KOMATSU MITSUHISA 駒津光久

… Alternative Names

Komatsu Mitsuhisa 駒津光久

KOMATSU Mitsuhisa 駒津光久

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Researcher Number	90221978
Other IDs
External Links
Affiliation (Current)	2025: 信州大学, 学術研究院医学系, 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 信州大学, 学術研究院医学系, 教授 2014 – 2018: 信州大学, 学術研究院医学系, 教授 2012 – 2013: 信州大学, 医学部, 教授 2010 – 2011: 信州大学, 医学系研究科, 教授 2009: Shinshu University, 医学系研究科, 講師 … More 2006 – 2007: 信州大学, 大学院・医学系研究科, 講師 2005: Shinshu University Graduate School, Department of Aging Medicine and Geriatrics, Assistant Professor, 医学部附属病院, 講師 2003 – 2005: 信州大学, 大学院・医学研究科, 講師 2002: 信州大学, 医学部附属病院, 助手 2001: 信州大学, 医学部・附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Endocrinology / Basic Section 54040:Metabolism and endocrinology-related / Endocrinology / Metabolomics Except Principal Investigator Endocrinology / Obstetrics and gynecology
Keywords	Principal Investigator ブドウ糖 / インスリン分泌 / cAMP / インクレチン / インスリン / 膵β細胞 / パルミチン化 / type 2 diabetes / secretion / insulin release … More / 膵ベータ細胞 / 糖尿病 / PGRMC1 / プロテオーム解析 / 甘味受容体 / NADPH / パルミチル化 / branched-chian amino acids / proteosome / acvlation / プロテオーム / Ca2+ / acylation / 細胞内Ca^<2+>濃度 / アシル化 / 蛋白のアシル化 / 2型糖尿病 / カルシウム / アシル化蛋白 … More Except Principal Investigator vitamin D3 / PPAR / phage display system / transcriptional mediator / nuclear receptor / クローニング / リガンド / 相互作用 / 転写因子 / クロストーク / VDR / 共役因子 / T7ファージディスプレイ / ファージディスプレイ法 / 転写共役因子 / 核受容体 / 転写調節子 / 膣β組胞 / インスリンプロモーター / 転写調節因子 / 膵β細胞 / エストロゲン Less

ブドウ糖によるインスリン分泌を制御する新規分子PGRMC1の生理的意義の解明Principal Investigator
- Principal Investigator
  
  駒津光久
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Shinshu University
Identification of novel molecular mechanisms regulating insulin secretion from pancreatic beta cells and their physiological significancePrincipal Investigator
- Principal Investigator
  
  Komatsu Mitsuhisa
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Shinshu University
Elucidation of three new molecular bases in the mechanisms of insulin secretionPrincipal Investigator
- Principal Investigator
  
  Komatsu Mitsuhisa
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Shinshu University
Insight into mechanisms of insulin secretion induced by KATP-independent action and incretinPrincipal Investigator
- Principal Investigator
  
  KOMATSU Mitsuhisa
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Shinshu University
The effect of estrogen for carbohydrate metabolism in pancreatic beta cells
- Principal Investigator
  
  NISHIO Shin-ichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Shinshu University
Identification of novel acylated proteins regulating insulin secretion and exploration of their physiological significancePrincipal Investigator
- Principal Investigator
  
  KOMATSU Mitsuhisa
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Shinshu University
Search for novel mechanisms of insulin secretion by combination of proteom analysis and HPLCPrincipal Investigator
- Principal Investigator
  
  KOMATSU Mitsuhisa
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Shinshu University
Cloning of nuclear receptor specific co-factor by phage display system
- Principal Investigator
  
  MIYAMOTO Takahide
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Shinshu University
A Study on Acylation-Regulated Membrane Proteins Involved in Insulin ExocytosisPrincipal Investigator
- Principal Investigator
  
  KOMATSU Mitsuhisa
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Shinshu University

[Book] KATP Channel-Independent Pathway and the Glucoreceptor. In: Kojima I. (eds) Glucose-sensing Receptor in Pancreatic Beta-cells.2018
- Author(s)
  Aizawa T and Komatsu M
- Publisher
  Springer, Singapore
- ISBN
  9789811300011
- Data Source
  KAKENHI-PROJECT-16K09799
[Book] Bariatric surgery on obese type 2 diabetes patients. Advanced Bariatric and Metabolic Surgery2012
- Author(s)
  Mori J, Sato Y, Komatsu M
- Publisher
  Edited by Chin-Kun Huang, In Tech
- Data Source
  KAKENHI-PROJECT-21591128
[Book] アミノ酸, 脂肪酸とインスリン分泌糠尿病学2007
- Author(s)
  駒津光久
- Total Pages
  5
- Publisher
  西村書店
- Data Source
  KAKENHI-PROJECT-17590956
[Book] Glucose and nutrient-induced increase in insulin secretion in the absence of a rise in[Ca2+]i. In Commentaries on Perspectives in Diabetes2006
- Author(s)
  Komatsu M, Schermerhorn T, Noda M, Straub SG, Aizawa T, Sharp G
- Total Pages
  3
- Publisher
  Robertson RP, Ed., American Diabetes Association
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590956
[Book] Pancreatic β-Cell, a Unique Fuel Sensor. In Nutrients and Cell Signaling (K Dakshinamurti and J.Zempleni, eds)2005
- Author(s)
  Komatsu M
- Publisher
  Dekker/CRC Press
- Data Source
  KAKENHI-PROJECT-13671151
[Book] Pancreatic B-Cel, a Unique Fuel Sensor. (K Daksshinamurti and J Zempleni, eds) In Nurients and Cell Signaling2005
- Author(s)
  Komatsu M
- Publisher
  Dekker/CRC Press
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13671151
[Book] Pancreatic β-cell, a unique fuel senser.( Dakshinamurti K, Zempleni J (eds)) Nutients and Cell Signaling.2005
- Author(s)
  Komatsu M
- Total Pages
  32
- Publisher
  Dekker/CRC Press
- Data Source
  KAKENHI-PROJECT-17590956
[Journal Article] Repression of insulin gene transcription by indirect genomic signaling via the estrogen receptor in pancreatic beta cells.2019
- Author(s)
  Sekido T, Nishio S, Ohkubo Y, Sekido K, Kitahara J, Miyamoto T, Komatsu M
- Journal Title
  
