YOKOSUKA Osamu 横須賀收

Researcher Number	90182691
External Links
Affiliation *help	2015 : 千葉大学, 医学(系)研究科(研究院), 教授 2012 – 2013 : 千葉大学, 医学(系)研究科(研究院), 教授 2013 : 千葉大学, 医学部, 教授 2007 – 2011 : Chiba University, 大学院・医学研究院, 教授 2008 : 千葉大学, 大学院医学研究院, 教授 … More
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology Except Principal Investigator Gastroenterology / Gastroenterology / Statistical science / Gastroenterology
Keywords	Principal Investigator HBV DNA / B型肝炎ウイルス / Hepatitis C virus / C型肝炎ウィルス / B型肝炎ウィルス / Hepatitis B virus / 劇症肝炎 / C型肝炎ウイルス / 慢性肝炎 / A型肝炎 … More Except Principal Investigator hepatocellular carcinoma / 肝細胞癌 / Polymerase chain reaction / DNAメチル化 / DNA chip / mRNA / 肝臓癌 / Clonality / cDNA array / HBV / TRAP assay / 5-aza-2'deoxycytidine / C型肝炎ウイルス / 肝癌 / duck hepatitis B virus / アヒルB型肝炎ウイルス / HLA / 自己複製能 / DHBV / CpG island / NS5A / DNA methylation / telomerase / Southern blot hybridization / GBV-C / メチル化 / chronic hepatitis / telomere / 癌幹細胞 / Aflatoxin / 構造化データ / DNAチップ / サブファミリー / T細胞リセプター / 慢性肝炎 / EZH2蛋白 / preS遺伝子 / B型慢性肝疾患 / tumor suppressor gene / 肝炎 / Integration of DHBV / C型肝炎ウイルスコア蛋白 / 原発性胆汁性肝硬変 / 野生株 / トランスジェニックマウス / Aza-C / 超音波映像下穿刺 / 電子顕微鏡 / HBウイルス / Western blot法 / 肝発癌 / HRV / 癌 / core gene / サザンブロットハイブリダイゼーション / hepatitis B virus / suppression subtractive hybridization / HCV core蛋白 / interferon/vibavirin / トランスジェニックマウス / 遺伝子発現ベクター / IGF signaling / 腫瘍マーカー / expression vector / HEPADNA / DZNep / Xプロモーター / HCV core protein / SP細胞 / Suppression subtractive hybridization / wild type / SDS-PAGE / NF-κB / Telomerase活性 / HCVコアタンパク / PCR / 動物実験モデル / cDNAマイクロアレイ / C型ウイルス肝炎 / Enteric NANB virus / 知識発見 / Hepatocellular carcinoma / 動物モデル / ultrasonography guided liver biopsy / 細胞増殖 / IL-1B / ウイルスDNA組み込み / transcriptional regulation / TCR / HEDADNA VIRUS / hepatitis / PCR法 / Oncogenesis / enteric non-A, non-B hepatitis virus / mutation / NF-kB / 肝硬変 / CD133, CD90 / animal model / HCV / uotrasonography guided liver biopsy / 慢性肝疾患 / two laybrid system / HCC / IGFBP1 / インターフェロン / Western blot / 電子顕微鏡検索 / ヘパデイナウイルス / Mutant / 変異株 / CD90 / epigenetic disorder / エピジェネティック異常 / interferon / transactivation / precore mutant / 自己複製 / transgenic mouse / 化学発癌 / 消化器癌 / Bmil / hepadnavirus / hepatitis pathogenesis / data mining / IL1B / 分子クロ-ニング / precore変異株 / CD133 / Core遺伝子 / hepatitis C virus / fulminant / 肝発がん / 発現制御 / サブトラクション法 / 脱メチル化剤 / Telomere長 / Bmi1 / epigenetics / CpGアイランド / Fasシグナル伝達系 / ポリメラ-ゼ・チェ-ン反応 / B型肝炎ウイルス / phosphoglycerate kinase遺伝子 / machine learning / Northern blotting / hepatitis Cvirus / HEPADNA VIRUS / 分子生物学的性状 / HPRT遺伝子 / 科学データ / Ultrasonically guided thin-needle biopsy / ウイルスとの結合蛋白 / chronis hepatitis / EZH2 / フローサイトメトリー / siRNA / 転写活性化能 / anti-cancer agent / クローナリティ / non-A,non-B enteric hepatitis virus / 劇性肝炎 / 細胞周期 / 医薬生物 / demethylating agent / 統計解析 / 発癌抑止 / Methylation / 遺伝子 / 劇症肝炎 / ヘパディナウイルス / BMI1 / 抗がん剤 / TNF / ポリコーム群遺伝子 / ultrasonegraphy guided liven biopsy / ウイルス発癌 / cDNA microarray / gastric cancer / 組み込みDNA / PGK遺伝子 / マイクロアレイ / データマイニング / Phosphoglycerate kinase gene / 劇症 / PreーC変異株 / C型慢性肝炎 Less

