Otsuka Makoto 大塚誠

… Alternative Names

OTSUKA Makoto 大塚誠

MAKOTO Otsuka 大塚誠

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Researcher Number	90160548
External Links
Affiliation (Current)	2025: 静岡大学, 電子工学研究所, 特任教授
Affiliation (based on the past Project Information) *help	2018: 武蔵野大学, 薬学部, 教授 2016 – 2017: 武蔵野大学, 付置研究所, 教授 2014 – 2017: 武蔵野大学, 薬学研究所, 教授 2005 – 2006: 武蔵野大学, 薬学研究所, 教授 2001 – 2002: 神戸薬科大学, 薬学部, 助教授 1996 – 1999: 神戸薬科大学, 薬学部, 助教授 1994 – 1995: 神戸薬科大学, 薬学部・製剤学, 助教授
Review Section/Research Field	Principal Investigator Biomedical engineering/Biological material science / Biomedical engineering/Biological material science / Physical pharmacy / Biomedical engineering/Biological material science Except Principal Investigator Physical pharmacy / Optical engineering, Photon science
Keywords	Principal Investigator 人工骨 / バイオマテリアル / 薬物送達システム / 薬物放出制御 / Drug delivery system / アパタイト / 有機無機複合体 / bioaffinity / Artificial bone / Biomaterials … More / 生体親和性 / Bis-GMA / biomaterials / 骨密度 / 骨粗鬆症 / X線回折 / セルスキャホールド / 細胞親和性 / ハイドロキシアパタイト / インプラント / 骨再組織工学 / 亜鉛 / 骨再生 / サンゴ / 細胞組織工学 / 骨幹細胞 / 生体硬組織 / In-vitro薬剤放出試験 / 亜鉛徐放化マテリアル / In-vitro放出試験 / 非破壊計測 / 人工神経導管 / 骨系細胞スキャホールド / 有機・無機複合化マテリアル / 薬剤徐放化マテリアル / 骨組織再生医療 / 多変量解析 / 近赤外スペクトル / テラヘルツスペクトル / 非破壊・非接触生体活性評価 / 骨細胞スキャホールド / 分子配向性 / 振動分光法 / Bone regenerative medicine / nanoparticle / calcium phosphates / Controlled drug release / osteoporosis / 骨再生医療 / ナノ粒子 / リン酸カルシウム / 骨粗しょう症 / 薬物送還システム / artificial bone cement / drug delivery system / controlled drug release / bio-essential rear metal / Inorganic composite particle / Organic / Nano-Level structures / 有機・無機複合体セメント / 人工骨材料 / 人工骨セメント / DDS / 放出制御 / 生体必須微量金属 / 有機・無機複合化粒子 / ナノレベル構造体 / bone activity / hydroxyapatite / Cephalexin / 骨親和性 / ハイドロシアパタイト / セファレキシン / bone mineral density / intelligent materials / atificial bone / sustained drug release / apatite / Osteoporosis / 除放化 / インテリジェントマテリアル, / 人工骨, / 徐放化, / バイオマテリアル, / アパタイト, / 薬物送達システム, / 骨粗鬆症, / インテリジェントマテリアル / 徐放化 … More Except Principal Investigator 製剤特性 / 結晶多形 / 中分子量 / 微量検出 / 分析科学 / 中分子医薬品 / テラヘルツレーザー分光 / 医薬品検査 / 応用光学・量子光工学 / 薬学 / 分析化学 / テラヘルツ/赤外材料・素子 / 不純物検出 / 医薬品 / テラヘルツ / 格子欠陥 / テラヘルツ分光 / 微量不純物検出 / kinetics / pharmaceutical properties / powder characteristics / reaction rate / excipients / international harmonization / additives / Polymorphism / 速度論 / 粉体特性 / 反応速度 / 賦形剤 / 国際的調和 / 医薬品添加物 / X-ray diffractometry / design of pharmaceutical preparations / dissolution rate / physicochemical properties / stability / polymorphism / 生物学的利用能 / 溶解特性 / X線回折 / 製剤処方設計 / 溶解速度 / 物理化学的特性 / 安定性 Less

Study of impurity effects in organic crystal appearing in low frequency vibrational spectra and its application
- Principal Investigator
  
  Sasaki Tetsuo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Optical engineering, Photon science
- Research Institution
  Shizuoka University
Nondestructive bioactivity evaluation of molecular orientated hybrid bone cell scaffold by vibration spectroscopyPrincipal Investigator
- Principal Investigator
  
