HARUSAWA Shinya 春沢信哉

… Alternative Names

春沢信哉ハルサワシンヤ

春沢信也ハルサワシンヤ

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Researcher Number	90167601
Other IDs
External Links
Affiliation (Current)	2025: 大阪医科薬科大学, 薬学部, 客員研究員
Affiliation (based on the past Project Information) *help	2017: 大阪薬科大学, 薬学部, 教授 2016: 大阪薬科大学, 薬学部, 教授(移行) 2009 – 2015: Osaka University of Pharmaceutical Sciences, 薬学部, 教授 2006 – 2007: 大阪薬科大学, 薬学部, 教授 2005: 大阪薬科大学, 助教授 … More 1997 – 2005: 大阪薬科大学, 薬学部, 助教授 1993: Osaka University of Pharmaceutical Sciences, Pharmaceutical Sciences, Associate Professor, 薬学部, 助教授 1992: 大阪薬科大学, 第1薬品製造学教室, 助教授 Less
Review Section/Research Field	Principal Investigator Drug development chemistry / Chemical pharmacy / Chemical pharmacy Except Principal Investigator General pharmacology / Physical pharmacy / Chemical pharmacy / Drug development chemistry
Keywords	Principal Investigator アンタゴニスト / イミダゾール / H_3 / Yellow Scale Pheromone / ホスホロアミダイド / 増殖抑制 / ホスホロアミダイト / 乳癌 / リボザイム / C-ヌクレオシド … More / ヒスタミン / antagonist / H_4 / histamine / phosphoramidite / C-nueleoside / imidazole / ribozyme / マススペクトル / マトリックス / C-ヌグレオシド / H4 / H3 / Cyclic Allenes / MM Computations / Transition State / (Z)-Duoble Bonds / Sigmatropic Rearrangemennt / 立体選択的合成 / 10員環チオールカーボネート / 8員環チオノカーボネート / 中員環化合物 / [3,3]シグマトロピー転位 / 全合成 / イエロースケール / 性フェロモン / 環拡大反応 / 環状アレン / イエロスケールフェロモン / 分子力学計算 / 遷移状態 / (Z)-二重結合 / シグマトロピー転位 / ヒト乳癌細胞 / 乳癌細胞 / 癌 / 効率合成法 / アポトーシス / 合成法 / イソチオウレア / H3R / ハイブリッド / エストラジオール / RNA / 白金(II)二核錯体 / H_3アンタゴニスト / 17β-HSD / 乳癌増殖阻害 / chemo-genetic method / ホロアミダイド / Ｈ３アンタゴニスト / 白金錯体 / 抗癌剤 / マイクロウエーブ / 反応機構 / ヒスタミンH3 / DNA / ヒスタミンH3受容体 / テトラゾール / C-リボヌクレオシド / コンホメーション / アゴニスト / レセプター … More Except Principal Investigator ヒスタミン / H_3 / H_4 / アンタゴニスト / C-ヌクレオシド / イミダゾール / 薬物耐性 / 細胞内取込 / 核酸 / 金属錯体 / 白金制がん剤 / 細胞内蓄積 / 抗腫瘍効果 / 大腸がん / オキサリプラチン / 白金製剤 / 難治性がん / 創薬 / DDS / 制がん剤 / 白金錯体 / Histamine receptor antagonists / Ligands / Hypothalamus / Brain micrdialysis / OUP compounds / H4-receptor / H3-receptor / Histamine / 脱顆粒反応 / 肥満細胞 / RBL-2H3細胞 / テトラヒドロフラニルイミダゾール誘導体 / マイクロダイアリシス / テトラヒドロピラニルイミダゾール / テトラヒドロフラニルイミダゾール / H4受容体 / H3受容体 / ヒスタミン受容体遮断薬 / リガンド / 視床下部 / 脳微小透析法 / OUP化合物 / H_4受容体 / H_3受容体 / imifuramine / imidazole / antagonist / agonist / receptor / histamine / コンホメーション / レセプター / イミフラミン / アゴニスト / 受容体 / がん関連疲労感 / 炎症性サイトカイン / MAPK / 腫瘍壊死因子(TNF-α) / がん関連副作用 / がん化学療法 / がん関連倦怠感 / がん関連倦怠感(Cancer-Related Fatigue : CRF) / シスプラチン / 転写因子NF-κB / 活性酸素種(ROS) / 細胞内情報伝達系MAPK / 腫瘍壊死因子(TNF) α / マクロファージ / 抗悪性腫瘍薬 / がん治療関連倦怠感 / 腫瘍壊死因子(TNF)-α / ヒスタミンH4受容体 / マススペクトル / H3 / マトリックス / ホスホロアミダイト / リボザイム Less

Drug discovery research based on dinuclear platinum complexes with markedly high antitumor activity
- Principal Investigator
  
  Komeda Seiji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Suzuka University of Medical Science
Approach toward anti-breast cancer agents using novel histamine H3 antagonistsPrincipal Investigator
- Principal Investigator
  
  Harusawa Shinya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Osaka University of Pharmaceutical Sciences
Probing the catalytic mechnism of ribozymes and breast cancer inhibitory effects based on imidazole C-nucleosidesPrincipal Investigator
- Principal Investigator
  
  HARUSAWA Shinya
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Osaka University of Pharmaceutical Sciences
The role of histamine H4 receptor in the development of cancer-related fatigue
- Principal Investigator
  
  YAMATODANI Atsushi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka University
イミダゾールC-ヌクレオシドの合成研究に基づくH4受容体及びRNA触媒機能解明
- Principal Investigator
  
  栗原拓史
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Osaka University of Pharmaceutical Sciences
Synthetic studies for functional elucidation of RNA catalysis and H4 receptorPrincipal Investigator
- Principal Investigator
  
  HARUSAWA Shinya
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
Development of selective ligands to histamine H3 and H4 receptors and its application to elucidate the physiological function of the receptors.
- Principal Investigator
  
  YAMATODANI Atsushi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka University
Development and Application of Novel Histamine H_3 agonist Imifuramine
- Principal Investigator
  
  KURIHARA Takushi
- Project Period (FY)
  1999 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
強力なH_3-アゴニスト活性を持つ新規イミダゾールC-ヌクレオシドの設計と合成Principal Investigator
- Principal Investigator
  
  春沢信哉
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
Sigmatropic Ring Expansion : Quantitative Evaluation of the Transition States and its Synthetic Application to Natural ProductsPrincipal Investigator
- Principal Investigator
  
  HARUSAWA Shinya
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences

[Book] 有機医薬品合成化学ターゲット分子の合成2011
- Author(s)
  春沢信哉, 他
- Publisher
  廣川書店
- Data Source
  KAKENHI-PROJECT-21590130
[Book] 有機医薬品合成化学ターゲット分子の合成2011
- Author(s)
  春沢信哉
- Total Pages
  333
- Publisher
  廣川書店
- Data Source
  KAKENHI-PROJECT-21590130
[Book] Mass determination of phosphoramidites (Unit 10.11)2006
- Author(s)
  Shinya Harusawa
- Total Pages
  26
- Publisher
  John Wiley & Sons, Inc.
- Data Source
  KAKENHI-PROJECT-16590024
[Book] Mass determination of phosphoramidites (Unit 10.11)2006
- Author(s)
  Shinya Harusawa
- Total Pages
  26
- Publisher
  John Wiley & Sons, Inc.
- Data Source
  KAKENHI-PROJECT-16590089
[Journal Article] Specific Conformational Change in Giant DNA Caused by Anticancer2017
- Author(s)
  S. Komeda, H. Yoneyama, M. Uemura, A. Muramatsu, N. Okamoto,
- Journal Title
  
  Inorg. Chem.
  
