YAMANAKA KUNITOSHI 山中邦俊

… Alternative Names

YAMANAKA Kunitoshi 山中邦俊

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Researcher Number	90212290
Other IDs
External Links
Affiliation (Current)	2022: 熊本大学, 発生医学研究所, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2022: 熊本大学, 発生医学研究所, 准教授 2015: 熊本大学, 学内共同利用施設等, 准教授 2014: 熊本大学, 発生医学研究所, 准教授 2009 – 2011: 熊本大学, 発生医学研究所, 准教授 2006 – 2008: Kumamto University, Institute of Molecular Embryology and Genetics, Associate Professor … More 2002 – 2006: 熊本大学, 発生医学研究センター, 助教授 2000 – 2001: 熊本大学, 発生医学研究センター, 助手 1990 – 1995: 熊本大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Molecular biology / Basic Section 48040:Medical biochemistry-related / Molecular biology / General medical chemistry Except Principal Investigator 遺伝学 / Biological Sciences / Functional biochemistry / Molecular biology / Basic Section 52020:Neurology-related / Neurology / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
Keywords	Principal Investigator 線虫 / ATPase / 分子シャペロン / p97 / VCP / AAAタンパク質 / 遺伝性痙性対麻痺 / 神経変性疾患 / ポリグルタミン病 / AAA protein … More / hereditary spastic paraplegia / molecular chaperone / neurodegenerative disease / polyglutamine disease / AAAシャペロン / CDC-48 / 寿命 / 大腸菌 / 染色体分配 / mukB / 低温ショック蛋白質 / cspC / cspE / DNA結合蛋白質 / マルチコピーサプレッサー / C. elegans / spastin / fidgetin / C.elegans / UBXN-6 / ユビキチン / 生体分子 / PTEN … More Except Principal Investigator ATPase / 染色体分配 / 分子シャペロン / AAAタンパク質 / ミトコンドリア / 線虫 / トランスサイレチン / アミロイドーシス / MukB蛋白 / シャペロン / MukB / 神経変性疾患 / 微小管 / プロテアーゼ / 大腸菌 / 大腸菌ゲノム / ftsH遺伝子 / 抑制変異 / DNA結合蛋白 / ピルビン酸脱水素酵素 / 膜蛋白 / ATP / DNAメチラーゼ / SeqA / 複製フォーク / MutS / 複製装置 / DNAスライデングクランプ / 高速原子間力顕微鏡 / トランスロケーション / タンパク質凝集体 / プロテアソーム / 膜蛋白質 / chromosome partitioning / protease / FtsH / 遺伝性痙性対麻痺 / ポリグルタミン病 / chaperone / AAA protein / 抗体治療 / 病態モデル / アミロイド・ブレイカー / 塩基配列 / mukB遺伝子 / tolC遺伝子 / 膜タンパク質 / タンパク質の局在化 / secY遺伝子 / ペニシリン結合タンパク質 / fur遺伝子 / アルコ-ル脱水素酵素 / ヌクレオチド結合能 / 細胞内フィラメント / fts遺伝子 / 蛋白の局在化 / ペニシリン結合蛋白 / β-ラクタマーゼ / 分泌蛋白 / コイルドコイル蛋白 / DNA結合 / GTP結合 / スピロゾーム / アルコール脱水素酵素 / AAA タンパク質 / 酵母 / Aurora Bキナーゼ / TDP-43 / ATP加水分解 / 品質管理機構 / spastin / ClpX / Bcs1p / 線虫の性決定 / 性決定機構 / p97/VCP/CDC-48/Cdc48 / Katanin / katanin / p97/CDC-48/Cdc48 / ポリグルタミン凝集体 / 26Sプロテアソーム / プラスミド / 染色体DNA / アポリポ蛋白質 / 成長ホルモン / 細胞分裂 / トポイソメラ-ゼ / 大腸菌染色体の分配 / 核様体 / muk変異 / Fプラスミド / hop変異 / ジャイレ-ス / プラスミドの分配 / プラスミドの複製 / 無核細胞 / 変異核 / ヒトアポリポタンパク / ApoCーIII / ApoE5 / ApoE7 / 分配機構 / 大腸菌変異体 / DNAジャイレース / エキソヌクレアーゼV / DNAー蛋白複合体 / muk遺伝子 / ATPアーゼ / コールドショック蛋白 / GTP結合能 / DNA結合能 / FtsH蛋白 / muk gene / ftsH gene / cold shock protein / DNA binding protein / membrane protein / 膜会合細胞骨格様構造 / Muk蛋白 / 蛍光抗体法 / σ32 / ATPasc / σ因子 / MACS / Muk protein / immunofluorescence method / sigma^<32> / DNAメチールトランスフェラーゼ / SeqA蛋白質 / MukB蛋白質 / 姉妹染色体接着 / DNAメチレーション / 複製起点 / 複製開始 / DnaA / Muts / ミスマッチ修復 / DNA methyltransferase / SeqA protein / MukB protein / replication fork / DNA sliding clump / sister chromosome cohesion / シャベロン / タンパク質のアンフォールディング / 結晶構造 / 疾患モデル / E. coli / C. elegans / mitochondria / hereditary spastic paraplegia / polyglutamine disease / ATP依存性プロテアーゼ / 遺伝性疾患 / アンフォールディング / 転写制御 / ATP-dependent protease / C.elegans / genetic diseases / protein aggregation / microtubule / 家族性アミロイドポリニューロパチー / ドラッグリポジショニング / アミロイド / タンパク質分解 / タンパク質の品質管理 / オートファジー / リソソーム / 細胞内タンパク質分解 / リボソーム品質管理 / アミロイドブレイカー / 薬剤スクリーニング / Drug repositioning / レドックス Less

