Koyama Yoshikazu 小山芳一

… Alternative Names

Researcher Number	90186841
Other IDs
Affiliation (Current)	2022: 北海学園大学, 工学部, 教授
Affiliation (based on the past Project Information) *help	2012 – 2015: 北海学園大学, 工学部, 教授 2007 – 2008: 北海道情報大学, 経営情報学部, 教授 2006: Hokkaido University, Graduate School of Medicine, Instructor, 大学院医学研究科, 助手 2004 – 2005: Hokkaido University, Grad.School of Medicine, assistant professor, 大学院・医学研究科, 助手 2000 – 2001: 北海道大学, 医学研究科, 助手 … More
Review Section/Research Field	Principal Investigator Tumor immunology / General medical chemistry Except Principal Investigator Orthopaedic surgery / Biological Sciences / Pathological medical chemistry
Keywords	Principal Investigator AFP / ワクチン療法 / 抗自己サイトカイン / IBD / MIF / 発がん / DNAワクチン / 転写因子 / 遺伝子発現 / サイレンサー … More Except Principal Investigator α-フェトプロテイン / トランスジェニックマウス / マクロファージ遊走阻止因子 / DNAワクチン / 転写因子 / MIF / マクロファージ / エンドトキシンショック / サイトカイン / ATBF1 / macrophage migration inhibitory factor / DNA vaccine / レクチン親和電気泳動法 / Znフィンガー / 不飽和脂肪酸 / エストロゲン結合能 / モノクロナル抗体 / 発生工学 / 糖鎖 / 実験的甲状腺炎 / がん性変化 / 免疫抑制活性 / レクチン / 血管新生 / 癌浸潤 / 磨耗粉 / 骨溶解 / in vivo イメージング / in vivoイメージング / 骨吸収 / α-フェトプロテイン遺伝子 / ホメオドメイン / Zn-フィンガー構造 / 選択的スブライシング / 神経細胞分化 / 細胞増殖 / Zn- フィンガー / 選択的スプライシング / 神経分化 / alpha-fetoprotein gene / Transcription factor / Homeotic-domain / Zn-finger structure / Alternative splicing / Neuronal differentiation / Cell growth control / 免疫抑制 / 自己免疫疾患 / T細胞 / 肝癌 / 実験的アレルギー性骨髄炎(EAE) / 多発性硬化症 / ミエリン塩基性タンパク / リュウマチ性関節炎 / 免疫抑制能 / 自己免疫性甲状腺炎 / α-fetoprotein / immunosupression / auto-imune doseases / T-Cell / hepatocellular cacinoma / transgenic mice / 関節リウマチ / ワクチン / 慢性関節リウマチ / rheumatoid arthritis / 骨粗鬆症 / 卵巣摘出 / ノックアウトマウス / 遺伝子多型 / リスクファクター / osteoporosis / ovariectom Less

Development of MIF vaccine therapy against inflammation-related colon carcinogenesisPrincipal Investigator
- Principal Investigator
  
  Koyama Yoshikazu
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor immunology
- Research Institution
  Hokkai-Gakuen University
Role of MIF in wear particle-induced oeteolysis and its regulation by MIF-DNA vaccination
- Principal Investigator
  
  ONODERA Shin
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hokkaido University
The pathomechanism of postmenopausal osteoporosis-the involvement of MIF and therapeutic approach using MIF-DNA vaccine
- Principal Investigator
  
  ONODERA Shin
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hokkaido University
The development of MIF vaccine and its therapeutic effect on murine arthritis model
- Principal Investigator
  
  ONODERA Shin
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hokkaido University
癌細胞浸潤及び血管新生におけるマクロファージ遊走阻止因子の機能に関する基礎的研究
- Principal Investigator
  
  西平順
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
癌細胞浸潤及び血管新生におけるマクロファージ遊走阻止因子の機能に関する基礎的研究
- Principal Investigator
  