Ｂ型肝炎、Ｃ型肝炎による病態と自然免疫に関する研究Host Researcher
- Host Researcher
  
  横須賀收
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
Elucidation of the molecular mechanisms on the pathology and treatment of hepatitis by computational approach
- Principal Investigator
  
  HO Tu Bao
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Statistical science
- Research Institution
  Japan Advanced Institute of Science and Technology
The analysis of the predictive marker for the efficacy of the angiogenesis inhibitor for the treatment of hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  YOKOSUKA Osamu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
B型肝炎ウイルスによるエピジェネティック修飾異常と肝発癌に関する検討
- Principal Investigator
  
  深井健一
- Project Period (FY)
  2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
Investigation of novel target genes regulated by polycomb group genes in hepatocellular carcinoma
- Principal Investigator
  
  CHIBA Tetsuhiro
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
Analysis of the relationship between epigenetic disorder, micro RNA in gastroenterological cancerPrincipal Investigator
- Principal Investigator
  
  YOKOSUKA Osamu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
Investigation of cancer stem cell system in hepatocellular carcinoma
- Principal Investigator
  
  CHIBA Tetsuhiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
Procaine has anti-proliferative effect and functions as an inhibitor of DNA methylation in human hepatocellular carcinoma and gastric cancer
- Principal Investigator
  
  FUKAI Kenichi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
Analysis of Viral and host factors influencing the pathophysiology and effect of therapy of pesisitent hepatitis virus infectionPrincipal Investigator
- Principal Investigator
  
  YOKOSUKA Osamu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
STUDIES ON HOST FACTORS RELATED TO FULMINANT HEPATITISPrincipal Investigator
- Principal Investigator
  
  YOKOSUKA Osamu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  CHIBA UNIVERSITY
Genome-wide screen for hepermethylated genes in hepatocellular carcinoma
- Principal Investigator
  
  IMAZEKI Fumio
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
FUNCTIONAL ROBES OF HEPATITIS A VIRUS NONSTRUCTURAL PROTEINS IN SIGNAL TRANSDUCTIONPrincipal Investigator
- Principal Investigator
  
  YOKOSUKA Osamu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  CHIBA UNIVERSITY
Functional analysis of HCV core protein using HCV core transgenic mouse
- Principal Investigator
  
  IMAZEKI Fumio
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
HBV DNA integration and expression of HBx messages in HCCPrincipal Investigator
- Principal Investigator
  
  YOKOSUKA Osamu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
Animal model of chronic hepatitis using duck hapatitis B virus precore mutant infection.
- Principal Investigator
  
  TAGAWA Masami
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
ANALYSES OF HEPATITIS A VIRUS GENOME FROM PATIENTS WITH FULMINANT TYPE A HEPATITISPrincipal Investigator
- Principal Investigator
  
  YOKOSUKA Osamu
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  CHIBA UNIVERSITY
Analysis of telomerase activity and telomere length in various liver diseases
- Principal Investigator
  
  IMAZEKI Fumio
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
Integrated studies for inhibition of progression of chronic hepatitis Cleading to hepatocellular
- Principal Investigator
  
  OMATA Masao
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tokyo
New gene expression vector using duck hepatitis B virus
- Principal Investigator
  
  TAGAWA Masami
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
ANALYSIS OF MUTATIONS IN HEPATITIS B VIRUS ENHANCER 2/CORE PROMOTER ANT THEIR FUNCTIONAL ROLES IN HEPATITIS BPrincipal Investigator
- Principal Investigator
  