Development of ATTR amyloid clearance therapies
- Principal Investigator
  
  植田光晴
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kumamoto University
アダプタータンパク質とPDZタンパク質の相互作用がもたらすCDC-48の機能制御Principal Investigator
- Principal Investigator
  
  山中邦俊
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kumamoto University
ATTRアミロイドーシスの加齢依存的な発症を制御する環境要因の同定
- Principal Investigator
  
  佐藤卓史
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Kumamoto University
Analysis of CDC-48 defaulting by ASPS-1 and establishment of a novel nematode diabetes modelPrincipal Investigator
- Principal Investigator
  
  Yamanaka Kunitoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kumamoto University
Screening methods to discover ATTR amyloid disrupters
- Principal Investigator
  
  Ueda Mitsuharu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kumamoto University
Elucidation of substrate-processing mechanisms of ring-shaped AAA chaperones by in vitro systems
- Principal Investigator
  
  OGURA Teru
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kumamoto University
Analysis of a novel regulatory mechanism "CLIP Model" of CDC-48, a AAA chaperonePrincipal Investigator
- Principal Investigator
  
  YAMANAKA KUNITOSHI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kumamoto University
Novel experimental model of TTR amyloidosis using TTR fragments
- Principal Investigator
  
  Ueda Mitsuharu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kumamoto University
Molecular mechanisms of AAA proteins revealed by biochemical analyses and high-speed atomic force microscopic observations
- Principal Investigator
  
  OGURA Teru
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kumamoto University
Mechanisms of remodeling and quality control of proteins by AAA chaperones
- Principal Investigator
  
  OGURA Teru
- Project Period (FY)
  2007 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Molecular analysis of C.elegans AAA proteins related to genetic diseases and developmental disordersPrincipal Investigator
- Principal Investigator
  
  YAMANAKA Kunitoshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  KUMAMOTO UNIVERSITY
Molecular, cellular, and developmental studies on AAA chaperones
- Principal Investigator
  
  OGURA Teru
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Molecular and cellular biology of C. elegans AAA proteins involved in human genetic diseasesPrincipal Investigator
- Principal Investigator
  
  YAMANAKA Kunitoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  KUMAMOTO UNIVERSITY
プロテオバクテリアにおけるメチル化DNA関連遺伝子群の網羅的研究
- Principal Investigator
  
  平賀壮太
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Structural and functional studies on AAA proteins in E. coli and C. elegans.
- Principal Investigator
  
  OGURA Teru
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Molecular biology
- Research Institution
  Kumamoto University
DYNAMIC LOCALIZATION OF PROTEINS AND CHROMOSOME IN BACTERIA
- Principal Investigator
  
