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ISHIBASHI Shun  石橋 俊

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… Alternative Names

石橋 俊  イシバシ シユン

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Researcher Number 90212919
Other IDs
Affiliation (Current) 2025: 自治医科大学, 医学部, 客員教授
Affiliation (based on the past Project Information) *help 2022 – 2023: 自治医科大学, 医学部, 客員教授
2005 – 2021: 自治医科大学, 医学部, 教授
2001: Jichi Medical University, Internal Medicine, Professor, 医学部, 教授
1996 – 2001: University of Tokyo, Faculty of Medicine, Research Associate, 医学部・附属病院, 助手
1999: 東京大学, 医学部・付属病院, 助手 … More
1999: 東京大学, 糖尿病代謝内科, 助手
1996 – 1998: 東京大学, 医学部附属病院, 助手
1997: 東京大学, 医科部・附属病院, 助手
1993 – 1995: 東京大学, 医学部(病), 助手
1989: 東京大学, 医学部(病)第三内科, 助手 Less
Review Section/Research Field
Principal Investigator
Metabolomics / Metabolomics / 内分泌・代謝学 / Basic Section 54040:Metabolism and endocrinology-related / Biological Sciences
Except Principal Investigator
内分泌・代謝学 / Metabolomics / Metabolomics / Digestive surgery / Chemical pharmacy / Biological Sciences
Keywords
Principal Investigator
コレステロール / マクロファージ / 動脈硬化 / ノックアウトマウス / 肥満 / リパーゼ / ホルモン感受性リパーゼ / HMG-CoA還元酵素 / オキシステロール / アポトーシス … More / 糖尿病 / ジーンターゲティング / Cholesterol / ノックアウト / 肝臓 / マウス / ACAT / トランスジェニックマウス / 脂肪酸 / トリグリセリド / 細胞死 / スクアレン合成酵素 / スクワレン合成酵素 / ノックアウアトマウス / アデノウイルス / リポタンパクリパーゼ / LDLレセプター / 遺伝子治療 / 酵素 / トランスジェニック / 泡沫細胞 / 小胞体ストレス / 脂肪組織 / インスリン抵抗性 / 脂肪細胞 / 膵β細胞 / ブドウ糖 / インスリン / Bcl-2 / 酸化LDL / プラーク / アポリポタンパクE / リポタンパク / 炎症 / インスリン抵抗生 / インスリン感受性 / 低分子G蛋白 / 脂肪肝 / 遺伝子 / 動物 / 脂質 / β細胞 / ランゲルハンス島 / コレステロール合成 / グルカゴン / スタチン / liver dysfunction / knockout / mouse / albumin / liver / squalene synthase / HMG-CoA reductase / cholesterol / 細胞増殖 / ミエリン / 血管平滑筋細胞 / 肝障害 / アルブミン / IMG-CoA還元酵素 / hormone-sensitive lipase / adenovirus / gene targeting / atherosclerosis / コレステロールエステル / アデノウィルス / catecholamoine / Free fatty acids / Infertility / Triacylglycerol / Hormone-sensitive lipase / Adipocytes / Obesity / カテコラミン / 遊離脂肪酸 / 不妊 / Neural tube defect / Farneso1 / Hedgehog / Knockout mouse / Gene targeting / Squalene synthase / Development / キメラマウス / ES細胞 / ターゲティング / HMGCoA還元酵素 / 発生分化 / 神経管閉鎖不全 / ヘッジホッグ / 先天奇形 / スクワレン / Trasgenic / Knockout / Lipoprotein lipase / Apolipoprotein / Lipoprotein / Triglyceride / Atherosclerosis / 高脂血症 / 細胞間質 / レムナント / アポタンパク / asiaoglycoprotein receptor / apolipoprotein E / low density lipoprotein receptor / lipoprotein lipase / knockout mice / transgenic mice / familial hypercholesterolemia / gene therapy / コレステロール 7α-ヒドロキシラーゼ / 肝幹細胞 / Bcl2 / コレステロール7α水酸化酵素 / 相同的組換え / 移植 / シアル酸 / ガラクトース / アシアロ糖蛋白受容体 / アシアロ糖タンパクレセプター / アポリポタンパク / 家族性高コレステロール血症 / エステル / 小胞体 / 加水分解 / NCEH1 / ERストレス / 脂質代謝異常 / 摂食調節 / メタボリックシンドローム / 遺伝子発現 / ヒト / トリグリセライド / 脂肪毒性 / トリグリセライド水解酵素 / リバーゼ / トリングリセライド / メバロン酸 / ミトコンドリア / caspase 3 / CPP32 / カイロミクロンレムナント、 / トリグリセリド、 / リポタンパクリパーゼ、 / LDLレセプター、 / ノックアウトマウス、 / 動脈硬化、 / リポタンパク代謝、 / LDL受容体 / アポE … More
Except Principal Investigator
動脈硬化 / atherosclerosis / マクロファージ / 脂質代謝 / インスリン抵抗性 / 糖尿病 / QTL / M-CSF / ACAT / Atheroscherosis / Molecular engineering / ノックアウトマウス / LPL / 発生工学 / リポ蛋白リパーゼ / 動脈硬化症 / 遺伝子 / アポE / Cardiomyopathy / Lipase / Steatosis / Diabetic Cardiomvonathv / 心筋症 / リパーゼ / 脂肪蓄積 / Chromosome 9 / Gene / Animal model / Insulin resistance / キヌレニン / 高血圧 / ラット / QTL解析 / SHR / 9番染色体 / モデル動物 / transcription / fatty acid / insulin resistance / SREBP / 脂肪酸 / Bcl2 (anti-apoptotic gene) / adenovirus / insulin / transplantation / pancreas / 膵臓移植 / 拒絶反応 / Bcl_2 / アデノウィルス / インスリン / アポトーシス / Bcl2 / アデノウイルス / 膵移植 / knockout mouse / hormone-sensitive lipase / obesity / ホルモン感受性リパーゼ / 肥満 / smooth / macrophage / foam cell / 平滑筋細胞 / 泡沫細胞 / Hormone-sensitive lipase / Gene targeting / コレステロール / 遺伝子ターゲティング / 分子工学 / gene therapy / LDL receptor / Apo E / ジーンターゲティング / 高脂血症 / リポタンパクリパーゼ / LDL受容体 / トランスジェニックマウス / 遺伝子治療 / LDLレセプター / 肝臓 / 粥状動脈硬化症 / 泡沫化 / コレステロールエステル / ACATアイソザイム / 医療・福祉 / ケミカルバイオロジー / ACAT アイソザイム / がん / トコフェロール / ビタミンE / 遺伝子診断 / 合併症 / リポ蛋白 / LDLレセプタ- / 神経再生 / 糖尿病性神経症 / アポリポ蛋白 Less
  • Research Projects