  西平順
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Functional analysis of α-fetoprotein by genetically engineered mice
- Principal Investigator
  
  NISHI Shinzo
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Hokkaido University
Analysis of Transcription Factors Involved in Liver Specific Gene Expression: Cloning of Silencer Binding ProteinPrincipal Investigator
- Principal Investigator
  
  KOYAMA Yoshikazu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  HOKKAIDO UNIVERSITY
発生工学を応用したα-フェトプロティンの糖鎖構造および機能の解析
- Principal Investigator
  
  西信三
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
α-フェトプロテインの構造、機能および発現の研究
- Principal Investigator
  
  NISHI Shinzo
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
Studies on Multiple Homeodomain/Zn Finger ATBF1 Gene Family
- Principal Investigator
  
  NISHI Shinzo
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Hokkaido University

All 2016 2013 2008 2007 2006 2004 Other

All Journal Article Presentation Patent

[Journal Article] A novel DNA vaccine targeting macrophage migration inhibitory factor improves the survival of mice with sepsis2008
- Author(s)
  TohyamaS, Onodera S, Tohyama H, Yasuda K, Nishihira J, Mizue Y, Hamasaka A, Abe R, Koyama Y
- Journal Title
  
  Gene Therapy 15(23)
  
  Pages: 1513-1522
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591746
[Journal Article] Active immunization against macrophage migration inhibitory factor using a novel DNA vaccine prevents ovariectomy-induced bone loss in mice2008
- Author(s)
  Onodera S, Oshima S, Nishihira J, Yasuda K, Tohyama H, Irie K, Koyama Y
- Journal Title
  
  Vaccine 26(6)
  
  Pages: 829-836
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591746
[Journal Article] A novel DNA vaccine targeting macrophage migration inhibitory factor protects joints from inflammation and destruction in murine models of arthritis.2007
- Author(s)
  Onodera S, Oshima S, Tohyama H, Yasuda K, Nishihira J, Iwakura Y, Matsuda I, Minami A, Koyama Y
- Journal Title
  
  Arthritis Rheum 56(2)
  
  Pages: 521-530
- NAID
  40017099467
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591542
[Journal Article] Transgenic Mice Overexpressing Macrophage Migration Inhibitory Factor (MIF) Exhibit High-Turnover Osteoporosis.2006
- Author(s)
  Onodera S, Sasaki S, Ohshima S, Amizuka N, Li M, Udagawa N, Irie K, Nishihira J, Koyama Y, Shiraishi A, Tohyama H, Yasuda K
- Journal Title
  
  J Bone Min Res 21(6)
  
  Pages: 876-885
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591542
[Journal Article] Macrophage Migration Inhibitory Factor-Deficient Mice Are Resistant to Ovariectomy-Induced Bone Loss.2006
- Author(s)
  Oshima S, Onodera S, Amizuka N, Li M, Irie K, Watanabe S, Koyama Y, Nishihira J, Yasuda K, Minami A
- Journal Title
  
  FEBS Lett 580(5)
  
  Pages: 1251-6
- NAID
  120000953646
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591542
[Journal Article] Macrophage Migration Inhibitory Factor (MIF) Up-regulates Expression of Interleukin (IL)-8 mRNA in Synovial Fibroblasts of Rheumatoid Arthritis ; Common Transcriptional Regulatory Mechanism between IL-8 and IL-1β.2004
- Author(s)
  Onodera S, Nishihira J, Koyama Y, Majima T, Aoki Y, Ichiyama H, Ishibashi T, Minami A
- Journal Title
  