  HIRAGA Sota
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Molecular biology
- Research Institution
  KUMAMOTO UNIVERSITY
Genes of Chromosome Partition and the FtsH Protein
- Principal Investigator
  
  HIRAGA Sota
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KUMAMOTO UNIVERSITY
大腸菌染色体分配に関与するDNA結合因子の遺伝生化学的解析Principal Investigator
- Principal Investigator
  
  山中邦俊
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Molecular biology
- Research Institution
  Kumamoto University
真核細胞の小胞体経路に類似した大腸菌の膜蛋白局在化機構
- Principal Investigator
  
  小椋光
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
大腸菌における駆動力発生酵素および細胞質性フィラメントの分子生物学的研究
- Principal Investigator
  
  平賀壯太
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  遺伝学
- Research Institution
  Kumamoto University
Prokaryotic force-generating enzyme and protein transport.
- Principal Investigator
  
  HIRAGA Sota
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KUMAMOTO UNIVERSITY
真核細胞の小胞体経路に類似した大腸菌の膜蛋白局存化機構
- Principal Investigator
  
  OGURA Teru
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
大腸菌における染色体分配を司る遺伝子群の研究
- Principal Investigator
  
  平賀壮太
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  遺伝学
- Research Institution
  Kumamoto University
大腸菌ゲノムの分配を可る遺伝子群の全体像
- Principal Investigator
  
  HIRAGA Sota
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
遺伝性疾患及び細胞増殖に関与する遺伝子群の分子遺伝学的研究
- Principal Investigator
  
  平賀壯太 (平賀壮太)
- Project Period (FY)
  1987 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  遺伝学
- Research Institution
  Kumamoto University

[Journal Article] Functional characterization of UBXN-6, a C-terminal cofactor of CDC-48, in C. elegans2019
- Author(s)
  Mojumder Suman、Sawamura Rie、Murayama Yuki、Ogura Teru、Yamanaka Kunitoshi
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 509 Pages: 462-468
- DOI
  10.1016/j.bbrc.2018.12.155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04764, KAKENHI-PROJECT-16K08594
[Journal Article] Development of transgenic Caenorhabditis elegans expressing human transthyretin as a model for drug screening2018
- Author(s)
  Tsuda Yukimoto、Yamanaka Kunitoshi、Toyoshima Risa、Ueda Mitsuharu、Masuda Teruaki、Misumi Yohei、Ogura Teru、Ando Yukio
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Pages: 17884-17884
- DOI
  10.1038/s41598-018-36357-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07502, KAKENHI-PROJECT-18K15455, KAKENHI-PROJECT-15H04841, KAKENHI-PROJECT-16K08594
[Journal Article] Characterization of C-terminal adaptors, UFD-2 and UFD-3, of CDC-48 on the polyglutamine aggregation in C. elegans.2015
- Author(s)
  Murayama, Y., Ogura, T., and Yamanaka, K.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 459 Pages: 154-160
- DOI
  10.1016/j.bbrc.2015.02.088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24370056
[Journal Article] The C-terminal a-helix of SPAS-1, a Caenorhabditis elegans spastinhomologue, is crucial for microtubule severing.2012
- Author(s)
  Onitake, A., Matsushita-Ishiodori, Y., Johjima, A., Esaki, M., Ogura, T., and Yamanaka, K.
- Journal Title
  
  Journal Of Structural Biology
  
  Volume: (in press) Pages: 138-142
- DOI
  10.1016/j.jsb.2012.04.010
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012, KAKENHI-PROJECT-24370056, KAKENHI-PROJECT-24659432, KAKENHI-PROJECT-24770189
[Journal Article] Recent advances in p97/VCP/Cdc48 cellular functions.2012
- Author(s)
  Sasagawa Y, Higashitani A, Urano T, Ogura T, Yamanaka K.
- Journal Title
  
  J. Struct. Biol.
  
  Volume: 179 Pages: 104-111
- DOI
  10.1016/j.jsb.2012.06.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370076, KAKENHI-PROJECT-24370056, KAKENHI-PROJECT-24659432
[Journal Article] Recent advances in p97/VCP/Cdc48 cellular functions2012
- Author(s)
  Yamanaka, K., Sasagawa, Y., and Ogura, T.
- Journal Title
  
