TSUCHIYA Mikako 土屋美加子

Researcher Number	90188582
Other IDs
Affiliation *help	2018 : 島根大学, 学術研究院医学・看護学系, 教授 2015 – 2017 : 島根大学, 医学部, 教授 2009 – 2013 : Shimane University, 医学部, 教授 2006 : Shimane University Faculty of Medicine, Medical Biochemistry, Professor, 医学部, 教授 1995 – 1997 : SHIMANE MEDICAL UNIV.BIOCHEMISTRY.PROFESSOR, 医学部, 教授 1992 – 1994 : 島根医科大学, 医学部, 助教授 1986 – 1988 : Department of biochemistry, Shimane medical university assistant, 医学部, 助手
Review Section/Research Field	Principal Investigator Orthopaedic surgery / General medical chemistry / Functional biochemistry / Metabolomics Except Principal Investigator General medical chemistry / 代謝生物化学 / Environmental physiology (including Physical medicine and Nutritional physiology) / Rehabilitation science/Welfare engineering
Keywords	Principal Investigator cDNAクローニング / グリコサミノグリカン / ADP-リボシル転移酵素 / ADP-ribosylation / GAG / 質量分析 / アルギニン / ADP-ribose転移酵素 / コラーゲン / コレステロール … More Except Principal Investigator 翻訳後修飾 / cryogen / p33 / モノ(ADP-リボース) / mim-1 / ADP-リボース転移酵素核たんぱく質 / 膜たんぱく質 / 低体温症 / アルギニン / 核たんぱく質 / Mono(ADP-ribose) / ADP-リボシル化受容体 / POST-TRANSLATIONAL MODIFICATION / hypothermia / ADP-リボシル転移酵素 / thermoregulation / プロテオミクス解析 / leukocyte / 骨髄性白血病 / 体温調節 / ADP-RIBOSYLATED PROTEIN / ADP-リボース転移酵素 / myeloid leukemia / ADP-ribosylation / タンパク質 / たんぱく燐酸化反応 / 力学特性 / 免疫組織化学 / 低体温 / Protein phosphorylation / ARGININE / 低体温誘導物質 / 多形核白血球 / モノ(ADPーリボース) / Protein / ADP-リボシル化反応 / 肝初代培養 / ADP-RIBOSYLTRANSFERASE / 軟骨マトリックス / 関節軟骨 / Membran proteins / 発生 / post-translational modification / モノクロナル抗体 / ADPーリボース転移酵素 Less

質量分析による軟骨基質構成分子網羅的解析の変性疾患、再生医学への応用Principal InvestigatorOngoing
- Principal Investigator
  
  土屋美加子
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shimane University
Application of GAGomics to cartilage, ligament and tendonPrincipal Investigator
- Principal Investigator
  
  TSUCHIYA MIKAKO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shimane University
Property of articular cartilage during maturation for a basic study of rehabilitation
- Principal Investigator
  
  MIURA Mikiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Rehabilitation science/Welfare engineering
- Research Institution
  Shimane University
Does nicotinic acid increase HDL-cholesterol through activation of longevity factor SIRT1?Principal Investigator
- Principal Investigator
  
  TSUCHIYA Mikako
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Shimane University
Analysis of unknown cryogens existing in the blood of a hypothermic patient
- Principal Investigator
  
  SHIDO Osamu
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  Shimane University
ANALYSIS OF ADP-RIBOSYLATION ON MOUSE LYMPHOCYTES USING BIOTINYL NADPrincipal Investigator
- Principal Investigator
  
  TSUCHIYA Mikako
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  SHIMANE MEDICAL UNIVERSITY
Arg-特異的ADP-R転移酵素のクローニングと組換え体タンパク質の発現Principal Investigator
- Principal Investigator
  
  土屋美加子
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Shimane Medical University
EFFECT OF ADP-RIBOSYLATION OF p33 AND ACTIN ON POLYMORPHONUCLEAR LEUKOCYTE DIFFERENTIATION
- Principal Investigator
  
  SHIMOYAMA Makoto
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  SHIMANE MEDICAL UNIVERSITY
真核細胞のアルギニン特異的ADP-リボシル転移酵素のcDNAクローニングPrincipal Investigator
- Principal Investigator
  
