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YOKOSUKA Osamu  横須賀 收

ORCIDConnect your ORCID iD *help
… Alternative Names

横須賀 收  ヨコスカ オサム

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Researcher Number 90182691
External Links
Affiliation (based on the past Project Information) *help 2015: 千葉大学, 医学(系)研究科(研究院), 教授
2013: 千葉大学, 医学部, 教授
2012 – 2013: 千葉大学, 医学(系)研究科(研究院), 教授
2007 – 2011: Chiba University, 大学院・医学研究院, 教授
2008: 千葉大学, 大学院医学研究院, 教授 … More
2006: Chiba University, Graduate School of Medcine・Department of Medicine and Clinical Oncology, Professor, 医学部附属病院, 教授
2006: 千葉大学, 大学院医学研究院, 教授
2001 – 2005: Chiba University, Graduate School of Medicine, Lecturer, 大学院・医学研究院, 講師
1994 – 2000: Chiba University Lecturer, 医学部, 講師
1996: 千葉大学, 医学部・附属病院, 講師
1995 – 1996: 千葉大学, 医学部(病), 講師
1992 – 1994: 千葉大学, 医学部附属病院, 講師
1993: CHIBA UNIVERSITY, UNIV HOSPITAL, LECTURER, 医学部・附属病院, 講師
1991: Chiba University, assistant, 医学部, 助手
1990: 千葉大学, 医学部附属病院, 助手
1988 – 1989: 千葉大学, 医学部, 助手
1987: 千葉大学, 医学部附属病院, 助手 Less
Review Section/Research Field
Principal Investigator
Gastroenterology / Gastroenterology
Except Principal Investigator
Gastroenterology / Gastroenterology / Statistical science / Gastroenterology
Keywords
Principal Investigator
B型肝炎ウイルス / HBV DNA / C型肝炎ウィルス / C型肝炎ウイルス / Hepatitis C virus / B型肝炎ウィルス / Hepatitis B virus / 劇症肝炎 / ポリメラ-ゼ・チェイン・リアクション法 / 合成DNA … More / 急性肝炎 / 慢性肝炎 / HCV RNA / Interferon / HCV-RNA / HBV-DNA / A型肝炎ウイルス / 変異 / A型肝炎 / 塩基配列決定 / PCR / HAV-VP3 / SRE / アポトーシス / NFkB / AP-1 / マイクロRNA / エピジェネティクス / 異常メチル化 / マイクロアレイ / 発現解析 / 細胞増殖能 / 培養細胞 / トランスフェクション / 脱メチル化剤 / マイクロRN / エピジェネティク / 肝臓学 / 肝細胞癌 / 血管新生阻害薬 / HCDーRNA / プライマ- / インタ-フェロン / HCVーRNA / ポリメラ-ゼ・チェイン・リアクション / 遺伝子 / Polymerase chain reaction / Synthetic DNA / Primer / Acute hepatitis / Chronic hepatitis / 中和抗体 / HCV表面関連抗原(E2) / 蛋白発現ベクター / E2抗体 / HCV表面関連抗原(EZ) / 表面関連抗原(E2) / Neutralizing antibody / E2 antibody / Expression vector / エンハンサー領域 / コアープロモーター / CAT活性 / HBV‐DNA / コアプロモーター / Enhancer 2 / Core promoter / CAT actiity / 劇症可燃 / 塩基配列 / ウイルス変異 / Hepatitis A virus / fulminant hepatitis / mutation / sequence / Hepatis A / 肝癌 / 組み込み / 発癌 / 分子機構 / HBX / fusion蛋白 / Alu-HBV / Hepatocellular Carcinoma / Hepatitis C Virus / Integration / HBx gene / Fusion protein / ALU-HBV / 非構造蛋白 / シグナル伝達 / ルシフェラーゼアッセイ / 構造蛋白 / ルシフェラーゼ アッセイ / 弱毒化ウイルス / HEPATITIS A / HEPATITIS AVIRUS / NONSTRUCTURAL PROTEIN / STONAL TRANSDUCTlON / LUCIFERASE ASSAY / STRUCTURAL PROTEIN / 肝再生 / 蛋白合成 / DNAマイクロアレイ / osteopontin / 遺伝子発現 / オーバル細胞 / IGFBP1 / DNAチップ / SNP解析 / サイトカイン / FAS / FLIP / FULMINANT HEPATITIS / LIVER REGENERATION / PROTEIN SYNTHESIS / DNA MICROARRAY / OSTEOPONTIN / GENE EXPRESSION / OVAL CELL / B型肝炎 / C型肝炎 / インターフェロン / リバビリン / ラミブジン / Ribavirin / Mutation / Lamivudine / HBe抗原・抗体系 / 直接シ-クエンス法 / pre-C領域 / 慢性肝疾患 / HBs抗原 / HBs抗原サブタイプ / ポリメラーゼ・チェイン・リアクション法 / HBVDNA / 超高感度検出法 / HBe抗体 / 肝疾患 / hepatitis B virus / polymerase chain reaction / HBeAg / Ab / direct sequencing / chronic liver disease … More
