YAMANAKA Kunitoshi 山中邦俊

Researcher Number	90212290
Other IDs
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Affiliation *help	2016 – 2018 : 熊本大学, 発生医学研究所, 准教授 2015 : 熊本大学, 学内共同利用施設等, 准教授 2014 : 熊本大学, 発生医学研究所, 准教授 2009 – 2011 : 熊本大学, 発生医学研究所, 准教授 2006 – 2008 : Kumamto University, Institute of Molecular Embryology and Genetics, Associate Professor … More
Review Section/Research Field	Principal Investigator Molecular biology / Molecular biology / General medical chemistry Except Principal Investigator Biological Sciences / 遺伝学 / Molecular biology / Functional biochemistry / Basic Section 52020:Neurology-related / Neurology
Keywords	Principal Investigator p97 / VCP / ATPase / ポリグルタミン病 / 分子シャペロン / molecular chaperone / 遺伝性痙性対麻痺 / AAAタンパク質 / neurodegenerative disease / hereditary spastic paraplegia … More Except Principal Investigator ATPase / 染色体分配 / 分子シャペロン / AAAタンパク質 / ミトコンドリア / 微小管 / プロテアーゼ / MukB蛋白 / シャペロン / 神経変性疾患 / MukB / 線虫 / 大腸菌 / ポリグルタミン病 / 高速原子間力顕微鏡 / protease / アミロイドーシス / MutS / 複製フォーク / プロテアソーム / DNAスライデングクランプ / 膜蛋白質 / FtsH / AAA protein / 抑制変異 / ATP / ピルビン酸脱水素酵素 / DNA結合蛋白 / SeqA / chromosome partitioning / 膜蛋白 / chaperone / 複製装置 / DNAメチラーゼ / タンパク質凝集体 / トランスサイレチン / ftsH遺伝子 / 大腸菌ゲノム / トランスロケーション / 遺伝性痙性対麻痺 / ApoE5 / ApoE7 / spastin / Katanin / DNAジャイレース / 線虫の性決定 / muk遺伝子 / プラスミドの複製 / σ因子 / 染色体DNA / Aurora Bキナーゼ / DNAメチレーション / sigma^<32> / mukB遺伝子 / 分配機構 / hereditary spastic paraplegia / ATP加水分解 / 成長ホルモン / ApoCーIII / 性決定機構 / GTP結合能 / E. coli / DNA sliding clump / Muts / sister chromosome cohesion / SeqA protein / MukB protein / 無核細胞 / 膜タンパク質 / 転写制御 / リボソーム品質管理 / DnaA / secY遺伝子 / ペニシリン結合タンパク質 / σ32 / 複製起点 / DNA結合能 / immunofluorescence method / プラスミド / 塩基配列 / DNAー蛋白複合体 / 姉妹染色体接着 / tolC遺伝子 / ftsH gene / DNA binding protein / 品質管理機構 / アルコール脱水素酵素 / 蛍光抗体法 / ATP依存性プロテアーゼ / Muk蛋白 / ミスマッチ修復 / 細胞分裂 / microtubule / C. elegans / hop変異 / 変異核 / ATPアーゼ / アポリポ蛋白質 / 核様体 / エキソヌクレアーゼV / コイルドコイル蛋白 / FtsH蛋白 / fur遺伝子 / DNA結合 / muk gene / ペニシリン結合蛋白 / AAA タンパク質 / 細胞内フィラメント / katanin / C.elegans / Fプラスミド / ポリグルタミン凝集体 / genetic diseases / β-ラクタマーゼ / ClpX / 細胞内タンパク質分解 / 膜会合細胞骨格様構造 / TDP-43 / 分泌蛋白 / membrane protein / プラスミドの分配 / Bcs1p / コールドショック蛋白 / ATPasc / スピロゾーム / 大腸菌変異体 / アミロイド / トポイソメラ-ゼ / DNAメチールトランスフェラーゼ / p97/VCP/CDC-48/Cdc48 / 26Sプロテアソーム / mitochondria / アンフォールディング / タンパク質の局在化 / ヒトアポリポタンパク / muk変異 / シャベロン / SeqA蛋白質 / 大腸菌染色体の分配 / ATP-dependent protease / replication fork / タンパク質のアンフォールディング / 遺伝性疾患 / ジャイレ-ス / ヌクレオチド結合能 / Muk protein / cold shock protein / DNA methyltransferase / MACS / 蛋白の局在化 / 酵母 / fts遺伝子 / 複製開始 / protein aggregation / 疾患モデル / p97/CDC-48/Cdc48 / タンパク質分解 / アルコ-ル脱水素酵素 / 結晶構造 / MukB蛋白質 / polyglutamine disease / GTP結合 Less

