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Ohta Masatsugu
大田 雅嗣
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Alternative Names
OHTA Masatsugu 大田 雅嗣
大田 雅嗣
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Researcher Number
90160514
Other IDs
Affiliation (Current)
2023: 福島県立医科大学, 公私立大学の部局等, 教授
Affiliation (based on the past Project Information)
*help
1995 – 1998: Hokkaido University.School of Medicine, Associate Professor, 医学部, 助教授
1988 – 1994: Jichi Medical School, Lecturer, 医学部, 講師
1986: Jichi Medical School ・ Associate, 医学部, 助手
Review Section/Research Field
Principal Investigator
Hematology
/
Cell biology
Except Principal Investigator
Hematology
/
広領域
Keywords
Principal Investigator
造血幹細胞 / 白血病細胞 / 造血支持細胞 / ヌ-ドマウス / 分化誘導 / 細胞外マトリックス / 細胞間相互作用 / 間質細胞 / Transforming Growth Factorーβ(TGFーβ) / 造血抑制因子
…
More
/ 白血病担癌動物 / 細胞融合 / 高電圧パルス法 / 担癌動物モデル / 生理活性糖脂質 / TGFーβ / 分化誘導療法 / 骨髄間質示持細胞 / 造血因子 / 造血微小 / 細胞接着 / 長期骨髄培養 / 膜糖鎖分子種
…
More
Except Principal Investigator
細胞周期 / ガングリオシド / ガングリオシドGM3 / ヒト骨髄性白血病細胞 / 造血因子 / 合成シアロ糖化合物 / 増殖因子 / シグナル伝達 / ガングリオシドGM3合成酵素 / 分化誘導 / シアロ糖脂質 / tumorigenicity / autocrine growth / electroporation / 網膜芽腫遺伝子産物Rb / cdc2遺伝子産物 / 細胞外マトリックス / テネイシンC / 間質・上皮間相互作用 / Extracellular Matrix (ECM) glycoproteins / Stromal-epithelial interactions / シアル酸転移酵素-1 / II型膜蛋白質 / 細胞外マトリックス糖蛋白 / シアロコレステロール / インターロイキン3 / 生理活性ガングリオシド / トリチウム標識 / 分化誘導機序 / 単球マクロファ-ジ系分化 / ガングリオシド代謝 / トリプシン処理 / リン酸化 / 造血幹細胞 / 自己再生 / 分化 / 増殖 / アプトーシス / 転写因子 / 増殖因子受容体 / 細胞増殖 / 細胞分化 / アポトーシス / 造血因子受容体 / ミュータントマクス / レセプター・チロシンキナーゼ / 造血因子レセプター / 造血支持細胞 / 白血病 / 複合糖質 / 糖脂質糖鎖 / シグナル伝達系 / α2→6シアル酸転移酵素 / 細胞外マトリックス糖蛋白テネイシン / レチノイン酸耐性HL-60変異株 / 糖鎖構造特異性 / 天然シアロ糖脂質ガングリオシド / 分化方向決定機序 / 分化誘導現象 / クローン増殖 / インターロイキン1 / 単球性白血病細胞株 / 白血病細胞の増殖分化 / 合成ペプチド / 白血病の病態生理 / 自己増殖因子 / インターロイキン1抑制性サイトカイン / 自律増殖能 / インタ-ロイキン(ILー1,ILー3) / 増殖因子(非)依存性 / 造腫瘍性 / オ-トクリン(Autocrine)機構 / エレクトロポレ-ション法(電気穿孔法) / 癌関連抗原シアロ糖脂質(GangliosideGD3) / ガングリオシドGD3 / 癌関連抗原ガングリオシドGD3 / 細胞融合法 / 高電圧パルス法 / エレクトロポレ-ション(Electroporation)法 / autonomous growth / Interleukins (IL-1, Il-3) / factor-dependent / -independent / hemopoietins / tumor-related gangliosides / TGF-β / 糖蛋白テネイシン / 細胞外マトリックスECM / (非)リン酸化型Rb / E2F結合部位 / クロマチン構造変化 / 非上皮系間質細胞 / (非)上皮系細胞 / Cell Cycle / cdc2 Gene Product / E2F Binding Site / Glycoprotein Tenascin / Extracellular Matrix / Nonepithelial Stroma Cells / Cell Growth Factors / Change Chromatin Structure / 細胞外マトリックス(ECM)糖蛋白 / アポトーシス抑制遺伝子bc1-2 / 分化形質発現 / アポトーシス感受性 / 細胞分化の制御 / アポトーシス抑制遺伝子bcl-2 / 水溶性細胞増殖因子EGF / 細胞外マトリックス糖蛋白分子 / Rbリン酸化抑制 / アポトーシス誘起 / bc1-2遺伝子 / ECM糖蛋白テネイシン / Retinoblastoma gene product (Rb) / Tenascin-C / Apoptosis inhibitory gene bcl-2 / Differentiation expression / Cell cycle / Apoptosis susceptibility / アポトーシス誘導 / フィブロネクチン / シアリルモティーフ / インテグリン分子VLA-5 / シアル酸転移酵素-I / インテグリンVLA-5 / 単球系分化 / 顆粒球系分化 / 細胞死アポトーシス / Fibronectin / Tenascin C / Monocytic differentiation / Granulocytic differentiation / Integrin VLA-5 / Programd cell death (Apoptosis) / 脂質性シアロ糖化合物 / cDNAクローニング / ゲノム構造解析 / テネイシン / シアル酸転移酵素遺伝子 / 5'-RACE法 / アミノCTH合成酵素 / ヒトLARGE遺伝子 / シアリルモチーフ / ガングリオシドGD3合成酵素 / ガングリオシドGM3糖鎖ポリマー / 白血病分化誘導 / ガングリオシド類縁体 / シアロジグリセリド / 光学異性体β-アノマー / ゲノム構造 / ヒト骨髄性白血病 / 分化誘導・増殖抑制 / Gangliosides / Synthetic Sialoglycolipids / Ganglioside GM3 synthase / cDNA Cloning / Genomic Structure Analysis / Sialocholesterol / Tenascin / Extracellular Matrix Glycoprotein / プリッキング法 / 外来性遺伝子導 / プラスミドgAE1A / Abelson白血病ウイルス / 細胞性腫瘍遺伝子c-myb / NFS-60細胞株 / Pricking method / Exogenous gene introduction / Plasmid gAE1A / Abelson murine leukemia virus(A-MuLV) / Cellular oncogene c-myb rearrangement / Hemopoietic Growth factors / Interleukin-3(IL-3) / 骨髄性白血病 / 3分化誘導 / 増殖制御 / 薬剤耐性変異株 / シアログリセリド / レチノイン酸耐性HLー60変異株 / 分化誘導活性 / HL-60細胞株 / グリコシド結合 / シアル酸 / glycosphingolipids / gangliosides / alpha-sialocholesterol / alpha-sialoglyceride / differentiation-induction / HL-60 / 無限増殖能 / 増殖因子依存性増殖 / 自律増殖機構 / 白血病幹細胞 / 分化異常 / 癌形質(白血病性形質) / 遺伝子導入 / エレクトロポレーション / 無制限増殖能 / gene transfection / malignant phenotype / FCC-P2 / NFS-60
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Research Projects
(
20
results)
Co-Researchers
(
20
People)
Project Start Year (Newest)
Project Start Year (Oldest)
白血病細胞の間質依存性増殖・分化制御機構における細胞接着・認識と臨床応用
Principal Investigator
Principal Investigator
大田 雅嗣
Project Period (FY)
1998
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Hematology
Research Institution
Hokkaido University
制癌の標的分子としての複合糖質糖鎖
Principal Investigator
斎藤 政樹
Project Period (FY)
1997
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Hokkaido University
Exploitation on Biological Activities of Sialoglycosphingolipids and Their Synthetic Family Compounds (Neoglycollipids)
Principal Investigator
SAITO Masaki
Project Period (FY)
1997 – 1999
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
広領域
Research Institution
National Cancer Center Research Institute
Hokkaido University
Glyco-Signals in Regulatory Mechanisms For Proliferation, Differentiation, Senescence And Apoptosis of Hematopoietic Cells.
Principal Investigator
SAITO Masaki
Project Period (FY)
1996 – 1997
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Hematology
Research Institution
Hokkaido University
造血幹細胞の定着・増殖・分化・死のシグナル
Principal Investigator
北村 幸彦
Project Period (FY)
1994 – 1997
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Osaka University
間質系細胞が表現する膜糖脂質分子種による間質・造血幹細胞情報伝達機構の解明
Principal Investigator
Principal Investigator
大田 雅嗣
Project Period (FY)
1994
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Cell biology
Research Institution
Jichi Medical University
Regulatory Mochanisms For Proliferation, Differentiation, And Apoptosis of Leukemic Cells In Reference To Cell Cycle Phases.