  Volume: 56 Issue: 2 Pages: 802-811
- DOI
  10.1021/acs.inorgchem.6b02239
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460160, KAKENHI-PROJECT-15K07905, KAKENHI-PLANNED-25103012
[Journal Article] Synthesis of fluorinated isoxazoles using SelectfluorTM: preparation and2016
- Author(s)
  K. Sato, G. Sandford, K. Shimizu, S. Akiyama, M. J. Lancashire, D. S.Yufita, A.Tarui, M. Omote, I. Kumadaki, S. Harusawa and A. Ando
- Journal Title
  
  Tetrahedron
  
  Volume: 72 Issue: 13 Pages: 1690-1698
- DOI
  10.1016/j.tet.2016.02.026
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460160
[Journal Article] Mitsunobu Reaction in My Chemistry: Lecture at VU Study Tour2016
- Author(s)
  S. Harusawa
- Journal Title
  
  Bull. Osaka Univ. Pharm. Sci.,
  
  Volume: 10 Pages: 75-85
- NAID
  120007152771
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460160
[Journal Article] Efficient Approaches to S-alkyl-N-alkylisothioureas and Application to Novel Histamine H3R Antagonists2016
- Author(s)
 米山弘樹, 山本大助，大和谷厚，春沢信哉
- Journal Title
 
 YAKUGAKU ZASSHI
 
 Volume: 136 Issue: 9 Pages: 1217-1232
- DOI
 10.1248/yakushi.16-00023
- NAID
 130005261339
- ISSN
 0031-6903, 1347-5231
- Year and Date
 2016-09-01
- Language
 Japanese
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
 KAKENHI-PROJECT-26460160
[Journal Article] Diethyl Phosphorocyanidate (DEPC)：　a versatile reagent for organic synthesis2016
- Author(s)
  S. Harusawa, T. Shioiri
- Journal Title
  
  Tetrahedron
  
  Volume: 72 Issue: 50 Pages: 8125-8200
- DOI
  10.1016/j.tet.2016.09.070
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460160
[Journal Article] Histamine H3 receptor antagonist OUP-186 attenuates the proliferation of cultured human breast cancer cell2016
- Author(s)
  S. Tanaka, M. Sakaguchi, H. Yoneyama, Y. Usami, S. Harusawa
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 480 Issue: 3 Pages: 479-485
- DOI
  10.1016/j.bbrc.2016.10.077
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460160
[Journal Article] Efficient Synthesis of N-[4-(4-Chlorophenyl)butyl]-S-(3-piperidinoproyl)- isothiourea (OUP-186) and Its Analogues Using 2-Nitrophenylacetyl Isothiocyanate: Application to Novel Histamine H3R Antagonists2015
- Author(s)
  H. Yoneyama, T. Magata, K. Uemura, Y. Usami, S. Tanaka, M. Takaoka, and S. Harusawa
- Journal Title
  
  Synthesis
  
  Volume: 47 Pages: 1291-1302
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460160
[Journal Article] Synthesis of C4-linked C_0- and C_2-imidazole 2'-deoxyribonucleoside phosphoramidites and imidazole base pairing effects on DNA2014
- Author(s)
  S. Harusawa, H. Yoneyama, Y. Usami, D. Yamamoto, Z. Zhao
- Journal Title
  
  Synthesis
  
  Volume: (in press)(SS-2014-05-0308-OP)
- Data Source
  KAKENHI-PROJECT-21590130
[Journal Article] Synthesis and evaluation of N-alkyl-S-[3-(piperidin-1-yl)propyl]isothioureas : High affinity and human/rat species-selective histamine H_3 receptor antagonists Bioorg2013
- Author(s)
  Harusawa, K. Sawada, T. Magata, H. Yoneyama, L. Araki, Y. Usami, K. Hatano, K. Yamamoto, D. Yamamoto, A.Yamatodani
- Journal Title
  
  Med. Chem. Lett
  
  Volume: 23 Pages: 6415-6420
- Data Source
  KAKENHI-PROJECT-21590130
[Journal Article] マイクロウエーブを活用したいくつかのの機能性分子の合成2013
- Author(s)
  春沢信哉
- Journal Title
  
  大阪薬科大学紀要
  
  Volume: 7 Pages: 109-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590130
[Journal Article] マイクロウエーブを活用したいくつかのの機能性分子の合成2013
- Author(s)
  春沢信哉、米山弘樹、宇佐美吉英
- Journal Title
  
  大阪薬科大学紀要
  
  Volume: Vol 7 Pages: 109-127
- Data Source
  KAKENHI-PROJECT-21590130
[Journal Article] Synthesis and evaluation of N-alkyl-S-[3-(piperidin-1-yl)propyl]isothioureas: High affinity and human/rat species-selective histamine H3 receptor antagonists2013
- Author(s)
  S. Harusawa, K. Sawada, T. Magata, H. Yoneyama, L. Araki, Y. Usami,
- Journal Title
  
  Bioorg, Med. Chem. Lett.
  