    (32 results)
  • Research Products

    (69 results)
  • Co-Researchers

    (42 People)
  •  Elucidation of the mechanisms of alleviation of insulin resistance and hepatic steatosis by modulating cholesterol metabolism in myeloid cellsPrincipal Investigator

    • Principal Investigator
      Ishibashi Shun
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Jichi Medical University
  •  Diabetes mellitus induced by inhibition of cholesterol synthesis: clarification of the pathogenesis and development of its therapyPrincipal Investigator

    • Principal Investigator
      Ishibashi Shun
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Jichi Medical University
  •  Development of a novel therapy for atherosclerosis based on alleviation of lipotoxicity of macrophagesPrincipal Investigator

    • Principal Investigator
      ISHIBASHI SHUN
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Metabolomics
    • Research Institution
      Jichi Medical University
  •  The roles of hepatic lipoprotein lipase and its regulating factors on the hepatic lipotoxicity

    • Principal Investigator
      YAGYU Hiroaki
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Jichi Medical University
  •  Genetic analysis of molecular mechanisms of foam cell formation in atherosclerosis

    • Principal Investigator
      OSUGA JUN-ICHI
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Jichi Medical University
  •  Study on the endoplasmic stress induced by oxsterol ester and its implication to diseasesPrincipal Investigator

    • Principal Investigator
      ISHIBASHI Shun
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Metabolomics
    • Research Institution
      Jichi Medical University
  •  摂食調節におけるホルモン感受性リパーゼの意義Principal Investigator

    • Principal Investigator
      石橋 俊
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Metabolomics
    • Research Institution
      Jichi Medical University
  •  脂肪細胞内lipolysisの分子機構Principal Investigator

    • Principal Investigator
      石橋 俊
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Jichi Medical University
  •  Discovery and development of selectivity-defined inhibitors toward two acyl-CoA : cholesterol acyltransferase isozymes

    • Principal Investigator
      TOMODA Hiroshi
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Kitasato University
  •  The role of macrophage lipoprotein lipase on the development of atherosclerosis

    • Principal Investigator
      YAGYU Hiroaki
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Jichi Medical University
  •  膵β細胞脂肪毒性解除による新規2型糖尿病治療法の開発Principal Investigator

    • Principal Investigator
      石橋 俊
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Metabolomics
    • Research Institution
      Jichi Medical University
  •  Elucidation of novel functions of cholesterol and its metabolites using genetic manipulation in micePrincipal Investigator

    • Principal Investigator
      ISHIBASHI Shun
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Metabolomics
    • Research Institution
      Jichi Medical University
  •  Function of hormone-sensitive lipase in the development of diabetic cardiomyopathy

    • Principal Investigator
      SUZUKI Jinya
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      University of Fukui
  •  ビタミンE転送蛋白質遺伝子と発ガンリスクの個体差に関する分子疫学的研究

    • Principal Investigator
      GOTODA Takanari
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Genetic analysis of the molecular basis of insulin resistance both in animal models and in humans.

    • Principal Investigator
      GOTODA Takanari
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Metabolomics
    • Research Institution
      Tokyo Woman's Medical University
      The University of Tokyo
  •  New therapeutic targets for atherosclerotic plaques - The role of acyl CoA : cholesterol acyltransferase and neutral cholesterol ester hydrolase in foam cell formationPrincipal Investigator

    • Principal Investigator
      ISHIBASHI Shun
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Metabolomics
    • Research Institution
      The University of Tokyo
  •  Roles of fatty acids in pathogenesis of insulin resisitance and atherosclerosis

    • Principal Investigator
      YAMADA Nobuhiro
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Metabolomics
    • Research Institution
      University of Tsukuba
  •  Transgenic study on the heterogeneity of intacellular triacylglycerol lipasePrincipal Investigator

    • Principal Investigator
      ISHIBASHI Shun
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Metabolomics
    • Research Institution
      University of Tokyo
  •  アポトーシスの誘導と死細胞除去におけるオキシステロールの役割Principal Investigator

    • Principal Investigator
      石橋 俊
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Metabolomics
    • Research Institution
      The University of Tokyo
  •  Development of a novel animal model to investigate the role of cholesterol metabolism in the development and differentiationPrincipal Investigator

    • Principal Investigator
      ISHIBASHI Shun
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Metabolomics
    • Research Institution
      The University of Tokyo
  •  Adenovirus-mediated anti-apoptotic gene (bcl-2) transfer in the transplant pancreas

