      10014165787

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590768
  • [Journal Article] A prostacyclin analogue, OP-41483α-CD, restores the ability of a β_2 -adrenergic agonist to stimulate alveolar fluid clearance in rats.2004

    • Author(s)
      Sakuma T, Toga H, et al.
    • Journal Title

      Surg Today 34

      Pages: 429-436

    • NAID

      10014173400

    • Data Source
      KAKENHI-PROJECT-16590768
  • [Journal Article] Role of CXC chemokines in ventilator- induced lung injury in rats.2004

    • Author(s)
      Toga H, et al.
    • Journal Title

      J Jpn Med Soc Biol Interface 35

      Pages: 9-16

    • NAID

      10013598287

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590768
  • [Journal Article] Mechanical stress on type II alveolar epithelial cells and production of CXC chemokines.2003

    • Author(s)
      Toga, H
    • Journal Title

      J JPn Med Soc Biol Interface 34

      Pages: 77-80

    • NAID

      50000000314

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13670621
  • [Journal Article] Mechanical stress on type II alveolar epithelial cells and production of CXC chemokines.2003

    • Author(s)
      Toga H, Tsuchihara K, Hida M, Nakamura K, Tsuchihara C, Tobe T, Iguchi M, Ishigaki M, Nambu Y, Osanai K, Sakuma T, Takahashi K.
    • Journal Title

      J Jpn Med Soc Biol Interface 34

      Pages: 77-80

    • NAID

      50000000314

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13670621
  • [Journal Article] Time dependent effect of pneumonectorny on alveolar epithelial fluid clearance in rat lungs.2002

    • Author(s)
      Sakuma T, Sagawa M, Hida M, Nambu Y, Osanai K, Toga H, Takahashi K, Ohya N, Matthay M.
    • Journal Title

      J Thorac Cardiov Surg 124

      Pages: 668-674

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13670621
  • [Journal Article] Apoptosis of alveolar type II cells in acute respiratory distress syndrome.2001

    • Author(s)
      Toga, H
    • Journal Title

      J Jpn Med Soc Biol Interface 32

      Pages: 24-25

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13670621
  • [Journal Article] Expression and localization of a novel rab small G protein (rab38) in the rat lung.2001

    • Author(s)
      Osanai K, Iguchi M, Takahashi K, Nambu Y, Sakuma T, Toga H, Ohya N, Shimizu H, Fisher JH, Voelker DR.
    • Journal Title

      Am J Pathol 158

      Pages: 1665-1675

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13670621
  • [Journal Article] Apoptosis of alveolar type II cells in acute respiratory distress syndrome.2001

    • Author(s)
      Toga H, Kasakura H, Tobe T, Ueda Y, Yang G, Okada T, Nambu Y, Osanai K, Sakuma T, Takahashi K, Ohya N.
    • Journal Title

      J Jpn Med Soc Biol Interface 32

      Pages: 24-25

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13670621
  • [Journal Article] Inducible nitric oxide synthase expression and nuclear factor κB activation in alveolar type II cells in lung in jury.2001

    • Author(s)
      Toga, H
    • Journal Title

      Exp Lung Res 27

      Pages: 485-504

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13670621
  • [Journal Article] Effects of hypoxia on alveolar fluid transport capacity in rat lungs.2001

    • Author(s)
      Sakuma T, Hida M, Nambu Y, Osanai K, Toga H, Takahashi K, Ohya N, Inoue M, Watanabe Y.
    • Journal Title

      J Appl Physiol 91

      Pages: 1766-1774

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13670621
  • [Journal Article] Inducible nitric oxide synthase expression and nuclear factor KB activation in alveolar type II cells in lung injury.2001

    • Author(s)
      Toga H, Tobe T, Ueda Y, Yang G-H, Osanai K, Ishigaki M, Okazaki H, Katsuda S, Takahashi K, Ohya N.
    • Journal Title

      Exp Lung Res 27

      Pages: 485-504

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13670621
  • [Presentation] Abnormal lung phenotype in Rab38-deficient rats, rodent models of Hermansky-Pudlak syndrome.2009

    • Author(s)
      K. Osanai, H. Toga, et al
    • Organizer
      FASEB Meeting
    • Place of Presentation
      New Orleans
    • Year and Date
      2009-04-19
    • Data Source
      KAKENHI-PROJECT-19590920
  • [Presentation] Rab38-deficient rats show phenotype of Hermansky-Pudlak synd-rome.2007

    • Author(s)
      K. Osanai, R. Oikawa, J. Higuchi, T. Miwa, H. Toga
    • Organizer
      American Thoracic Society
    • Place of Presentation
      San-Francisco
    • Year and Date
      2007-05-21
    • Data Source
      KAKENHI-PROJECT-19590920
  • [Presentation] Dobbs Leland: Expression of VEGF in alveolar type I and type II cell.2007

    • Author(s)
      戸部勇保, 齋藤雅俊, 小島好司, 田中篤利, 舘 由貴, 及川理恵子, 中川 研, 土原一真, 井口晶晴, 関 利満, 高橋昌克, 長内和弘, 黄 正寿, 栂 博久
    • Organizer
      日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2007-05-12
    • Data Source
      KAKENHI-PROJECT-19590920
  • 1.  TAKAHASHI Keiji (50004685)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 6 results
  • 2.  UEDA Yoshimichi (50271375)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  OSANAI Kazuhiro (70221158)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  ISHIZAKI Takeshi (80151364)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  MATSUKAWA Shigeru (00092809)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  SAKAI Akio (70020758)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  KOIZUMI Tomonori (20273097)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  AMESHIMA Shingo (60262614)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  NAMBU Yoshihiro (20237639)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  MATSUDA Masafumi (30165831)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  OKAZAKI Hiroshi (70267730)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  ISHIGAKI Masanobu (10247439)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  TOBE Takeyasu (90329409)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 14.  HIGASHI Kotaro (50189750)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  ALMAZ Aldashev
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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