  Biochim.Biophys.Acta
  
  Volume: 1823 Pages: 130-137
- DOI
  10.1016/j.bbamcr.2011.07.001
- NAID
  120004141045
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] Caenorhabditis elegans fidgetin homologFIGL-1, a nuclear-localized AAAATPase, binds to SUMO.2012
- Author(s)
  Onitake, A., Yamanaka, K., Esaki, M., and Ogura, T.
- Journal Title
  
  Struct. Biol
  
  Volume: (in press) Pages: 143-151
- DOI
  10.1016/j.jsb.2012.04.022
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012, KAKENHI-PROJECT-24370056, KAKENHI-PROJECT-24659432, KAKENHI-PROJECT-24770189
[Journal Article] Positive cooperativity of the p97 AAA ATPase is critical for essential functions2011
- Author(s)
  Nishikori, S., Esaki, M., Yamanaka, K., Sugimoto, S., and Ogura, T.
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 15815-15820
- DOI
  10.1074/jbc.m110.201400
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012, KAKENHI-PROJECT-22880034, KAKENHI-PROJECT-23590521
[Journal Article] AAA+ chaperone ClpX regulates dynamics of prokaryotic cytoskeletal protein FtsZ.2010
- Author(s)
  Sugimoto, S., Yamanaka, K., Nishikori, S., Miyagi, A., Ando, T., and Ogura, T.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 285 Pages: 6648-6657
- DOI
  10.1074/jbc.m109.080739
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] AAA+ chaperone ClpX regulates dynamics of prokaryotic cytoskeletal protein FtsZ.2010
- Author(s)
  Sugimoto, S., Yamanaka, K., Nishikori, S., Miyagi, A.,o, T., Ogura, T.
- Journal Title
  
  J. Biol. Chem. 285
  
  Pages: 6648-6657
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] C. elegans UBX cofactors for CDC-48/p97 control spermatogenesis.2010
- Author(s)
  Sasagawa, Y., Yamanaka, K. Saito-Sasagawa, Y., and Ogura, T.
- Journal Title
  
  Genes Cells 15
  
  Pages: 1201-1215
- DOI
  10.1111/j.1365-2443.2010.01454.x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] Conserved aromatic and basic amino acid residues in the pore region of C. elegans spastin play critical roles in microtubule-severing.2009
- Author(s)
  Matsushita-Ishiodori, Y., Yamanaka, K., Hashimoto, H., Esaki, M., and Ogura, T.
- Journal Title
  
  Genes Cells
  
  Volume: 14 Pages: 925-940
- DOI
  10.1111/j.1365-2443.2009.01320.x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] Caenorhabditis elegans p97 controls germline-specific sex determination by controlling TRA-1 level in a CUL-2-dependent manner.2009
- Author(s)
  Sasagawa, Y., Otani, M., Higashitani, N., Higashitani, A., Sato, K., Ogura, T., and Yamanaka, K.
- Journal Title
  
  J. Cell Sci.
  
  Volume: 122 Pages: 3663-3672
- DOI
  10.1242/jcs.052415
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] onserved aromatic and basic amino acid residues in the pore region of C. elegans spastin play critical roles in microtubule-severing.2009
- Author(s)
  Matsushita-Ishiodori, Y., Yamanaka, K., Hashimoto, H., Esaki, M., Ogura, T.
- Journal Title
  
  Genes Cells 14
  
  Pages: 925-940
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] Caenorhabditis elegans p97 controls germline-specific sex determination by controlling TRA-1 level in a CUL-2-dependent manner.2009
- Author(s)
  Sasagawa, Y., Otani, M., Higashitani, N., Higashitani, A., Sato, K., Ogura, T., Yamanaka, K.
- Journal Title
  
  J. Cell Sci. 122
  
  Pages: 3663-3672
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] Involvement of HMG-12 and CAR-1 in the cdc-48.1 expression of Caenorhabditis elegans.2008
- Author(s)
  Yamauchi, S., Higashitani, N., Otani, M., Higashitani, A., Ogura, T., and Yamanaka, K.
- Journal Title
  
  Dev. Biol.
  