    • Principal Investigator
      MAKUUCHI Masatoshi, 青柳 信嘉
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Tokyo University
  •  プラークの形成と破綻における泡沫細胞の細胞死の役割を解明するためのモデルの樹立Principal Investigator

    • Principal Investigator
      石橋 俊
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  糖尿病性血管合併症に特異的な遺伝子マーカーの分離同定

    • Principal Investigator
      山田 信博
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      内分泌・代謝学
    • Research Institution
      The University of Tokyo
  •  Molecular biology of form cell generation in atherosclerosis

    • Principal Investigator
      YAMADA Nobuhiro
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内分泌・代謝学
    • Research Institution
      University of Tokyo
  •  Study on the role of arterial retention of lipoprotein and its regulators in the development of atheroselerosisPrincipal Investigator

    • Principal Investigator
      ISHIBASHI Syun
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内分泌・代謝学
    • Research Institution
      The University of Tokyo
  •  Development of animal models for atherosclerosis and obesity, and molecular mechanism of the common pathway

    • Principal Investigator
      YAMADA Nobuhiro
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内分泌・代謝学
    • Research Institution
      University of Tokyo
  •  動脈硬化形成における小腸由来リポタンパクに関する発生工学的研究Principal Investigator

    • Principal Investigator
      石橋 俊
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内分泌・代謝学
    • Research Institution
      The University of Tokyo
  •  ノックアウトマウスを用いた生体内コレステロール輸送の解析Principal Investigator

    • Principal Investigator
      石橋 俊
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内分泌・代謝学
    • Research Institution
      The University of Tokyo
  •  Gene targeting study on mechanisms for cholesterol accumulation in the artery

    • Principal Investigator
      YAMADA Nobuhiro
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内分泌・代謝学
    • Research Institution
      University of Tokyo
  •  Development of basic techniques for the liver-directed gene therapyPrincipal Investigator

    • Principal Investigator
      ISHIBASHI Shun
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      内分泌・代謝学
    • Research Institution
      University of Tokyo
  •  Establishment of animal models for atheroscherosis and gene therapy

    • Principal Investigator
      YAMADA Nobuhiro
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      内分泌・代謝学
    • Research Institution
      University of Tokyo
  •  糖尿病性神経症におけるアポEの役割

    • Principal Investigator
      YAMADA Nobuhiro
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内分泌・代謝学
    • Research Institution
      The University of Tokyo

All 2022 2021 2020 2019 2018 2017 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book Other

  • [Book] Hormone-sensitive lipase is involved in hepatic cholesterol ester hydrolysis

    • Author(s)
      Sekiya, M., Osuga, JI., Yahagi, N., Okazaki, H., Tamura, Y., Igarashi, M., Takase, S., Harada, K., Okazaki, S., Iizuka, Y., Ohashi, K., Yagyu, H., Okazaki, M., Gotoda, T., Nagai, R., Kadowaki, T., Shimano, H., Yamada, N., Ishibashi, S
    • Publisher
      J Lipid Res in press
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390266
  • [Journal Article] Loss of myeloid lipoprotein lipase exacerbates adipose tissue fibrosis with collagen VI deposition and hyperlipidemia in leptin-deficient obese mice2022

    • Author(s)
      Takahashi M, Yamamuro D, Wakabayashi T, Takei A, Takei S, Nagashima S, Okazaki H, Ebihara K, Yagyu H, Takayanagi Y, Onaka T, Goldberg IJ, Ishibashi S.
    • Journal Title

      J Biol Chem

      Volume: 298 Issue: 9 Pages: 102322-102322

    • DOI

      10.1016/j.jbc.2022.102322

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08892, KAKENHI-PROJECT-20K08870, KAKENHI-PROJECT-23K21443, KAKENHI-PROJECT-19H03712
  • [Journal Article] AAA-ATPase valosin-containing protein binds the transcription factor SREBP1 and promotes its proteolytic activation by rhomboid protease RHBDL4.2022

    • Author(s)
      Shibuya K, Ebihara K, Ebihara C, Sawayama N, Isoda M, Yamamuro D, Takahashi M, Nagashima S, Ishibashi S
    • Journal Title

      J Biol Chem

      Volume: 298 Issue: 6 Pages: 101936-101936

    • DOI

      10.1016/j.jbc.2022.101936

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08892, KAKENHI-PROJECT-20K08870, KAKENHI-PROJECT-19H03712
  • [Journal Article] Leptin sensitizing effect of 1,3-butanediol and its potential mechanism2021

    • Author(s)
      Masayo Isoda, Ken Ebihara, Nagisa Sawayama, Akiko Murakami, Chihiro Ebihara, Koji Shibuya, Akihito Takei, Shoko Takei, Tetsuji Wakabayashi, Daisuke Yamamuro , Manabu Takahashi, Shuichi Nagashima, Shun Ishibashi
    • Journal Title

      Sci Report

      Volume: 11 Issue: 1 Pages: 17691-17691

    • DOI

      10.1038/s41598-021-96460-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03712, KAKENHI-PROJECT-20K08892
  • [Journal Article] Peripheral circadian rhythms in the liver and white adipose tissue of mice are attenuated by constant light and restored by time-restricted feeding2020

    • Author(s)
      Yamamuro Daisuke、Takahashi Manabu、Nagashima Shuichi、Wakabayashi Tetsuji、Yamazaki Hisataka、Takei Akihito、Takei Shoko、Sakai Kent、Ebihara Ken、Iwasaki Yusaku、Yada Toshihiko、Ishibashi Shun
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 6 Pages: e0234439-e0234439

