YAMANAKA Kunitoshi 山中邦俊

Researcher Number	90212290
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2016 – 2024: 熊本大学, 発生医学研究所, 准教授 2015: 熊本大学, 学内共同利用施設等, 准教授 2014: 熊本大学, 発生医学研究所, 准教授 2009 – 2011: 熊本大学, 発生医学研究所, 准教授 2006 – 2008: Kumamto University, Institute of Molecular Embryology and Genetics, Associate Professor … More 2002 – 2006: 熊本大学, 発生医学研究センター, 助教授 2000 – 2001: 熊本大学, 発生医学研究センター, 助手 1990 – 1995: 熊本大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 48040:Medical biochemistry-related / Molecular biology / General medical chemistry / Molecular biology Except Principal Investigator Biological Sciences / 遺伝学 / Basic Section 52020:Neurology-related / Molecular biology / Functional biochemistry / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Neurology
Keywords	Principal Investigator 線虫 / VCP / p97 / 分子シャペロン / ATPase / CDC-48 / AAAシャペロン / AAAタンパク質 / 寿命 / polyglutamine disease … More / neurodegenerative disease / molecular chaperone / hereditary spastic paraplegia / AAA protein / ポリグルタミン病 / 神経変性疾患 / 遺伝性痙性対麻痺 / PDZドメイン / PTEN / 生体分子 / ユビキチン / UBXN-6 / C.elegans / fidgetin / spastin / C. elegans / マルチコピーサプレッサー / DNA結合蛋白質 / cspE / cspC / 低温ショック蛋白質 / mukB / 染色体分配 / 大腸菌 … More Except Principal Investigator ATPase / 染色体分配 / ミトコンドリア / AAAタンパク質 / 分子シャペロン / アミロイドーシス / トランスサイレチン / 線虫 / 大腸菌 / プロテアーゼ / 微小管 / 神経変性疾患 / MukB / シャペロン / MukB蛋白 / アミロイド・ブレイカー / アミロイドブレイカー / 病態モデル / 抗体治療 / AAA protein / chaperone / ポリグルタミン病 / 遺伝性痙性対麻痺 / FtsH / protease / chromosome partitioning / 膜蛋白質 / プロテアソーム / タンパク質凝集体 / トランスロケーション / 高速原子間力顕微鏡 / DNAスライデングクランプ / 複製装置 / MutS / 複製フォーク / SeqA / DNAメチラーゼ / ATP / 膜蛋白 / ピルビン酸脱水素酵素 / DNA結合蛋白 / 抑制変異 / ftsH遺伝子 / 大腸菌ゲノム / 加齢 / レドックス / Drug repositioning / 薬剤スクリーニング / リボソーム品質管理 / 細胞内タンパク質分解 / リソソーム / オートファジー / タンパク質の品質管理 / タンパク質分解 / アミロイド / ドラッグリポジショニング / 家族性アミロイドポリニューロパチー / microtubule / protein aggregation / genetic diseases / C.elegans / ATP-dependent protease / 転写制御 / アンフォールディング / 遺伝性疾患 / ATP依存性プロテアーゼ / polyglutamine disease / hereditary spastic paraplegia / mitochondria / C. elegans / E. coli / 疾患モデル / 結晶構造 / タンパク質のアンフォールディング / シャベロン / sister chromosome cohesion / DNA sliding clump / replication fork / MukB protein / SeqA protein / DNA methyltransferase / ミスマッチ修復 / Muts / DnaA / 複製開始 / 複製起点 / DNAメチレーション / 姉妹染色体接着 / MukB蛋白質 / SeqA蛋白質 / DNAメチールトランスフェラーゼ / sigma^<32> / immunofluorescence method / Muk protein / MACS / σ因子 / ATPasc / σ32 / 蛍光抗体法 / Muk蛋白 / 膜会合細胞骨格様構造 / membrane protein / DNA binding protein / cold shock protein / ftsH gene / muk gene / FtsH蛋白 / DNA結合能 / GTP結合能 / コールドショック蛋白 / ATPアーゼ / muk遺伝子 / DNAー蛋白複合体 / エキソヌクレアーゼV / DNAジャイレース / 大腸菌変異体 / 分配機構 / ApoE7 / ApoE5 / ApoCーIII / ヒトアポリポタンパク / 変異核 / 無核細胞 / プラスミドの複製 / プラスミドの分配 / ジャイレ-ス / hop変異 / Fプラスミド / muk変異 / 核様体 / 大腸菌染色体の分配 / トポイソメラ-ゼ / 細胞分裂 / 成長ホルモン / アポリポ蛋白質 / 染色体DNA / プラスミド / 26Sプロテアソーム / ポリグルタミン凝集体 / p97/CDC-48/Cdc48 / katanin / Katanin / p97/VCP/CDC-48/Cdc48 / 性決定機構 / 線虫の性決定 / Bcs1p / ClpX / spastin / 品質管理機構 / ATP加水分解 / TDP-43 / Aurora Bキナーゼ / 酵母 / AAA タンパク質 / アルコール脱水素酵素 / スピロゾーム / GTP結合 / DNA結合 / コイルドコイル蛋白 / 分泌蛋白 / β-ラクタマーゼ / ペニシリン結合蛋白 / 蛋白の局在化 / fts遺伝子 / 細胞内フィラメント / ヌクレオチド結合能 / アルコ-ル脱水素酵素 / fur遺伝子 / ペニシリン結合タンパク質 / secY遺伝子 / タンパク質の局在化 / 膜タンパク質 / tolC遺伝子 / mukB遺伝子 / 塩基配列 Less