  YOKOSUKA Osamu
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  CHIBA UNIBERSITY
B型肝炎及び原発性胆汁性肝硬変症における肝組織内T細胞リセプターの解析
- Principal Investigator
  
  ITO Yosimi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
Analysis of clonality in hepatocellular carcinoma
- Principal Investigator
  
  IMAZEKI Fumio
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
EXPRESSION OF HEPATITIS C VIRUS ENVELOPE RELATED PROTEINS AND DETECTION OF ANTIBODIES TO PROTEINS.Principal Investigator
- Principal Investigator
  
  YOKOSUKA Osamu
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
Investigation of the Mechanism of Fulminant and Severe Hepatitis Correlated with Hepatitis B Virus Mutations
- Principal Investigator
  
  OMATA Masao
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tokyo
  Chiba University
Detection of hepatitis C virus RNA by sensitive PCR methodPrincipal Investigator
- Principal Investigator
  
  YOKOSUKA Osamu
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
Study of enteric non-A, non-B hepatitis virus
- Principal Investigator
  
  ITO Yoshimi
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
Detection of hepatitis B virus nucleic acid by PCR method.Principal Investigator
- Principal Investigator
  
  YOKOSUKA Osamu
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
Interaction of viral and chemical hepatocarcinogenesis
- Principal Investigator
  
  OMATA Masao
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University School of Medicine

All 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2005 2004 Other

All Journal Article Presentation

[Journal Article] Possible Involvement of Hepatitis B Virus Infection of Hepatocytes in the Attenuation of Apoptosis in Hepatic Stellate Cells2016
- Author(s)
  Sasaki R, Kanda T, Nakamura M, Nakamoto S, Haga Y, Wu S, Shirasawa H, Yokosuka O.
- Journal Title
  
  PLoS ONE
  
  Volume : 11 Pages : 1-17
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430155, KAKENHI-PROJECT-13F03100
[Journal Article] Sofosbuvir treatment and hepatitis C virus infection2016
- Author(s)
  Nakamura M, Kanda T, Haga Y, Sasaki R, Wu S, Nakamoto S, Yasui S, Arai M, Imazeki F, Yokosuka O
- Journal Title
  
  World Journal of Hepatology
  
  Volume : 8 Pages : 183-190
- DOI
  10.4254/wjh.v8.i3.183
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13F03100
[Journal Article] Cooperative effects of hepatitis B virus and TNF might play important roles in activation of metabolic pathways through activation of NF-κB2016
- Author(s)
  SHUANG WU, TATSUO KANDA, SHINGO NAKAMOTO, XIA JIANG, MASATO NAKAMURA, REINA SASAKI, YUKI HAGA, HIROSHI SHIRASAWA and OSAMU YOKOSUKA
- Journal Title
  
  International Journal of Molecular Medicine
  
  Volume : 37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13F03100
[Journal Article] Recent Trend of Hepatitis E Virus Infection in Chiba Area, Japan: 3 of 5 Cases with Rheumatoid Arthritis2015
- Author(s)
  Kanda T, Yasui S, Nakamura M, Arai M, Sasaki R, Haga Y, Wu S, Nakamoto S, Okamoto H, Yokosuka O
- Journal Title
  
  Case Rep Gastroenterol
  
  Volume : 9 Pages : 317-326
- DOI
  10.1159/000441387
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13F03100
[Journal Article] Direct-acting Antivirals and Host-targeting Agents against the Hepatitis A Virus2015
- Author(s)
  Kanda T, Nakamoto S, Wu S, Nakamura M, Jiang X, Haga Y, Sasaki R, Yokosuka O
- Journal Title
  
  J Clin Transl Hepatol
  
  Volume : 3 Pages : 205-210
- DOI
  10.14218/JCTH.2015.00016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13F03100
[Journal Article] MicroRNA-122 Inhibits the Production of Inflammatory Cytokines by Targeting the PKR Activator PACT in Human Hepatic Stellate Cells2015
- Author(s)
  Nakamura M, Kanda T, Sasaki R, Haga Y, Jiang X, Wu S, Nakamoto S, Yokosuka O
- Journal Title
  