    • DOI

      10.1371/journal.pone.0234439

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08892, KAKENHI-PROJECT-19K22611, KAKENHI-PROJECT-19H04045, KAKENHI-PROJECT-17K09865, KAKENHI-PROJECT-19H03712
  • [Journal Article] β-Cell-specific deletion of HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase causes overt diabetes due to reduction of β-cell mass and impaired insulin secretion.2020

    • Author(s)
      Takei Shoko, Nagashima Shuichi, Takei Akihito, Yamamuro Daisuke, Wakabayashi Tetsuji, Murakami Akiko, Isoda Masayo, Yamazaki Hisataka, Ebihara Chihiro, Takahashi Manabu, Ebihara Ken, Dezaki Katsuya, Takayanagi Yuki, Onaka Tatsushi, Fujiwara Ken, Yashiro Takashi, Ishibashi Shun
    • Journal Title

      Diabetes

      Volume: 69 Issue: 11 Pages: 2352-2363

    • DOI

      10.2337/db19-0996

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08524, KAKENHI-PROJECT-20K07249, KAKENHI-PROJECT-20K08892, KAKENHI-PROJECT-17K08517, KAKENHI-PROJECT-17K09865, KAKENHI-PROJECT-19H03712
  • [Journal Article] Myeloid HMG-CoA Reductase Determines Adipose Tissue Inflammation, Insulin Resistance, and Hepatic Steatosis in Diet-Induced Obese Mice2019

    • Author(s)
      Takei Akihito、Nagashima Shuichi、Takei Shoko、Yamamuro Daisuke、Murakami Akiko、Wakabayashi Tetsuji、Isoda Masayo、Yamazaki Hisataka、Ebihara Chihiro、Takahashi Manabu、Ebihara Ken、Ishibashi Shun
    • Journal Title

      Diabetes

      Volume: 69 Issue: 2 Pages: 158-164

    • DOI

      10.2337/db19-0076

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03712
  • [Journal Article] Inflammasome Activation Aggravates Cutaneous Xanthomatosis and Atherosclerosis in ACAT1 (Acyl-CoA Cholesterol Acyltransferase 1) Deficiency in Bone Marrow2018

    • Author(s)
      Wakabayashi Tetsuji、Takahashi Manabu、Yamamuro Daisuke、Karasawa Tadayoshi、Takei Akihito、Takei Shoko、Yamazaki Hisataka、Nagashima Shuichi、Ebihara Ken、Takahashi Masafumi、Ishibashi Shun
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology

      Volume: 38 Issue: 11 Pages: 2576-2589

    • DOI

      10.1161/atvbaha.118.311648

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08485, KAKENHI-PROJECT-16K09789
  • [Journal Article] Myeloid HMG-CoA (3-Hydroxy-3-Methylglutaryl-Coenzyme A) Reductase Determines Atherosclerosis by Modulating Migration of Macrophages2018

    • Author(s)
      Sakai Kent、Nagashima Shuichi、Wakabayashi Tetsuji、Tumenbayar Bayasgalan、Hayakawa Hiroko、Hayakawa Morisada、Karasawa Tadayoshi、Ohashi Ken、Yamazaki Hisataka、Takei Akihito、Takei Shoko、Yamamuro Daisuke、Takahashi Manabu、Yagyu Hiroaki、Osuga Jun-ichi、Takahashi Masafumi、Tominaga Shin-ichi、Ishibashi Shun
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology

      Volume: 38 Issue: 11 Pages: 2590-2600

    • DOI

      10.1161/atvbaha.118.311664

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08485, KAKENHI-PROJECT-16K09789, KAKENHI-PROJECT-17K09865
  • [Journal Article] Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy.2015

    • Author(s)
      Osaki Y, Nakagawa Y, Miyahara S, Iwasaki H, Ishii A, Matsuzaka T, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Sone H, Ohashi K, Ishibashi S, Yamada N, Shimano H
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 466(3) Issue: 3 Pages: 536-540

    • DOI

      10.1016/j.bbrc.2015.09.065

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15344, KAKENHI-PROJECT-15H02541, KAKENHI-PROJECT-15H03093, KAKENHI-PROJECT-13J00607, KAKENHI-PROJECT-26560391, KAKENHI-PROJECT-26560392, KAKENHI-PROJECT-25293213, KAKENHI-PLANNED-23116006, KAKENHI-PROJECT-15H03092
  • [Journal Article] New pyripyropene derivatives, highly SOAT2-selective inhibitors, improve hypercholesterolemia and atherosclerosis in atherogenic mouse model.2015

    • Author(s)
      Ohshiro, T.; Ohtawa, M.; Nagamitsu, T.; Matsuda, D.; Yagyu, H.; Davis, M. A.; Rudel, L. L.; Ishibashi, S.; Tomoda, H.
    • Journal Title

      Journal of Pharmacology and Experimental Therapeutics

      Volume: 355 Issue: 2 Pages: 299-309

    • DOI

      10.1124/jpet.115.227348

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25460152, KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26253009
  • [Journal Article] Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver.2015

    • Author(s)
      Nagashima S, Yagyu H, Tozawa R, Tazoe F, Takahashi M, Kitamine T, Yamamuro D, Sakai K, Sekiya M, Okazaki H, Osuga J, Honda A, Ishibashi S.
    • Journal Title

      J Lipid Res

      Volume: 56 Issue: 5 Pages: 998-1005

    • DOI

      10.1194/jlr.m057406

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533
  • [Journal Article] Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages2014