Except Principal Investigator
hepatocellular carcinoma / 肝細胞癌 / DNAメチル化 / Polymerase chain reaction / 癌幹細胞 / 肝臓癌 / 自己複製能 / HLA / HBV / Clonality / メチル化 / Southern blot hybridization / C型肝炎ウイルス / NS5A / GBV-C / 肝癌 / アヒルB型肝炎ウイルス / duck hepatitis B virus / telomerase / telomere / TRAP assay / chronic hepatitis / cDNA array / DNA chip / mRNA / 5-aza-2'deoxycytidine / CpG island / DNA methylation / DHBV / B型慢性肝疾患 / 原発性胆汁性肝硬変 / T細胞リセプター / サブファミリー / Bmi1 / CD133, CD90 / Bmil / CD133 / CD90 / フローサイトメトリー / 自己複製 / SP細胞 / B型肝炎ウイルス / 肝発がん / EZH2蛋白 / Xプロモーター / preS遺伝子 / ポリコーム群遺伝子 / BMI1 / EZH2 / DZNep / 医薬生物 / 統計解析 / データマイニング / data mining / machine learning / interferon/vibavirin / hepatitis pathogenesis / HCV / siRNA / epigenetics / hepatitis C virus / 知識発見 / 科学データ / 構造化データ / HBウイルス / Core遺伝子 / 変異株 / 野生株 / 肝炎 / 劇症 / Mutant / 劇症肝炎 / 劇性肝炎 / PreーC変異株 / TCR / 慢性肝炎 / hepatitis B virus / core gene / mutation / wild type / hepatitis / fulminant / phosphoglycerate kinase遺伝子 / 超音波映像下穿刺 / クローナリティ / PGK遺伝子 / HPRT遺伝子 / サザンブロットハイブリダイゼーション / PCR法 / Hepatocellular carcinoma / Phosphoglycerate kinase gene / Methylation / Ultrasonically guided thin-needle biopsy / インターフェロン / 転写活性化能 / 肝発癌 / 肝硬変 / 腫瘍マーカー / ウイルスとの結合蛋白 / two laybrid system / C型ウイルス肝炎 / 発癌抑止 / hepatitis Cvirus / interferon / transactivation / 遺伝子発現ベクター / ヘパディナウイルス / ヘパデイナウイルス / expression vector / hepadnavirus / uotrasonography guided liver biopsy / ultrasonegraphy guided liven biopsy / chronis hepatitis / 慢性肝疾患 / Telomerase活性 / Telomere長 / ultrasonography guided liver biopsy / precore変異株 / 動物実験モデル / precore mutant / animal model / HCV core蛋白 / トランスジェニック マウス / Suppression subtractive hybridization / トランスジェニックマウス / C型肝炎ウイルスコア蛋白 / サブトラクション法 / DNAチップ / C型慢性肝炎 / Northern blotting / HCVコアタンパク / Fasシグナル伝達系 / 細胞周期 / 細胞増殖 / HCV core protein / transgenic mouse / suppression subtractive hybridization / cDNAマイクロアレイ / CpGアイランド / Aza-C / cDNA microarray / 消化器癌 / 遺伝子 / エピジェネティック異常 / 発現制御 / 抗がん剤 / 脱メチル化剤 / 動物モデル / 癌 / マイクロアレイ / gastric cancer / epigenetic disorder / transcriptional regulation / anti-cancer agent / demethylating agent / tumor suppressor gene / HEDADNA VIRUS / ウイルス発癌 / 化学発癌 / ウイルスDNA組み込み / HEPADNA VIRUS / HEPADNA / PCR / 組み込みDNA / Oncogenesis / Aflatoxin / Integration of DHBV / HCC / Enteric NANB virus / Western blot法 / 分子クロ-ニング / ポリメラ-ゼ・チェ-ン反応 / 電子顕微鏡 / non-A,non-B enteric hepatitis virus / SDS-PAGE / 分子生物学的性状 / 電子顕微鏡検索 / enteric non-A, non-B hepatitis virus / Western blot / TNF / IL-1B / NF-kB / IGFBP1 / IGF signaling / IL1B / NF-κB / HRV Less
  • Research Projects