  OTSUKA Makoto
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Musashino University
生体硬組織を標的とした薬物放出制御と骨幹細胞を用いた細胞組織工学Principal Investigator
- Principal Investigator
  
  大塚誠
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Musashino University
Bone Generation by using Three-Dimensional Geometrical Structural Controlled Cell Scaffold and Osteogenetic Growth Stimulated Factor Controlled Delivery SystemPrincipal Investigator
- Principal Investigator
  
  OTSUKA Makoto
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Musashino University
Controlled essential rare-metal release from organic/inorganic nano-composite materialsPrincipal Investigator
- Principal Investigator
  
  MAKOTO Otsuka
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kobe Pharmaceutical University
Biosignal responsive drug delivery system by using bioactive polymer/ceramic composite bone cementPrincipal Investigator
- Principal Investigator
  
  OTSUKA Makoto
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  KOBE PHARMACEUTICAL UNIVERSITY
Effect of pharmaceutical additives on physicochemical properties of pharmaceutical preparations.
- Principal Investigator
  
  MATSUDA Yoshihsa
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kobe Pharmaceutical University
Endogenous signal-responsive drug release from bioactive bone cementPrincipal Investigator
- Principal Investigator
  
  OTSUKA Makoto
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kobe Pharmaceutical Univesity
International harmonization of stability evaluation for formulation of solid-dosage form containing polymorphic form.
- Principal Investigator
  
  MATSUDA Yoshihisa
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kobe Pharmaceutical University, Department of Pharmaceutical Technology.

All 2019 2018 2017 2016 2015 2014 2013 2006 2005

All Journal Article Presentation Book

[Book] 生体吸収性材料の開発とその安全性評価(No.1927)、２章　再生医療用足場材料に用いる生体吸収性材料の開発と評価、5節　有機-無機複合体を用いた生体組織足場材料の作製2017
- Author(s)
  照喜名孝之,服部祐介，大塚誠
- Total Pages
  487
- Publisher
  株）技術情報協会.
- Data Source
  KAKENHI-PROJECT-15K07902
[Journal Article] 病態応答性薬物放出特性を持つアパタイト系人工骨の設計2018
- Author(s)
  大塚誠
- Journal Title
  
  PHOSPHORUS LETTER
  
  Volume: 91 Pages: 6-17
- NAID
  40021513658
- Data Source
  KAKENHI-PROJECT-15K07902
[Journal Article] Sharp Absorption Peaks in THz Spectra Valuable for Crystal Quality Evaluation of Middle Molecular Weight Pharmaceuticals2018
- Author(s)
  Sasaki Tetsuo、Sakamoto Tomoaki、Otsuka Makoto
- Journal Title
  
  J Infrared Milli Terahz Waves
  
  Volume: 39 Issue: 9 Pages: 828-839
- DOI
  10.1007/s10762-018-0494-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H03882
[Journal Article] Detection of Impurities in Organic Crystals by High-Accuracy Terahertz Absorption Spectroscopy2018
- Author(s)
  Sasaki Tetsuo、Sakamoto Tomoaki、Otsuka Makoto
- Journal Title
  
  Analytical Chemistry
  
  Volume: 90 Issue: 3 Pages: 1677-1682
- DOI
  10.1021/acs.analchem.7b03220
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H03882
[Journal Article] Development of Controllable Simvastatin- Releasing PLGA/β-TCP Composite Microspheres Sintered Scaffolds as Synthetic Bone Substitutes2017
- Author(s)
  T. Terukina, T. Numaguchi, Y. Hattori, M. Otsuka
- Journal Title
  
  Key Engineering Materials 758:126-131 (2017)
  
  Volume: 758 Pages: 126-131
- DOI
  10.4028/www.scientific.net/kem.758.126
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07902
[Journal Article] 骨粗鬆症病態応答性亜鉛徐放特性を持つリン酸カルシウム系人工骨の設計2017
- Author(s)
  大塚誠，服部祐介
- Journal Title
  
  Biomedical Research on Trace Elements
  
  Volume: 28 Pages: 127-134
- NAID
  130006286266
- Data Source
  KAKENHI-PROJECT-15K07902
[Journal Article] 薬物放出性骨補填材としてのシンバスタチン徐放性PLGAマイクロスフェア／炭酸アパタイト複合体の開発と評価2017
- Author(s)
  照喜名孝之，齊藤花江，沼口貴範，服部祐介，大塚誠
- Journal Title
  
  バイオインテグレイション学会誌、7, 59-65 (2017).
  