  PLoS ONE
  
  Volume : 10
- DOI
  10.1371/journal.pone.0144295
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13F03100
[Journal Article] Treatment of hepatitis C virus infection in the future2014
- Author(s)
  Kanda T, Yokosuka O, Omata M
- Journal Title
  
  Clinical Translation Medicine
  
  Volume : 11, 2(1):9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300105
[Journal Article] Hepatitis C virus NS5A inhibitors and drug resistance mutations2014
- Author(s)
  Nakamoto, S., Kanda, T., Wu, S., Shirawasa, H., Yokosuka, O
- Journal Title
  
  World Journal of Gastroenterol
  
  Volume : 20(11) Pages : 2902-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300105
[Journal Article] Regulation of microRNA by hepatitis B virus infection and their possible association with control of innate immunity.2014
- Author(s)
  Jiang X, Kanda T, Wu S, Nakamura M, Miyamura T, Nakamoto S, Banerjee A, Yokosuka O.
- Journal Title
  
  World J Gastroenterol.
  
  Volume : 20 Pages : 7197-7206
- DOI
  10.3748/wjg.v20.i23.7197
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13F03100, KAKENHI-PROJECT-26860491
[Journal Article] Suppression of La Antigen Exerts Potential Antiviral Effects against Hepatitis A Virus2014
- Author(s)
  Jiang X, Kanda T, Wu S, Nakamoto S, Saito K, Shirasawa H, Kiyohara T, Ishii K, Wakita T, Okamoto H, Yokosuka O.
- Journal Title
  
  PLoS ONE
  
  Volume : 9
- DOI
  10.1371/journal.pone.0101993
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13F03100, KAKENHI-PROJECT-24590955, KAKENHI-PROJECT-24792175, KAKENHI-PROJECT-25460580, KAKENHI-PROJECT-26430155
[Journal Article] Hepatitis C virus NS5A inhibitors and drug resistance mutations2014
- Author(s)
  Shingo Nakamoto, Tatsuo Kanda, Shuang Wu, Hiroshi Shirasawa, Osamu Yokosuka
- Journal Title
  
  World Journal of Gastroenterology
  
  Volume : 20(11) Pages : 2902-2912
- Data Source
  KAKENHI-PROJECT-23300105
[Journal Article] Occurrence and Recurrence of Hepatocellular Carcinoma Were Not Rare Events during Phlebotomy in Older Hepatitis C Virus-Infected Patients.2014
- Author(s)
  Kanda T, Nakamoto S, Yasui S, Nakamura M, Miyamura T, Wu S, Jiang X, Arai M, Imazeki F, Yokosuka O.
- Journal Title
  
  Case Rep Oncol.
  
  Volume : 7 Pages : 288-296
- DOI
  10.1159/000362869
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13F03100
[Journal Article] Natural interferon-beta plus ribavirin therapy led to sustained virological response after seven unsuccessful courses of anti-viral treatment in a chronic hepatitis C patient2013
- Author(s)
  Kandat T., Nakamoto S., Arai, M., Miyamura, T., Wu, S., Fujiwara, K., Yokosuka O
- Journal Title
  
  Clinical Journal Gastroentorology
  
  Volume : 6(2)
- DOI
  10.1007/s12328-013-0366-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300105
[Journal Article] Antiviral therapy for " difficult -to-treat" hepatitis C virus-infected patients2013
- Author(s)
  Kanda T, Yokosuka O, Omata M
- Journal Title
  
  Chin Med J (Engl)
  
  Volume : 126(23) Pages : 4568-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300105
[Journal Article] Platelet count and sustained virological response in hepatitis C treatment2013
- Author(s)
  Kandat T., Kato K., Tsubota, A., Takada, N., Nishino, T., Mikami, S., Miyamura, T., Maruoka D., We, S., Nakamoto, S., Arai, M., Fujiwara, K., Imazeki, F., Yokosuka O
- Journal Title
  
  World Journal of Hepatology
  
  Volume : 5(4) Pages : 182-188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300105
[Journal Article] A Semi- Supervised Learning Method for Discriminative Motif Finding and Its Application2013
- Author(s)
  Le N., Ho T.B., Kanda T., Kawasaki S., Takabayashi K., Wu S., Yokosuka O.
- Journal Title
  