  土屋美加子
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Shimane Medical University
ADP-ribosylation of p33 (mim-1 protein) and its effect on differentiation and growth of blood cells
- Principal Investigator
  
  SHIMOYAMA Makoto
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Shimane Medical University
ラジオイムノアッセイによるモノADPーリボース化たんぱく質定量法の確立とその応用
- Principal Investigator
  
  谷河精規
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  代謝生物化学
- Research Institution
  Shimane Medical University
Mono(ADP-ribosyl)ation reaction and its functions in primary cultured hepatocytes
- Principal Investigator
  
  TANIGAWA Yoshinori
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Depertment of biochemistry, Shimane medical university

All 2016 2015 2014 2011 2010 2009

All Journal Article Presentation

[Journal Article] Glycosaminoglycans detection methods: applications of tandem mass spectrometry2016
- Author(s)
  Kubaski F., Osago H., Mason R. W., Yamaguchi S., Tsuchiya M., Tomatsu S.
- Journal Title
  
  Frontiers in Bioscience
  
  Volume : 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462371
[Journal Article] Nicotinamidephos phoribosyl transferase/visfatin does not catalyze nicotinamide mononucleotide formation in blood plasma2011
- Author(s)
  Hara N, Yamada K, Shibata T, Osago H, Tsuchiya M.
- Journal Title
  
  PLoS One.
  
  Volume : 6(8)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591163
[Journal Article] Interferon-. elevates nicotinamide N-methyltransferase activity and nicotinamide level in human glioma cells2010
- Author(s)
  Yamada K., Miyazaki T., Hara N., Tsuchiya M.
- Journal Title
  