根治療法の切り札アミロイド・ブレイカー開発とそれを用いた毒性メカニズム探求Ongoing
- Principal Investigator
  
  植田光晴
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kumamoto University
リング状AAA型シャペロンの基質への作用機構のin vitro系による解明Ongoing
- Principal Investigator
  
  小椋光
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kumamoto University
AAA型シャペロンCDC-48の新規制御機構「クリップモデル」の検証Principal InvestigatorOngoing
- Principal Investigator
  
  山中邦俊
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kumamoto University
TTRの断片化を活用したFAP病態解明へのブレイクスルーと新規疾患モデル構築Ongoing
- Principal Investigator
  
  植田光晴
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kumamoto University
Molecular mechanisms of AAA proteins revealed by biochemical analyses and high-speed atomic force microscopic observations
- Principal Investigator
  
  OGURA Teru
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kumamoto University
Mechanisms of remodeling and quality control of proteins by AAA chaperones
- Principal Investigator
  
  OGURA Teru
- Project Period (FY)
  2007 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Molecular analysis of C.elegans AAA proteins related to genetic diseases and developmental disordersPrincipal Investigator
- Principal Investigator
  
  YAMANAKA Kunitoshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  KUMAMOTO UNIVERSITY
Molecular, cellular, and developmental studies on AAA chaperones
- Principal Investigator
  
  OGURA Teru
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Molecular and cellular biology of C. elegans AAA proteins involved in human genetic diseasesPrincipal Investigator
- Principal Investigator
  
  YAMANAKA Kunitoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  KUMAMOTO UNIVERSITY
プロテオバクテリアにおけるメチル化DNA関連遺伝子群の網羅的研究
- Principal Investigator
  
  平賀壮太
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Structural and functional studies on AAA proteins in E. coli and C. elegans.
- Principal Investigator
  
  OGURA Teru
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Molecular biology
- Research Institution
  Kumamoto University
DYNAMIC LOCALIZATION OF PROTEINS AND CHROMOSOME IN BACTERIA
- Principal Investigator
  
  HIRAGA Sota
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Molecular biology
- Research Institution
  KUMAMOTO UNIVERSITY
Genes of Chromosome Partition and the FtsH Protein
- Principal Investigator
  
  HIRAGA Sota
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KUMAMOTO UNIVERSITY
大腸菌染色体分配に関与するDNA結合因子の遺伝生化学的解析Principal Investigator
- Principal Investigator
  
  山中邦俊
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Molecular biology
- Research Institution
  Kumamoto University
真核細胞の小胞体経路に類似した大腸菌の膜蛋白局在化機構
- Principal Investigator
  
  小椋光
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
大腸菌における駆動力発生酵素および細胞質性フィラメントの分子生物学的研究
- Principal Investigator
  
  平賀壯太
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  遺伝学
- Research Institution
  Kumamoto University
Prokaryotic force-generating enzyme and protein transport.
- Principal Investigator
  
  HIRAGA Sota
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KUMAMOTO UNIVERSITY
真核細胞の小胞体経路に類似した大腸菌の膜蛋白局存化機構
- Principal Investigator
  
  OGURA Teru
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
大腸菌における染色体分配を司る遺伝子群の研究
- Principal Investigator
  
  平賀壮太
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  遺伝学
- Research Institution
  Kumamoto University
大腸菌ゲノムの分配を可る遺伝子群の全体像
- Principal Investigator
  
  HIRAGA Sota
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
遺伝性疾患及び細胞増殖に関与する遺伝子群の分子遺伝学的研究
- Principal Investigator
  
  平賀壯太
- Project Period (FY)
  1987 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  遺伝学
- Research Institution
  Kumamoto University