  Volume: 318 Pages: 348-359
- DOI
  10.1016/j.ydbio.2008.02.057
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] From the common molecular basis of the AAA protein to various energy-dependent and -independent activities of AAA proteins.2008
- Author(s)
  Ogura, T., Matsushita-Ishiodori, Y., Johjima, A., Nishizono, M., Nishikori, S., Esaki, M., and Yamanaka, K.
- Journal Title
  
  Biochem. Soc. Trans.
  
  Volume: 36 Pages: 68-71
- DOI
  10.1042/bst0360068
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] T. p97 homologs from C. elegans, CDC-48. 1 and CDC-48. 2, suppress the aggregate formation of huntingtin exon1 containing expanded polyQ repeat.2008
- Author(s)
  Nishikori, S., Yamanaka, K., Sakurai, T., Esaki, M., Ogura, T.
- Journal Title
  
  Genes Cells 13
  
  Pages: 827-838
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] p97 homologs from C. elegans, CDC-48.1 and CDC-48.2, suppress the aggregate formation of huntingtin exon1 containing expanded polyQ repeat.2008
- Author(s)
  Nishikori, S., Yamanaka, K., Sakurai, T., Esaki, M., and Ogura, T.
- Journal Title
  
  Genes Cells
  
  Volume: 13 Pages: 827-838
- DOI
  10.1111/j.1365-2443.2008.01214.x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] The C. elegans homologue of the spastic paraplegia protein, spastin, disassembles microtubules.2007
- Author(s)
  Matsushita-Ishiodori, Y., Yamanaka, K., and Ogura, T.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 359 Pages: 157-162
- DOI
  10.1016/j.bbrc.2007.05.086
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] Caenorhabditis elegans p97/CDC-48 is crucial for progression of meiosis I.2007
- Author(s)
  Sasagawa, Y., Yamanaka, K., Nishikori, S., and Ogura, T.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 358 Pages: 920-924
- DOI
  10.1016/j.bbrc.2007.05.022
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] ER E3 ubiquitin ligase HRD-1 and its specific partner chaperone BiP play important roles in ERAD and developmental growth in C. Elegans.2007
- Author(s)
  Sasagawa, Y., Yamanaka, K., and Ogura, T.
- Journal Title
  
  Genes Cells
  
  Volume: 12 Pages: 1063-1073
- DOI
  10.1111/j.1365-2443.2007.01108.x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] Differential expression pattern of UBX family genes in Caenorhabditis elegans.2007
- Author(s)
  Yamauchi, S., Sasagawa, Y., Ogura, T., and Yamanaka, K.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 358 Pages: 545-552
- DOI
  10.1016/j.bbrc.2007.04.163
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] ER E3 ubiquitin ligase HRD-1 and its specific partner chaperone BiP play important roles in ERAD and developmental growth in C. elegans.2007
- Author(s)
  Sasagawa, Y., Yamanaka, K., Ogura, T.
- Journal Title
  
  Genes Cells 12
  
  Pages: 1063-1073
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] An AAA protease FtsH can initiate proteolysis from internal sites of a model substrate, apo-flavodoxin.2006
- Author(s)
  Okuno, T., Yamanaka, K., Ogura, T.
- Journal Title
  
  Genes Cells 11
  
  Pages: 261-268
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570147
[Journal Article] Analysis of the two p97/VCP/Cdc48p proteins of Caenorhabditis elegans and their suppression of polyglutamine-induced protein aggregation.2004
- Author(s)
  K. Yamanaka
- Journal Title
  
  J. Struct. Biol. 146
  
  Pages: 242-250
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14037256
[Journal Article] Analysis of the two p97/VCP/Cdc48p proteins of Caenorhabditis elegans and their suppression of polyglutamine・induced protein aggregation.2004
- Author(s)
  K. Yamanaka
- Journal Title
  
  J. Struct. Biol. 146
  
  Pages: 242-260
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-14037256
[Journal Article] 線虫を用いたAAA蛋白質に起因する神経変性疾患モデル2004
- Author(s)
  山中邦俊
- Journal Title
  