  Volume: 7 Pages: 59-65
- NAID
  130007877759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07902
[Journal Article] Development and effect of a sustainable and controllable simvastatin-releasing device based on PLGA microspheres/carbonate apatite cement composite: In vitro evaluation for use as a drug delivery system from bone-like biomaterial.2017
- Author(s)
  T. Terukina, H. Saito, Y. Tomita, Y. Hattori, M. Otsuka
- Journal Title
  
  Journal of Drug Delivery Science and Technology
  
  Volume: 37 Pages: 74-80
- DOI
  10.1016/j.jddst.2016.10.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07902
[Journal Article] シンバスタチン含有ゼラチン・ハイドロキシアパタイト球形顆粒の開発とシンバスタチンの放出制御,2016
- Author(s)
  齊藤花江，照喜名孝之，細越貴裕，服部祐介，大塚誠,
- Journal Title
  
  バイオインテグレション学会誌
  
  Volume: 6 Pages: 63-69
- NAID
  130007877781
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07902
[Journal Article] Effect of biomimetic zinc-containing tricalcium phosphate (Zn—TCP) on the growth and osteogenic differentiation of mesenchymal stem cells2014
- Author(s)
  Chou J, Hao J, Hatoyama H, Ben-Nissan B, Milthorpe B, Otsuka M
- Journal Title
  
  J Tissue Engineering & Regenerative Medicine
  
  Volume: 9(7) Issue: 7 Pages: 852-858
- DOI
  10.1002/term.1901
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-12F02814, KAKENHI-PROJECT-15K07902
[Journal Article] Strontium- and magnesium-enriched biomimetic β-TCP macrospheres2014
- Author(s)
  J. Chou, S. M. Valenzuela, J. Santos, D. Bishop, B. Milthorpe, D. W. Green, M. Otsuka, B. Ben-Nissan,
- Journal Title
  
  J. Tissue Engineering and Regenerative Medicine
  
  Volume: 8 Issue: 10 Pages: 771-778
- DOI
  10.1002/term.1576
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-12F02814
[Journal Article] The therapeutic effect on bone mineral formation from biomimetic zinc containing tricalcium phosphate (ZnTCP) in zinc-deficient osteoporotic mice2014
- Author(s)
  Chou J, Hao J, Hatoyama H, Ben-Nissan B, Milthorpe B, Otsuka M
- Journal Title
  
  PLoS ONE
  
  Volume: 8(8) Issue: 8 Pages: e71821-e71821
- DOI
  10.1371/journal.pone.0071821
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12F02814
[Journal Article] Antibiotic delivery potential of nano and microporous marine structure2014
- Author(s)
  J. Chou , S. Valenzuela, D. W Green, L. Kohan , B. Milthorpe, M. Otsuka, B. Ben-Nissan,
- Journal Title
  
  Nanomedicine
  
  Volume: 9 Issue: 8 Pages: 1131-1139
- DOI
  10.2217/nnm.13.116
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-12F02814
[Journal Article] Bone regeneration of calvarial defect using marine calcareous-derived beta-tricalcium phosphate macrosphere2014
- Author(s)
  Chou J, Hao J, Shinji K, Ben-Nissan B, Milthorpe B, Otsuka M
- Journal Title
  
  Journal of Tissue Engineering
  
  Volume: 5 Pages: 1-7
- DOI
  10.1177/2041731414523441
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-12F02814
[Journal Article] Bone regeneration of rat tibial defect by zinc-tricalcium phosphate (Zn-TCP) from porous Foraminifera carbonate macrospheres2013
- Author(s)
  Chou J, Hao J, Kuroda S, Ben-Nissan B. Milthorpe B, Otsuka M
- Journal Title
  
  Marine Drugs
  
  Volume: 11 Pages: 5148-5158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12F02814
[Journal Article] Controlled Release of Simvastatin from Biomimeticβ-TCP Drug Delivery System,2013
- Author(s)
  J. Chou, T. Ito, D. Bishop, M. Otsuka, B. Ben-Nissan, B. Milthorpe,
- Journal Title
  