Principal Investigator
SAITO Masaki
Project Period (FY)
1994 – 1995
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Hematology
Research Institution
Hokkaido University
Jichi Medical University
TGF-βによるRB遺伝子産物の脱リン酸と癌細胞増殖抑制機序の解明
Principal Investigator
古川 雄祐
Project Period (FY)
1992
Research Category
Grant-in-Aid for Cancer Research
Research Institution
Jichi Medical University
Effects of cdc2 gene and EMC tenasc in on regulation of growth and differentiation of hematopoietic cells
Principal Investigator
SAITO Masaki
Project Period (FY)
1992 – 1993
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Hematology
Research Institution
Jichi Medical School
ヒト白血病細胞担癌動物モデルを用いた癌細胞の増殖・分化機構の解析と臨床応用
Principal Investigator
Principal Investigator
大田 雅嗣
Project Period (FY)
1991
Research Category
Grant-in-Aid for Cancer Research
Research Institution
Jichi Medical University
新たな手法を用いた造血幹細胞・造血微小環境相互作用の分子機構の解析
Principal Investigator
Principal Investigator
大田 雅嗣
Project Period (FY)
1991
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Hematology
Research Institution
Jichi Medical University
培養系及び担癌動物系でのTransforming Growth Factorーβ(TGFーβ)による白血病細胞増殖抑制効果の検討と臨床応用
Principal Investigator
Principal Investigator
大田 雅嗣
Project Period (FY)
1990
Research Category
Grant-in-Aid for Cancer Research
Research Institution
Jichi Medical University
正常血液細胞=白血病細胞 融合細胞株の生物学的特性と臨床応用
Principal Investigator
Principal Investigator
大田 雅嗣
Project Period (FY)
1990
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Hematology
Research Institution
Jichi Medical University
Studies on Expression-Mechanism (s) of Malignant Phenotypes Using Growth-Factor Gene-Transfer Methods
Principal Investigator
SAITO Masaki
Project Period (FY)
1990 – 1991
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Hematology
Research Institution
Jichi Medical School
シアロ糖化合物による制癌(白血病細胞増殖抑制・分化誘導)機構の解析と応用:生理活性ガングリオシドGM3の取込み、分布、代謝
Principal Investigator
SAITO Masaki
Project Period (FY)
1989
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Jichi Medical University
シロア糖脂質(ガングリオシド)及び有機合成類似体による制癌の試み:抗白血病作用の特異的分子機構の解析
Principal Investigator
斎藤 政樹
Project Period (FY)
1988
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Jichi Medical University
単球性細胞株JOSK-Iの産生するIL-1の生理活性と臨床応用
Principal Investigator
古川 雄祐
Project Period (FY)
1988
Research Category
Grant-in-Aid for Cancer Research
Research Institution
Jichi Medical University
Autocrine Proliferation and Differentiation-Capacities of Leukemic Cells, and Molecular Analyses of Leukemic Phenotypes
Principal Investigator
SAITO Masaki
Project Period (FY)
1987 – 1988
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Hematology
Research Institution
Jichi Medical School
Bioactive Sialoglycosphingolipids(Gangliosides) and Their Related Amphipathic Sialoglycocompounds:Fundamental Studies and Applications of Anti-Leukemic(Differentiation-Inducing) Activities
Principal Investigator
SAITO Masaki
Project Period (FY)
1986 – 1988
Research Category
Grant-in-Aid for Developmental Scientific Research
Research Field
Hematology
Research Institution
Jichi Medical School
Establishment of Hemopoietic Stem Cell Lines By Introduction of Oncogenes and Biochemical Studies on Mechanisms of Hemopoietic Cell Differentiation Using the Established Cell Lines
Principal Investigator
SAITO Masaki
Project Period (FY)
1985 – 1986
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Hematology
Research Institution
Jichi Medical School
# of Projects (Dsc)
# of Projects (Asc)
1.
SAITO Masaki
(60012762)
# of Collaborated Projects:
11 results
# of Collaborated Products:
0 results
2.
NAKAMURA Mitsuru
(20198237)
# of Collaborated Projects:
10 results
# of Collaborated Products:
0 results
3.
KITAGAWA Sei-ichi
(50133278)
# of Collaborated Projects:
8 results
# of Collaborated Products:
0 results
4.
FURUKAWA Yusuke
(00199431)
# of Collaborated Projects:
7 results
# of Collaborated Products:
0 results
5.
NOJIRI Hisao
(70180742)
# of Collaborated Projects:
4 results
# of Collaborated Products:
0 results
6.
YABUNAKA Noriyuki
(70240637)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
7.
MOTOYOSHI Kazuo
(80137702)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
8.
ISHII Atsushi
(20232225)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
9.
SUDA Toshio
(60118453)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
10.
SAKAI Takao
(10235111)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
11.
MATSUDA Kazuhiro
(80251502)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
12.
HAMANAKA Yuichiro
(40189618)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
13.
SAKAI Ryuichi
(40215603)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
14.
北村 幸彦
(70028520)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
15.
平井 久丸
(90181130)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
16.
辻本 賀英
(70132735)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
17.
帯刀 益夫
(10099971)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
18.
西川 伸一
(60127115)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
19.
井川 洋二
(40085618)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
20.
ITOH Masayoshi
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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