  蛋白質核酸酵素 49
  
  Pages: 1124-1126
- Data Source
  KAKENHI-PROJECT-16570147
[Journal Article] Identification of a cysteine residue important for the ATPase activity of C.elegans fidgetin homologue.2004
- Author(s)
  Yakushiji, Y., Yamanaka, K., Ogura, T.
- Journal Title
  
  FEBS Lett. 578
  
  Pages: 191-197
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570147
[Journal Article] Analysis of the two p97/VCP/Cdc48p proteins of Caenorhabditis elegans and their suppression of polyglutamine-induced protein aggregation.2004
- Author(s)
  Yamanaka, K.
- Journal Title
  
  J.Struct.Biol. 146
  
  Pages: 242-250
- Data Source
  KAKENHI-PROJECT-16570147
[Journal Article] Analysis of the two p97/VCP/Cdc48p proteins of Caenorhabditis elegans and their suppression of polyglutamine-induced protein aggregation.2004
- Author(s)
  Yamanaka, K.
- Journal Title
  
  J.Struct.Biol. 146
  
  Pages: 242-250
- Data Source
  KAKENHI-PROJECT-14037256
[Journal Article] 線虫を用いたAAA蛋白質に起因する神経変性疾患モデル2004
- Author(s)
  山中邦俊
- Journal Title
  
  蛋白質核酸酵素 49
  
  Pages: 1124-1126
- Data Source
  KAKENHI-PROJECT-14037256
[Journal Article] Mutational analysis of the functional motifs in the ATPase domain of C.elegans fidgetin homologue FIGL-1 : Firm evidence for an intersubunit catalysis mechanism of ATP hydrolysis by AAA ATPases.
- Author(s)
  Yakushiji, Y., Nishikori, S., Yamanaka, K., Ogura, T.
- Journal Title
  
  J.Struc.Biol. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570147
[Journal Article] Characterization of mutants of the Escherichia coli AAA protease, FtsH, carrying a mutation in the central pore region
- Author(s)
  Okuno, T., Yamanaka, K., Ogura, T.
- Journal Title
  
  J.Struc.Biol. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570147
[Journal Article] Flavodoxin, a new fluorescent substrate for monitoring proteolytic activity of FtsH lacking a robust unfolding activity.
- Author(s)
  Okuno, T., Yamanaka, K., Ogura, T.
- Journal Title
  