All 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2004 Other

All Journal Article Presentation

[Journal Article] Characterization of C-terminal adaptors, UFD-2 and UFD-3, of CDC-48 on the polyglutamine aggregation in C. elegans.2015
- Author(s)
  Murayama, Y., Ogura, T., and Yamanaka, K.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume : 459 Pages : 154-160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24370056
[Journal Article] Caenorhabditis elegans fidgetin homolog FIGL-1, a nuclear-localized AAA ATPase, binds to SUMO2012
- Author(s)
  Onitake, A., Yamanaka, K., Esaki, M., and Ogura.T.
- Journal Title
  
  Struct. Biol
  
  Volume : 179(Epub 2012 May 7.) Pages : 143-151
- DOI
  10.1016/j.jsb.2012.04.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24370056, KAKENHI-PROJECT-24770189, KAKENHI-PLANNED-19058012
[Journal Article] The C-terminal a-helix of SPAS-1, a Caenorhabditis elegans spastin homologue, is crucial for microtubule severing2012
- Author(s)
  Onitake, A., Matsushita-Ishiodori, Y., Johjima, A., Esaki, M., Ogura, T., and Yamanaka, K.
- Journal Title
  
  Struct. Biol
  
  Volume : 179(Epub 2012 Apr 27.) Pages : 138-142
- DOI
  10.1016/j.jsb.2012.04.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24370056, KAKENHI-PROJECT-24770189, KAKENHI-PLANNED-19058012
[Journal Article] Recent advances in p97/VCP/Cdc48 cellular functions.2012
- Author(s)
  Sasagawa Y, Higashitani A, Urano T, Ogura T, Yamanaka K.
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume : 179 Pages : 104-111
- DOI
  10.1016/j.jsb.2012.06.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370076, KAKENHI-PROJECT-24370056
[Journal Article] Recent advances in p97/VCP/Cdc48 cellular functions.2012
- Author(s)
  Yamanaka, K., Sasagawa, Y., and Ogura, T.
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume : 1823 Issue : 1 Pages : 130-137
- Publisher
  Elsevier
- DOI
  10.1016/j.bbamcr.2011.07.001
- PMID
  21781992
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] Positive cooperativity of the p97 AAA ATPase is critical for essential functions2011
- Author(s)
  Nishikori, S., Esaki, M., Yamanaka, K., Sugimoto, S., and Ogura, T.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume : 286 Pages : 15815-15820
- DOI
  10.1074/jbc.M110.201400
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012, KAKENHI-PROJECT-22880034, KAKENHI-PROJECT-23590521
[Journal Article] C. elegans UBX cofactors for CDC-48/p97 control spermatogenesis.2010
- Author(s)
  Sasagawa, Y., Yamanaka, K. Saito-Sasagawa, Y., and Ogura, T.
- Journal Title
  
  Genes Cells 15
  
  Pages : 1201-1215
- DOI
  10.1111/j.1365-2443.2010.01454.x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] AAA+ chaperone ClpX regulates dynamics of prokaryotic cytoskeletal protein FtsZ.2010
- Author(s)
  Sugimoto, S., Yamanaka, K., Nishikori, S., Miyagi, A., Ando, T., and Ogura, T.
- Journal Title
  
  J. Biol. Chem.
  
  Volume : 285 Pages : 6648-6657
- DOI
  10.1074/jbc.M109.080739
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] AAA+ chaperone ClpX regulates dynamics of prokaryotic cytoskeletal protein FtsZ.2010
- Author(s)
  Sugimoto, S., Yamanaka, K., Nishikori, S., Miyagi, A.,o, T., Ogura, T.
- Journal Title
  
  J. Biol. Chem. 285
  
  Pages : 6648-6657
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] Caenorhabditis elegans p97 controls germline-specific sex determination by controlling TRA-1 level in a CUL-2-dependent manner.2009
- Author(s)
  Sasagawa, Y., Otani, M., Higashitani, N., Higashitani, A., Sato, K., Ogura, T., and Yamanaka, K.
- Journal Title
  
  J. Cell Sci.
  
  Volume : 122 Pages : 3663-3672
- DOI
  10.1242/jcs.052415
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] Conserved aromatic and basic amino acid residues in the pore region of C. elegans spastin play critical roles in microtubule-severing.2009
- Author(s)
  Matsushita-Ishiodori, Y., Yamanaka, K., Hashimoto, H., Esaki, M., and Ogura, T.
- Journal Title
  