アダプタータンパク質とPDZタンパク質の相互作用がもたらすCDC-48の機能制御Principal Investigator
- Principal Investigator
  
  山中邦俊
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kumamoto University
ATTR amyloid clearance for definitive therapy
- Principal Investigator
  
  植田光晴
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kumamoto University
Exploring environmental factors determining the age-dependent development of ATTR amyloidosis.
- Principal Investigator
  
  Sato Takashi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Kumamoto University
Analysis of CDC-48 defaulting by ASPS-1 and establishment of a novel nematode diabetes modelPrincipal Investigator
- Principal Investigator
  
  Yamanaka Kunitoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kumamoto University
Screening methods to discover ATTR amyloid disrupters
- Principal Investigator
  
  Ueda Mitsuharu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kumamoto University
Elucidation of substrate-processing mechanisms of ring-shaped AAA chaperones by in vitro systems
- Principal Investigator
  
  OGURA Teru
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kumamoto University
Analysis of a novel regulatory mechanism "CLIP Model" of CDC-48, a AAA chaperonePrincipal Investigator
- Principal Investigator
  
  YAMANAKA KUNITOSHI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kumamoto University
Novel experimental model of TTR amyloidosis using TTR fragments
- Principal Investigator
  
  Ueda Mitsuharu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kumamoto University
Molecular mechanisms of AAA proteins revealed by biochemical analyses and high-speed atomic force microscopic observations
- Principal Investigator
  
  OGURA Teru
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kumamoto University
Mechanisms of remodeling and quality control of proteins by AAA chaperones
- Principal Investigator
  
  OGURA Teru
- Project Period (FY)
  2007 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Molecular analysis of C.elegans AAA proteins related to genetic diseases and developmental disordersPrincipal Investigator
- Principal Investigator
  
  YAMANAKA Kunitoshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  KUMAMOTO UNIVERSITY
Molecular, cellular, and developmental studies on AAA chaperones
- Principal Investigator
  
  OGURA Teru
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Molecular and cellular biology of C. elegans AAA proteins involved in human genetic diseasesPrincipal Investigator
- Principal Investigator
  
  YAMANAKA Kunitoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  KUMAMOTO UNIVERSITY
プロテオバクテリアにおけるメチル化DNA関連遺伝子群の網羅的研究
- Principal Investigator
  
  平賀壮太
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Structural and functional studies on AAA proteins in E. coli and C. elegans.
- Principal Investigator
  
  OGURA Teru
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Molecular biology
- Research Institution
  Kumamoto University
DYNAMIC LOCALIZATION OF PROTEINS AND CHROMOSOME IN BACTERIA
- Principal Investigator
  
  HIRAGA Sota
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Molecular biology
- Research Institution
  KUMAMOTO UNIVERSITY
Genes of Chromosome Partition and the FtsH Protein
- Principal Investigator
  
  HIRAGA Sota
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KUMAMOTO UNIVERSITY
大腸菌染色体分配に関与するDNA結合因子の遺伝生化学的解析Principal Investigator
- Principal Investigator
  