  Universal Computer Science
  
  Volume : 19(4) Pages : 563-580
- Data Source
  KAKENHI-PROJECT-23300105
[Journal Article] Hepatitis C virus protease inhibitor-resistance mutations: Our experience and review2013
- Author(s)
  Shuang Wu, Tatsuo Kanda, Shingo Nakamoto, Fumio Imazeki, Osamu Yokosuka
- Journal Title
  
  World Journal of Gastroenterology
  
  Volume : 19(47) Pages : 8940-8948
- Data Source
  KAKENHI-PROJECT-23300105
[Journal Article] Platelet count and sustained virological response in hepatitis C treatment2013
- Author(s)
  Tatsuo Kanda, Keizo Kato, Akihito Tsubota, Nobuo Takada, Takayoshi Nishino, Shigeru Mikami, Tatsuo Miyamura, Daisuke Maruoka, Shuang Wu, Shingo Nakamoto, Makoto Arai, Keiichi Fujiwara, Fumio Imazeki, Osamu Yokosuka
- Journal Title
  
  World journal of hepatology
  
  Volume : 5(4) Pages : 182-188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300105
[Journal Article] Safety and tolerance of sorafenib in Japanese patients with advanced hepatocellular carcinoma2011
- Author(s)
  Sadahisa Ogasawara, Osamu Yokosuka, Fumihiko Kanai, et al.
- Journal Title
  
  Hepatology International
  
  Volume : 5 Pages : 850-856
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390225
[Journal Article] Safety and tolerance of sorafenib in Japanese patients with advanced hepatocellular carcinoma2011
- Author(s)
  Ogasawara S, Kanai F, Obi S, Sato S, Yamaguchi T, Azemoto R, Mizumoto H, Koushima Y, Morimoto N, Hirata N, Toriyabe T, Shinozali Y, Ooka Y, Mikata R, Chiba T, Okabe S, Imazeki F, Yoshikawa M, Yokosuka O
- Journal Title
  
  Hepatol Int
  
  Volume : 5 Pages : 850-856
- DOI
  10.1007/s12072-010-9249-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390225
[Journal Article] Bmil promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.2010
- Author(s)
  Chiba T, Seki A, Aoki R, Ichikawa H, Negishi M, Miyagi S, Oguro H, Saraya A, Kamiya A, Nakauchi H, Yokosuka O, Iwama A.
- Journal Title
  
  Hepatology 52
  
  Pages : 1111-1123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790649
[Journal Article] The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells.2010
- Author(s)
  Chiba T, Aoki R, Miyagi S, Negishi M, Konuma T, Taniguchi H, Ogawa M, Yokosuka O, Iwama A.
- Journal Title
  
  J Hepatol 52
  
  Pages : 854-863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790649
[Journal Article] Cancer stem cells in hepatocellular carcinoma : Recent progress and perspective.2009
- Author(s)
  Chiba T, Kamiya A, Yokosuka O, Iwama A.
- Journal Title
  
  Cancer Lett, 286
  
  Pages : 145-153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790649
[Journal Article] The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma.2008
- Author(s)
  Chiba T, Miyagi S, Saraya A, Ryutaro Aoki R, Seki A, Morita Y, Yonemitsu Y, Yokosuka O, Taniguchi H, Nakauchi H,Iwama A.
- Journal Title
  
  Cancer Res 68
  
  Pages : 7742-7749
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790468
[Journal Article] Down-regulation of hedgehoginteracting protein through genetic ,, epigenetic alterations in human hepatocellular carcinoma2008
- Author(s)
  多田素久、今関文夫、横須賀收, 他10
- Journal Title
  
  Clin Cancer Res 14(12)
  
  Pages : 3768-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390195
[Journal Article] genes up-regulated by the demethylating agent, 5-aza- 2' deoxycytidine, in esophageal squamous cell carcinoma2008
- Author(s)
  新井誠人、今関文夫、横須賀收, 他6名
- Journal Title
  
  Oncol Rep 20(2)
  
  Pages : 405-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390195
[Journal Article] The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma2008
- Author(s)
  千葉哲博、横須賀收, 他9名
- Journal Title
  