  Genes Cells
  
  Volume : 14 Pages : 925-940
- DOI
  10.1111/j.1365-2443.2009.01320.x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] Caenorhabditis elegans p97 controls germline-specific sex determination by controlling TRA-1 level in a CUL-2-dependent manner.2009
- Author(s)
  Sasagawa, Y., Otani, M., Higashitani, N., Higashitani, A., Sato, K., Ogura, T., Yamanaka, K.
- Journal Title
  
  J. Cell Sci. 122
  
  Pages : 3663-3672
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] onserved aromatic and basic amino acid residues in the pore region of C. elegans spastin play critical roles in microtubule-severing.2009
- Author(s)
  Matsushita-Ishiodori, Y., Yamanaka, K., Hashimoto, H., Esaki, M., Ogura, T.
- Journal Title
  
  Genes Cells 14
  
  Pages : 925-940
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] p97 homologs from C. elegans, CDC-48.1 and CDC-48.2, suppress the aggregate formation of huntingtin exon1 containing expanded polyQ repeat.2008
- Author(s)
  Nishikori, S., Yamanaka, K., Sakurai, T., Esaki, M., and Ogura, T.
- Journal Title
  
  Genes Cells
  
  Volume : 13 Pages : 827-838
- DOI
  10.1111/j.1365-2443.2008.01214.x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] From the common molecular basis of the AAA protein to various energy-dependent and -independent activities of AAA proteins.2008
- Author(s)
  Ogura, T., Matsushita-Ishiodori, Y., Johjima, A., Nishizono, M., Nishikori, S., Esaki, M., and Yamanaka, K.
- Journal Title
  
  Biochem. Soc. Trans.
  
  Volume : 36 Pages : 68-71
- DOI
  10.1042/BST0360068
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] Involvement of HMG-12 and CAR-1 in the cdc-48.1 expression of Caenorhabditis elegans.2008
- Author(s)
  Yamauchi, S., Higashitani, N., Otani, M., Higashitani, A., Ogura, T., and Yamanaka, K.
- Journal Title
  
  Dev. Biol.
  
  Volume : 318 Pages : 348-359
- DOI
  10.1016/j.ydbio.2008.02.057
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] T. p97 homologs from C. elegans, CDC-48. 1 and CDC-48. 2, suppress the aggregate formation of huntingtin exon1 containing expanded polyQ repeat.2008
- Author(s)
  Nishikori, S., Yamanaka, K., Sakurai, T., Esaki, M., Ogura, T.
- Journal Title
  
  Genes Cells 13
  
  Pages : 827-838
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] Differential expression pattern of UBX family genes in Caenorhabditis elegans.2007
- Author(s)
  Yamauchi, S., Sasagawa, Y., Ogura, T., and Yamanaka, K.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume : 358 Pages : 545-552
- DOI
  10.1016/j.bbrc.2007.04.163
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] Caenorhabditis elegans p97/CDC-48 is crucial for progression of meiosis I.2007
- Author(s)
  Sasagawa, Y., Yamanaka, K., Nishikori, S., and Ogura, T.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume : 358 Pages : 920-924
- DOI
  10.1016/j.bbrc.2007.05.022
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] The C. elegans homologue of the spastic paraplegia protein, spastin, disassembles microtubules.2007
- Author(s)
  Matsushita-Ishiodori, Y., Yamanaka, K., and Ogura, T.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume : 359 Pages : 157-162
- DOI
  10.1016/j.bbrc.2007.05.086
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] ER E3 ubiquitin ligase HRD-1 and its specific partner chaperone BiP play important roles in ERAD and developmental growth in C. Elegans.2007
- Author(s)
  Sasagawa, Y., Yamanaka, K., and Ogura, T.
- Journal Title
  
  Genes Cells
  
  Volume : 12 Pages : 1063-1073
- DOI
  10.1111/j.1365-2443.2007.01108.x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] ER E3 ubiquitin ligase HRD-1 and its specific partner chaperone BiP play important roles in ERAD and developmental growth in C. elegans.2007
- Author(s)
  Sasagawa, Y., Yamanaka, K., Ogura, T.
- Journal Title
  