  Volume: 23 Issue: 23 Pages: 6415-6420
- DOI
  10.1016/j.bmcl.2013.09.052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590130
[Journal Article] LSI/FABを用いる多官能性ヌクレオシドホスホロアミダイトのマススペクトル測定2013
- Author(s)
  藤嶽美穂代、春沢信哉
- Journal Title
  
  薬学雑誌
  
  Volume: 133 Pages: 823-841
- NAID
  130003361966
- Data Source
  KAKENHI-PROJECT-21590130
[Journal Article] Efficient Transformation of Inactive Nitriles into 5-Substituted-1H-tetrazoles Using Microwave Irradiation and Their Applications2013
- Author(s)
  H. Yoneyama, Y. Usami,, S. Komeda, S. Harusawa
- Journal Title
  
  Synthesis
  
  Volume: 45 Pages: 1051-1059
- Data Source
  KAKENHI-PROJECT-21590130
[Journal Article] Synthesis of Novel Tetrazole C5-linked C0- and C2-Ribonucleoside Phosphoramidites Using MePOM and POM groups for probing RNA catalysis2012
- Author(s)
  S. Harusawa
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 53 Issue: 44 Pages: 5891-5894
- DOI
  10.1016/j.tetlet.2012.08.082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590130
[Journal Article] Divergent Synthesis and Evaluation of Inhibitory Activities against Cyclooxygenases-1 and -2 of Natural Withasomnines and Analogues2012
- Author(s)
  Y. Usami, R. Watanabe, Y. Fujino, M. Shibano, C. Ishida, H. Yoneyama, S. Harusawa, H. Ichikawa
- Journal Title
  
  Chem. Pharm. Bull
  
  Volume: 60 Pages: 1550-1560
- NAID
  130002459938
- Data Source
  KAKENHI-PROJECT-21590130
[Journal Article] Synthesis of novel tetrazole C5-linked C_0- and C_2-ribonucleoside Phosphoramidites Using MePOM and POM groups for probing RNA catalysis2012
- Author(s)
  S. Harusawa, H. Yoneyama, D. Fujisue, M. Nishiura, M. Fujitake, Y. Usami, Z. Zhao, S. A. McPhee, T. J. Wilson, D. M. Lilley
- Journal Title
  
  Tetrahedron Lett
  
  Volume: 53 Pages: 5891-5894
- Data Source
  KAKENHI-PROJECT-21590130
[Journal Article] Synthesis of Imidazole C_1- and C_3-Ribonucleoside Phosphoramidites for Probing Catalytic Mechnism in Ribozyme2011
- Author(s)
  S. Harusawa, K. Fujii, M. Nishiura, L. Araki, Y. Usami, Z. Zhao, D. M. J. Lilley
- Journal Title
  
  Heterocycles
  
  Volume: 83 Pages: 2041-2055
- Data Source
  KAKENHI-PROJECT-21590130
[Journal Article] イミダゾールC-ヌクレオシドホスホロアミダイトのマススペクトル測定の実際2011
- Author(s)
  藤嶽美穂代、春沢信哉
- Journal Title
  
  大阪薬科大学紀要
  
  Volume: Vol 5 Pages: 49-57
- NAID
  120007152822
- Data Source
  KAKENHI-PROJECT-21590130
[Journal Article] Heck-Mizoroki Reaction of 4-Iodo-1H-pyrazoles2011
- Author(s)
  Y. Usami, H. Ichikawa, S. Harusawa
- Journal Title
  
  Heterocycles
  
  Volume: 83 Pages: 827-835
- NAID
  40018733655
- Data Source
  KAKENHI-PROJECT-21590130
[Journal Article] Synthesis of Imidazole C_1 and C_3-Ribonucleoside Phosphoramidites for Probing Catalytic Mechnism in Ribozymes2011
- Author(s)
  S.Harusawa
- Journal Title
  
  Heterocycles
  
  Volume: 83 Issue: 9 Pages: 2041-2055
- DOI
  10.3987/com-11-12263
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590130
[Journal Article] 生体機能性分子を目的としたイミダゾールC-ヌクレオシドの合成2010
- Author(s)
  荒木理佐、春沢信哉
- Journal Title
  
  研究薬学雑誌
  
  Volume: 130 Pages: 1707-1724
- Data Source
  KAKENHI-PROJECT-21590130
[Journal Article] Synthesis of Two Estradiol-imidazole C-Ribonucleoside Hybrid Compounds Exhibiting Inhibitory Effects Against Type 1 17β-Hydroxysteroid Dehydrogenase2010
- Author(s)
  S.Harusawa
- Journal Title
  
  Heterocycles
  
  Volume: 81 Pages: 2817-2830
- NAID
  40017375391
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590130
[Journal Article] Efficient Synthesis of 2'-O-Cyanoethylated Imidazole C-Ribonucleoside Phosphoramidite : A Practical Building Block for Probing the Catalytic Mechnism of Ribozymes2010
- Author(s)
  L. Araki, Z. Zhao, D. M. Lilley, S. Harusawa
- Journal Title
  
  Heterocycles
  
  Volume: 81 Pages: 1861-1869
- Data Source
  KAKENHI-PROJECT-21590130
[Journal Article] Synthesis of Two Estradiol-imidazole C-Ribonucleoside Hybrid Compounds Exhibiting Inhibitory Effects Against Type 1 17β-Hydroxysteroid Dehydrogenase2010
- Author(s)
  Harusawa, C. Kojima, K. Fujii, Y. Yamashita, T. Tanaka, L. Araki, T. Yoshimura, M. Sakaguchi, Y. Usami, M. Takaoka
- Journal Title
  
  Heterocycles
  
  Volume: 81 Pages: 2817-283
- NAID
  40017375391
- Data Source
  KAKENHI-PROJECT-21590130
[Journal Article] Synthesis of Novel C4-Linked C_2-Imidazole Ribonucleoside Phosphoramidite and Its Application to Probing the Catalytic Mechanism of a Ribozyme2009
- Author(s)
  L. Araki, K. Morita, M. Yamaguchi, Z. Zhao, T.J. Wilson, D. M. Lilley, S. Harusawa
- Journal Title
  
  J. Org. Chem
  
  Volume: 74 Pages: 2350-2356
- Data Source
  KAKENHI-PROJECT-21590130
[Journal Article] ヒスタミンH_4受容体リガンドの開発とその現状2009
- Author(s)
  春沢信哉
- Journal Title
  
  大阪薬科大学紀要 3
  
  Pages: 65-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590130
[Journal Article] ヒスタミンH4受容体リガンドの開発とその現状2009
- Author(s)
  春沢信哉、荒木理佐
- Journal Title
  
  大阪薬科大学紀要
  
  Volume: Vol 3 Pages: 65-78
- NAID
  120007152842
- Data Source
  KAKENHI-PROJECT-21590130
[Journal Article] Synthesis of Novel 4(5)-(5-Aminotetrahydropyran-2-yl)imidazole Derivatives and Their in vivo Release of Neuronal Histamine Measured by Brain Microdialysis2007
- Author(s)
  S. Harusawa
- Journal Title
  
  Chem. Pharm. Bull. 55
  
  Pages: 1245-1253
- NAID
  110006366548
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590024
[Journal Article] Synthesis of Novel 4(5)-(5-Aminotetrahydropyran-2-y1)imidazole Derivatives and Their in vivo Release of Neuronal Histamine Measured by Brain Microdialysis2007
- Author(s)
  S.Harusawa
- Journal Title
  
  Chem.Pharm.Bull. 55
  
  Pages: 1245-1253
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590024
[Journal Article] Synthesis of Novel 4 (5)-(5-Aminotetrahydropyran-2-yl)imidazole Derivatives and Their In Vivo Release of Neuronal Histamine Measured by Brain Microdialysis2007
- Author(s)
  Shinya Harusawa
- Journal Title
  