  Cancer Res 68(19)
  
  Pages : 7742-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390195
[Journal Article] Quantitative analysis of vascular endothelial growth factor in liver metastases from pancreatic carcinoma as a predictor of chemotherapeutic effect, prognosis2008
- Author(s)
  太和田勝之、横須賀收, 他5名
- Journal Title
  
  Clin Cancer Res 14(22)
  
  Pages : 7438-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390195
[Journal Article] Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation.2007
- Author(s)
  Chiba T, Zheng YW, Kita K, Yokosuka O, Saisho H, Onodera M, Miyoshi M, Nakano M, Nakauchi H, Iwama A, Taniguchi H.
- Journal Title
  
  Gastroenterology 133
  
  Pages : 937-950
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790468
[Journal Article] Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation2007
- Author(s)
  千葉哲博、横須賀收, 他11名
- Journal Title
  
  Gastroenterology 133(3)
  
  Pages : 937-50
- Data Source
  KAKENHI-PROJECT-19390195
[Journal Article] Evaluation of Clinical Usefulness of Second Generation HCV Core Antigen Assay : Comparison with COBAS AMPLICOR HCV MONITOR Assay Version 2.0.2005
- Author(s)
  Yokosuka Osamu, et al.
- Journal Title
  
  Liver International 25
  
  Pages : 1136-1141
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590576
[Journal Article] Evaluation of Clinical Usefulness of Second Generation HCV Core Antigen Assay : Comparison with COBAS AMPLICOR HCV MONITOR Assay Version 2.02005
- Author(s)
  Yokosuka Osamu
- Journal Title
  
  Liver International 25
  
  Pages : 1136-1141
- Data Source
  KAKENHI-PROJECT-16590576
[Journal Article] High SVR rate after IFN therapy in selected Japanese hepatitis C patients with either a low HCV RNA titer or HCV serotype 22004
- Author(s)
  Yokosuka Osamu
- Journal Title
  
  Intervirology 47
  
  Pages : 328-334
- Data Source
  KAKENHI-PROJECT-16590576
[Journal Article] High SVR rate after IFN therapy in selected Japanese hepatitis C patients with either a low HCV RNA titer or HCV serotype 22004
- Author(s)
  Yokosuka Osamu
- Journal Title
  
  Intervirology 47
  
  Pages : 328-34
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590576
[Journal Article] High SVR rate after IFN therapy in selected Japanese hepatitis C patients with either a low HCV RNA titer or HCV serotype 22004
- Author(s)
  Yokosuka O, et al.
- Journal Title
  
  Intervirology 47
  
  Pages : 328-334
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590576
[Journal Article] Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma.
- Author(s)
  Yonemitsu Y, Imazeki F, Chiba T, Fukai K, Nagai Y, Miyagi S, Arai M, Aoki R, Miyazaki M, Nakatani Y, Iwama A, Yokosuka O.
- Journal Title
  