  山中邦俊
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Molecular biology
- Research Institution
  Kumamoto University
真核細胞の小胞体経路に類似した大腸菌の膜蛋白局在化機構
- Principal Investigator
  
  小椋光
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
大腸菌における駆動力発生酵素および細胞質性フィラメントの分子生物学的研究
- Principal Investigator
  
  平賀壯太
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  遺伝学
- Research Institution
  Kumamoto University
Prokaryotic force-generating enzyme and protein transport.
- Principal Investigator
  
  HIRAGA Sota
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KUMAMOTO UNIVERSITY
真核細胞の小胞体経路に類似した大腸菌の膜蛋白局存化機構
- Principal Investigator
  
  OGURA Teru
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
大腸菌における染色体分配を司る遺伝子群の研究
- Principal Investigator
  
  平賀壮太
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  遺伝学
- Research Institution
  Kumamoto University
大腸菌ゲノムの分配を可る遺伝子群の全体像
- Principal Investigator
  
  HIRAGA Sota
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
遺伝性疾患及び細胞増殖に関与する遺伝子群の分子遺伝学的研究
- Principal Investigator
  
  平賀壯太 (平賀壮太)
- Project Period (FY)
  1987 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  遺伝学
- Research Institution
  Kumamoto University

[Journal Article] Functional characterization of UBXN-6, a C-terminal cofactor of CDC-48, in C. elegans2019
- Author(s)
  Mojumder Suman、Sawamura Rie、Murayama Yuki、Ogura Teru、Yamanaka Kunitoshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 509 Issue: 2 Pages: 462-468
- DOI
  10.1016/j.bbrc.2018.12.155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04764, KAKENHI-PROJECT-16K08594
[Journal Article] Development of transgenic Caenorhabditis elegans expressing human transthyretin as a model for drug screening2018
- Author(s)
  Tsuda Yukimoto、Yamanaka Kunitoshi、Toyoshima Risa、Ueda Mitsuharu、Masuda Teruaki、Misumi Yohei、Ogura Teru、Ando Yukio
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 17884-17884
- DOI
  10.1038/s41598-018-36357-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07502, KAKENHI-PROJECT-18K15455, KAKENHI-PROJECT-15H04841, KAKENHI-PROJECT-16K08594
[Journal Article] Characterization of C-terminal adaptors, UFD-2 and UFD-3, of CDC-48 on the polyglutamine aggregation in C. elegans.2015
- Author(s)
  Murayama, Y., Ogura, T., and Yamanaka, K.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 459 Issue: 1 Pages: 154-160
- DOI
  10.1016/j.bbrc.2015.02.088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24370056
[Journal Article] The C-terminal -helix of SPAS-1, a Caenorhabditis elegans spastin homologue, is crucial for microtubule severing.2012
- Author(s)
  Onitake, A., Matsushita-Ishiodori, Y., Johjima, A., Esaki, M., Ogura, T., and Yamanaka, K.
- Journal Title
  
  J. Struct. Biol.
  
  Volume: (in press) Issue: 2 Pages: 138-142
- DOI
  10.1016/j.jsb.2012.04.010
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012, KAKENHI-PROJECT-24370056, KAKENHI-PROJECT-24659432, KAKENHI-PROJECT-24770189
[Journal Article] CDC-48/p97 is required for proper meiotic chromosome segregation via controlling AIR-2/Aurora B kinase localization in Caenorhabditis elegans.2012
- Author(s)
  Sasagawa Y, Higashitani A, Urano T, Ogura T, Yamanaka K.
- Journal Title
  
  J Struct Biol.
  
  Volume: 179 Issue: 2 Pages: 104-111
- DOI
  10.1016/j.jsb.2012.06.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370076, KAKENHI-PROJECT-24370056, KAKENHI-PROJECT-24659432
[Journal Article] Recent advances in p97/VCP/Cdc48 cellular functions.2012
- Author(s)
  Yamanaka, K., Sasagawa, Y., and Ogura, T.
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume: 1823 Issue: 1 Pages: 130-137
- DOI
  10.1016/j.bbamcr.2011.07.001
- NAID
  120004141045
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] Caenorhabditis elegans fidgetin homolog FIGL-1, a nuclear-localized AAA ATPase, binds to SUMO.2012
- Author(s)
  Onitake, A., Yamanaka, K., Esaki, M., and Ogura, T.
- Journal Title
  
