UYAMA Eiichiro 宇山英一郎

Researcher Number	90185075
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2002 – 2006: 熊本大学, 医学部附属病院, 講師 1999 – 2001: 熊本大学, 医学部・附属病院, 助手 1996 – 1998: 熊本大学, 医学部附属病院, 助手 1997: Kumamoto University School of Medicine, Department of Neurology, Assistant Professor, 医学部・附属病院, 助手 1995: Kumamoto University Hospital Assis. Prof., 医学部・附属病院, 助手 1993 – 1994: 熊本大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Neurology / Neurology
Keywords	Principal Investigator 眼咽頭筋ジストロフィー / PABP2 / OPMD / GCGリピート / 核内封入体 / 嚥下障害 / rimmed vacuoles / PABPN1 / ポリアラニン病 / oculopharyngeal muscular dystrophy … More / 14q11.2-q13 / ハプロタイプ解析 / Gaucher-like disease / reduction of IN aggregation and cell death / intranuclear inclusion / OPMD model mouse / OPMD cell model / polyalanine disease / 細胞死抑制効果 / HSP70 / コンドーレッド / DMRV / 縁取り空胞 / ポリアラニン / PABPN1核内凝集体 / トレハロース / OPMDモデルマウス / コンゴーレッド / ポリグルタミン病 / PABPN1核内凝集 / 凝集細胞抑制 / ドキシサイクリン / OPMDモデル細胞 / ptosis and dysphagia / necrotic fibers / apoptosis / 13-alanine stretch / transgenic mouse / intranuclear inclusions / PABPN1 ; PABP2 / プロモーター / 細胞モデル / ポリアラニン伸長 / シャペロン / マイクロインジェクション / チキンβアクチン(CAG)プロモーター / アラニン異常伸長 / アポトーシス / CAGプロモーター / トランスジェニックマウス / PABPN1(PABP2) / polyclonal antibody / aniti-PABP2 / intranuclear inclusion body / GCG repeats / poly (A) binding protein / oculo har n eal muscular d stro h / GCG異状伸長 / リピート病 / 14g11 / 眼咽頭筋ジスロフィー / 遺伝子型 / 表現型 / GCG リピート / ポリクローナル抗体 / トリープレット・リピート病 / 創始者効果 / 眼咽頭遠位型ミオパチー / 抗PABP2抗体 / poly(A)-binding protein / dysphagia / ptosis / intranuclear tubulofilamentous inclusions / haplotype analysis / two point linkage analysis / autosomal dominant dsiorder / 14q11・.2-q13 / 眼瞼下垂 / 骨格筋筋鞘核内封入体 / 2点連鎖解析 / 常染色体優性遺伝 / hereditary leptomeningeal fibrosis / hereditary corneal opacities / hereditary hydrocephalus / a new syndrome / hereditary deafness / hereditary valvular heart disease / beta-glucocerebrosidase / beta-glucocerebrosidase欠損症 / 遺伝性心弁膜症 / Pseudo-Gaucher disease / 新しい糖脂質蓄積症 / β-alucocerebrosidase欠損症 / 新しい症候群 / 遺伝性くも膜肥厚症 / 遺伝性角膜混濁症 / 遺伝性水頭症 / 遺伝性難聴症 / 遺伝性心臓弁膜症 / β-glucocerebrosidase欠損症 Less

Research for the pathogenesis and therapy of oculopharyngeal muscular dystrophy - by using cell and animal modelsPrincipal Investigator
- Principal Investigator
  
  UYAMA Eiichiro
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kumamoto University
Research for the pathogenesis of oculopharyngeal muscular dystrophya -establish an animal modelPrincipal Investigator
- Principal Investigator
  
  UYAMA Eiichiro
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kumamoto University
Oculopharyngeal muscular dystrophy : studies on molecular pathology and molecular biologyPrincipal Investigator
- Principal Investigator
  
  UYAMA Eiichiro
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kumamoto University
Oculopharyngeal muscular dystrophy in Japan : studies on muscle pathology, immunohistochemistry, and molecular biologyPrincipal Investigator
- Principal Investigator
  
  UYAMA Eiichiro
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kumamoto University
A new syndrome associated with beta-glucocerebrosidase feficiency : morphological, biochemical, and mollecular genetic studiesPrincipal Investigator
- Principal Investigator
  
  UYAMA Eiichiro
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kumamoto University