  Hum Pathol (in press.)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790468
[Presentation] ソラフェニブ治療における早期治療効果予測2012
- Author(s)
  小笠原定久、横須賀收、金井文彦, 他
- Organizer
  第5回肝がん分子標的治療研究会
- Place of Presentation
  大手町サンケイプラザ
- Year and Date
  2012-01-14
- Data Source
  KAKENHI-PROJECT-21390225
[Presentation] 肝細胞癌における血管新生および細胞増殖関連因子の発現の検討2011
- Author(s)
  多田素久、横須賀收、金井文彦, 他
- Organizer
  第47回日本肝臓学会総会
- Place of Presentation
  ホテルグランパシフィック LE DAIBA
- Year and Date
  2011-06-02
- Data Source
  KAKENHI-PROJECT-21390225
[Presentation] ソラフェニブ治療における早期の有効性サロゲートマーカーとしてのRECISTの検証2011
- Author(s)
  小笠原定久、横須賀收、金井文彦, 他
- Organizer
  第47回日本肝臓学会総会
- Place of Presentation
  ホテルグランパシフィック LE DAIBA
- Year and Date
  2011-06-03
- Data Source
  KAKENHI-PROJECT-21390225
[Presentation] ソラフェニブ治療における早期の有効性サロゲートマーカーとしてのRECISTの検証2011
- Author(s)
  多田素久, 横須賀收, 金井文彦, 他
- Organizer
  第47回日本肝臓学会総会ポスターセッション
- Place of Presentation
  ホテルグランパシフィックLE DAIBA
- Year and Date
  2011-06-02
- Data Source
  KAKENHI-PROJECT-21390225
[Presentation] Finding HCV NS5A Discriminative Motifs for Assessment of IFN/Ribavarin Therapy Effect2011
- Author(s)
  Ho, T.B., Kawasaki, S., Le, N.T., Kanda, T., Le, T.N., Takabayashi, K., Yokosuka, O.
- Organizer
  Workshop Data Mining in Genomics and Proteomics, International Conference ECML/PKDD
- Place of Presentation
  Athens, Greece
- Data Source
  KAKENHI-PROJECT-23300105
[Presentation] Regulation of liver cancer stem cells by polycomb group proteins.2011
- Author(s)
  千葉哲博、岩間厚志、横須賀収
- Organizer
  第3回JCA-AACR Special Joint Conference
- Place of Presentation
  千葉県
- Year and Date
  2011-03-04
- Data Source
  KAKENHI-PROJECT-21790649
[Presentation] Finding HCV NS5A Discriminative Motifs for Assessment of IFN/Ribavarin Therapy Effect2011
- Author(s)
  Ho, T.B., Kawasaki, S., Le, N.T., Kanda, T., Le, T.N., Takabayashi, K., Yokosuka, O
- Organizer
  Workshop Data Mining in Genomics and Proteomics, International Conference ECML/PKDD
- Place of Presentation
  Athens, Greece
- Data Source
  KAKENHI-PROJECT-23300105
[Presentation] 肝細胞癌における血管新生および細胞増殖関連因子の発現の検討2011
- Author(s)
  多田素久, 横須賀收, 金井文彦, 他
- Organizer
  第47回日本肝臓学会総会一般口演
- Place of Presentation
  ホテルグランパシフィックLE DAIBA
- Year and Date
  2011-06-02
- Data Source
  KAKENHI-PROJECT-21390225
[Presentation] ポリコーム群タンパクによる肝幹細胞の制御機構2010
- Author(s)
  千葉哲博、青木竜太郎、横須賀収
- Organizer
  第96回日本消化器病学会総会
- Place of Presentation
  新潟県
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-21790649
[Presentation] 肝細胞癌の増殖および腫瘍血管新生に関わる遺伝子発現プロファイルの検討2010
- Author(s)
  横須賀牧
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  ホテルメトロポリタン山形
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-21390225
[Presentation] 肝細胞癌の増殖および腫瘍血管新生に関する遺伝子発現プロファイルの検討2010
- Author(s)
  鳥谷部武志, 横須賀收, 金井文彦
- Organizer
  第46回日本肝臓学会総会シンポジウム
- Place of Presentation
  ホテルメトロポリタン山形
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-21390225
[Presentation] Regulatory machinery of Bmil in both normal and cancer stem cells in liver2009
- Author(s)
  千葉哲博、青木竜太郎、横須賀収、岩間厚志
- Organizer
  第68回日本癌学会総会
- Place of Presentation
  神奈川県
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-21790649
[Presentation] 大腸癌由来培養細胞において脱メチル化剤投与により発現上昇したマイクロRNAの解析2008
- Author(s)
  田中健史、新井誠人、今関文夫、横須賀收
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19390195
[Presentation] Molecular machinery in the establishment and maintenance of liver cancer stem cell system.2008
- Author(s)
  千葉哲博、宮城聡、横須賀收、岩間厚志
- Organizer
  第67回日本癌学会総会
- Place of Presentation
  愛知県
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19790468
[Presentation] 肝臓における癌幹細胞システムの成立・維持メカニズム2008
- Author(s)
  千葉哲博、横須賀收、岩間厚志
- Organizer
  第16回日本消化器病学会関連週間
- Place of Presentation
  東京都
- Year and Date
  2008-10-01
- Data Source
  KAKENHI-PROJECT-19790468
[Presentation] 肝癌細胞株におけるエピジェネティク異常とマイクロRNAの関わりの検討2007
- Author(s)
  新井誠人、今関文夫、横須賀收
- Organizer
  第43回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2007-05-31
- Data Source
  KAKENHI-PROJECT-19390195
[Presentation] The polycomb gene product BMI1 is required for the tumor-initiating capacity of hepatocellular carcinoma cells.2007
- Author(s)
  千葉哲博、宮城聡、横須賀收、岩間厚志
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  神奈川県
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-19790468
[Presentation] Investigation of cancer stem cell system in hepatocellular carcinoma.2007
- Author(s)
  Chiba T, Miyagi S, Yokosuka O, Taniguchi H, Nakauchi H, Iwama A.
- Organizer
  17th APASL conference
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2007-03-29
- Data Source
  KAKENHI-PROJECT-19790468