  Chemical Pharmaceutical Bulletin 55
  
  Pages: 1245-1253
- NAID
  110006366548
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590024
[Journal Article] β-Stereoselective synthesis of pyrazole C-nucleoside via diazofulvene intermediates2006
- Author(s)
  S.Harusawa
- Journal Title
  
  Synthesis
  
  Pages: 793-798
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590024
[Journal Article] Mass Determination of Phosphoramidites2006
- Author(s)
  S.Harusawa
- Journal Title
  
  Current Protocols in Nucleic Acid Chemistry
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590024
[Journal Article] Efficient and β-stereoselective synthesis of pyrazole C-nucleosides2006
- Author(s)
  Shinya Harusawa
- Journal Title
  
  Synthesis (5)
  
  Pages: 793-798
- Data Source
  KAKENHI-PROJECT-16590089
[Journal Article] Efficient and β-stereoselective synthesis of pyrazole C-nucleosides2006
- Author(s)
  Shinya Harusawa
- Journal Title
  
  Synthesis 2006・5
  
  Pages: 793-798
- Data Source
  KAKENHI-PROJECT-16590024
[Journal Article] Efficient and β-stereoselective synthesis of pyrazole C-nucleosides2006
- Author(s)
  Shinya Harusawa
- Journal Title
  
  Synthesis (5)
  
  Pages: 793-798
- Data Source
  KAKENHI-PROJECT-16590024
[Journal Article] Mass Determination of Phosphoramidites.2006
- Author(s)
  S. Harusawa
- Journal Title
  
  Current Protocols in Nucleic Acid Chemistry
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590024
[Journal Article] β-Stereoselective synthesis of pyrazole C-nucleoside via diazofulvene intermediates.2006
- Author(s)
  S. Harusawa
- Journal Title
  
  Synthesis
  
  Pages: 793-798
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590024
[Journal Article] Effect of H4-receptor ligands on IgE mediated histamine release from RBL-2H3 cells.2004
- Author(s)
  T.Hashimoto, R.Hidaka, S.Harusawa
- Journal Title
  
  J.Pharmacol.Sci. 94 Suppl I
  
  Pages: 204-204
- Data Source
  KAKENHI-PROJECT-15590225
[Journal Article] Design and synthesis of an aminobenzo-15-crown-5-labeled estradiol tethered with disulfide linkage2004
- Author(s)
  Shinya Harusawa
- Journal Title
  
  Tetrahedron 60・51
  
  Pages: 11911-11922
- NAID
  130006996706
- Data Source
  KAKENHI-PROJECT-16590024
[Journal Article] Design and synthesis of an aminobenzo-15-crown-5-labeled estradiol tethered with disulfide linkage2004
- Author(s)
  Shinya Harusawa
- Journal Title
  
  Tetrahedron 60・51
  
  Pages: 11911-11922
- NAID
  130006996706
- Data Source
  KAKENHI-PROJECT-16590089
[Journal Article] Design and synthesis of an aminobenzo-15-crown-5-labeled estradiol tethered with disulfide linkage.2004
- Author(s)
  S. Harusawa
- Journal Title
  
  Tetrahedron Lett. 60
  
  Pages: 11911-11922
- NAID
  130006996706
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590024
[Journal Article] in vivoアッセイにおけるヒスタミンH3-受容体に対する4(5)-(5-アミノテトラヒドロピラン-2-イル)イミダゾールの立体配置と薬理作用の関係2004
- Author(s)
  藤田岳志, 山本亮子, 春沢信哉, 大和谷厚他
- Journal Title
  
  第8回日本ヒスタミン研究会抄録集
  
  Pages: 16-16
- Data Source
  KAKENHI-PROJECT-15590225
[Journal Article] Design and synthesis of an aminobenzo-15-crown-5-labeled estradiol tethered with disulfide linkage2004
- Author(s)
  S.Harusawa
- Journal Title
  
  Tetrahedron 60
  
  Pages: 11911-11922
- NAID
  130006996706
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590024
[Journal Article] Efficient synthesis of trans- or cis-4(5)-(5-aminomethyltetrahydrofuran-2-yl)imidazoles via diazafulvene intermediates : Synthetic approach toward human histamine H4-ligands.2003
- Author(s)
  S.Harusawa, et al.
- Journal Title
  
  Chem.Pharm.Bull. 51(7)
  
  Pages: 832-837
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590225
[Journal Article] Efficient synthesis of trans- or cis-4(5)-(5-aminomethyltetrahydrofuran-2-yl)imidazoles via diazafulvene intermediates : Synthetic approach toward human histamine H4-ligands2003
- Author(s)
  S.Harusawa, et al.
- Journal Title
  
  Chem.Pharm.Bull. 51(7)
  
  Pages: 832-837
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590225
[Journal Article] Formation of two 4-imidazolylmethylphosphoniumu salts and their synthetic studies toward histamine H3-ligands.2003
- Author(s)
  S.Harusawa, et al.
- Journal Title
  