  Plos One
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12F02814
[Journal Article] Therapeutic Effect of Selected Biomaterials (Mg/Z/F-CaPs, Administrated by Injection) on Bone Properties of Ovariectomized Rats2006
- Author(s)
  M.Otsuka, A.Oshinbe, A.Ito, K.Otsuka, et al.
- Journal Title
  
  Key Engineering Materials 309-311
  
  Pages: 243-246
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17500322
[Journal Article] Prediction of Tablet Hardness Based on Near Infrared Spectra of Raw Mixed Powders by Chemometrics2006
- Author(s)
  M.Otsuka, I.Yamane
- Journal Title
  
  J. Pharm. Sci. 95 (7)巻
  
  Pages: 1425-1433
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17500322
[Journal Article] Prediction of Tablet Hardness Based on Near Infrared Spectra of Raw Mixed Powders by Chemometrics,2006
- Author(s)
  M.Otsuka, I.Yamane
- Journal Title
  
  J.Pharm.Sci. 95 (7)
  
  Pages: 1425-1433
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500322
[Journal Article] Effect of Nanostructure on Biodegradation Behaviors of Self-Setting Apatite/Collagen Composite Cements Containing Vitamin K_2 in Rats2006
- Author(s)
  M.Otsuka, T.Kuninaga, K.Otsuka, W.I.Higuchi
- Journal Title
  
  J.Biomedical Mater.Res.B, App.Biomat. 79B
  
  Pages: 176-184
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500322
[Journal Article] Prediction of Tablet Hardness Based on Near Infrared Spectra of Raw Mixed Powders by Chemometrics2006
- Author(s)
  M.Otsuka, I.Yamane
- Journal Title
  
  J. Pharm. Sci. 95(7)巻
  
  Pages: 1425-1433
- Data Source
  KAKENHI-PROJECT-17500322
[Journal Article] Therapeutic Effect of Selected Biomaterials (Mg/Z/F-CaPs, Administrate red by Injection) on Bone Properties of Ovariectomized Rats,2006
- Author(s)
  M.Otsuka, A.Oshinbe, A.Ito, K.Otsuka, W.I.Higuchi, R.Z.LeGeros
- Journal Title
  
  Key Engineering Materials 309-311
  
  Pages: 243-246
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500322
[Journal Article] Therapeutic Effect of Selected Biomaterials (Mg/Z/F-CaPs, Administrated by Injection) on Bone Properties of Ovariectomized Rats,2006
- Author(s)
  M.Otsuka, A.Oshinbe, A.Ito, K.Otsuka, et al.
- Journal Title
  
  Key Engineering Materials 309-311
  
  Pages: 243-246
- Data Source
  KAKENHI-PROJECT-17500322
[Journal Article] Effect of Nanostructure on Biodegradation Behaviors of Self-Setting Apatite/Collagen Composite Cements Containing Vitamin K_2 in Rats2006
- Author(s)
  M.Otsuka, T.Kuninaga, K.Otsuka, W.I.Higuchi
- Journal Title
  
  J. Biomedical Mater. Res. B, App. Biomat. 79B巻
  
  Pages: 176-184
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17500322
[Journal Article] Comparative evaluation of bioactivity change of crystalline trypsin during compression by Chemoinformatics and 2-D Fourier-transform Infrared2006
- Author(s)
  M.Otsuka, Y.Fukui, K.Otsuka, Y.Ozaki
- Journal Title
  
  Analyst 131巻
  
  Pages: 1116-1121
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17500322
[Journal Article] Comparative evaluation of bioactivity change of crystalline trypsin during compression by Chemoinformaties and 2-D Fourier-transform Infrared,2006
- Author(s)
  M.Otsuka, Y.Fukui, K.Otsuka, Y.Ozaki
- Journal Title
  
  Analyst 131
  
  Pages: 1116-1121
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500322
[Journal Article] An Accurate Quantitative Analysis of Polymorphs Based on Artificial Neural Networks2006
- Author(s)
  T.Okumura, M.Nakazono, M.Otsuka, K.Takayama
- Journal Title
  
  Colloid and Surfaces B : Biointerface 49巻
  
  Pages: 153-157
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17500322
[Journal Article] An Accurate Quantitative Analysis of Polymorphs Based on Artificial Neural Networks,2006
- Author(s)
  T.Okumura, M.Nakazono, M.Otsuka, K.Takayama
- Journal Title
  