    • Author(s)
      Sakai K, Igarashi M, Yamamuro D, Ohshiro T, Nagashima S, Takahashi M, Enkhtuvshin B, Sekiya M, Okazaki H, Osuga J, Ishibashi S.
    • Journal Title

      J Lipid Res

      Volume: 55 Issue: 10 Pages: 2033-2040

    • DOI

      10.1194/jlr.m047787

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533
  • [Journal Article] Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages.2014

    • Author(s)
      Sekiya M, Yamamuro D, Ohshiro T, Honda A, Takahashi M, Kumagai M, Sakai K, Nagashima S, Tomoda H, Igarashi M, Okazaki H, Yagyu H, Osuga J, Ishibashi S.
    • Journal Title

      J Lipid Res

      Volume: 55 Issue: 10 Pages: 2082-2092

    • DOI

      10.1194/jlr.m050864

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533, KAKENHI-PROJECT-26253009
  • [Journal Article] Macrophage lipoprotein lipase modulates the development of atherosclerosis but not adiposity2013

    • Author(s)
      Takahashi M, Yagyu H, Tazoe F, Nagashima S, Ohshiro T, Okada K, Osuga J, Goldberg IJ, Ishibashi S.
    • Journal Title

      J Lipid Res

      Volume: 54(4) Issue: 4 Pages: 1124-34

    • DOI

      10.1194/jlr.m035568

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390187, KAKENHI-PROJECT-23591339, KAKENHI-PROJECT-25293213
  • [Journal Article] Apolipoprotein C-II deficiency with no rare variant in the APOC2 gene2013

    • Author(s)
      Takase S, Osuga J, Fujita H, Hara K, Sekiya M, Igarashi M, Takanashi M, Takeuchi Y, Izumida Y, Ohta K, Kumagai M, Nishi M, Kubota M, Masuda Y, Taira Y, Okazaki S, Iizuka Y, Yahagi N, Ohashi K, Yoshida H, Yanai H, Tada N, Gotoda T, Ishibashi S, Kadowaki T, Okazaki H
    • Journal Title

      J Atheroscler Thromb

      Volume: 20(5)(Epub 2013 Mar 7) Pages: 481-93

    • NAID

      130004444688

    • URL

      https://www.jstage.jst.go.jp/article/jat/20/5/20_16592/_article

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591339
  • [Journal Article] Current smoking status may be associated with overt albuminuria in female patients with type 1 diabetes mellitus: a cross-sectional study.2012

    • Author(s)
      Okada K, Osuga J, Kotani K, Yagyu H, Miyamoto M, Nagasaka S, Ishibashi S.
    • Journal Title

      Tob Induc Dis.

      Volume: 10 Issue: 1 Pages: 12-12

    • DOI

      10.1186/1617-9625-10-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591339
  • [Journal Article] Liver-specific deletion of 3-hydroxy-3-methylglutaryl coenzyme A reductase causes hepatic steatosis and death.2012

    • Author(s)
      Nagashima S, Yagyu H, Ohashi K, Tazoe F, Takahashi M, Ohshiro T, Bayasgalan T, Okada K, Sekiya M, Osuga J, Ishibashi S.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 32(8) Issue: 8 Pages: 1824-31

    • DOI

      10.1161/atvbaha.111.240754

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390187, KAKENHI-PROJECT-23591339
  • [Journal Article] Ezetimibe, an inhibitor of Niemann-Pick C1-like 1 protein, decreases cholesteryl ester transfer protein in type 2 diabetes mellitus.2012

    • Author(s)
      Yagyu H, Nagashima S, Takahashi M, Miyamoto M, Okada K, Osuga J, Ishibashi S.
    • Journal Title

      Endocr J.

      Volume: 59 Pages: 1077-1084

    • NAID

      10031146718

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591339
  • [Journal Article] The role of neutral cholesterol ester hydrolysis in macrophage foam cells2011

    • Author(s)
      Sekiya M, Osuga J, Igarashi M, Okazaki H, Ishibashi S
    • Journal Title

      J Atheroscler Thromb

      Volume: 18(5)(Epub 2011 Apr 6) Pages: 359-64

    • NAID

      130004845376

    • URL

      https://www.jstage.jst.go.jp/article/jat/18/5/18_7013/_article

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591339
  • [Journal Article] Depot-Specific Expression of Lipolytic Genes in Human Adipose Tissues.2011

    • Author(s)
      Nagashima S, Yagyu H, Kurashina T, Ishibashi S, et al
    • Journal Title

      J Atheroscler Thromb.

      Volume: 18 Pages: 190-199

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20659147
  • [Journal Article] Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement.2011

    • Author(s)
      Ohta K, Yagyu H, Ishibashi S, Osuga J, et al
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 404 Pages: 254-260

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20659147
  • [Journal Article] an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia.2011

    • Author(s)
      Ohshiro T, Matsuda D, Sakai K, Degirolamo C, Yagyu H, Rudel LL, Omura S, Ishibashi S, Tomoda H. Pyripyropene A
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 31(5) Issue: 5 Pages: 1108-15

    • DOI

      10.1161/atvbaha.111.223552

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390187
  • [Journal Article] Molecular analysis of a novel LCAT mutation (Gly179→Arg) found in a patient with complete LCAT deficiency2011

    • Author(s)
      Wang XL, Osuga J, Tazoe F, Okada K, Nagashima S, Takahashi M, Ohshiro T, Bayasgalan T, Yagyu H, Okada K, Ishibashi S
    • Journal Title

      J Atheroscler Thromb

      Volume: 18(8)(Epub 2011 May 20) Pages: 713-9

    • NAID

      130004444539

    • URL

      https://www.jstage.jst.go.jp/article/jat/18/8/18_8003/_article

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591339
  • [Journal Article] Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence2010

    • Author(s)
      Igarashi M, Osuga J, Ishibashi S, et al
    • Journal Title

      J Lipid Res 51

      Pages: 274-285

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20659147
  • [Journal Article] The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages.2010

    • Author(s)
      Igarashi M, Osuga J, Nagashima S, Ishibashi S, et al
    • Journal Title

      Circ Res.