    (28 results)
  • Research Products

    (52 results)
  • Co-Researchers

    (36 People)
  •  B型肝炎、C型肝炎による病態と自然免疫に関する研究Host Researcher

    • Host Researcher
      横須賀 收
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for JSPS Fellows
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  Elucidation of the molecular mechanisms on the pathology and treatment of hepatitis by computational approach

    • Principal Investigator
      TU・BAO Ho
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Statistical science
    • Research Institution
      Japan Advanced Institute of Science and Technology
  •  The analysis of the predictive marker for the efficacy of the angiogenesis inhibitor for the treatment of hepatocellular carcinomaPrincipal Investigator

    • Principal Investigator
      YOKOSUKA Osamu
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  B型肝炎ウイルスによるエピジェネティック修飾異常と肝発癌に関する検討

    • Principal Investigator
      深井 健一
    • Project Period (FY)
      2009
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  Investigation of novel target genes regulated by polycomb group genes in hepatocellular carcinoma

    • Principal Investigator
      CHIBA Tetsuhiro
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  Analysis of the relationship between epigenetic disorder, micro RNA in gastroenterological cancerPrincipal Investigator

    • Principal Investigator
      YOKOSUKA Osamu
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  Investigation of cancer stem cell system in hepatocellular carcinoma

    • Principal Investigator
      CHIBA Tetsuhiro
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  Procaine has anti-proliferative effect and functions as an inhibitor of DNA methylation in human hepatocellular carcinoma and gastric cancer

    • Principal Investigator
      FUKAI Kenichi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  Analysis of Viral and host factors influencing the pathophysiology and effect of therapy of pesisitent hepatitis virus infectionPrincipal Investigator

    • Principal Investigator
      YOKOSUKA Osamu
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  STUDIES ON HOST FACTORS RELATED TO FULMINANT HEPATITISPrincipal Investigator

    • Principal Investigator
      YOKOSUKA Osamu
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      CHIBA UNIVERSITY
  •  Genome-wide screen for hepermethylated genes in hepatocellular carcinoma

    • Principal Investigator
      IMAZEKI Fumio
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  FUNCTIONAL ROBES OF HEPATITIS A VIRUS NONSTRUCTURAL PROTEINS IN SIGNAL TRANSDUCTIONPrincipal Investigator

    • Principal Investigator
      YOKOSUKA Osamu
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      CHIBA UNIVERSITY
  •  Functional analysis of HCV core protein using HCV core transgenic mouse

    • Principal Investigator
      IMAZEKI Fumio
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  HBV DNA integration and expression of HBx messages in HCCPrincipal Investigator

    • Principal Investigator
      YOKOSUKA Osamu
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  Animal model of chronic hepatitis using duck hapatitis B virus precore mutant infection.

    • Principal Investigator
      TAGAWA Masami
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  ANALYSES OF HEPATITIS A VIRUS GENOME FROM PATIENTS WITH FULMINANT TYPE A HEPATITISPrincipal Investigator

    • Principal Investigator
      YOKOSUKA Osamu
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      CHIBA UNIVERSITY
  •  Analysis of telomerase activity and telomere length in various liver diseases

    • Principal Investigator
      IMAZEKI Fumio
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  Integrated studies for inhibition of progression of chronic hepatitis Cleading to hepatocellular

    • Principal Investigator
      OMATA Masao
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Tokyo
  •  New gene expression vector using duck hepatitis B virus

    • Principal Investigator
      TAGAWA Masami
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  ANALYSIS OF MUTATIONS IN HEPATITIS B VIRUS ENHANCER 2/CORE PROMOTER ANT THEIR FUNCTIONAL ROLES IN HEPATITIS BPrincipal Investigator

    • Principal Investigator
      YOKOSUKA Osamu
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      CHIBA UNIBERSITY
  •  B型肝炎及び原発性胆汁性肝硬変症における肝組織内T細胞リセプターの解析

    • Principal Investigator
      ITO Yosimi
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  Analysis of clonality in hepatocellular carcinoma

    • Principal Investigator
      IMAZEKI Fumio
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  EXPRESSION OF HEPATITIS C VIRUS ENVELOPE RELATED PROTEINS AND DETECTION OF ANTIBODIES TO PROTEINS.Principal Investigator