  Colloid and Surfaces B : Biointerface 49
  
  Pages: 153-157
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500322
[Journal Article] Effect of Tablet Geometrical Structure on the Dehdration of Creatine Monohydrate Tablets, and Their Pharmaceutical Properties2005
- Author(s)
  Y.Sakata, S.Shiraishi, M.Otsuka
- Journal Title
  
  AAPS Pharm Sci Tech 6巻
- Data Source
  KAKENHI-PROJECT-17500322
[Journal Article] Zinc-Containing Tricalcium Phosphate and Related Materials for Promoting Bone Formation,2005
- Author(s)
  A.Ito, M.Otsuka, H.Kawamura, M.Ikeuchi, et al.
- Journal Title
  
  Current Applied Physics 5巻
  
  Pages: 402-406
- Data Source
  KAKENHI-PROJECT-17500322
[Journal Article] Two-Dimensional Correlation Spectroscopy As a Tool For Analyzing Vibrational Images,2005
- Author(s)
  S.S as ic, M.Morimoto, M.Otsuka, Y.Ozaki
- Journal Title
  
  Vibrational Spect. 37巻
  
  Pages: 217-224
- Data Source
  KAKENHI-PROJECT-17500322
[Journal Article] Evaluation of the microcrystallinity of a drug substance, indomethacin, in a pharmaceutical model tablet by chemometric FT-Raman spectroscopy2005
- Author(s)
  T.Okumura, M.Otsuka
- Journal Title
  
  Pharm Res. 22巻
  
  Pages: 1350-1357
- Data Source
  KAKENHI-PROJECT-17500322
[Journal Article] Zinc-Containing Tricalcium Phosphate and Related Materials for Promoting Bone Formation2005
- Author(s)
  A.Ito, M.Otsuka, H.Kawamura, M.Ikeuchi, et al.
- Journal Title
  
  Current Applied Physics 5巻
  
  Pages: 402-406
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17500322
[Journal Article] A Novel Standard Sample Powder Preparation Method for Quantitative Analysis of Polymorphs.2005
- Author(s)
  T.Okumura, M.Otsuka
- Journal Title
  
  J.Phrma.Sci. 94巻
  
  Pages: 1013-1023
- Data Source
  KAKENHI-PROJECT-17500322
[Journal Article] Zinc-Containing Tricalcium Phosphate and Related Materials for Promoting Bone Formation,2005
- Author(s)
  A.Ito, M.Otsuka, H.Kawamura, M.Ikeuchi, H.Ohgushi, Y.Sogo, N.Ichinose
- Journal Title
  