  J. Struct. Biol.
  
  Volume: (in press) Issue: 2 Pages: 143-151
- DOI
  10.1016/j.jsb.2012.04.022
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012, KAKENHI-PROJECT-24370056, KAKENHI-PROJECT-24659432, KAKENHI-PROJECT-24770189
[Journal Article] Positive cooperativity of the p97 AAA ATPase is critical for essential functions.2011
- Author(s)
  Nishikori, S., Esaki, M., Yamanaka, K., Sugimoto, S., and Ogura, T.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 286 Issue: 18 Pages: 15815-15820
- DOI
  10.1074/jbc.m110.201400
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012, KAKENHI-PROJECT-22880034, KAKENHI-PROJECT-23590521
[Journal Article] AAA+ chaperone ClpX regulates dynamics of prokaryotic cytoskeletal protein FtsZ.2010
- Author(s)
  Sugimoto, S., Yamanaka, K., Nishikori, S., Miyagi, A., Ando, T., and Ogura, T.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 285 Issue: 9 Pages: 6648-6657
- DOI
  10.1074/jbc.m109.080739
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] AAA+ chaperone ClpX regulates dynamics of prokaryotic cytoskeletal protein FtsZ.2010
- Author(s)
  Sugimoto, S., Yamanaka, K., Nishikori, S., Miyagi, A.,o, T., Ogura, T.
- Journal Title
  
  J. Biol. Chem. 285
  
  Pages: 6648-6657
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] C. elegans UBX cofactors for CDC-48/p97 control spermatogenesis.2010
- Author(s)
  Sasagawa, Y., Yamanaka, K. Saito-Sasagawa, Y., and Ogura, T.
- Journal Title
  
  Genes Cells 15
  
  Volume: 15 Issue: 12 Pages: 1201-1215
- DOI
  10.1111/j.1365-2443.2010.01454.x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] Conserved aromatic and basic amino acid residues in the pore region of C. elegans spastin play critical roles in microtubule-severing.2009
- Author(s)
  Matsushita-Ishiodori, Y., Yamanaka, K., Hashimoto, H., Esaki, M., and Ogura, T.
- Journal Title
  
  Genes Cells
  
  Volume: 14 Issue: 8 Pages: 925-940
- DOI
  10.1111/j.1365-2443.2009.01320.x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] Caenorhabditis elegans p97 controls germline-specific sex determination by controlling TRA-1 level in a CUL-2-dependent manner.2009
- Author(s)
  Sasagawa, Y., Otani, M., Higashitani, N., Higashitani, A., Sato, K., Ogura, T., and Yamanaka, K.
- Journal Title
  
  J. Cell Sci.
  
  Volume: 122 Issue: 20 Pages: 3663-3672
- DOI
  10.1242/jcs.052415
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] onserved aromatic and basic amino acid residues in the pore region of C. elegans spastin play critical roles in microtubule-severing.2009
- Author(s)
  Matsushita-Ishiodori, Y., Yamanaka, K., Hashimoto, H., Esaki, M., Ogura, T.
- Journal Title
  
  Genes Cells 14
  
  Pages: 925-940
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] Caenorhabditis elegans p97 controls germline-specific sex determination by controlling TRA-1 level in a CUL-2-dependent manner.2009
- Author(s)
  Sasagawa, Y., Otani, M., Higashitani, N., Higashitani, A., Sato, K., Ogura, T., Yamanaka, K.
- Journal Title
  
  J. Cell Sci. 122
  
  Pages: 3663-3672
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] Involvement of HMG-12 and CAR-1 in the cdc-48.1 expression of Caenorhabditis elegans.2008
- Author(s)
  Yamauchi, S., Higashitani, N., Otani, M., Higashitani, A., Ogura, T., and Yamanaka, K.
- Journal Title
  
  Dev. Biol.
  
  Volume: 318 Issue: 2 Pages: 348-359
- DOI
  10.1016/j.ydbio.2008.02.057
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] From the common molecular basis of the AAA protein to various energy-dependent and -independent activities of AAA proteins.2008
- Author(s)
  Ogura, T., Matsushita-Ishiodori, Y., Johjima, A., Nishizono, M., Nishikori, S., Esaki, M., and Yamanaka, K.
- Journal Title
  
  Biochem. Soc. Trans.
  