    • Principal Investigator
      YOKOSUKA Osamu
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  Investigation of the Mechanism of Fulminant and Severe Hepatitis Correlated with Hepatitis B Virus Mutations

    • Principal Investigator
      OMATA Masao
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Tokyo
      Chiba University
  •  Detection of hepatitis C virus RNA by sensitive PCR methodPrincipal Investigator

    • Principal Investigator
      YOKOSUKA Osamu
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  Study of enteric non-A, non-B hepatitis virus

    • Principal Investigator
      ITO Yoshimi
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  Detection of hepatitis B virus nucleic acid by PCR method.Principal Investigator

    • Principal Investigator
      YOKOSUKA Osamu
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  Interaction of viral and chemical hepatocarcinogenesis

    • Principal Investigator
      OMATA Masao
    • Project Period (FY)
      1987 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University School of Medicine

All 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2005 2004 Other

All Journal Article Presentation

  • [Journal Article] Possible Involvement of Hepatitis B Virus Infection of Hepatocytes in the Attenuation of Apoptosis in Hepatic Stellate Cells2016

    • Author(s)
      Sasaki R, Kanda T, Nakamura M, Nakamoto S, Haga Y, Wu S, Shirasawa H, Yokosuka O.
    • Journal Title

      PLoS ONE

      Volume: 11 Pages: 1-17

    • DOI

      10.1371/journal.pone.0146314

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26430155, KAKENHI-PROJECT-26860491, KAKENHI-PROJECT-13F03100
  • [Journal Article] Cooperative effects of hepatitis B virus and TNF might play important roles in activation of metabolic pathways through activation of NF-κB2016

    • Author(s)
      SHUANG WU, TATSUO KANDA, SHINGO NAKAMOTO, XIA JIANG, MASATO NAKAMURA, REINA SASAKI, YUKI HAGA, HIROSHI SHIRASAWA and OSAMU YOKOSUKA
    • Journal Title

      International Journal of Molecular Medicine

      Volume: 37

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-13F03100
  • [Journal Article] Sofosbuvir treatment and hepatitis C virus infection2016

    • Author(s)
      Nakamura M, Kanda T, Haga Y, Sasaki R, Wu S, Nakamoto S, Yasui S, Arai M, Imazeki F, Yokosuka O
    • Journal Title

      World Journal of Hepatology

      Volume: 8 Pages: 183-190

    • DOI

      10.4254/wjh.v8.i3.183

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-13F03100
  • [Journal Article] MicroRNA-122 Inhibits the Production of Inflammatory Cytokines by Targeting the PKR Activator PACT in Human Hepatic Stellate Cells2015

    • Author(s)
      Nakamura M, Kanda T, Sasaki R, Haga Y, Jiang X, Wu S, Nakamoto S, Yokosuka O
    • Journal Title

      PLoS ONE

      Volume: 10

    • DOI

      10.1371/journal.pone.0144295

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-13F03100
  • [Journal Article] Direct-acting Antivirals and Host-targeting Agents against the Hepatitis A Virus2015

    • Author(s)
      Kanda T, Nakamoto S, Wu S, Nakamura M, Jiang X, Haga Y, Sasaki R, Yokosuka O
    • Journal Title

      J Clin Transl Hepatol

      Volume: 3 Pages: 205-210

    • DOI

      10.14218/jcth.2015.00016

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-13F03100
  • [Journal Article] Recent Trend of Hepatitis E Virus Infection in Chiba Area, Japan: 3 of 5 Cases with Rheumatoid Arthritis2015

    • Author(s)
      Kanda T, Yasui S, Nakamura M, Arai M, Sasaki R, Haga Y, Wu S, Nakamoto S, Okamoto H, Yokosuka O
    • Journal Title

      Case Rep Gastroenterol

      Volume: 9 Pages: 317-326

    • DOI

      10.1159/000441387

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-13F03100
  • [Journal Article] Hepatitis C virus NS5A inhibitors and drug resistance mutations2014

    • Author(s)
      Nakamoto, S., Kanda, T., Wu, S., Shirawasa, H., Yokosuka, O
    • Journal Title

      World Journal of Gastroenterol

      Volume: 20(11) Pages: 2902-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300105
  • [Journal Article] Regulation of microRNA by hepatitis B virus infection and their possible association with control of innate immunity.2014

    • Author(s)
      Jiang X, Kanda T, Wu S, Nakamura M, Miyamura T, Nakamoto S, Banerjee A, Yokosuka O.
    • Journal Title

      World J Gastroenterol.