  Current Applied Physics 5
  
  Pages: 402-406
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500322
[Presentation] 連続波テラヘルツレーザー分光測定による医薬品品質検査2019
- Author(s)
  佐々木哲朗、坂本知昭、大塚誠、西澤潤一
- Organizer
  学振182委員会研究会, 2019.2.12, えんてつ駅前貸会議室、浜松
- Invited
- Data Source
  KAKENHI-PROJECT-16H03882
[Presentation] Quantitative impurity measurement in pharmaceuticals by THz laser spectrometer2019
- Author(s)
  Tetsuo Sasaki, Tomoaki Sakamoto, Makoto Otsuka
- Organizer
  PITTCON 2019 Philadelphia, USA, 2019.3.17-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03882
[Presentation] 医薬品のテラヘルツ分光スペクトルデータベースの構築2019
- Author(s)
  佐々木哲朗、坂本知昭、大塚誠
- Organizer
  日本薬学会 139年会（2019.3.20-23）千葉
- Data Source
  KAKENHI-PROJECT-16H03882
[Presentation] Quantitative Impurity Measurement In Organic Crystals By Precise Measurements Of THz Absorption Frequencies2018
- Author(s)
  Tetsuo Sasaki, Tomoaki Sakamoto, Makoto Otsuka
- Organizer
  43rd International Conference on Infrared, Millimeter and Terahertz Waves (IRMMW-THz 2018), Nagoya, Japan, 2018.9.10 - 9.14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03882
[Presentation] 骨誘導性機能を有する薬物徐放性足場材料としての低温焼結 PLGA マイクロスフェアブロックの開発とin vivo の評価2018
- Author(s)
  沼口貴範, 照喜名孝之, 服部祐介, 大塚誠
- Organizer
  日本薬学会 138年会
- Data Source
  KAKENHI-PROJECT-15K07902
[Presentation] 高精度テラヘルツ分光スペクトル測定による有機結晶中の高感度不純物検出2018
- Author(s)
  佐々木哲朗, 坂本知昭, 大塚誠
- Organizer
  日本薬学会 138年会金沢
- Data Source
  KAKENHI-PROJECT-16H03882
[Presentation] Spectroscopy by coherent monochromatic terahertz wave2018
- Author(s)
  Tetsuo Sasaki, Tomoaki Sakamoto, Makoto Otsuka
- Organizer
  FY 2017 RIEC Annual Meeting on Cooperative Research Projects "Compass for Next Generation ICT", RIEC, Tohoku Univ., Miyagi
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03882
[Presentation] リン酸カルシウム被覆PLGAナノ粒子封入アルギン酸ビーズの開発と評価2018
- Author(s)
  松林信人，照喜名孝之，服部祐介，大塚誠, 佐々木哲郎
- Organizer
  平成29年度生体医歯工学共同研究拠点　成果報告会
- Data Source
  KAKENHI-PROJECT-15K07902
[Presentation] イブプロフェン/ニコチンアミドによるコクリスタル形成過程の分子挙動とその速度論解析2018
- Author(s)
  石原聡恵，照喜名孝之，服部祐介，大塚誠, 佐々木哲朗
- Organizer
  平成29年度生体医歯工学共同研究拠点　成果報告会
- Data Source
  KAKENHI-PROJECT-15K07902
[Presentation] 高精度テラヘルツ分光スペクトル測定による有機結晶中の高感度不純物検出2018
- Author(s)
  佐々木哲朗, 坂本知昭, 大塚誠
- Organizer
  日本薬学会 138年会
- Data Source
  KAKENHI-PROJECT-15K07902
[Presentation] Evaluation of a-Cyclodextrin Hexahydrate Crystal by High Accuracy Terahertz Spectroscopy2018
- Author(s)
  Tetsuo Sasaki, Tomoaki Sakamoto, Makoto Otsuka
- Organizer
  ICS2018, 2018.4.29, Sophia Univ., Tokyo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03882
[Presentation] High accuracy and high resolution terahertz spectroscopy for impurity detection in pharmaceutical drugs2018
- Author(s)
  Tetsuo Sasaki, Tomoaki Sakamoto, Makoto Otsuka
- Organizer
  the 4th International Conference on Nano Electronics Research Education 2018 (ICNERE 2018), 2018.11.28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03882
[Presentation] Development of simvastatin-releasing nano-hydroxyapatite/PLGA composite microspheres sintered scaffolds,2017
- Author(s)
  T. Terukina, T. Numaguchi, Y. Hattori, M. Otsuka
- Organizer
  2017 Annual Meeting of American Association of Pharmaceutical Scientists,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07902
[Presentation] 細胞送達キャリアとしての多機能性アルギン酸ビーズの開発2017
- Author(s)
  松林信人，照喜名孝之，服部祐介，大塚誠
- Organizer
  日本薬剤学会第32年会
- Data Source
  KAKENHI-PROJECT-15K07902
[Presentation] Continuous Wave Gallium Phosphide THz Spectrometer applied for Pharmaceutical Industry2017
- Author(s)
  Tetsuo Sasaki, Tomoaki Sakamoto, Makoto Otsuka
- Organizer
  8th International THz-Bio Workshop, (THz-BIO2017), Frascati, Italy
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03882
[Presentation] 亜鉛含有リン酸カルシウムの合成機構の解明および結晶性・亜鉛放出性の予測2017
- Author(s)
  齊藤花江，照喜名孝之，服部祐介，佐々木哲朗，大塚　誠
- Organizer
  日本薬学会　第137年会
- Place of Presentation
  仙台市東北大学
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K07902
[Presentation] 薬物放出性骨補填材としてのシンバスタチン徐放性PLGAマイクロスフェア／炭酸アパタイト複合体の開発と評価2017
- Author(s)
  照喜名孝之，齊藤花江，沼口貴範，服部祐介，大塚誠
- Organizer
  第7回バイオインテグレーション学会
- Place of Presentation
  仙台市東北大学
- Year and Date
  2017-03-10
- Data Source
  KAKENHI-PROJECT-15K07902
[Presentation] Detection of impurities contained in organic crystals by terahertz spectroscopy measurement2017
- Author(s)
  Tetsuo Sasaki, Tomoaki Sakamoto, Makoto Otsuka
- Organizer
  The 2nd International Symposium on Biomedical Engineering, Tokyo Institute of Technology, Tokyo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03882