  J. Nutr. Sci. Vitaminol.
  
  Volume : 56巻 Pages : 83-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591163
[Presentation] ヒト腰部黄色靭帯におけるグリコサミノグリカンの解析2016
- Author(s)
  長子晴美、河野通快、三浦美樹子、濱崎由文、原　伸正、日吉峰麗、内尾祐司、土屋美加子
- Organizer
  第41回日本医用マススペクトル学会年会
- Place of Presentation
  (名古屋) ウィンクあいち
- Year and Date
  2016-09-15
- Data Source
  KAKENHI-PROJECT-16K10903
[Presentation] 定量的オミクス解析のための結合組織の完全可溶化の試み2016
- Author(s)
  長子晴美、三浦美樹子、原　伸正、日吉峰麗、土屋美加子
- Organizer
  第89回日本生化学大会
- Place of Presentation
  （仙台）仙台国際センター他
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K10903
[Presentation] 質量分析によるヒト腰椎黄色靭帯のグリコサミノグリカン解析2016
- Author(s)
  河野通快、長子晴美、土屋美加子、内尾祐司
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  （福岡）福岡国際会議場
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K10903
[Presentation] ヒト靭帯におけるグリコサミノグリカンの解析2015
- Author(s)
  長子晴美、原　伸正、日吉峰麗、河野通快、内尾祐司、土屋美加子
- Organizer
  第40回日本医用マススペクトル学会年会
- Place of Presentation
  アクトシティ浜松（静岡）
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-25462371
[Presentation] 確認イオン比を利用したGAG二糖異性体の一斉定量解析2015
- Author(s)
  長子晴美、原　伸正、日吉峰麗、河野通快、内尾祐司、土屋美加子
- Organizer
  第63回質量分析総合討論会
- Place of Presentation
  つくば国際会議場（茨城）
- Year and Date
  2015-06-17
- Data Source
  KAKENHI-PROJECT-25462371
[Presentation] 質量分析による腰椎黄色靭帯のグリコサミノグリカン解析2015
- Author(s)
  河野通快、長子晴美、土屋美加子、松崎雅彦、内尾祐司
- Organizer
  第30回日本整形外科学会基礎学術集会
- Place of Presentation
  富山国際会議場（富山）
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-25462371
[Presentation] ラット支持組織におけるグリコサミノグリカン組成の比較2015
- Author(s)
  長子晴美、三浦美樹子、原　伸正、日吉峰麗、土屋美加子
- Organizer
  第88回日本生化学大会
- Place of Presentation
  神戸ポートピアホテル（兵庫）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25462371
[Presentation] 質量分析法を用いたグリコサミノグリカンの定量的な成分解析2014
- Author(s)
  長子晴美、土屋美加子
- Organizer
  平成26年度　北海道大学　総合技術研究会
- Place of Presentation
  北海道大学（北海道）
- Data Source
  KAKENHI-PROJECT-25462371
[Presentation] ニコチン酸の薬理作用は細胞内NADレベルの増加を介するか?2011
- Author(s)
  原伸正, 山田和夫, 柴田朋子, 長子晴美, 土屋美加子
- Organizer
  第84回日本生化学大会
- Place of Presentation
  京都国際会館(京都)
- Data Source
  KAKENHI-PROJECT-21591163
[Presentation] 細胞外Nicotinamide phosphoribosyltransferaseの生理的意義について2011
- Author(s)
  土屋美加子
- Organizer
  第423回ビタミンB研究協議会
- Place of Presentation
  東京
- Year and Date
  2011-02-05
- Data Source
  KAKENHI-PROJECT-21591163
[Presentation] LC/MS/MSを用いた細胞の酸処理による酸化および還元型NADPの同時定量法の確立2011
- Author(s)
  山田和夫, 原伸正, 長子晴美, 土屋美加子
- Organizer
  第84回日本生化学大会
- Place of Presentation
  京都国際会館(京都)
- Data Source
  KAKENHI-PROJECT-21591163
[Presentation] LC/MS/MSによるNADとNADHの同時定量2011
- Author(s)
  土屋美加子
- Organizer
  第425回ビタミンB研究協議会
- Place of Presentation
  ホテル宍道湖(松江)
- Year and Date
  2011-09-01
- Data Source
  KAKENHI-PROJECT-21591163
[Presentation] 細胞外Nicotinamide phosphoribosyltransferaseの生理的意義について2011
- Author(s)
  土屋美加子
- Organizer
  第423回ビタミンB研究協議会
- Place of Presentation
  東京商工会議所ビル(東京)
- Year and Date
  2011-02-04
- Data Source
  KAKENHI-PROJECT-21591163
[Presentation] LC/MS/MSによるNADとNADHの同時定量2011
- Author(s)
  土屋美加子
- Organizer
  第425回ビタミンB研究協議会
- Place of Presentation
  ホテル宍道湖(松江市)
- Year and Date
  2011-09-02
- Data Source
  KAKENHI-PROJECT-21591163
[Presentation] 質量分析によるNADH酸分解産物を用いたNADH定量法とこの方法の細胞の酸化還元状態の解析への応用の検討2010
- Author(s)
  山田和夫, 原伸正, 柴田朋子, 長子晴美, 土屋美加子
- Organizer
  第83回日本生化学大会
- Place of Presentation
  神戸コンベンションセンター(神戸)
- Data Source
  KAKENHI-PROJECT-21591163
[Presentation] Visfatin/nicotinamide phosphoribosyltransferase dose not function as an extracellular NAD synthetic enzyme2010
- Author(s)
  原伸正, 山田和夫, 柴田朋子, 長子晴美, 土屋美加子
- Organizer
  第83回日本生化学大会
- Place of Presentation
  神戸コンベンションセンター(神戸)
- Data Source
  KAKENHI-PROJECT-21591163
[Presentation] Elevation of Cellular NAD Levels by Nicotinic Acid and Involvement of Nicotinic Acid Phosphoribosyltrans-ferase in Human Cells2009
- Author(s)
  Nobumasa Hara, Kazuo Yamada, Tomoko Shibata, Harumi Osago, Mikako Tsuchiya
- Organizer
  NAD METABOLISM AND SIGNALING
- Place of Presentation
  CAREFREE, ARIZONA
- Data Source
  KAKENHI-PROJECT-21591163
[Presentation] 質量分析によるアルギニン特異的ADP-リボシル化ペプチドの同定2009
- Author(s)
  長子晴美, 山田和夫, 柴田朋子, 原伸正, 土屋美加子
- Organizer
  第82回日本生化学大会
- Place of Presentation
  神戸ポートアイランド(神戸)
- Data Source
  KAKENHI-PROJECT-21591163
[Presentation] Tight regulation of the intracellular nicotinamide concentration in human cells2009
- Author(s)
  山田和夫, 原伸正, 柴田朋子, 長子晴美, 土屋美加子
- Organizer
  第82回日本生化学大会
- Place of Presentation
  神戸ポートアイランド(神戸)
- Data Source
  KAKENHI-PROJECT-21591163
[Presentation] Quantitative determination of NAD turnover using deuterium-labeled nicotinamide and nicotinic acid2009
- Author(s)
  原伸正, 山田和夫, 柴田朋子, 長子晴美, 土屋美加子
- Organizer
  第82回日本生化学大会
- Place of Presentation
  神戸ポートアイランド(神戸)
- Data Source
  KAKENHI-PROJECT-21591163
[Presentation] 質量分析計によるArg-ADP-リボシル化ペプチドの同定2009
- Author(s)
  土屋美加子
- Organizer
  第418回ビタミンB研究協議会
- Place of Presentation
  京都会館(京都)
- Year and Date
  2009-11-28
- Data Source
  KAKENHI-PROJECT-21591163
[Presentation] Measurement of the Precursors of NAD Biosynthesis in Mammalian Cells2009
- Author(s)
  Kazuo Yamada, Nobumasa Hara, Tomoko Shibata, Harumi Osago, Mikako Tsuchiya
- Organizer
  NAD METABOLISM AND SIGNALING
- Place of Presentation
  CAREFREE, ARIZONA
- Data Source
  KAKENHI-PROJECT-21591163