      Volume: 20 Pages: 7197-7206

    • DOI

      10.3748/wjg.v20.i23.7197

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-13F03100, KAKENHI-PROJECT-26860491
  • [Journal Article] Hepatitis C virus NS5A inhibitors and drug resistance mutations2014

    • Author(s)
      Shingo Nakamoto, Tatsuo Kanda, Shuang Wu, Hiroshi Shirasawa, Osamu Yokosuka
    • Journal Title

      World Journal of Gastroenterology

      Volume: 20(11) Pages: 2902-2912

    • Data Source
      KAKENHI-PROJECT-23300105
  • [Journal Article] Occurrence and Recurrence of Hepatocellular Carcinoma Were Not Rare Events during Phlebotomy in Older Hepatitis C Virus-Infected Patients.2014

    • Author(s)
      Kanda T, Nakamoto S, Yasui S, Nakamura M, Miyamura T, Wu S, Jiang X, Arai M, Imazeki F, Yokosuka O.
    • Journal Title

      Case Rep Oncol.

      Volume: 7 Pages: 288-296

    • DOI

      10.1159/000362869

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-13F03100
  • [Journal Article] Treatment of hepatitis C virus infection in the future2014

    • Author(s)
      Kanda T, Yokosuka O, Omata M
    • Journal Title

      Clinical Translation Medicine

      Volume: 11, 2(1):9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300105
  • [Journal Article] Suppression of La Antigen Exerts Potential Antiviral Effects against Hepatitis A Virus2014

    • Author(s)
      Jiang X, Kanda T, Wu S, Nakamoto S, Saito K, Shirasawa H, Kiyohara T, Ishii K, Wakita T, Okamoto H, Yokosuka O.
    • Journal Title

      PLOS One

      Volume: 9

    • DOI

      10.1371/journal.pone.0101993

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-13F03100, KAKENHI-PROJECT-24590955, KAKENHI-PROJECT-24792175, KAKENHI-PROJECT-25460580, KAKENHI-PROJECT-26430155
  • [Journal Article] A Semi- Supervised Learning Method for Discriminative Motif Finding and Its Application2013

    • Author(s)
      Le N., Ho T.B., Kanda T., Kawasaki S., Takabayashi K., Wu S., Yokosuka O.
    • Journal Title

      Universal Computer Science

      Volume: 19(4) Pages: 563-580

    • Data Source
      KAKENHI-PROJECT-23300105
  • [Journal Article] Platelet count and sustained virological response in hepatitis C treatment2013

    • Author(s)
      Tatsuo Kanda, Keizo Kato, Akihito Tsubota, Nobuo Takada, Takayoshi Nishino, Shigeru Mikami, Tatsuo Miyamura, Daisuke Maruoka, Shuang Wu, Shingo Nakamoto, Makoto Arai, Keiichi Fujiwara, Fumio Imazeki, Osamu Yokosuka
    • Journal Title

      World journal of hepatology

      Volume: 5(4) Pages: 182-188

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300105
  • [Journal Article] Antiviral therapy for " difficult -to-treat" hepatitis C virus-infected patients2013

    • Author(s)
      Kanda T, Yokosuka O, Omata M
    • Journal Title

      Chin Med J (Engl)

      Volume: 126(23) Pages: 4568-74

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300105
  • [Journal Article] Natural interferon-beta plus ribavirin therapy led to sustained virological response after seven unsuccessful courses of anti-viral treatment in a chronic hepatitis C patient2013

    • Author(s)
      Kandat T., Nakamoto S., Arai, M., Miyamura, T., Wu, S., Fujiwara, K., Yokosuka O
    • Journal Title

      Clinical Journal Gastroentorology

      Volume: 6(2)

    • DOI

      10.1007/s12328-013-0366-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300105
  • [Journal Article] Platelet count and sustained virological response in hepatitis C treatment2013

    • Author(s)
      Kandat T., Kato K., Tsubota, A., Takada, N., Nishino, T., Mikami, S., Miyamura, T., Maruoka D., We, S., Nakamoto, S., Arai, M., Fujiwara, K., Imazeki, F., Yokosuka O
    • Journal Title

      World Journal of Hepatology

      Volume: 5(4) Pages: 182-188

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300105
  • [Journal Article] Hepatitis C virus protease inhibitor-resistance mutations: Our experience and review2013

    • Author(s)
      Shuang Wu, Tatsuo Kanda, Shingo Nakamoto, Fumio Imazeki, Osamu Yokosuka
    • Journal Title