  Volume: 36 Issue: 1 Pages: 68-71
- DOI
  10.1042/bst0360068
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] T. p97 homologs from C. elegans, CDC-48. 1 and CDC-48. 2, suppress the aggregate formation of huntingtin exon1 containing expanded polyQ repeat.2008
- Author(s)
  Nishikori, S., Yamanaka, K., Sakurai, T., Esaki, M., Ogura, T.
- Journal Title
  
  Genes Cells 13
  
  Pages: 827-838
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] p97 homologs from C. elegans, CDC-48.1 and CDC-48.2, suppress the aggregate formation of huntingtin exon1 containing expanded polyQ repeat.2008
- Author(s)
  Nishikori, S., Yamanaka, K., Sakurai, T., Esaki, M., and Ogura, T.
- Journal Title
  
  Genes Cells
  
  Volume: 13 Issue: 8 Pages: 827-838
- DOI
  10.1111/j.1365-2443.2008.01214.x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] The C. elegans homologue of the spastic paraplegia protein, spastin, disassembles microtubules.2007
- Author(s)
  Matsushita-Ishiodori, Y., Yamanaka, K., and Ogura, T.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 359 Issue: 1 Pages: 157-162
- DOI
  10.1016/j.bbrc.2007.05.086
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] Caenorhabditis elegans p97/CDC-48 is crucial for progression of meiosis I.2007
- Author(s)
  Sasagawa, Y., Yamanaka, K., Nishikori, S., and Ogura, T.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 358 Issue: 3 Pages: 920-924
- DOI
  10.1016/j.bbrc.2007.05.022
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] ER E3 ubiquitin ligase HRD-1 and its specific partner chaperone BiP play important roles in ERAD and developmental growth in C. Elegans.2007
- Author(s)
  Sasagawa, Y., Yamanaka, K., and Ogura, T.
- Journal Title
  
  Genes Cells
  
  Volume: 12 Issue: 9 Pages: 1063-1073
- DOI
  10.1111/j.1365-2443.2007.01108.x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] Differential expression pattern of UBX family genes in Caenorhabditis elegans.2007
- Author(s)
  Yamauchi, S., Sasagawa, Y., Ogura, T., and Yamanaka, K.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 358 Issue: 2 Pages: 545-552
- DOI
  10.1016/j.bbrc.2007.04.163
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] ER E3 ubiquitin ligase HRD-1 and its specific partner chaperone BiP play important roles in ERAD and developmental growth in C. elegans.2007
- Author(s)
  Sasagawa, Y., Yamanaka, K., Ogura, T.
- Journal Title
  
  Genes Cells 12
  
  Pages: 1063-1073
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] An AAA protease FtsH can initiate proteolysis from internal sites of a model substrate, apo-flavodoxin.2006
- Author(s)
  Okuno, T., Yamanaka, K., Ogura, T.
- Journal Title
  
  Genes Cells 11
  
  Pages: 261-268
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570147
[Journal Article] Analysis of the two p97/VCP/Cdc48p proteins of Caenorhabditis elegans and their suppression of polyglutamine-induced protein aggregation.2004
- Author(s)
  K. Yamanaka
- Journal Title
  
  J. Struct. Biol. 146
  
  Pages: 242-250
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14037256
[Journal Article] Analysis of the two p97/VCP/Cdc48p proteins of Caenorhabditis elegans and their suppression of polyglutamine・induced protein aggregation.2004
- Author(s)
  K. Yamanaka
- Journal Title
  
  J. Struct. Biol. 146
  
  Pages: 242-260
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-14037256
[Journal Article] 線虫を用いたAAA蛋白質に起因する神経変性疾患モデル2004
- Author(s)
  山中邦俊
- Journal Title
  
  蛋白質核酸酵素 49
  
  Pages: 1124-1126
- Data Source
  KAKENHI-PROJECT-16570147
[Journal Article] Identification of a cysteine residue important for the ATPase activity of C.elegans fidgetin homologue.2004
- Author(s)
  Yakushiji, Y., Yamanaka, K., Ogura, T.
- Journal Title
  
  FEBS Lett. 578
  
  Pages: 191-197
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570147
[Journal Article] Analysis of the two p97/VCP/Cdc48p proteins of Caenorhabditis elegans and their suppression of polyglutamine-induced protein aggregation.2004
- Author(s)
  Yamanaka, K.
- Journal Title
  