  Synthesis 18
  
  Pages: 2844-2850
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590225
[Presentation] メチル基を有するテトラゾラト架橋白金(II)二核錯体のDNAとの相互作用および細胞内取り込みにおけるフッ素導入効果の検討2018
- Author(s)
  植村雅子，米山弘樹，春沢信哉，米田誠治
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K07905
[Presentation] 顕著な抗腫瘍効果を有する白金(II)二核錯体のユニークな作用機構2017
- Author(s)
  植村雅子、米田誠治、吉川研一、吉川祐子、春沢信哉、米山弘樹
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台市
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K07905
[Presentation] DNA interaction and structure-activity telationship of tetrazolato-bridged dinuclear platinum(II) complexes with fluoromethyl group2017
- Author(s)
  植村雅子，米山弘樹，坂﨑智哉，長江紀樹，小井阪あゆみ，春沢信哉，米田誠治
- Organizer
  第27回金属の関与する生体関連反応シンポジウム
- Data Source
  KAKENHI-PROJECT-15K07905
[Presentation] 制がん白金(II)二核錯体のDNA凝縮能および細胞内取り込みに関する研究2017
- Author(s)
  植村雅子, 米山弘樹, 岡本直人, 村松晃, 福田青郎, 小西宏明, 髙木陽光, 松﨑健, 春沢信哉, 吉川祐子, 今中忠行, 吉川研一，米田誠治
- Organizer
  第63回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-15K07905
[Presentation] Structure-activity relationships, DNA compaction efficiencies and intracellular accumulations on anticancer-active tetrazolato-bridged dinuclear platinum(II) complexes2017
- Author(s)
  Komeda, S.; Uemura, M.; Hiramoto, K.; Yoshikawa, Y.; Yoshikawa, K.; Yoneyama, H.; Harusawa, S.
- Organizer
  14th International Symposium on Applied Bioinorganic Chemistry
- Data Source
  KAKENHI-PROJECT-15K07905
[Presentation] DNA interactions and structure-activity relationship of tetrazolato-bridged dinuclear platinum(II) complexes with methyl and fluoromethyl group2017
- Author(s)
  Uemura, M.; Yoneyama, H.; Harusawa, S.; Komeda, S.
- Organizer
  12th International Symposium on Platinum Coordination Compounds in Cancer Chemotherapy
- Data Source
  KAKENHI-PROJECT-15K07905
[Presentation] 長短鎖アルキル基を導入した制がんテトラゾラト架橋白金(II)二核錯体の細胞内取込およびDNA凝縮能2016
- Author(s)
  米田誠治, 植村雅子, 米山弘樹, 岡本直人, 村松晃, 福田青郎, 小西宏明, 髙木陽光, 松﨑健, 春沢信哉, 吉川祐子, 今中忠行, 吉川研一
- Organizer
  日本薬学会第136年会横浜市年月日201603-201603
- Place of Presentation
  横浜市
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K07905
[Presentation] テトラゾールのフラグメンテーションを活用したカルボニル化合物からアルキンへの変換反応　その22016
- Author(s)
  米山弘樹、上村健司，沼田雅博，宇佐美吉英，春沢信哉
- Organizer
  第66回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪薬科大学
- Data Source
  KAKENHI-PROJECT-26460160
[Presentation] テトラゾールのフラグメンテーションを活用したカルボニル化合物からアルキンへの変換反応　その12016
- Author(s)
  上村健司，米山弘樹，沼田雅博，宇佐美吉英，春沢信哉
- Organizer
  第66回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪薬科大学
- Data Source
  KAKENHI-PROJECT-26460160
[Presentation] Biological efficiency of anticancer tetrazolato-bridged dinuclear platinum(II) complexes with different length of alkyl substituent in relation to the structural effect of DNA2016
- Author(s)
  Komeda, S.; Uemura, M.; Yoneyama, H.; Muramatsu, A.; Okamoto, N.; Harusawa, S.; Yoshikawa, Y.; Yoshikawa, K.
- Organizer
  金属の関与する生体関連反応シンポジウム (SRM2016)
- Place of Presentation
  札幌市
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-15K07905
[Presentation] 培養ヒト乳がん細胞の生存に及ぼすヒスタミンH3受容体拮抗薬OUP-186の影響2016
- Author(s)
  田中　智、北口大毅、兼安俊尚、嶋野昌以子、田口玲実、米山弘樹、宇佐美吉英、坂口　実、春沢信哉
- Organizer
  第66回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪薬科大学
- Data Source
  KAKENHI-PROJECT-26460160
[Presentation] テトラゾールのフラグメンテーションを活用したカルボニル化合物からアルキンへの変換反応　その3　-トリアゾールホスホロアミダイドのためのC1-ホスホロアミダイド合成への応用-2016
- Author(s)
  日笠史子、米山弘樹、上村健司，宇佐美吉英，春沢信哉
- Organizer
  第66回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪薬科大学
- Data Source
  KAKENHI-PROJECT-26460160
[Presentation] Transformation of carbonyl compounds into alkynes using fragmentation of tetrazol intermediates2016
- Author(s)
  Shinya Harusawa, Kenji Uemura, Masahiro Numata, Yoshihide Usami, Hiroki Yoneyama
- Organizer
  17th Tetrahedron Symposium
- Place of Presentation
  バルセロナ
- Year and Date
  2016-06-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460160
[Presentation] テトラゾールのフラグメンテーションを活用したカルボニル化合物からアルキンへの変換反応　その4　各種アルデヒドからアルキンへの変換2016
- Author(s)
  半田直己、杉原夏菜、日笠史子、上村健司，米山弘樹、宇佐美吉英，春沢信哉
- Organizer
  第66回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪薬科大学
- Data Source
  KAKENHI-PROJECT-26460160
[Presentation] 中性条件下におけるカルボニル化合物からアルキンへの変換反応：テトラゾールのフラグメンテーション2016
- Author(s)
  米山弘樹，上村健司，沼田雅博，宇佐美吉英，春沢信哉
- Organizer
  第42回反応と合成の進歩シンポジウム
- Place of Presentation
  清水
- Year and Date
  2016-11-07
- Data Source
  KAKENHI-PROJECT-26460160
[Presentation] Biological Efficiency of Anticancer Tetrazolato-Bridged Dinuclear Platinum(II) Complexes with Different Length of Alkyl Substituent in Relation to the Structural Effect of DNA2016
- Author(s)
  Seiji Komeda, Masako Uemura, Hiroki Yoneyama, Akira Muramatsu, Naoto Okamoto, Shinya Harusawa, Yuko Yoshikawa and Kenichi Yoshikawa
- Organizer
  第26回金属の関与する生体関連反応シンポジウム（SRM2016）
- Place of Presentation
  広島
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-26460160
[Presentation] Cellular Uptake and DNA Compaction of Anticancer Tetrazolato-Bridged Dinuclear Platinum(II) Complexes with Various Substituents at Tetrazole C52015
- Author(s)
  Masako Uemura, Hiroki Yoneyama, Yuko Yoshikawa, Takahiro Tsuchiya, Miyuu Hoshiyama, Takaji Sato, Kenichi Yoshikawa, Shinya Harusawa, and Seiji Komeda
- Organizer
  1st International Symposium on Clinical and Experimental Metallodrugs in Medicine: Cancer Chemotherapy” (CEMM)
- Place of Presentation
  Ｈａｗａｉｉ
- Year and Date
  2015-12-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460160
[Presentation] Action of novel anticancer-active, dinuclear platinum complexes with ester group on the higher order structure and genomic activity of DNA2015
- Author(s)
  Shimizu, Y; Yoshikawa, Y; TaTsuchiya, T; Hiroki Yoneyama, H; Harusawa, S; Komeda, S; Imanaka, T; Kenmotsu, T; Yoshikawa, K.
- Organizer
  第53回生物物理学会日本薬学会
- Place of Presentation
  金沢市
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-15K07905
[Presentation] 閉環メタセシスを鍵反応とする新規ピラゾール融合複素環化合物の合成2015
- Author(s)
  宇佐美吉英、町谷裕大、辻内寧之、飯尾竜五、米山弘樹、春沢信哉
- Organizer
  第65回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪大谷
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26460160
[Presentation] Synthesis of (+)-Pericosine E: Naturally Occurring Minor Enantiomer2015
- Author(s)
  Koji Mizuki, Makio Shibano, Rikiya Kawahata, Hiroki Yoneyama, Shinya Harusawa,　and Yoshihide Usami
- Organizer
  13th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-13)
- Place of Presentation
  Kyoto
- Year and Date
  2015-09-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460160
[Presentation] シアノホスフェートからα-アジドテトラゾールの生成とその反応性2015