[Presentation] 高精度テラヘルツ分光スペクトル測定による中分子量医薬品のスペクトル観察2017
- Author(s)
  佐々木哲朗, 坂本知昭, 大塚誠
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター、宮城県仙台市
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16H03882
[Presentation] 骨再生足場材料への応用を目指した低温焼結 PLGA マイクロスフェアの開発2017
- Author(s)
  沼口貴範，照喜名孝之，服部祐介，大塚誠
- Organizer
  日本薬剤学会第32年会
- Data Source
  KAKENHI-PROJECT-15K07902
[Presentation] テラヘルツ分光スペクトル測定による有機結晶含有微量不純物検出2017
- Author(s)
  佐々木哲朗、坂本知昭、大塚誠
- Organizer
  第46回結晶成長国内会議（JCCG-46）、ホテルコンコルド浜松、静岡
- Data Source
  KAKENHI-PROJECT-16H03882
[Presentation] Development of controllable simvastatin-releasing PLGA/β-TCP composite microspheres sintered scaffolds as synthetic bone substitutes2017
- Author(s)
  T. Terukina, T. Numaguchi, Y. Hattori, M. Otsuka
- Organizer
  29th Symposium and Annual Meeting of the International Society for Ceramics in Medicine (Bioceramics29)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07902
[Presentation] 高周波数精度連続波テラヘルツ分光吸収スペクトル測定による有機結晶中の微量不純物の高感度検出2017
- Author(s)
  佐々木哲朗、坂本知昭、大塚誠
- Organizer
  第78回応用物理学会秋季学術講演会、福岡国際会議場（福岡）
- Data Source
  KAKENHI-PROJECT-16H03882
[Presentation] Elucidation of the Reaction Mechanism in Mechanochemical Synthesis of Zinc Containing Calcium Phosphate, and the Prediction of Their Crystallinity by Nearinfrared Spectroscopy2016
- Author(s)
  Hanae Saito, Takayuki Terukina, Yusuke Hattori, Tetsuo Sasaki, Makoto Otsuka
- Organizer
  Asian Near-Infrared Spectroscopy Symposium
- Place of Presentation
  鹿児島市城山観光ホテル
- Year and Date
  2016-12-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07902
[Presentation] Development of controllable simvastatin-releasing device based on PLGA microspheres/carbonate apatite cement composite2016
- Author(s)
  T. Terukina, H. Saito, Y. Tomita, Y. Hattori1, M. Otsuka
- Organizer
  International Symposium on Biomedical Engineering
- Place of Presentation
  東京医科歯科大学
- Year and Date
  2016-11-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07902
[Presentation] シンバスタチン含有ゼラチン・ハイドロキシアパタイト球形化顆粒からの薬物放出制御2016
- Author(s)
  ２５．齋藤花江，細越貴裕，服部祐介，大塚誠
- Organizer
  日本薬学会第136年会
- Place of Presentation
  ハシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K07902
[Presentation] 骨粗鬆症治療のためのシンバスタチン封入 PLGA 粒子／炭酸含有アパタイト複合体の開発2016
- Author(s)
  照喜名孝之，齊藤花江，冨田湧矢，服部祐介，大塚誠
- Organizer
  第38回バイオマテリアル学会
- Place of Presentation
  福岡市福岡国際会議場
- Year and Date
  2016-11-21
- Data Source
  KAKENHI-PROJECT-15K07902
[Presentation] 多孔性亜鉛含有リン酸三カルシウム球形顆粒の調製と亜鉛放出制御2016
- Author(s)
  大塚誠，鳩山宏一，Joshua CHOU, 服部祐介
- Organizer
  日本薬学会第136年会
- Place of Presentation
  ハシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K07902
[Presentation] Development of Sustainable and Controllable Simvastatin-Releasing Device Based on PLGA Microspheres/Carbonate Apatite Cement Composite Scaffold for Useful Osteoporosis Treatment2016
- Author(s)
  T. Terukina, Y. Tomita, Y. Hattori, M. Otsuka
- Organizer
  2016 Annual Meeting of American Association of Pharmaceutical Scientists,
- Place of Presentation
  Denver, Colorado、USA
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07902
[Presentation] 亜鉛含有リン酸カルシウム・ゼラチン複合化神経細胞再生チューブからのIn-vitro亜鉛放出制御2015
- Author(s)
  ５．小室摩記，服部祐介，大塚誠，
- Organizer
  日本薬剤学会第30年会、
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K07902
[Presentation] ゼラチン・ハイドロキシアパタイト球形化顆粒からの抗骨粗鬆症薬の放出制御2015
- Author(s)
  １７．齊藤花江，細越貴裕，服部祐介，大塚誠
- Organizer
  若手医療薬科学シンポジウム
- Place of Presentation
  千葉大学薬学部（千葉県千葉市）
- Year and Date
  2015-11-07
- Data Source
  KAKENHI-PROJECT-15K07902
[Presentation] Non-destructive Testing of Physical Property and Chemical Content of Tablets by Diffuse Transmitted Laser Beam Pattern Analysis2015
- Author(s)
  Yusuke Hattori, Hideaki Fuji, Makoto Otsuka，
- Organizer
  American Association Pharamcutical Scientists,
- Place of Presentation
  Orlando市,（米国）
- Year and Date
  2015-10-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07902
[Presentation] 多孔性亜鉛リン酸三カルシウム球形粒子の有用性の検証2014
- Author(s)
  鳩山宏一，Joshua　Chou，　服部祐介，　大塚誠
- Organizer
  日本バイオマテリアル学会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2014-11-18
- Data Source
  KAKENHI-PROJECT-12F02814
[Presentation] Biomimetic Zinc Tricalcium Phosphate (Zn-TCP) Derived from Coral for Bone Formation and Repair2013
- Author(s)
  J Chou, J Hao, H Mori, B Ben-Nissan, B Milthorpe, M Otsuka
- Organizer
  25th Symposium and Annual Meeting of the International Society for Ceramics in Medicine
- Place of Presentation
  Bucharest市 Romania
- Year and Date
  2013-07-10
- Data Source
  KAKENHI-PROJECT-12F02814