      Volume: 107 Pages: 1387-1395

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20659147
  • [Journal Article] Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis2009

    • Author(s)
      Sekiya M, Osuga J, Ishibashi S, et al
    • Journal Title

      Cell Metab 10

      Pages: 219-228

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20659147
  • [Journal Article] Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lep(ob)(/)(ob)mice2009

    • Author(s)
      Sekiya M, Yahagi H, Ishibashi S, et al
    • Journal Title

      Biochem Biophys Res Commun 387

      Pages: 511-515

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20659147
  • [Journal Article] Induction of ABCA1 by overexpression of hormone-sensitive lipase in macrophages.2008

    • Author(s)
      Tazoe F, Ishibashi S, et al
    • Journal Title

      Biochem Biophys Res Commun 376

      Pages: 111-115

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20659147
  • [Journal Article] Hormone-sensitive lipase is involved in hepatic cholesterol ester hydrolysis.2008

    • Author(s)
      Sekiya M, Ishibashi S, et al
    • Journal Title

      J Lipid Res 49

      Pages: 1829-1838

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20659147
  • [Journal Article] Leptin inhibits and ghrelin augments hypothalamicnoradrenalin release after stress.2008

    • Author(s)
      Kawakami A, Ishibashi S, Onaka T, et al
    • Journal Title

      Stress 11

      Pages: 363-369

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20659147
  • [Journal Article] Ligand-independent activation of vascular endothelial growth factor receptor 1 by low-density lipoprotein.2007

    • Author(s)
      Usui, R., Ishibashi, S., et. al.
    • Journal Title

      EMBO Rep 8

      Pages: 1155-1161

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390266
  • [Journal Article] Sterol regulatory element-binding protein(SREBP) -1-independent regulation of lipogenic gene expression in adipocytes2007

    • Author(s)
      Sekiya, M., Yahagi, N., Matsuzaka, T., Takeuchi, Y., Nakagawa, Y., Takahashi, H., Okazaki, H., Iizuka Y, Ohashi, K., Gotoda, T., Ishibashi, S., Nagai, R., Yamazaki, T., Kadowaki, T., Yamada, N., Osuga, JI., Shimano, H
    • Journal Title

      J Lipid Res 48(7)

      Pages: 1581-1591

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390266
  • [Journal Article] Sterol regulatory element-binding protein (SREBP)-1-independent regulation of lipogenic gene expression in adipocytes.2007

    • Author(s)
      Sekiya, M., Ishibashi, S., et. al.
    • Journal Title

      J Lipid Res 48

      Pages: 1581-1591

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18052017
  • [Journal Article] Sterol regulatory element-binding protein(SREBP)-1-independent regulation of lipogenic gene expression in adipocytes.2007

    • Author(s)
      Sekiya, M., Ishibashi, S., et. al.
    • Journal Title

      J Lipid Res 48

      Pages: 1581-1591

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390266
  • [Journal Article] Involvement of apolipoprotein E in excess fat accumulation and insulin resistance.2007

    • Author(s)
      Gao, J., Ishibashi, S., et. al.
    • Journal Title

      Diabetes 56

      Pages: 24-33

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18052017
  • [Journal Article] Ligand-independent activation of vascular endothelial growth factor receptor 1 by low-density lipoprotein2007

    • Author(s)
      Usui, R., Shibuya, M., Ishibashi, S., Maru, Y
    • Journal Title

      EMBO Rep 8(12)

      Pages: 1155-1161

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390266
  • [Journal Article] Regulation of hormone-sensitive lipase in islets.2007

    • Author(s)
      Shen, W. J., Ishibashi, S., et. al.
    • Journal Title

      Diabetes Res Clin Pract 75

      Pages: 14-26

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17659278
  • [Journal Article] Ligand-independent activation of vascular endothelial growth factor receptor 1 by low-density lipoprotein.2007

    • Author(s)
      Usui, R., Ishibashi, S., et. al.
    • Journal Title

      EMBO Rep 8

      Pages: 1155-1161

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18052017
  • [Journal Article] Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol : a potential role in adipocyte lipolysis.2006

    • Author(s)
      Okazaki, H., Ishibashi, S., et al.
    • Journal Title

      Diabetes 55

      Pages: 2091-2097

    • Data Source
      KAKENHI-PROJECT-17390266
  • [Journal Article] Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol : a potential role in adipocyte lipolysis2006

    • Author(s)
      Okazaki, H., Igarashi, M., Nishi, M., Tajima, M., Sekiya, M., Okazaki, S., Yahagi, N., Ohashi, K., Tsukamoto, K., Amemiya-Kudo, M., Matsuzaka, T., Shimano, H., Yamada, N., Aoki, J., Morikawa, R., Takanezawa, Y., Arai, H., Nagai, R., Kadowaki, T., Osuga, J., Ishibashi, S
    • Journal Title

      Diabetes 55(7)

      Pages: 2091-2097

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390266
  • [Journal Article] Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver.2006