  J.Struc.Biol. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570147
[Presentation] レドックス環境変化によるATTRアミロイドーシス発症制御機構の解明2021
- Author(s)
  稲田祐貴，佐々木亮子，小野祐一朗，山下拓真，小橋川敬博，鬼木健太郎，猿渡淳二，山中邦俊，首藤剛，甲斐広文，森岡弘志，佐藤卓史
- Organizer
  第38回日本薬学会九州支部大会
- Data Source
  KAKENHI-PROJECT-21K06529
[Presentation] Functional analysis of ASPS-1, an N-domain binding adaptor of CDC-48, in C. elegans.2020
- Author(s)
  Yamanaka K. and Ogura T.
- Organizer
  Keystone Symposia on “AAA+ Proteins: from Atomic Structures to Organisms”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07371
[Presentation] 線虫を用いたCDC-48のNドメイン結合アダプターASPS-1の機能解析2019
- Author(s)
  山中　邦俊、小椋　光
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07371
[Presentation] Elucidation of UBXN-6 function in CDC-48-regulated ERAD in C. elegans2017
- Author(s)
  Mojumder, S., Sawamura, R., Ogura, T., and Yamanaka, K.
- Organizer
  第４０回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K08594
[Presentation] High-speed AFM imaging of the 26S proteasome dynamics.2014
- Author(s)
  Okuno, T., Noi, K., Okawa, A., Tsuchiya, H., Saeki, Y., Takahashi, K., Inobe, T., Yamanaka, K., and Ogura, T.
- Organizer
  231st IMEG seminars & Minisymposium
- Place of Presentation
  熊本市　熊本大学発生医学研究所
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] Adaptors of p97 and disease-associated p97 mutations.2014
- Author(s)
  Yamanaka, K., Murayama, Y., and Ogura, T.
- Organizer
  231st IMEG seminars & Minisymposium
- Place of Presentation
  熊本市　熊本大学発生医学研究所
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] 高速AFMによる26Sプロテアソームのダイナミクス解析.2013
- Author(s)
  奥野貴士, 野井健太郎, 大川阿紀子, 土屋光, 佐伯泰, 高橋一暢, 伊野部智由, 山中邦俊, 小椋光
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸市、神戸国際展示場
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] 線虫を用いた疾患型変異CDC-48/p97/VCPの機能解析2013
- Author(s)
  山中邦俊, 村山佑樹, 小椋光
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸市、神戸国際展示場
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] AAA chaperones, focusing on the molecular mecanism of p97.2013
- Author(s)
  Ogura, T., Noi, K., Arita-Morioka, K., Yamamoto, D., Ando, T., Nishikori, S., Esaki, M., and Yamanaka, K.
- Organizer
  EMBO Conference The biology of molecular chaperones
- Place of Presentation
  Margherita de Pula, Italy
- Invited
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] Dynamics of p97 and the 26S proteasome in action revealed by high-speed atomic force microscopy.2013
- Author(s)
  Ogura, T., Noi, K., Okuno, T., Arita-Morioka, K., Yamamoto, D., Okawa, A., Tsuchiya, H., Saeki, Y., Ando, T., Esaki, M., and Yamanaka, K.
- Organizer
  EMBO Workshop on AAA+ Proteins
- Place of Presentation
  Commundo Hotel, Neuss, Germany.
- Invited
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] Functional analysis of disease-associated mutant CDC-48/p97/VCP in C. elegans.2013
- Author(s)
  Yamanaka, K., Murayama, Y., and Ogura, T.
- Organizer
  EMBO Workshop on AAA+ Proteins
- Place of Presentation
  Commundo Hotel, Neuss, Germany.
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] Multiple aspects of multifunctional p97.2011
- Author(s)
  Ogura, T., Noi, K., Arita-Morioka, K., Esaki, M., Murayama, Y., and Yamanaka, K.
- Organizer
  9th International Conference on AAA Protein
- Place of Presentation
  熊本市国際交流会館, Kumamoto, Japan.
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] C.elegans CDC-48/p97 controls germline-specific sex determination.2010
- Author(s)
  Yamanaka, K.
- Organizer
  BIT Life Sciences' 3rd Annual Protein and Peptide Conference (PepCon-2010)
- Place of Presentation
  International Convention Center, Beijing, China
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] Involvement of C.elegans p97-cofactor complexes in sex determination.2010
- Author(s)
  Yamanaka, K.
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  ホテル日航奈良Nara, Japan
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] C. elegans CDC-48/p97 controls germline-specific sex determination.2010
- Author(s)
  Yamanaka, K., Sasagawa, Y., and Ogura, T.
- Organizer
  BIT Life Sciences' 3rd Annual Protein and Peptide Conference (PepCon-2010)
- Place of Presentation
  Beijing, China
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] 線虫を用いたp97/VCP/CDC48の機能解析2010
- Author(s)
  山中邦俊
- Organizer
  新潟脳神経研究会第290回例会
- Place of Presentation
  新潟大学脳研究所新潟
- Year and Date
  2010-06-04
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] Involvement of C. elegans p97-cofactor complexes in sex determination.2010
- Author(s)
  Yamanaka, K., Sasagawa, Y., Murayama, Y., and Ogura, T.
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  ホテル日航奈良, Nara, Japan
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] Roles of p97/VCP, a multifunctional AAA chaperone, in protein oligomerization and aggregation in neurodegenerative diseases.2009
- Author(s)
  Ogura, T., Nishikori, S., Yamanaka, K., and Esaki, M.
- Organizer
  BIT Life Sciences' 2_<nd> Annual Protein and Peptide Conference (PepCon-2009)
- Place of Presentation
  Seoul, South Korea
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] C.elegans p97/CDC-48UFD-1-NPL-4 controls germline specific sex determination by regulating CUL-2-mediated TRA-1 degradation.2009
- Author(s)
  Yamanaka, K.
- Organizer
  8th International Conference on AAA Proteins
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] Molecular mechanisms of homologs of spastin and p97/VCP related to human genetic disorders.2009
- Author(s)
  Ogura, T., Matsushita-Ishiodori, Y., Yamanaka, K., Nishikori, S., and Esaki, M.
- Organizer
  8th International Conference on AAA Proteins
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] p97/CDC-48.1による線虫生殖細胞の性決定の制御2008
- Author(s)
  山中邦俊
- Organizer
  第31回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] C. elegans p97, HRD-1 and BiP are required for ERAD and developmental growth.2007
- Author(s)
  Yamanaka, K.
- Organizer
  16th biennial International C. elegans conference
- Place of Presentation
  UCLA, USA.
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] Functional analysis of p97NCP in C. elegans.2007
- Author(s)
  Yamanaka, K.
- Organizer
  The 7th International conference on AAA proteins
- Place of Presentation
  Cirencester, UK
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] ポリグルタミン凝集体形成における線虫CDC-48 C末端アダプターの役割
- Author(s)
  村山佑樹、小椋光、山中邦俊
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜市　パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] ヒト疾患関連AAAタンパク質BCS1Lの酵母ホモログBcs1pの機能解析
- Author(s)
  澤村理英、江崎雅俊、山中邦俊、小椋光
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜市　パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] Visualization of dynamics of the 26S proteasome and proteasome-substrate complexes by high-speed AFM
- Author(s)
  Okuno, T., Noi, K., Okawa, A., Tsuchiya, H., Saeki, Y., Takahashi, K., Inobe, T., Yamanaka, K., and Ogura, T.
- Organizer
  Key Forum: From Stem Cells to Organs
- Place of Presentation
  熊本市　熊本市医師会館
- Year and Date
  2014-09-04 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-24370056