1. MATSUDA Yoshihisa (30068332)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. Sasaki Tetsuo (20321630)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
3. CHOU Joshua

# of Collaborated Projects: 2 results

# of Collaborated Products: 27 results
4. TERAOKA Reiko (50165693)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SUGIYAMA Yuichi (80090471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TAKASHI Nakamura (10201675)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OHGUSHI Hajime (80213669)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 坂本知昭 (40311386)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results

Otsuka Makoto 大塚 誠

OTSUKA Makoto 大塚 誠

MAKOTO Otsuka 大塚 誠

Research Projects

Research Products

Co-Researchers

Study of impurity effects in organic crystal appearing in low frequency vibrational spectra and its application

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Nondestructive bioactivity evaluation of molecular orientated hybrid bone cell scaffold by vibration spectroscopyPrincipal Investigator

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生体硬組織を標的とした薬物放出制御と骨幹細胞を用いた細胞組織工学Principal Investigator

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Bone Generation by using Three-Dimensional Geometrical Structural Controlled Cell Scaffold and Osteogenetic Growth Stimulated Factor Controlled Delivery SystemPrincipal Investigator

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Controlled essential rare-metal release from organic/inorganic nano-composite materialsPrincipal Investigator

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Biosignal responsive drug delivery system by using bioactive polymer/ceramic composite bone cementPrincipal Investigator

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Effect of pharmaceutical additives on physicochemical properties of pharmaceutical preparations.

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Endogenous signal-responsive drug release from bioactive bone cementPrincipal Investigator

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International harmonization of stability evaluation for formulation of solid-dosage form containing polymorphic form.

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[Book] 生体吸収性材料の開発とその安全性評価(No.1927)、２章 再生医療用足場材料に用いる生体吸収性材料の開発と評価、5節 有機-無機複合体を用いた生体組織足場材料の作製2017

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[Journal Article] 病態応答性薬物放出特性を持つアパタイト系人工骨の設計2018

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NAID

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[Journal Article] Sharp Absorption Peaks in THz Spectra Valuable for Crystal Quality Evaluation of Middle Molecular Weight Pharmaceuticals2018

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DOI

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[Journal Article] Detection of Impurities in Organic Crystals by High-Accuracy Terahertz Absorption Spectroscopy2018

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Otsuka Makoto 大塚誠

OTSUKA Makoto 大塚誠

MAKOTO Otsuka 大塚誠

[Book] 生体吸収性材料の開発とその安全性評価(No.1927)、２章　再生医療用足場材料に用いる生体吸収性材料の開発と評価、5節　有機-無機複合体を用いた生体組織足場材料の作製2017