      World Journal of Gastroenterology

      Volume: 19(47) Pages: 8940-8948

    • Data Source
      KAKENHI-PROJECT-23300105
  • [Journal Article] Safety and tolerance of sorafenib in Japanese patients with advanced hepatocellular carcinoma2011

    • Author(s)
      Sadahisa Ogasawara, Osamu Yokosuka, Fumihiko Kanai, et al.
    • Journal Title

      Hepatology International

      Volume: 5 Pages: 850-856

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390225
  • [Journal Article] Safety and tolerance of sorafenib in Japanese patients with advanced hepatocellular carcinoma2011

    • Author(s)
      Ogasawara S, Kanai F, Obi S, Sato S, Yamaguchi T, Azemoto R, Mizumoto H, Koushima Y, Morimoto N, Hirata N, Toriyabe T, Shinozali Y, Ooka Y, Mikata R, Chiba T, Okabe S, Imazeki F, Yoshikawa M, Yokosuka O
    • Journal Title

      Hepatol Int

      Volume: 5 Pages: 850-856

    • DOI

      10.1007/s12072-010-9249-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390225
  • [Journal Article] The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells.2010

    • Author(s)
      Chiba T, Aoki R, Miyagi S, Negishi M, Konuma T, Taniguchi H, Ogawa M, Yokosuka O, Iwama A.
    • Journal Title

      J Hepatol 52

      Pages: 854-863

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790649
  • [Journal Article] Bmil promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.2010

    • Author(s)
      Chiba T, Seki A, Aoki R, Ichikawa H, Negishi M, Miyagi S, Oguro H, Saraya A, Kamiya A, Nakauchi H, Yokosuka O, Iwama A.
    • Journal Title

      Hepatology 52

      Pages: 1111-1123

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790649
  • [Journal Article] Cancer stem cells in hepatocellular carcinoma : Recent progress and perspective.2009

    • Author(s)
      Chiba T, Kamiya A, Yokosuka O, Iwama A.
    • Journal Title

      Cancer Lett, 286

      Pages: 145-153

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790649
  • [Journal Article] Quantitative analysis of vascular endothelial growth factor in liver metastases from pancreatic carcinoma as a predictor of chemotherapeutic effect, prognosis2008

    • Author(s)
      太和田勝之、横須賀收, 他5名
    • Journal Title

      Clin Cancer Res 14(22)

      Pages: 7438-43

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390195
  • [Journal Article] Down-regulation of hedgehoginteracting protein through genetic ,, epigenetic alterations in human hepatocellular carcinoma2008

    • Author(s)
      多田素久、今関文夫、横須賀收, 他10
    • Journal Title

      Clin Cancer Res 14(12)

      Pages: 3768-76

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390195
  • [Journal Article] The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma.2008

    • Author(s)
      Chiba T, Miyagi S, Saraya A, Ryutaro Aoki R, Seki A, Morita Y, Yonemitsu Y, Yokosuka O, Taniguchi H, Nakauchi H,Iwama A.
    • Journal Title

      Cancer Res 68

      Pages: 7742-7749

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790468
  • [Journal Article] genes up-regulated by the demethylating agent, 5-aza- 2' deoxycytidine, in esophageal squamous cell carcinoma2008

    • Author(s)
      新井誠人、今関文夫、横須賀收, 他6名
    • Journal Title

      Oncol Rep 20(2)

      Pages: 405-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390195
  • [Journal Article] The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma2008

    • Author(s)
      千葉哲博、横須賀收, 他9名
    • Journal Title

      Cancer Res 68(19)

      Pages: 7742-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390195
  • [Journal Article] Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation2007

    • Author(s)
      千葉哲博、横須賀收, 他11名
    • Journal Title

      Gastroenterology 133(3)

      Pages: 937-50

    • Data Source
      KAKENHI-PROJECT-19390195
  • [Journal Article] Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation.2007

    • Author(s)
      Chiba T, Zheng YW, Kita K, Yokosuka O, Saisho H, Onodera M, Miyoshi M, Nakano M, Nakauchi H, Iwama A, Taniguchi H.
    • Journal Title

      Gastroenterology 133

      Pages: 937-950

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790468
  • [Journal Article] Evaluation of Clinical Usefulness of Second Generation HCV Core Antigen Assay : Comparison with COBAS AMPLICOR HCV MONITOR Assay Version 2.0.2005