1. OGURA Teru (00158825)

# of Collaborated Projects: 15 results

# of Collaborated Products: 43 results
2. HIRAGA Sota (40027321)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
3. NIKI Hironori (70208122)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
4. YAMAZOE Mitsuyoshi (00284745)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. ESAKI Masatoshi (70437911)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
6. Ueda Mitsuharu (60452885)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
7. 水口峰之 (30332662)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. ALINE Jaffe

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. MISUMI Yohei (80625781)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. ANDO Yukio (20253742)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
11. JAFFE Aline

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. BERND Bukau

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. OKUNO Takashi (80411031)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
14. YAMASHITA Taro (90381003)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 北岡光彦 (30117345)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 前田英雄 (90094044)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 森浩禎 (90182203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 野井健太郎 (30588405)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 田崎雅義 (50613402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 佐藤卓史 (70555755)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 森岡弘志 (20230097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. BEGG Kenneth j.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. VINELLA Daniel

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. BOULOC Philippe

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. DONACHIE Wil

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. DONACHIE William d.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. KENIIETH J.B

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. WILLIAM.D.DO ドナヒー

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. DANIEL Vinel

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. PHILIPPE Bou

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. CUTTING Simo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. SCHUMANN Wol

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. RUTMAN Andre

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. AMOS Oppenhe

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. BUKAU Bernd

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. SIMON Cutting

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. WOLFGANG Schumann

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. ANDREW Joel Rutman

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. OPPENHEIM Amos B

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. SIMON Cuttin

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. WOLFGANG Sch

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. ANDREW JOEL

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. OPPENHEIM Am

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. SUGIMOTO Shinya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
45. 増田曜章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
46. 東谷篤志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMANAKA KUNITOSHI 山中 邦俊

YAMANAKA Kunitoshi 山中 邦俊

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アダプタータンパク質とPDZタンパク質の相互作用がもたらすCDC-48の機能制御Principal Investigator

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Analysis of CDC-48 defaulting by ASPS-1 and establishment of a novel nematode diabetes modelPrincipal Investigator

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Analysis of a novel regulatory mechanism "CLIP Model" of CDC-48, a AAA chaperonePrincipal Investigator

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Molecular analysis of C.elegans AAA proteins related to genetic diseases and developmental disordersPrincipal Investigator

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Molecular and cellular biology of C. elegans AAA proteins involved in human genetic diseasesPrincipal Investigator

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YAMANAKA KUNITOSHI 山中邦俊

YAMANAKA Kunitoshi 山中邦俊