  J.Struct.Biol. 146
  
  Pages: 242-250
- Data Source
  KAKENHI-PROJECT-16570147
[Journal Article] Analysis of the two p97/VCP/Cdc48p proteins of Caenorhabditis elegans and their suppression of polyglutamine-induced protein aggregation.2004
- Author(s)
  Yamanaka, K.
- Journal Title
  
  J.Struct.Biol. 146
  
  Pages: 242-250
- Data Source
  KAKENHI-PROJECT-14037256
[Journal Article] 線虫を用いたAAA蛋白質に起因する神経変性疾患モデル2004
- Author(s)
  山中邦俊
- Journal Title
  
  蛋白質核酸酵素 49
  
  Pages: 1124-1126
- Data Source
  KAKENHI-PROJECT-14037256
[Journal Article] Mutational analysis of the functional motifs in the ATPase domain of C.elegans fidgetin homologue FIGL-1 : Firm evidence for an intersubunit catalysis mechanism of ATP hydrolysis by AAA ATPases.
- Author(s)
  Yakushiji, Y., Nishikori, S., Yamanaka, K., Ogura, T.
- Journal Title
  
  J.Struc.Biol. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570147
[Journal Article] Characterization of mutants of the Escherichia coli AAA protease, FtsH, carrying a mutation in the central pore region
- Author(s)
  Okuno, T., Yamanaka, K., Ogura, T.
- Journal Title
  
  J.Struc.Biol. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570147
[Journal Article] Flavodoxin, a new fluorescent substrate for monitoring proteolytic activity of FtsH lacking a robust unfolding activity.
- Author(s)
  Okuno, T., Yamanaka, K., Ogura, T.
- Journal Title
  