- Author(s)
  上村健司、沼田雅博、米山弘樹、宇佐美吉英、春沢信哉
- Organizer
  第41回反応と合成の進歩シンポジウム
- Place of Presentation
  近畿大学
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-26460160
[Presentation] Cellular Uptake and DNA Compaction of Anticancer Tetrazolato-Bridged Dinuclear Platinum(II) Complexes with Various Substituents at Tetrazole C52015
- Author(s)
  Masako UEMURA, Hiroki YONEYAMA, Yuko YOSHIKAWA, Takahiro TSUCHIYA, Miyuu HOSHIYAMA, Takaji SATO, Kenichi YOSHIKAWA, Shinya HARUSAWA, and Seiji KOMEDA
- Organizer
  第25回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  長崎大
- Year and Date
  2015-05-30
- Data Source
  KAKENHI-PROJECT-26460160
[Presentation] Conversion of alkynes from cyanophoshates via a-azidotetrazoles2015
- Author(s)
  M. Numata, H. Yoneyama, Y. Usami, S. Harusawa.
- Organizer
  16th Tetrahedron Symposium
- Place of Presentation
  Berlin, Ger.
- Year and Date
  2015-06-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460160
[Presentation] Cellular uptake and DNA compaction of anticancer tetrazolato-bridged dinuclear platinum(II) complexes with various substituents at tetrazole C52015
- Author(s)
  Uemura, M; Yoneyama, H; Yoshikawa, T; Tsuchiya, T; Hoshiyama, M; Sato, T; Yoshikawa, K; Harusawa, S; Komeda, S
- Organizer
  第25回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  長崎市
- Year and Date
  2015-05-30
- Data Source
  KAKENHI-PROJECT-15K07905
[Presentation] Cellular uptake and DNA compaction of anticancer tetrazolato-bridged dinuclear platinum(II) complexes with various substituents at tetrazole C52015
- Author(s)
  Uemura, M; Yoneyama, H; Yoshikawa, T; Tsuchiya, T; Hoshiyama, M; Sato, T; Yoshikawa, K; Harusawa, S; Komeda, S
- Organizer
  1st International Symposium on Clinical and Experimental Metallodrugs in Medicine: Cancer Chemotherapy
- Place of Presentation
  米国ハワイ州
- Year and Date
  2015-12-13
- Data Source
  KAKENHI-PROJECT-15K07905
[Presentation] テトラゾールホスフェートのフラグメンテーション―シアノホスフェートからアルキンの生成―2015
- Author(s)
  上村健司、米山弘樹、宇佐美吉英、春沢信哉
- Organizer
  第65回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪大谷
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26460160
[Presentation] 抗腫瘍性海洋天然物 pericosine A のエナンチオマー組成について2015
- Author(s)
  宇佐美吉英、中村公香、水木晃治、山田剛司、山下藍、米山弘樹、春沢信哉
- Organizer
  第65回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪大谷
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26460160
[Presentation] Action of novel anticancer-active, dinuclear platinum complexes with ester group on the higher-order structure and genomic activity of DNA2015
- Author(s)
  Yuta Shimizu, Yuko Yoshikawa, Takahiro Tsuchiya, Hiroki Yoneyama, Shinya Harusawa,
- Organizer
  第53回日本生物物理学会年会
- Place of Presentation
  金沢
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-26460160
[Presentation] Novel Synthesis of Arylalkynes via alfa-Aazidotetrazoles from Cyanophosphates2015
- Author(s)
  Hiroki Yoneyama, Masahiro Numata, Kenji Uemura, Yoshihide Usami, Shinya Harusawa
- Organizer
  The 3rd International Symposium of Process Chemistry
- Place of Presentation
  Kyoto International Conference Center
- Year and Date
  2015-07-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460160
[Presentation] Synthesis of C4-linked C0- and C2-imidazole 2’-deoxyribonucleoside phosphoramidites and imidazole effects on DNA base paring2014
- Author(s)
  ○S. Harusawa, H. Yoneyama, Y. Usami, S. Komeda, Z. Zhao.
- Organizer
  15th Tetrahedron Symposium
- Place of Presentation
  London
- Data Source
  KAKENHI-PROJECT-21590130
[Presentation] 海洋天然物 pericosine E の合成研究　(その3)2014
- Author(s)
  〇水木晃治、米山弘樹、春沢信哉、宇佐美吉英
- Organizer
  日本薬学会134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-21590130
[Presentation] ヒスタミンH3 受容体アンタゴニストのためのS-アルキル-N-アルキルイソチオウレア誘導体の改良合成法2014
- Author(s)
  〇上村健司、曲田拓司、米山弘樹、宇佐美吉英、春沢信哉
- Organizer
  日本薬学会134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-21590130
[Presentation] Synthesis of C4-linked C_0- and C_2-imidazole 2'-deoxyribonucleoside phosphoramidites and imidazole effects on DNA base paring2014
- Author(s)
  S. Harusawa
- Organizer
  15th Tetrahedron Symposium
- Place of Presentation
  London, UK
- Data Source
  KAKENHI-PROJECT-21590130
[Presentation] Pericosines 合成を目的としたシキミ酸誘導アルコール中間体の脱水反応2014
- Author(s)
  〇米重勇祐、水木晃治、米山弘樹、春沢信哉、宇佐美吉英
- Organizer
  日本薬学会134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-21590130
[Presentation] イミダゾール2’-デオキシリボヌクレオシドホスホロアミダイトの合成とイミダゾール含有オリゴマーの基礎研究2014
- Author(s)
  〇米山弘樹、宇佐美吉英、Zheng-yun Zhao、春沢信哉
- Organizer
  日本薬学会134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-21590130
[Presentation] Efficient Transformation of Inactive Nitriles into 5-Substituted-1H-tetrazoles using Microwave Irradiation and their Applications2013
- Author(s)
  S. Harusawa
- Organizer
  14th Tetrahedron Symposium
- Place of Presentation
  Viena, Austria
- Data Source
  KAKENHI-PROJECT-21590130
[Presentation] イソキサゾール類のフッ素化反応の開発－PETプローブを指向したC-F結合形成反応2013
- Author(s)
  佐藤和之、○清水啓史、樽井敦、表雅章、春沢信哉、安藤章
- Organizer
  第63回日本薬学会近畿支部総会・大会
- Place of Presentation
  同志社女子大・薬
- Data Source
  KAKENHI-PROJECT-21590130
[Presentation] テトラゾール5位にエステル基を導入した制がん白金(II)二核錯体の合成およびin vitro 細胞毒性2013
- Author(s)
  ○ 土屋考弘，米山弘樹，春沢信哉，小西宏明，髙木陽光，松﨑健，植村雅子，米田誠治
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2013
- Place of Presentation
  鈴鹿医療大学
- Data Source
  KAKENHI-PROJECT-21590130
[Presentation] 強力かつヒト/ラット選択的ヒスタミンH_3受容体アンタゴニストOUP-186の合成、薬理学的評価及び分子モデリング解析2013
- Author(s)
  春沢信哉
- Organizer
  第31回メディシナルケミストリーシンポジュウム
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-21590130
[Presentation] テトラゾール5位に飽和アルキル基を導入した制がん白金(II)二核錯体のDNAとの相互作用2013
- Author(s)
  ○ 岡本直人，植村雅子，米山弘樹，春沢信哉，小西宏明，髙木陽光，松﨑健，吉川祐子，今中忠行，吉川研一，米田誠治
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2013
- Place of Presentation
  鈴鹿医療大学
- Data Source
  KAKENHI-PROJECT-21590130
[Presentation] 海洋天然物pericosine E の合成研究（その2）2013
- Author(s)
  ○水木晃治、池田真侑子、米山弘樹、春沢信哉、宇佐美吉英
- Organizer
  第63回日本薬学会近畿支部総会・大会
- Place of Presentation
  同志社女子大・薬
- Data Source
  KAKENHI-PROJECT-21590130
[Presentation] RCMを用いる新規ピラゾール複素環の合成2013
- Author(s)
  ○河野葵、高桑政昭、米山弘樹、春沢信哉、宇佐美吉英
- Organizer
  第63回日本薬学会近畿支部総会・大会
- Place of Presentation
  同志社女子大・薬
- Data Source
  KAKENHI-PROJECT-21590130
[Presentation] Synthesis of New Types of Azole C2-Ribonucleoside Phosphoramidites for Probing RNA Catalysis2013
- Author(s)
  〇 H. Yoneyama, D. Fujisue, Y. Usami, S. Komeda, S. Harusawa.
- Organizer
  14th Tetrahedron Symposium
- Place of Presentation
  ソウル
- Data Source
  KAKENHI-PROJECT-21590130