All 2007 2006 2005 2004 Other

All Journal Article Book

[Book] 新臨床内科学第9版(医学書院)2007
- Author(s)
  宇山英一郎
- Publisher
  筋強直性ジストロフィー,先天性筋強直症(印刷製本中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590835
[Book] よくわかる病態生理、第8巻「神経疾患」-進行性筋ジストロフィー2007
- Author(s)
  宇山英一郎
- Publisher
  日本医事新報社(印刷製本中)
- Data Source
  KAKENHI-PROJECT-16590835
[Journal Article] Neurologic toxicity associated with interferon alpha therapy for renal cell carcinoma.2006
- Author(s)
  Wada Y, Kuwahara T, Uyama E, et al.
- Journal Title
  
  International Journal of Urology 13
  
  Pages: 811-813
- Data Source
  KAKENHI-PROJECT-16590835
[Journal Article] Effective repetitive dystrophin gene transfer into skeletal muscle of adult mdx mice using a helper-dependent adenovirus vector expressing the coxsakievirus and adenovirus receptor(CAR) and dystrophin2005
- Author(s)
  Uchida Y, ---Uyama E, et al.
- Journal Title
  
  The Journal of Gene Medicine 7
  
  Pages: 1010-1022
- Data Source
  KAKENHI-PROJECT-16590835
[Journal Article] Effective repetitive dystrophin gene transfer into skeletal muscle of adult mdx mice using a helper-dependent adenovirus vector expressing the coxsackievirus and adenovirus receptor (CAR) and dystrophin2005
- Author(s)
  Uchida Y, Maeda Y, Kimura E, Yamashita S, Nishida Y, Arima T, Hirano T, Uyama E, et al.
- Journal Title
  
  J Gene Med 7
  
  Pages: 1010-1022
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590835
[Journal Article] Distal myopathy with rimmed vacuoles : impaired O-glycan formation in muscular glycoproteins2005
- Author(s)
  Tajima Y, Uyama E, et al.
- Journal Title
  
  American Journal of Pathology 166
  
  Pages: 1121-1130
- Data Source
  KAKENHI-PROJECT-16590835
[Journal Article] Animal model of oculopharyngeal muscular dystrophy2005
- Author(s)
  Uyama E, Hino H, Araki K, et al.
- Journal Title
  
  Acta Myologica 24
  
  Pages: 84-88
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590835
[Journal Article] Distal myopathy with rimmed vacuoles : impaired O-glycan formation in muscular glycoproteins2005
- Author(s)
  Tajima Y, Uyama E, Go S, Tao N, Kotani M, Hino H, Suzuki A, Sanai Y, Kitajima K, Sakuraba H.
- Journal Title
  
  Am J Pathol 166
  
  Pages: 1121-1303
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590835
[Journal Article] Animal model of oculopharyngeal muscular dystrophy.2005
- Author(s)
  Uyama E, Hino H, Araki K, Takeya M, Uchino M, Yamamura K.
- Journal Title
  
  Acta Myologica 26
  
  Pages: 84-88
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590835
[Journal Article] Effective repetitive dystrophin gene transfer into skeletal muscle of adult mdx mice using : a helper-dependent adenovirus, vector, expressing, the coxackievirus and adenovirus receptor (CAR) and dystrophin.2005
- Author(s)
  Uchida Y, Maeda Y, Kimura E, Yamashita S, Nishida Y, Arima T, Hirano T, Uyama E, Mita S, Uchino M.
- Journal Title
  
  J Gene Med 7
  
  Pages: 1010-1022
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590835
[Journal Article] Distal myopathy with rimmed vacuoles; impaired 0-glycan formation in muscular glycoproteins2005
- Author(s)
  Tajima Y, Uyama E, Go S, Sato C, Tao N, Kotani M, et al.
- Journal Title
  
  Am J Pathol 166
  
  Pages: 1121-1130
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590835
[Journal Article] Animal model of oculopharyngeal muscular dystrophy2005
- Author(s)
  Uyama E, Hino H, et al.
- Journal Title
  
  Acta Myologica 24(2)
  
  Pages: 84-88
- Data Source
  KAKENHI-PROJECT-16590835
[Journal Article] Congo red, doxycycline, and HSP70 overexpression reduce aggregate formation and death in a cell model of oculopharyngeal muscluar dystrophy2004
- Author(s)
  Bao YP, Sarkar S, Uyama E, Rubinsztein DC
- Journal Title
  