1. UCHIO Yuji (20223547)

# of Collaborated Projects : 2results

# of Collaborated Products : 3results
2. SHIMOYAMA Makoto (30084859)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
3. YAMADA Kazuo (30240005)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
4. TERASHIMA Masaharu (40227517)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
5. TANIGAWA Yoshinori (60084860)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
6. MISHIMA Kouichi (90181875)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
7. OSAGO Harumi

# of Collaborated Projects : 2results

# of Collaborated Products : 6results
8. MIURA Mikiko (40447925)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
9. AOYAMA Tomoki (90378886)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. OHTANI Hiroki (20160533)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. KUROKI Hiroshi (20170110)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
12. TANABE Tuyoshi (80260678)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. FUJITA Yasuyuki (70173440)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
14. MIURA Takashi (10324617)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
15. YASUI Yukihiko (30174501)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
16. KUWATA Suguru (80509000)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
17. KONO Michihaya (30547740)

# of Collaborated Projects : 1results

# of Collaborated Products : 3results
18. SHIDO Osamu (40175386)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
19. HASHIMOTO M (70112133)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
20. WATANABE T (60182929)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
21. IMOTO T (10109639)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
22. KOIZUMI S (50019973)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
23. 片倉賢紀 (40383179)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
24. 丸山めぐみ (80346379)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
25. YAMAGUCHI Yoshimi

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

TSUCHIYA Mikako 土屋 美加子

Research Projects

Research Products

Co-Researchers

質量分析による軟骨基質構成分子網羅的解析の変性疾患、再生医学への応用Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Application of GAGomics to cartilage, ligament and tendonPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Property of articular cartilage during maturation for a basic study of rehabilitation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Does nicotinic acid increase HDL-cholesterol through activation of longevity factor SIRT1?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of unknown cryogens existing in the blood of a hypothermic patient

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ANALYSIS OF ADP-RIBOSYLATION ON MOUSE LYMPHOCYTES USING BIOTINYL NADPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Arg-特異的ADP-R転移酵素のクローニングと組換え体タンパク質の発現Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

EFFECT OF ADP-RIBOSYLATION OF p33 AND ACTIN ON POLYMORPHONUCLEAR LEUKOCYTE DIFFERENTIATION

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

真核細胞のアルギニン特異的ADP-リボシル転移酵素のcDNAクローニングPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ADP-ribosylation of p33 (mim-1 protein) and its effect on differentiation and growth of blood cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ラジオイムノアッセイによるモノADPーリボース化たんぱく質定量法の確立とその応用

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mono(ADP-ribosyl)ation reaction and its functions in primary cultured hepatocytes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Glycosaminoglycans detection methods: applications of tandem mass spectrometry2016

Author(s)

Journal Title

Data Source

TSUCHIYA Mikako 土屋美加子