[Presentation] ヒトH_3RアンタゴニストOUP186のヒト/ラット種選択性に関する分子モデリング研究2013
- Author(s)
  春沢信哉
- Organizer
  第17回日本ヒスタミン学会
- Place of Presentation
  松江
- Data Source
  KAKENHI-PROJECT-21590130
[Presentation] E2-イミダゾール-C2-ヌクレオシドハイブリッド化合物の合成とヒト乳癌細胞に対する増殖抑制2013
- Author(s)
  ○沼田雅博、竹村康平、吉田麻理、米山弘樹，田中智、宇佐美吉英，春沢信哉、高岡昌徳
- Organizer
  第63回日本薬学会近畿支部総会・大会
- Place of Presentation
  同志社女子大・薬
- Data Source
  KAKENHI-PROJECT-21590130
[Presentation] ヒトH3RアンタゴニストOUP186のヒト/ラット種選択性に関する分子モデリング研究2013
- Author(s)
  山本大助,米山弘樹, 曲田拓司,宇佐美吉英,澤田紘一,山本浩一, 大和谷厚,〇春沢信哉
- Organizer
  第17回日本ヒスタミン学会
- Place of Presentation
  松江
- Data Source
  KAKENHI-PROJECT-21590130
[Presentation] イソオキサゾール類の選択的フッ素化反応の開発2013
- Author(s)
  〇佐藤和之、清水啓史、秋山慧美、樽井　厚、表　雅章、安藤　章、春沢信哉、G. Sandford
- Organizer
  第36回フッ素化学討論会
- Place of Presentation
  筑波
- Data Source
  KAKENHI-PROJECT-21590130
[Presentation] 強力かつヒト/ラット選択的ヒスタミンH3受容体アンタゴニストOUP-186の合成、2013
- Author(s)
  〇春沢信哉、澤田紘一、曲田拓司、米山弘樹、荒木理佐、宇佐美吉英、波多野浩太、
- Organizer
  第31回メディシナルケミストリーシンポジュウム
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-21590130
[Presentation] マイクロウエーブを活用した2,3の機能性分子の合成2012
- Author(s)
  春沢信哉
- Organizer
  第31回Microwave Surgery研究会
- Place of Presentation
  大阪大学中之島センター
- Data Source
  KAKENHI-PROJECT-21590130
[Presentation] OUP-186: Histamine H3 receptor antagonist nonactive in rat but specifically potent in human2012
- Author(s)
  S. Harusawa
- Organizer
  13th Tetrahedron Symposium
- Place of Presentation
  Amsterdam
- Data Source
  KAKENHI-PROJECT-21590130
[Presentation] OUP-186: Histamine H3 receptor antagonist nonactive in rat but specifically potent in human2012
- Author(s)
  S. Harusawa
- Organizer
  13th Tetrahedron Symposium
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-21590130
[Presentation] β-イミダゾールC-ヌクレオシドからヒスタミンH3受容体リガンドを作る2011
- Author(s)
  春沢信哉
- Organizer
  CPhI Japan 2011 Osaka
- Place of Presentation
  インテックス大阪
- Year and Date
  2011-07-13
- Data Source
  KAKENHI-PROJECT-21590130
[Presentation] Synthesis and Evaluation of Potent Non-imidazole Histamine H_3 Antagonists Basedon S-Alkyl-N-alkylisothiourea Structure2011
- Author(s)
  Hiroki Yoneyama, Takuji Magata, Yoshiheide Usami, Shinya Harusawa, Kouichi Sawada, Kouichi Yamamoto, Atsushi Yamatodani
- Organizer
  TIMECS11
- Place of Presentation
  東京
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-21590279
[Presentation] β-イミダゾールC-ヌクレオシドからヒスタミンH3受容体リガンドを作る2011
- Author(s)
  春沢信哉
- Organizer
  CPhI Japan 2011 Osaka
- Place of Presentation
  インテックス大阪1号館
- Year and Date
  2011-07-13
- Data Source
  KAKENHI-PROJECT-21590130
[Presentation] 乳癌増殖抑制を目的としたエストラジオール-イミダゾールC-ヌクレオシド組み合わせ化合物の合成研究2010
- Author(s)
  春沢信哉
- Organizer
  第60回日本薬学会近畿支部総会・大会
- Place of Presentation
  近畿大学
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-21590130
[Presentation] 新規テトラヒドロピラニルイミダゾール誘導体の合成とヒスタミンH3アンタゴニスト活性2007
- Author(s)
  春沢信哉
- Organizer
  第57回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪薬科大学
- Year and Date
  2007-11-27
- Data Source
  KAKENHI-PROJECT-16590024
[Presentation] 機能性C4(5)-イミダゾール誘導体の創製研究:ヒスタミンH3,H4リガンド及びRNA触媒プローブへの応用2007
- Author(s)
  春沢信哉
- Organizer
  大阪薬科大学ハイテク・リサーチ・センター平成19年度公開シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2007-12-08
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590024
[Presentation] ヒスタミンH4受容体発見による選択的リガンド開発とその現状2007
- Author(s)
  春沢信哉
- Organizer
  第11回日本ヒスタミン学会
- Place of Presentation
  富山
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590024
[Presentation] ヒスタミンH4受容体発見による選択的リガンド開発とその現状2007
- Author(s)
  春沢信哉
- Organizer
  第11回日本ヒスタミン学会
- Place of Presentation
  富山市民プラザ
- Data Source
  KAKENHI-PROJECT-16590024
[Presentation] Development and current sitsuation of histamine H4 receptor ligands.2007
- Author(s)
  S. Harusawa
- Organizer
  11th The Japan histamine research society
- Place of Presentation
  Toyama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590024
[Presentation] Synthetic studies of C4(5)-imidazole derivatives: Application to histamine H_3, H_4-ligands and RNA probes.2007
- Author(s)
  S. Harusawa
- Organizer
  Symposium of high technology research(Osaka Univ. of Pharm. Sci.)
- Place of Presentation
  Osaka
- Year and Date
  2007-12-08
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590024
[Presentation] 機能性C4(5)-イミダゾール誘導体の創製研究:ヒスタミンH3, H4リガンド及びRNA触媒プローブへの応用2007
- Author(s)
  春沢信哉
- Organizer
  大阪薬科大学ハイテク・リサーチ・センター平成19年度公開シンポジュウム
- Place of Presentation
  大阪薬科大学
- Year and Date
  2007-12-08
- Data Source
  KAKENHI-PROJECT-16590024
[Presentation] in vivoアッセイにおけるヒスタミンH_3-受容体に対する4(5)-(5-アミノテトラヒドロピラン-2-イル)イミダゾールの立体配置と薬理作用の関係2005
- Author(s)
  春沢信哉
- Organizer
  第125年会日本薬学会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590024
[Presentation] Relationship between configurations and pharmacological effects of 4(5)-(5-aminotetrahydropyran-2-yl)imidazoles against in vivo assay.2005
- Author(s)
  S. Harusawa
- Organizer
  125th The pharamaceutical Society of Japan
- Place of Presentation
  Tokyo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590024
[Presentation] Design and synthesis of an aminobenzo-15-crown-5-labeled Estrdiol tethered with disulfide linkage.2004
- Author(s)
  S. Harusawa
- Organizer
  30th Symposium on progress in organic reactions and syntheses-applications in the life sciences-
- Place of Presentation
  Sapporo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590024
[Presentation] ジスフィド結合で架橋したクラウンエーテル標識エストラジオールの合成2004
- Author(s)
  春沢信哉
- Organizer
  第30回反応と合成の進歩シンポジウム
- Place of Presentation
  札幌
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590024
[Presentation] S-アルキル-N-アルキルイソチオウレアの効率的合成法とヒト/ラット選択的ヒスタミンH3アンタゴニストの創製
- Author(s)
  米山弘樹，曲田拓司、上村健司、澤田紘一、宇佐美吉英、波多野浩太、山本浩一、山本大助、大和谷厚、春沢信哉
- Organizer
  第12回次世代を担う有機化学シンポジュウム
- Place of Presentation
  東京、長井記念ホール
- Year and Date
  2014-05-23 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26460160
[Presentation] ヒスタミンH3受容体アンタゴニストを基盤とした乳がん細胞増殖抑制物質の合成研究
- Author(s)
  米山弘樹、上村健司、宇佐美吉英，坂口実，高岡　昌徳、春沢　信哉
- Organizer
  第18回日本ヒスタミン学会
- Place of Presentation
  尼崎
- Year and Date
  2014-10-10 – 2014-10-11
- Data Source
  KAKENHI-PROJECT-26460160
[Presentation] Effects of histamine H3 and H4 receptor antagonists on cell proliferation in cultured human breast cancer cells
- Author(s)
  Satoshi Tanaka, Minoru Sakaguchi, Aika Tsujimoto, Yuki Tanaka, Mari Yoshida, Takako Soda, Hiroki Yoneyama, Yoshihide Usami, Shinya Harusawa, Masanori Takaoka
- Organizer
  第88回日本薬理学会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-26460160