    • Author(s)
      Okazaki, H., Ishibashi, S., et al.
    • Journal Title

      J Lipid Res 29

      Pages: 1950-1958

    • Data Source
      KAKENHI-PROJECT-18052017
  • [Journal Article] Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver.2006

    • Author(s)
      Okazaki, H., Ishibashi, S., et al.
    • Journal Title

      J Lipid Res 29

      Pages: 1950-1958

    • Data Source
      KAKENHI-PROJECT-17390266
  • [Journal Article] Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver.2006

    • Author(s)
      Okazaki, H., Ishibashi, S., et al.
    • Journal Title

      J Lipid Res 29

      Pages: 1950-1958

    • Data Source
      KAKENHI-PROJECT-17659278
  • [Journal Article] Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol : a potential role in adipocyte lipolysis.2006

    • Author(s)
      Okazaki, H., Ishibashi, S., et al.
    • Journal Title

      Diabetes 55

      Pages: 2091-2097

    • Data Source
      KAKENHI-PROJECT-18052017
  • [Journal Article] Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol : a potential role in adipocyte lipolysis.2006

    • Author(s)
      Okazaki, H., Ishibashi, S., et al.
    • Journal Title

      Diabetes 55

      Pages: 2091-2097

    • Data Source
      KAKENHI-PROJECT-17659278
  • [Journal Article] Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver2006

    • Author(s)
      Okazaki, H., Tazoe, F., Okazaki, S., Isoo, N., Tsukamoto, K., Sekiya, M., Yahagi, N., Iizuka, Y., Ohashi, K., Kitamine, T., Tozawa, R., Inaba, T., Yagyu, H., Okazaki, M., Shimano, H., Shibata, N., Arai, H., Nagai, R.Z., Kadowaki, T., Osuga, J., Ishibashi, S
    • Journal Title

      J Lipid Res 47

      Pages: 1950-1958

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390266
  • [Journal Article] High cholesterol level is essential for myelin membrane growth.2005

    • Author(s)
      G.Saher, S.Ishibashi, et al.
    • Journal Title

      Nat Neurosci 8

      Pages: 468-475

    • Data Source
      KAKENHI-PROJECT-17390266
  • [Journal Article] Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47.2005

    • Author(s)
      M.Amemia-Kudo, S.Ishibashi, et al.
    • Journal Title

      J Biol Chem 280

      Pages: 34577-34589

    • Data Source
      KAKENHI-PROJECT-17659278
  • [Journal Article] High cholesterol level is essential for myelin membrane growth2005

    • Author(s)
      Saher, G., Brugger, B., Lappe-Siefke, C., Mobius, W., Tozawa, R., Wehr, M. C., Wieland, F., Ishibashi, S., Nave, K.A
    • Journal Title

      Nature Neuroscience 8

      Pages: 468-475

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390266
  • [Journal Article] Cholesterol reduction and atherosclerosis of inhibition by bezafibrate in low density lipoprotein receptor knockout mice

    • Author(s)
      Inaba, T. Yagyu, H. Itabashi, N. Tazoe, F. Fujita, N. Nagashima, S. Okada, K. Okazaki, M. Furukawa, Y. Ishibashi, S
    • Journal Title

      Hypertens Res (in press)

    • NAID

      10021935912

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390266
  • [Presentation] マクロファージの脂質代謝に魅せられて.2021

    • Author(s)
      石橋 俊:
    • Organizer
      第53回日本動脈硬化学会総会,
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03712
  • [Presentation] 膵β細胞のHMG-CoA還元酵素欠損は 膵β細胞の減少とインスリン分泌能の低下による糖尿病を誘発する.2021

    • Author(s)
      永島 秀一, 武井 祥子, 武井 暁一, 原 一雄, 石橋 俊:
    • Organizer
      第64回日本糖尿病 学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-19H03712
  • [Presentation] コレステロール合成系と糖代謝のcross talk 組織特異的遺伝子改変マウスを用いた検討2018

    • Author(s)
      永島 秀一, 武井 祥子, 武井 暁一, 石橋 俊
    • Organizer
      日本糖尿病学会年次学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K09789
  • [Presentation] 膵β細胞特異的HMG-CoA還元酵素欠損マウスにおける糖尿病発症機序の解析2017

    • Author(s)
      武井祥子,永島 秀一,武井 暁一,若林 徹治,山﨑 久隆,山室 大介,海老原 千尋,高橋 学,倉科 智行,海老原 健,出崎 克也,中田 正範,大橋 健,野牛 宏章,矢田 俊彦,屋代 隆,石橋 俊.
    • Organizer
      日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-16K09789
  • [Presentation] コレステロールエステル水解反応によるマクロファージ制御2015

    • Author(s)
      石橋俊
    • Organizer
      日本糖尿病学会年次学術集会
    • Place of Presentation
      下関市民会館
    • Year and Date
      2015-05-23
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293213
  • [Presentation] 動脈硬化とマクロファージ:コレステロールエステル水解機構を中心に2015

    • Author(s)
      石橋俊
    • Organizer
      日本動脈硬化学会年次学術集会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2015-07-09
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293213
  • [Presentation] マクロファージ特異的リポタンパクリパーゼ欠損マウスにおける動脈硬化進展の短期及び長期的検討2009

    • Author(s)
      高橋学、野牛宏晃、田副文子、永島秀一、岡田健太、宮本倫聡、大城太一、江藤一弘、石橋俊
    • Organizer
      第52回糖尿病学会年次集会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-18590998
  • [Presentation] ACAT2 選択的阻害剤ピリピロペンA の抗動脈硬化作用2009