  J.Struc.Biol. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570147
[Presentation] レドックス制御を介した加齢に伴うトランスサイレチン凝集体形成2023
- Author(s)
  佐藤卓史，稲田祐貴，山下拓真，山中邦俊，小橋川敬博，森岡弘志
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06529
[Presentation] レドックス制御によるトランスサイレチン凝集体形成の分子機構解析2023
- Author(s)
  山下拓真，稲田祐貴，山中邦俊，間渕周子，小橋川敬博，森岡弘志，佐藤卓史
- Organizer
  第22回次世代を担う若手ファーマ・バイオフォーラム2023
- Data Source
  KAKENHI-PROJECT-21K06529
[Presentation] CDC-48のNドメイン結合コファクターASPS-1の線虫を用いた機能解析2023
- Author(s)
  山中邦俊
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K06886
[Presentation] トランスサイレチンの凝集体構成因子S-S dimerのin vivo定量解析に向けた発光プローブの開発2023
- Author(s)
  山下拓真，稲田祐貴，山中邦俊，間渕周子，小橋川敬博，森岡弘志，佐藤卓史
- Organizer
  令和5年度日本生化学会九州支部例会
- Data Source
  KAKENHI-PROJECT-21K06529
[Presentation] レドックス環境変化によるATTRアミロイドーシス発症制御機構の解明2021
- Author(s)
  稲田祐貴，佐々木亮子，小野祐一朗，山下拓真，小橋川敬博，鬼木健太郎，猿渡淳二，山中邦俊，首藤剛，甲斐広文，森岡弘志，佐藤卓史
- Organizer
  第38回日本薬学会九州支部大会
- Data Source
  KAKENHI-PROJECT-21K06529
[Presentation] Functional analysis of ASPS-1, an N-domain binding adaptor of CDC-48, in C. elegans.2020
- Author(s)
  Yamanaka K. and Ogura T.
- Organizer
  Keystone Symposia on “AAA+ Proteins: from Atomic Structures to Organisms”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07371
[Presentation] 線虫を用いたCDC-48のNドメイン結合アダプターASPS-1の機能解析2019
- Author(s)
  山中　邦俊、小椋　光
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07371
[Presentation] Elucidation of UBXN-6 function in CDC-48-regulated ERAD in C. elegans2017
- Author(s)
  Mojumder, S., Sawamura, R., Ogura, T., and Yamanaka, K.
- Organizer
  第４０回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K08594
[Presentation] High-speed AFM imaging of the 26S proteasome dynamics.2014
- Author(s)
  Okuno, T., Noi, K., Okawa, A., Tsuchiya, H., Saeki, Y., Takahashi, K., Inobe, T., Yamanaka, K., and Ogura, T.
- Organizer
  231st IMEG seminars & Minisymposium
- Place of Presentation
  熊本市　熊本大学発生医学研究所
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] Adaptors of p97 and disease-associated p97 mutations.2014
- Author(s)
  Yamanaka, K., Murayama, Y., and Ogura, T.
- Organizer
  231st IMEG seminars & Minisymposium
- Place of Presentation
  熊本市　熊本大学発生医学研究所
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] 高速AFMによる26Sプロテアソームのダイナミクス解析.2013
- Author(s)
  奥野貴士, 野井健太郎, 大川阿紀子, 土屋光, 佐伯泰, 高橋一暢, 伊野部智由, 山中邦俊, 小椋光
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸市、神戸国際展示場
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] 線虫を用いた疾患型変異CDC-48/p97/VCPの機能解析2013
- Author(s)
  山中邦俊, 村山佑樹, 小椋光
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸市、神戸国際展示場
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] AAA chaperones, focusing on the molecular mecanism of p97.2013
- Author(s)
  Ogura, T., Noi, K., Arita-Morioka, K., Yamamoto, D., Ando, T., Nishikori, S., Esaki, M., and Yamanaka, K.
- Organizer
  EMBO Conference The biology of molecular chaperones
- Place of Presentation
  Margherita de Pula, Italy
- Invited
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] Dynamics of p97 and the 26S proteasome in action revealed by high-speed atomic force microscopy.2013
- Author(s)
  Ogura, T., Noi, K., Okuno, T., Arita-Morioka, K., Yamamoto, D., Okawa, A., Tsuchiya, H., Saeki, Y., Ando, T., Esaki, M., and Yamanaka, K.
- Organizer
  EMBO Workshop on AAA+ Proteins
- Place of Presentation
  Commundo Hotel, Neuss, Germany.
- Invited
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] Functional analysis of disease-associated mutant CDC-48/p97/VCP in C. elegans.2013
- Author(s)
  Yamanaka, K., Murayama, Y., and Ogura, T.
- Organizer
  EMBO Workshop on AAA+ Proteins
- Place of Presentation
  Commundo Hotel, Neuss, Germany.
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] Multiple aspects of multifunctional p97.2011
- Author(s)
  Ogura, T., Noi, K., Arita-Morioka, K., Esaki, M., Murayama, Y., and Yamanaka, K.
- Organizer
  9th International Conference on AAA Protein
- Place of Presentation
  熊本市国際交流会館, Kumamoto, Japan.
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] C.elegans CDC-48/p97 controls germline-specific sex determination.2010
- Author(s)
  Yamanaka, K.
- Organizer
  BIT Life Sciences' 3rd Annual Protein and Peptide Conference (PepCon-2010)
- Place of Presentation
  International Convention Center, Beijing, China
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] Involvement of C.elegans p97-cofactor complexes in sex determination.2010
- Author(s)
  Yamanaka, K.
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  ホテル日航奈良Nara, Japan
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] C. elegans CDC-48/p97 controls germline-specific sex determination.2010
- Author(s)
  Yamanaka, K., Sasagawa, Y., and Ogura, T.
- Organizer
  BIT Life Sciences' 3rd Annual Protein and Peptide Conference (PepCon-2010)
- Place of Presentation
  Beijing, China
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] 線虫を用いたp97/VCP/CDC48の機能解析2010
- Author(s)
  山中邦俊
- Organizer
  新潟脳神経研究会第290回例会
- Place of Presentation
  新潟大学脳研究所新潟
- Year and Date
  2010-06-04
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] Involvement of C. elegans p97-cofactor complexes in sex determination.2010
- Author(s)
  Yamanaka, K., Sasagawa, Y., Murayama, Y., and Ogura, T.
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  ホテル日航奈良, Nara, Japan
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] Roles of p97/VCP, a multifunctional AAA chaperone, in protein oligomerization and aggregation in neurodegenerative diseases.2009
- Author(s)
  Ogura, T., Nishikori, S., Yamanaka, K., and Esaki, M.
- Organizer
  BIT Life Sciences' 2_<nd> Annual Protein and Peptide Conference (PepCon-2009)
- Place of Presentation
  Seoul, South Korea
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] C.elegans p97/CDC-48UFD-1-NPL-4 controls germline specific sex determination by regulating CUL-2-mediated TRA-1 degradation.2009
- Author(s)
  Yamanaka, K.
- Organizer
  8th International Conference on AAA Proteins
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] Molecular mechanisms of homologs of spastin and p97/VCP related to human genetic disorders.2009
- Author(s)
  Ogura, T., Matsushita-Ishiodori, Y., Yamanaka, K., Nishikori, S., and Esaki, M.
- Organizer
  8th International Conference on AAA Proteins
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] p97/CDC-48.1による線虫生殖細胞の性決定の制御2008
- Author(s)
  山中邦俊
- Organizer
  第31回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] C. elegans p97, HRD-1 and BiP are required for ERAD and developmental growth.2007
- Author(s)
  Yamanaka, K.
- Organizer
  16th biennial International C. elegans conference
- Place of Presentation
  UCLA, USA.
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] Functional analysis of p97NCP in C. elegans.2007
- Author(s)
  Yamanaka, K.
- Organizer
  The 7th International conference on AAA proteins
- Place of Presentation
  Cirencester, UK
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] ポリグルタミン凝集体形成における線虫CDC-48 C末端アダプターの役割
- Author(s)
  村山佑樹、小椋光、山中邦俊
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜市　パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] ヒト疾患関連AAAタンパク質BCS1Lの酵母ホモログBcs1pの機能解析
- Author(s)
  澤村理英、江崎雅俊、山中邦俊、小椋光
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜市　パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] Visualization of dynamics of the 26S proteasome and proteasome-substrate complexes by high-speed AFM
- Author(s)
  Okuno, T., Noi, K., Okawa, A., Tsuchiya, H., Saeki, Y., Takahashi, K., Inobe, T., Yamanaka, K., and Ogura, T.
- Organizer
  Key Forum: From Stem Cells to Organs
- Place of Presentation
  熊本市　熊本市医師会館
- Year and Date
  2014-09-04 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-24370056