  Genes Cells 12
  
  Pages : 1063-1073
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058012
[Journal Article] An AAA protease FtsH can initiate proteolysis from internal sites of a model substrate, apo-flavodoxin.2006
- Author(s)
  Okuno, T., Yamanaka, K., Ogura, T.
- Journal Title
  
  Genes Cells 11
  
  Pages : 261-268
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570147
[Journal Article] Analysis of the two p97/VCP/Cdc48p proteins of Caenorhabditis elegans and their suppression of polyglutamine-induced protein aggregation.2004
- Author(s)
  K. Yamanaka
- Journal Title
  
  J. Struct. Biol. 146
  
  Pages : 242-250
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14037256
[Journal Article] Analysis of the two p97/VCP/Cdc48p proteins of Caenorhabditis elegans and their suppression of polyglutamine・induced protein aggregation.2004
- Author(s)
  K. Yamanaka
- Journal Title
  
  J. Struct. Biol. 146
  
  Pages : 242-260
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-14037256
[Journal Article] 線虫を用いたAAA蛋白質に起因する神経変性疾患モデル2004
- Author(s)
  山中邦俊
- Journal Title
  
  蛋白質核酸酵素 49
  
  Pages : 1124-1126
- Data Source
  KAKENHI-PROJECT-14037256
[Journal Article] 線虫を用いたAAA蛋白質に起因する神経変性疾患モデル2004
- Author(s)
  山中邦俊
- Journal Title
  
  蛋白質核酸酵素 49
  
  Pages : 1124-1126
- Data Source
  KAKENHI-PROJECT-16570147
[Journal Article] Identification of a cysteine residue important for the ATPase activity of C.elegans fidgetin homologue.2004
- Author(s)
  Yakushiji, Y., Yamanaka, K., Ogura, T.
- Journal Title
  
  FEBS Lett. 578
  
  Pages : 191-197
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570147
[Journal Article] Analysis of the two p97/VCP/Cdc48p proteins of Caenorhabditis elegans and their suppression of polyglutamine-induced protein aggregation.2004
- Author(s)
  Yamanaka, K.
- Journal Title
  
  J.Struct.Biol. 146
  
  Pages : 242-250
- Data Source
  KAKENHI-PROJECT-16570147
[Journal Article] Analysis of the two p97/VCP/Cdc48p proteins of Caenorhabditis elegans and their suppression of polyglutamine-induced protein aggregation.2004
- Author(s)
  Yamanaka, K.
- Journal Title
  
  J.Struct.Biol. 146
  
  Pages : 242-250
- Data Source
  KAKENHI-PROJECT-14037256
[Journal Article] Flavodoxin, a new fluorescent substrate for monitoring proteolytic activity of FtsH lacking a robust unfolding activity.
- Author(s)
  Okuno, T., Yamanaka, K., Ogura, T.
- Journal Title
  
  J.Struc.Biol. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570147
[Journal Article] Mutational analysis of the functional motifs in the ATPase domain of C.elegans fidgetin homologue FIGL-1 : Firm evidence for an intersubunit catalysis mechanism of ATP hydrolysis by AAA ATPases.
- Author(s)
  Yakushiji, Y., Nishikori, S., Yamanaka, K., Ogura, T.
- Journal Title
  
  J.Struc.Biol. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570147
[Journal Article] Characterization of mutants of the Escherichia coli AAA protease, FtsH, carrying a mutation in the central pore region
- Author(s)
  Okuno, T., Yamanaka, K., Ogura, T.
- Journal Title
  