    • Author(s)
      Yokosuka Osamu, et al.
    • Journal Title

      Liver International 25

      Pages: 1136-1141

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590576
  • [Journal Article] Evaluation of Clinical Usefulness of Second Generation HCV Core Antigen Assay : Comparison with COBAS AMPLICOR HCV MONITOR Assay Version 2.02005

    • Author(s)
      Yokosuka Osamu
    • Journal Title

      Liver International 25

      Pages: 1136-1141

    • Data Source
      KAKENHI-PROJECT-16590576
  • [Journal Article] High SVR rate after IFN therapy in selected Japanese hepatitis C patients with either a low HCV RNA titer or HCV serotype 22004

    • Author(s)
      Yokosuka O, et al.
    • Journal Title

      Intervirology 47

      Pages: 328-334

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590576
  • [Journal Article] High SVR rate after IFN therapy in selected Japanese hepatitis C patients with either a low HCV RNA titer or HCV serotype 22004

    • Author(s)
      Yokosuka Osamu
    • Journal Title

      Intervirology 47

      Pages: 328-34

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590576
  • [Journal Article] Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma.

    • Author(s)
      Yonemitsu Y, Imazeki F, Chiba T, Fukai K, Nagai Y, Miyagi S, Arai M, Aoki R, Miyazaki M, Nakatani Y, Iwama A, Yokosuka O.
    • Journal Title

      Hum Pathol (in press.)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790468
  • [Presentation] ソラフェニブ治療における早期治療効果予測2012

    • Author(s)
      小笠原定久、横須賀收、金井文彦, 他
    • Organizer
      第5回肝がん分子標的治療研究会
    • Place of Presentation
      大手町サンケイプラザ
    • Year and Date
      2012-01-14
    • Data Source
      KAKENHI-PROJECT-21390225
  • [Presentation] Finding HCV NS5A Discriminative Motifs for Assessment of IFN/Ribavarin Therapy Effect2011

    • Author(s)
      Ho, T.B., Kawasaki, S., Le, N.T., Kanda, T., Le, T.N., Takabayashi, K., Yokosuka, O
    • Organizer
      Workshop Data Mining in Genomics and Proteomics, International Conference ECML/PKDD
    • Place of Presentation
      Athens, Greece
    • Data Source
      KAKENHI-PROJECT-23300105
  • [Presentation] 肝細胞癌における血管新生および細胞増殖関連因子の発現の検討2011

    • Author(s)
      多田素久, 横須賀收, 金井文彦, 他
    • Organizer
      第47回日本肝臓学会総会一般口演
    • Place of Presentation
      ホテルグランパシフィックLE DAIBA
    • Year and Date
      2011-06-02
    • Data Source
      KAKENHI-PROJECT-21390225
  • [Presentation] ソラフェニブ治療における早期の有効性サロゲートマーカーとしてのRECISTの検証2011

    • Author(s)
      多田素久, 横須賀收, 金井文彦, 他
    • Organizer
      第47回日本肝臓学会総会ポスターセッション
    • Place of Presentation
      ホテルグランパシフィックLE DAIBA
    • Year and Date
      2011-06-02
    • Data Source
      KAKENHI-PROJECT-21390225
  • [Presentation] Regulation of liver cancer stem cells by polycomb group proteins.2011

    • Author(s)
      千葉哲博、岩間厚志、横須賀収
    • Organizer
      第3回JCA-AACR Special Joint Conference
    • Place of Presentation
      千葉県
    • Year and Date
      2011-03-04
    • Data Source
      KAKENHI-PROJECT-21790649
  • [Presentation] ソラフェニブ治療における早期の有効性サロゲートマーカーとしてのRECISTの検証2011

    • Author(s)
      小笠原定久、横須賀收、金井文彦, 他
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      ホテルグランパシフィック LE DAIBA
    • Year and Date
      2011-06-03
    • Data Source
      KAKENHI-PROJECT-21390225
  • [Presentation] 肝細胞癌における血管新生および細胞増殖関連因子の発現の検討2011

    • Author(s)
      多田素久、横須賀收、金井文彦, 他
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      ホテルグランパシフィック LE DAIBA
    • Year and Date
      2011-06-02
    • Data Source
      KAKENHI-PROJECT-21390225
  • [Presentation] ポリコーム群タンパクによる肝幹細胞の制御機構2010

    • Author(s)
      千葉哲博、青木竜太郎、横須賀収
    • Organizer
      第96回日本消化器病学会総会
    • Place of Presentation
      新潟県
    • Year and Date
      2010-04-23
    • Data Source
      KAKENHI-PROJECT-21790649
  • [Presentation] 肝細胞癌の増殖および腫瘍血管新生に関わる遺伝子発現プロファイルの検討2010