1. OGURA Teru (00158825)

# of Collaborated Projects: 15 results

# of Collaborated Products: 42 results
2. HIRAGA Sota (40027321)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
3. NIKI Hironori (70208122)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
4. YAMAZOE Mitsuyoshi (00284745)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. ESAKI Masatoshi (70437911)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
6. Ueda Mitsuharu (60452885)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
7. 水口峰之 (30332662)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. ALINE Jaffe

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. MISUMI Yohei (80625781)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. ANDO Yukio (20253742)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. JAFFE Aline

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. BERND Bukau

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. OKUNO Takashi (80411031)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
14. YAMASHITA Taro (90381003)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Sato Takashi (70555755)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
16. 北岡光彦 (30117345)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 前田英雄 (90094044)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 森浩禎 (90182203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 野井健太郎 (30588405)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 森岡弘志 (20230097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
21. 中原圭一 (60648591)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 田崎雅義 (50613402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. BEGG Kenneth j.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. VINELLA Daniel

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. BOULOC Philippe

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. DONACHIE Wil

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. DONACHIE William d.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. KENIIETH J.B

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. WILLIAM.D.DO ドナヒー

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. DANIEL Vinel

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. PHILIPPE Bou

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. CUTTING Simo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. SCHUMANN Wol

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. RUTMAN Andre

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. AMOS Oppenhe

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. BUKAU Bernd

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. SIMON Cutting

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. WOLFGANG Schumann

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. ANDREW Joel Rutman

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. OPPENHEIM Amos B

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. SIMON Cuttin

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. WOLFGANG Sch

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. ANDREW JOEL

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. OPPENHEIM Am

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. 東谷篤志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMANAKA Kunitoshi 山中 邦俊

Research Projects

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Co-Researchers

アダプタータンパク質とPDZタンパク質の相互作用がもたらすCDC-48の機能制御Principal Investigator

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Analysis of CDC-48 defaulting by ASPS-1 and establishment of a novel nematode diabetes modelPrincipal Investigator

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Analysis of a novel regulatory mechanism "CLIP Model" of CDC-48, a AAA chaperonePrincipal Investigator

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Molecular analysis of C.elegans AAA proteins related to genetic diseases and developmental disordersPrincipal Investigator

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Molecular and cellular biology of C. elegans AAA proteins involved in human genetic diseasesPrincipal Investigator

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YAMANAKA Kunitoshi 山中邦俊