  J.Struc.Biol. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570147
[Presentation] Adaptors of p97 and disease-associated p97 mutations.2014
- Author(s)
  Yamanaka, K., Murayama, Y., and Ogura, T.
- Organizer
  231st IMEG seminars & Minisymposium
- Place of Presentation
  熊本市　熊本大学発生医学研究所
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] High-speed AFM imaging of the 26S proteasome dynamics.2014
- Author(s)
  Okuno, T., Noi, K., Okawa, A., Tsuchiya, H., Saeki, Y., Takahashi, K., Inobe, T., Yamanaka, K., and Ogura, T.
- Organizer
  231st IMEG seminars & Minisymposium
- Place of Presentation
  熊本市　熊本大学発生医学研究所
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] 高速AFMによる26Sプロテアソームのダイナミクス解析.2013
- Author(s)
  奥野貴士, 野井健太郎, 大川阿紀子, 土屋光, 佐伯泰, 高橋一暢, 伊野部智由, 山中邦俊, 小椋光
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸市、神戸国際展示場
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] 線虫を用いた疾患型変異CDC-48/p97/VCPの機能解析2013
- Author(s)
  山中邦俊, 村山佑樹, 小椋光
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸市、神戸国際展示場
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] Functional analysis of disease-associated mutant CDC-48/p97/VCP in C. elegans.2013
- Author(s)
  Yamanaka, K., Murayama, Y., and Ogura, T.
- Organizer
  EMBO Workshop on AAA+ Proteins
- Place of Presentation
  Commundo Hotel, Neuss, Germany.
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] Dynamics of p97 and the 26S proteasome in action revealed by high-speed atomic force microscopy.2013
- Author(s)
  Ogura, T., Noi, K., Okuno, T., Arita-Morioka, K., Yamamoto, D., Okawa, A., Tsuchiya, H., Saeki, Y., Ando, T., Esaki, M., and Yamanaka, K.
- Organizer
  EMBO Workshop on AAA+ Proteins
- Place of Presentation
  Commundo Hotel, Neuss, Germany.
- Invited
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] AAA chaperones, focusing on the molecular mecanism of p97.2013
- Author(s)
  Ogura, T., Noi, K., Arita-Morioka, K., Yamamoto, D., Ando, T., Nishikori, S., Esaki, M., and Yamanaka, K.
- Organizer
  EMBO Conference The biology of molecular chaperones
- Place of Presentation
  Margherita de Pula, Italy
- Invited
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] Multiple aspects of multifunctional p97.2011
- Author(s)
  Ogura, T., Noi, K., Arita-Morioka, K., Esaki, M., Murayama, Y., and Yamanaka, K.
- Organizer
  9th International Conference on AAA Protein
- Place of Presentation
  熊本市国際交流会館, Kumamoto, Japan.
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] C. elegans CDC-48/p97 controls germline-specific sex determination.2010
- Author(s)
  Yamanaka, K., Sasagawa, Y., and Ogura, T.
- Organizer
  BIT Life Sciences' 3rd Annual Protein and Peptide Conference (PepCon-2010)
- Place of Presentation
  Beijing, China
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] 線虫を用いたp97/VCP/CDC48の機能解析2010
- Author(s)
  山中邦俊
- Organizer
  新潟脳神経研究会第290回例会
- Place of Presentation
  新潟大学脳研究所新潟
- Year and Date
  2010-06-04
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] Involvement of C.elegans p97-cofactor complexes in sex determination.2010
- Author(s)
  Yamanaka, K.
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  ホテル日航奈良Nara, Japan
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] Involvement of C. elegans p97-cofactor complexes in sex determination.2010
- Author(s)
  Yamanaka, K., Sasagawa, Y., Murayama, Y., and Ogura, T.
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  ホテル日航奈良, Nara, Japan
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] C.elegans CDC-48/p97 controls germline-specific sex determination.2010
- Author(s)
  Yamanaka, K.
- Organizer
  BIT Life Sciences' 3rd Annual Protein and Peptide Conference (PepCon-2010)
- Place of Presentation
  International Convention Center, Beijing, China
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] Roles of p97/VCP, a multifunctional AAA chaperone, in protein oligomerization and aggregation in neurodegenerative diseases.2009
- Author(s)
  Ogura, T., Nishikori, S., Yamanaka, K., and Esaki, M.
- Organizer
  BIT Life Sciences' 2_<nd> Annual Protein and Peptide Conference (PepCon-2009)
- Place of Presentation
  Seoul, South Korea
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] Molecular mechanisms of homologs of spastin and p97/VCP related to human genetic disorders.2009
- Author(s)
  Ogura, T., Matsushita-Ishiodori, Y., Yamanaka, K., Nishikori, S., and Esaki, M.
- Organizer
  8th International Conference on AAA Proteins
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] C.elegans p97/CDC-48UFD-1-NPL-4 controls germline specific sex determination by regulating CUL-2-mediated TRA-1 degradation.2009
- Author(s)
  Yamanaka, K.
- Organizer
  8th International Conference on AAA Proteins
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] p97/CDC-48.1による線虫生殖細胞の性決定の制御2008
- Author(s)
  山中邦俊
- Organizer
  第31回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] Functional analysis of p97NCP in C. elegans.2007
- Author(s)
  Yamanaka, K.
- Organizer
  The 7th International conference on AAA proteins
- Place of Presentation
  Cirencester, UK
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] C. elegans p97, HRD-1 and BiP are required for ERAD and developmental growth.2007
- Author(s)
  Yamanaka, K.
- Organizer
  16th biennial International C. elegans conference
- Place of Presentation
  UCLA, USA.
- Data Source
  KAKENHI-PLANNED-19058012
[Presentation] ヒト疾患関連AAAタンパク質BCS1Lの酵母ホモログBcs1pの機能解析
- Author(s)
  澤村理英、江崎雅俊、山中邦俊、小椋光
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜市　パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] ポリグルタミン凝集体形成における線虫CDC-48 C末端アダプターの役割
- Author(s)
  村山佑樹、小椋光、山中邦俊
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜市　パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24370056
[Presentation] Visualization of dynamics of the 26S proteasome and proteasome-substrate complexes by high-speed AFM
- Author(s)
  Okuno, T., Noi, K., Okawa, A., Tsuchiya, H., Saeki, Y., Takahashi, K., Inobe, T., Yamanaka, K., and Ogura, T.
- Organizer
  Key Forum: From Stem Cells to Organs
- Place of Presentation
  熊本市　熊本市医師会館
- Year and Date
  2014-09-04 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-24370056