  J Med Genet 41
  
  Pages: 47-51
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590835
[Journal Article] Pantothenate kinase-.associated neurodegeneration initially presenting as postural tremor alone in a Japanese family with homozygous N245S substitutions in the pantothenate kinase gene.2004
- Author(s)
  Yamashita S, Mapda Y, Ohmori H, Uchida Y, Hirano T, Ypnemura K, Uyama E, Uchino. M
- Journal Title
  
  J-Neuro1 Sci 225
  
  Pages: 129-33
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590835
[Journal Article] Congo red, doxycycline, and HSP70, overexpression reduce aggregate formation and cell death in cell model of oculopharyngeal muscular dystrophy.2004
- Author(s)
  Bao YP, Sarker S, Uyama E, Rubinsztein DC.
- Journal Title
  
  J Med Genet 41
  
  Pages: 45-51
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590835
[Journal Article] Congo red, doxycycline, and HSP70 overexpression reduce aggregate formation and cell death in cell models of oculopharyngeal muscular dystrophy2004
- Author(s)
  Bao YP, Sarker S, Uyama E, Rubinsztein DC.
- Journal Title
  
  J Med Genet 41
  
  Pages: 47-51
- Data Source
  KAKENHI-PROJECT-16590835
[Journal Article] Pantothenate kinase-associated neurodegeneration initially presenting as postural tremor alone in a Japanese family with homozygous N245S substitutions in the pantothenate kinase gene2004
- Author(s)
  Yamashita S, Maeda Y, Ohmori H, Uchida Y, Hirano T, Yonemura K, uyama E, Uchino M
- Journal Title
  
  J Neurol Sci 225
  
  Pages: 129-133
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590835
[Journal Article] Effective repetitive dystrophin gene transfer into skeletal muscle of adult Mouse using a helper-dependent adenovirus vector expressing ------
- Author(s)
  Uchida Y, ---6名, Uyama E, et al.
- Journal Title
  
  Gene Therapy (In press)
- Data Source
  KAKENHI-PROJECT-16590835
[Journal Article] Distal myopathy with rimmed vacuoles : impaired O-glycan formation in Sarcolemmal glycoproteins
- Author(s)
  Tajima Y, Uyama E, et al.
- Journal Title
  
  Am J Pathol (In press)
- Data Source
  KAKENHI-PROJECT-16590835

1. MURAKAMI Tatsuhumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. TOKUNAGA Makoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

UYAMA Eiichiro 宇山 英一郎

Research Projects

Research Products

Co-Researchers

Research for the pathogenesis and therapy of oculopharyngeal muscular dystrophy - by using cell and animal modelsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research for the pathogenesis of oculopharyngeal muscular dystrophya -establish an animal modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Oculopharyngeal muscular dystrophy : studies on molecular pathology and molecular biologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Oculopharyngeal muscular dystrophy in Japan : studies on muscle pathology, immunohistochemistry, and molecular biologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A new syndrome associated with beta-glucocerebrosidase feficiency : morphological, biochemical, and mollecular genetic studiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 新臨床内科学第9版(医学書院)2007

Author(s)

Publisher

Description

Data Source

[Book] よくわかる病態生理、第8巻「神経疾患」-進行性筋ジストロフィー2007

Author(s)

Publisher

Data Source

[Journal Article] Neurologic toxicity associated with interferon alpha therapy for renal cell carcinoma.2006

Author(s)

Journal Title

Data Source

[Journal Article] Effective repetitive dystrophin gene transfer into skeletal muscle of adult mdx mice using a helper-dependent adenovirus vector expressing the coxsakievirus and adenovirus receptor(CAR) and dystrophin2005

Author(s)

Journal Title

Data Source

[Journal Article] Effective repetitive dystrophin gene transfer into skeletal muscle of adult mdx mice using a helper-dependent adenovirus vector expressing the coxsackievirus and adenovirus receptor (CAR) and dystrophin2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Distal myopathy with rimmed vacuoles : impaired O-glycan formation in muscular glycoproteins2005

Author(s)

Journal Title

Data Source

[Journal Article] Animal model of oculopharyngeal muscular dystrophy2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Distal myopathy with rimmed vacuoles : impaired O-glycan formation in muscular glycoproteins2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Animal model of oculopharyngeal muscular dystrophy.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Effective repetitive dystrophin gene transfer into skeletal muscle of adult mdx mice using : a helper-dependent adenovirus, vector, expressing, the coxackievirus and adenovirus receptor (CAR) and dystrophin.2005

Author(s)

Journal Title

Description

Data Source

UYAMA Eiichiro 宇山英一郎