  Arthritis Rheum 50
  
  Pages: 1437-1447
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591560
[Patent] DNAワクチン2004
- Inventor(s)
  西平順, 小山芳一, 小野寺伸
- Industrial Property Rights Holder
  西平順, 小山芳一, 小野寺伸
- Industrial Property Number
  2004-280051
- Filing Date
  2004-09-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591560
[Patent] DNAワクチン2004
- Inventor(s)
  西平順, 小山芳一, 小野寺伸
- Industrial Property Rights Holder
  西平順, 小山芳一, 小野寺伸
- Industrial Property Number
  2004-280051
- Filing Date
  2004-09-27
- Data Source
  KAKENHI-PROJECT-15591560
[Presentation] Colonization of Staphylococcus aureus in the mucosal inflammatory area in the case of severe clinical bovine mastitis2016
- Author(s)
  Yuya Nagasawa, Yoshio Kiku, Yoshikazu Koyama, Tomonori Nochi, Hisashi Aso, Tomohito Hayashi
- Organizer
  World Buiatrics Congress
- Place of Presentation
  Dublin
- Year and Date
  2016-07-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24501332
[Presentation] Establishment of a new ELISA system for detection of total Staphylococcus aureus-specific antibodies in bovine milk2013
- Author(s)
  Tomohito Hayashi, Yoshio Kiku, Fuyuko Tanabe, Kazue Sugawara, Eiji Hata, Kazuhiro Kawai and Yoshikazu Koyama
- Organizer
  31st World Veterinary Congress
- Place of Presentation
  Prague, Czech Republic
- Invited
- Data Source
  KAKENHI-PROJECT-24501332
[Presentation] DISTRIBUTION OF ACCESSORY GENE REGULATOR GROUPS IN STAPHYLOCOCCUS AUREUS ISOLATED FROM BOVINE MASTITIC MILK IN JAPAN
- Author(s)
  Atsushi Watanabe, Yoshikazu Koyama, Eiji Hata, Ikuo Uchida, Yukio Chikayama, Yoshio Kiku, Tomohito Hayashi
- Organizer
  CoVet 2014
- Place of Presentation
  Prague, Czech
- Year and Date
  2014-10-23 – 2014-10-26
- Data Source
  KAKENHI-PROJECT-24501332

1. SAKAI Masaharu (50162269)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. NISHI Shinzo (20001894)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. ONODERA Shin (00359481)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
4. 西平順 (30189302)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
5. KAZUHARU Irie (70223352)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. NAKABYASHI Hidekazu (10033383)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 岩渕和也 (20184898)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 小林正伸 (80241321)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. KATO Takuma (60224515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SHIMA Tomoko (10172868)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. FURUYAMA Junichi (30068431)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. WATANABE Masahiko (70210945)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 松浦栄次 (20181688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MUNRO Neville

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MORINAGA Tomonori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TAMAOKI Taiki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. エリオットアルバート

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. ELLIOT Alpert

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 中野芳朗

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Koyama Yoshikazu 小山 芳一

YOSHIKAZU Koyama 小山 芳一

KOYAMA Yoshikazu 小山 芳一

Research Projects

Research Products

Co-Researchers

Development of MIF vaccine therapy against inflammation-related colon carcinogenesisPrincipal Investigator

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Analysis of Transcription Factors Involved in Liver Specific Gene Expression: Cloning of Silencer Binding ProteinPrincipal Investigator

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[Journal Article] A novel DNA vaccine targeting macrophage migration inhibitory factor improves the survival of mice with sepsis2008

Author(s)

Journal Title

Data Source

[Journal Article] Active immunization against macrophage migration inhibitory factor using a novel DNA vaccine prevents ovariectomy-induced bone loss in mice2008

Author(s)

Journal Title

Data Source

[Journal Article] A novel DNA vaccine targeting macrophage migration inhibitory factor protects joints from inflammation and destruction in murine models of arthritis.2007

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Transgenic Mice Overexpressing Macrophage Migration Inhibitory Factor (MIF) Exhibit High-Turnover Osteoporosis.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Macrophage Migration Inhibitory Factor-Deficient Mice Are Resistant to Ovariectomy-Induced Bone Loss.2006

Koyama Yoshikazu 小山芳一

YOSHIKAZU Koyama 小山芳一

KOYAMA Yoshikazu 小山芳一