1. YAMATODANI Atsushi (30116123)

# of Collaborated Projects: 6 results

# of Collaborated Products: 2 results
2. KURIHARA Takushi (90067281)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. MASANORI Takaoka (50140231)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. YAMAMOTO Kouichi (40362694)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. Komeda Seiji (60425056)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
6. HIRAMOTO Keiichi (90251793)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. YONEYAMA Hiroki (90627001)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
8. YOSHIKAWA Yuko (80291871)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
9. 坂口実 (90221267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 植村雅子 (70511997)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results

HARUSAWA Shinya 春沢 信哉

春沢 信哉 ハルサワ シンヤ

春沢 信也 ハルサワ シンヤ

Research Projects

Research Products

Co-Researchers

Drug discovery research based on dinuclear platinum complexes with markedly high antitumor activity

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Approach toward anti-breast cancer agents using novel histamine H3 antagonistsPrincipal Investigator

Principal Investigator

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Probing the catalytic mechnism of ribozymes and breast cancer inhibitory effects based on imidazole C-nucleosidesPrincipal Investigator

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The role of histamine H4 receptor in the development of cancer-related fatigue

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イミダゾールC-ヌクレオシドの合成研究に基づくH4受容体及びRNA触媒機能解明

Principal Investigator

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Synthetic studies for functional elucidation of RNA catalysis and H4 receptorPrincipal Investigator

Principal Investigator

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Development of selective ligands to histamine H3 and H4 receptors and its application to elucidate the physiological function of the receptors.

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Development and Application of Novel Histamine H_3 agonist Imifuramine

Principal Investigator

Project Period (FY)

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強力なH_3-アゴニスト活性を持つ新規イミダゾールC-ヌクレオシドの設計と合成Principal Investigator

Principal Investigator

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Sigmatropic Ring Expansion : Quantitative Evaluation of the Transition States and its Synthetic Application to Natural ProductsPrincipal Investigator

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[Book] 有機医薬品合成化学ターゲット分子の合成2011

Author(s)

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[Book] 有機医薬品合成化学ターゲット分子の合成2011

Author(s)

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Data Source

[Book] Mass determination of phosphoramidites (Unit 10.11)2006

Author(s)

Total Pages

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Data Source

HARUSAWA Shinya 春沢信哉

春沢信哉ハルサワシンヤ

春沢信也ハルサワシンヤ

[Journal Article] Diethyl Phosphorocyanidate (DEPC)：　a versatile reagent for organic synthesis2016