    • Author(s)
      坂井謙斗、大城太一、松田大介、野牛宏晃、Lawrence Rudel、大村智、石橋俊、供田洋
    • Organizer
      日本薬学会第129年回年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Data Source
      KAKENHI-PROJECT-18390008
  • [Presentation] グルコース刺激による膵β細胞内Ca^<2+>上昇のセロトニン5-HT_2B受容体アゴニストによる増強.2007

    • Author(s)
      安藤 明彦, 石橋 俊, 他
    • Organizer
      第50回日本糖尿病学会年次学術集会
    • Place of Presentation
      仙台市
    • Data Source
      KAKENHI-PROJECT-17659278
  • [Presentation] ヒト皮下及び内臓脂肪組織における各種脂肪分解酵素の遺伝子発現と肥満・インスリン抵抗性との関連について2007

    • Author(s)
      永島秀一、石橋 俊、他
    • Organizer
      第50回日本糖尿病学会年次総会
    • Place of Presentation
      仙台市
    • Data Source
      KAKENHI-PROJECT-18052017
  • [Presentation] Serotonin 2B receptor agonist BW723C86 increases cytosolic Ca<^2+> in βcells via PLC pathway and stimulates insulin and glucagons release at basal glucose in islets.2007

    • Author(s)
      Ando, A., Ishibashi, S., et. al.
    • Organizer
      43^<rd> Annual Meeting of the European Association for the Study of Diabetes
    • Place of Presentation
      Amsterdam
    • Data Source
      KAKENHI-PROJECT-17659278
  • [Presentation] Depot-specific gene expression of lipolytic enzymes in human adipose tissues. Association with adiposity and plasma lipids.2007

    • Author(s)
      永島秀一、石橋 俊、他
    • Organizer
      第67回米国糖尿病学会
    • Place of Presentation
      米国シカゴ
    • Data Source
      KAKENHI-PROJECT-18052017
  • [Presentation] 肝臓特異的スクアレン合成酵素欠損マウスにおける血清・肝臓の脂質代謝の検討2007

    • Author(s)
      永島 秀一、野牛 宏晃、田副 文子、石橋 俊, 他
    • Organizer
      第39回日本動脈硬化学会総会・学術集会,
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-13
    • Data Source
      KAKENHI-PROJECT-17390266
  • [Presentation] Lipid metabolism in liver-sepecific squalene synthase knockout mice.2007

    • Author(s)
      Nagashima, S., Yagyu, H., Tazoe, F., Ishibashi, S., et. al.
    • Organizer
      The 39th Annual Scientific Meeting of the Japan Atherosclerosis Society
    • Place of Presentation
      Osaka
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390266
  • [Presentation] Cell proliferation of vascular smooth muscle cells with defective cholesterol biosynthesis2006

    • Author(s)
      Tazoe, F., Yagyu, H., Nagashima, S., Ishibashi, S., et. al.
    • Organizer
      The 38th Annual Scientific Meeting of the Japan Atherosclerosis Society
    • Place of Presentation
      Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390266
  • [Presentation] ssential role of non-sterol pathway in the proliferation of vascular smooth muscle cells : A comparative study on the disruption of 3-hydroxy-3-Methylglutaryl coenzyme A reductase or squalene synthase2006

    • Author(s)
      Tazoe, F., Yagyu, H., Itabashi, N., Ohashi, K., Tozawa, R., Inaba, T., Nagashima, S., Kato, K., Khadbaatar, Z., Osuga, J., Ishibashi, S
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390266
  • []

  • []

  • 1.  YAMADA Nobuhiro (40200729)
    # of Collaborated Projects: 16 results
    # of Collaborated Products: 0 results
  • 2.  OOSUGA Junniti (10334400)
    # of Collaborated Projects: 15 results
    # of Collaborated Products: 10 results
  • 3.  HARADA Kenji
    # of Collaborated Projects: 12 results
    # of Collaborated Products: 0 results
  • 4.  GOTODA Takanari (60322062)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 5.  NAGASHIMA Shuichi (30406136)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 16 results
  • 6.  YAGYU Hiroaki (60348018)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 14 results
  • 7.  SHIMANO Hitoshi (20251241)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 1 results
  • 8.  TAKAHASHI Manabu (70406122)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 4 results
  • 9.  TAZOE Fumiko (20406127)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 7 results
  • 10.  加藤 秀樹 (20406094)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 11.  WANG Xiao li (10458325)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  MAKUUCHI Masatoshi (60114641)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  板橋 直樹 (00316522)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  OHASHI Ken
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  TOMODA Hiroshi (70164043)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 16.  INOKOSHI Junji (30151640)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  NAGAMITSU Tohru (90300756)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  SUNAZUKA Toshiaki (30226592)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  OKAZAKI Hiroaki (80610211)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  YAMAMURO DAISUKE (20739255)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 21.  SONE Hirohito (30312846)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  TOYOSHIMA Hideo (20197966)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  IWAMOTO Yasuhiko (60143434)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  SUZUKI Jinya (20293417)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  TAKAHASHI Sadao (50303376)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  KOIZUMI Tsutomu (40126579)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  安藤 明彦 (60249315)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 28.  坂井 謙斗 (30646352)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 29.  青柳 信嘉 (90292903)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  SHIMADA Masako
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  YAHAGI Naoya
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  SHIONOIRI Futoshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  MIURA Yasuaki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  ABE Hideki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  SUDOH Takako
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  TAKEI shoko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 37.  TAKEI akihito
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 38.  OHTAWA Masaki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 39.  高橋 将文
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 40.  唐澤 直義
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 41.  中川 嘉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 42.  出崎 克也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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