1. IMAZAKI Fumio (40223325)

# of Collaborated Projects : 15results

# of Collaborated Products : 4results
2. FUKAI Kenichi (60361432)

# of Collaborated Projects : 6results

# of Collaborated Products : 0results
3. TAGAWA Masami (90261916)

# of Collaborated Projects : 5results

# of Collaborated Products : 0results
4. ITO Yosimi (70159929)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
5. ARAI Makoto (30396684)

# of Collaborated Projects : 3results

# of Collaborated Products : 3results
6. OMATA Masao (90125914)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
7. EHATA Toshiki (20280919)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
8. HOSODA Kazuhiko

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
9. CHIBA Tetsuhiro (00381583)

# of Collaborated Projects : 2results

# of Collaborated Products : 13results
10. IWAMA Atsushi (70244126)

# of Collaborated Projects : 2results

# of Collaborated Products : 12results
11. MIYAGI Satoru (20400997)

# of Collaborated Projects : 2results

# of Collaborated Products : 7results
12. KANDA Tatsuo (20345002)

# of Collaborated Projects : 2results

# of Collaborated Products : 12results
13. KAWAI Sigenobu (10311606)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
14. TOKUHISA Takeshi (20134364)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
15. TADA Minoru

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
16. WU SHUANG

# of Collaborated Projects : 2results

# of Collaborated Products : 18results
17. KANAI Fumihiko (70334399)

# of Collaborated Projects : 1results

# of Collaborated Products : 8results
18. TADA Motohisa (00554239)

# of Collaborated Projects : 1results

# of Collaborated Products : 3results
19. HO Tu Bao (60301199)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
20. TAKABAYASHI Katsuhiko (90188079)

# of Collaborated Projects : 1results

# of Collaborated Products : 3results
21. DAM Hieu Chi (70397230)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
22. KAWASAKI Saori (40377437)

# of Collaborated Projects : 1results

# of Collaborated Products : 3results
23. SHIRATORI Yasushi (70196624)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
24. TANIKAWA Kyuichi (10080649)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
25. SATO Chifumi (60154069)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
26. KAKUMU Shinichi (10115545)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
27. MATSUMURA Masayuki

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
28. HONDA Arata

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
29. 丸泰司

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
30. 藤原慶一

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
31. 呉霜

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
32. Nakamoto Shingo

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
33. 白澤浩

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
34. 齋藤謙悟

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
35. 石井孝司

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
36. TUBAO Ho

# of Collaborated Projects : 0results

# of Collaborated Products : 3results

YOKOSUKA Osamu 横須賀 收

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Ｂ型肝炎、Ｃ型肝炎による病態と自然免疫に関する研究Host Researcher

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The analysis of the predictive marker for the efficacy of the angiogenesis inhibitor for the treatment of hepatocellular carcinomaPrincipal Investigator

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Analysis of the relationship between epigenetic disorder, micro RNA in gastroenterological cancerPrincipal Investigator

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Analysis of Viral and host factors influencing the pathophysiology and effect of therapy of pesisitent hepatitis virus infectionPrincipal Investigator

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STUDIES ON HOST FACTORS RELATED TO FULMINANT HEPATITISPrincipal Investigator

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FUNCTIONAL ROBES OF HEPATITIS A VIRUS NONSTRUCTURAL PROTEINS IN SIGNAL TRANSDUCTIONPrincipal Investigator

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HBV DNA integration and expression of HBx messages in HCCPrincipal Investigator

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YOKOSUKA Osamu 横須賀收