1. OGURA Teru (00158825)

# of Collaborated Projects : 14results

# of Collaborated Products : 42results
2. HIRAGA Sota (40027321)

# of Collaborated Projects : 8results

# of Collaborated Products : 0results
3. NIKI Hironori (70208122)

# of Collaborated Projects : 7results

# of Collaborated Products : 0results
4. YAMAZOE Mitsuyoshi (00284745)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
5. ESAKI Masatoshi (70437911)

# of Collaborated Projects : 3results

# of Collaborated Products : 14results
6. ALINE Jaffe

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
7. 植田光晴 (60452885)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
8. 水口峰之 (30332662)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
9. JAFFE Aline

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
10. BERND Bukau

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
11. OKUNO Takashi (80411031)

# of Collaborated Projects : 1results

# of Collaborated Products : 4results
12. 北岡光彦 (30117345)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. 前田英雄 (90094044)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
14. 森浩禎 (90182203)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
15. 野井健太郎 (30588405)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
16. BEGG Kenneth j.

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
17. VINELLA Daniel

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
18. BOULOC Philippe

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
19. DONACHIE Wil

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
20. DONACHIE William d.

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
21. KENIIETH J.B

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
22. WILLIAM.D.DO ドナヒー

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
23. DANIEL Vinel

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
24. PHILIPPE Bou

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
25. CUTTING Simo

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
26. SCHUMANN Wol

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
27. RUTMAN Andre

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
28. AMOS Oppenhe

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
29. BUKAU Bernd

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
30. SIMON Cutting

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
31. WOLFGANG Schumann

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
32. ANDREW Joel Rutman

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
33. OPPENHEIM Amos B

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
34. SIMON Cuttin

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
35. WOLFGANG Sch

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
36. ANDREW JOEL

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
37. OPPENHEIM Am

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
38. 杉本真也

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
39. 東谷篤志

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

YAMANAKA Kunitoshi 山中 邦俊

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根治療法の切り札アミロイド・ブレイカー開発とそれを用いた毒性メカニズム探求Ongoing

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リング状AAA型シャペロンの基質への作用機構のin vitro系による解明Ongoing

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AAA型シャペロンCDC-48の新規制御機構「クリップモデル」の検証Principal InvestigatorOngoing

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TTRの断片化を活用したFAP病態解明へのブレイクスルーと新規疾患モデル構築Ongoing

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Molecular analysis of C.elegans AAA proteins related to genetic diseases and developmental disordersPrincipal Investigator

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Molecular and cellular biology of C. elegans AAA proteins involved in human genetic diseasesPrincipal Investigator

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大腸菌染色体分配に関与するDNA結合因子の遺伝生化学的解析Principal Investigator

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YAMANAKA Kunitoshi 山中邦俊