    • Author(s)
      横須賀牧
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      ホテルメトロポリタン山形
    • Year and Date
      2010-05-28
    • Data Source
      KAKENHI-PROJECT-21390225
  • [Presentation] 肝細胞癌の増殖および腫瘍血管新生に関する遺伝子発現プロファイルの検討2010

    • Author(s)
      鳥谷部武志, 横須賀收, 金井文彦
    • Organizer
      第46回日本肝臓学会総会シンポジウム
    • Place of Presentation
      ホテルメトロポリタン山形
    • Year and Date
      2010-05-28
    • Data Source
      KAKENHI-PROJECT-21390225
  • [Presentation] Regulatory machinery of Bmil in both normal and cancer stem cells in liver2009

    • Author(s)
      千葉哲博、青木竜太郎、横須賀収、岩間厚志
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      神奈川県
    • Year and Date
      2009-10-02
    • Data Source
      KAKENHI-PROJECT-21790649
  • [Presentation] 肝臓における癌幹細胞システムの成立・維持メカニズム2008

    • Author(s)
      千葉哲博、横須賀收、岩間厚志
    • Organizer
      第16回日本消化器病学会関連週間
    • Place of Presentation
      東京都
    • Year and Date
      2008-10-01
    • Data Source
      KAKENHI-PROJECT-19790468
  • [Presentation] 大腸癌由来培養細胞において脱メチル化剤投与により発現上昇したマイクロRNAの解析2008

    • Author(s)
      田中健史、新井誠人、今関文夫、横須賀收
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Data Source
      KAKENHI-PROJECT-19390195
  • [Presentation] Molecular machinery in the establishment and maintenance of liver cancer stem cell system.2008

    • Author(s)
      千葉哲博、宮城聡、横須賀收、岩間厚志
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      愛知県
    • Year and Date
      2008-10-29
    • Data Source
      KAKENHI-PROJECT-19790468
  • [Presentation] The polycomb gene product BMI1 is required for the tumor-initiating capacity of hepatocellular carcinoma cells.2007

    • Author(s)
      千葉哲博、宮城聡、横須賀收、岩間厚志
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      神奈川県
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-19790468
  • [Presentation] Investigation of cancer stem cell system in hepatocellular carcinoma.2007

    • Author(s)
      Chiba T, Miyagi S, Yokosuka O, Taniguchi H, Nakauchi H, Iwama A.
    • Organizer
      17th APASL conference
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2007-03-29
    • Data Source
      KAKENHI-PROJECT-19790468
  • [Presentation] 肝癌細胞株におけるエピジェネティク異常とマイクロRNAの関わりの検討2007

    • Author(s)
      新井誠人、今関文夫、横須賀收
    • Organizer
      第43回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-05-31
    • Data Source
      KAKENHI-PROJECT-19390195
  • 1.  IMAZAKI Fumio (40223325)
    # of Collaborated Projects: 15 results
    # of Collaborated Products: 4 results
  • 2.  FUKAI Kenichi (60361432)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 3.  TAGAWA Masami (90261916)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 4.  ITO Yosimi (70159929)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  ARAI Makoto (30396684)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 3 results
  • 6.  OMATA Masao (90125914)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  EHATA Toshiki (20280919)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  HOSODA Kazuhiko
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  CHIBA Tetsuhiro (00381583)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 13 results
  • 10.  IWAMA Atsushi (70244126)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 12 results
  • 11.  MIYAGI Satoru (20400997)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 12.  KANDA Tatsuo (20345002)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 11 results
  • 13.  KAWAI Sigenobu (10311606)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  TOKUHISA Takeshi (20134364)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  TADA Minoru
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  WU SHUANG
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 18 results
  • 17.  KANAI Fumihiko (70334399)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 18.  TADA Motohisa (00554239)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 19.  TU・BAO Ho (60301199)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  TAKABAYASHI Katsuhiko (90188079)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 21.  DAM Hieu Chi (70397230)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  KAWASAKI Saori (40377437)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 23.  SHIRATORI Yasushi (70196624)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  TANIKAWA Kyuichi (10080649)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  SATO Chifumi (60154069)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  KAKUMU Shinichi (10115545)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  MATSUMURA Masayuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  HONDA Arata
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  丸 泰司
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  藤原 慶一
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  呉 霜
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  SAITO Kengo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  白澤 浩
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 34.  中本 晋吾
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 35.  HO Tu Bao
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 36.  石井 孝司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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