  In Vitro Cell Dev Biol Anim
  
  Volume: 55(4) Issue: 4 Pages: 226-236
- DOI
  10.1007/s11626-019-00328-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09799
[Journal Article] Loss of μ-crystallin causes PPARγ activation and obesity in high-fat diet-fed mice.2019
- Author(s)
  Ohkubo Y, Sekido T, Nishio SI, Sekido K, Kitahara J, Suzuki S, Komatsu M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 508(3) Issue: 3 Pages: 914-920
- DOI
  10.1016/j.bbrc.2018.12.038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09799
[Journal Article] KATP Channel-Independent Pathway and the Glucoreceptor2018
- Author(s)
  Toru Aizawa, Mitsuhisa Komatsu
- Journal Title
  
  Itaru Kojima (Eds): Glucose-sensing Receptor in Pancreatic Beta-cells
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09799
[Journal Article] Intracellular free fatty acid upholds β-cell glucose competence: The role of peroxisome proliferator-activated receptor δ and mitochondrial metabolism.2015
- Author(s)
  Takei M, Komatsu M, Aizawa T
- Journal Title
  
  J Diabetes Investig
  
  Volume: 2 Issue: 2 Pages: 133-136
- DOI
  10.1111/jdi.12257
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461383
[Journal Article] Lactisole inhibits the glucose-sensing receptor T1R3 expressed in mouse pancreatic β-cells.2015
- Author(s)
  amano K, Nakagawa Y, Ohtsu Y, Li L, Medina J, Tanaka Y, Masuda K, Komatsu M, Kojima I.
- Journal Title
  
  Journal of Endocrinology
  
  Volume: 226 Issue: 1 Pages: 57-66
- DOI
  10.1530/joe-15-0102
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461383
[Journal Article] Efficacy of combination therapy with sitagliptin and low-dose glimepiride in Japanese patients with type 2 diabetes.2014
- Author(s)
  Ishii H, Ohkubo Y, Takei M, Nishio S, Yamazaki M, Kumagai M, Sato Y, Suzuki S, Aoki Y, Miyamoto T, Kakizawa T, Sakuma T, Komatsu M
- Journal Title
  
  J Clin Med Res
  
  Volume: 2 Pages: 127-132
- DOI
  10.14740/jocmr1701w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461383
[Journal Article] SU薬のポジショニング　SU薬はもういらないのか2014
- Author(s)
  駒津光久
- Journal Title
  
  糖尿病診療マスター
  
  Volume: 12 Pages: 126-161
- Data Source
  KAKENHI-PROJECT-25461383
[Journal Article] ブドウ糖によるインシュリン分泌とインクレチンー生理的意義の理解に向けてー2014
- Author(s)
  駒津光久、佐藤吉彦、相澤徹
- Journal Title
  
  最新医学
  
  Volume: 69 Pages: 128-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461383
[Journal Article] KATP非依存性ブドウ糖応答性シグナルは生理的に重要か？2014
- Author(s)
  駒津光久
- Journal Title
  
  内分泌・糖尿病・代謝内科
  
  Volume: 39 Pages: 122-127
- Data Source
  KAKENHI-PROJECT-25461383
[Journal Article] A new experimental model of ATP-sensitive K<sup>+</sup> channel-independent insulinotropic action of glucose: a permissive role of cAMP for triggering of insulin release from rat pancreatic β-cells2013
- Author(s)
  Masahiro Takei
- Journal Title
  
  Endocr J
  
  Volume: 60 Issue: 5 Pages: 599-607
- DOI
  10.1507/endocrj.EJ12-0388
- NAID
  10031184527
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591128, KAKENHI-PROJECT-22591853, KAKENHI-PROJECT-23591320, KAKENHI-PROJECT-25461383
[Journal Article] Glucose-stimulated insulin secretion: A newer perspective2013
- Author(s)
  Komatsu M, Takei M, Ishii H, Sato Y.
- Journal Title
  
  J Diabetes Invest
  
  Volume: 4 Issue: 6 Pages: 511-516
- DOI
  10.1111/jdi.12094
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591128, KAKENHI-PROJECT-25461383
[Journal Article] Humoral hypercalcemia associated with gastric carcinoma secreting parathyroid hormone: a case report and review of the literature2013
- Author(s)
  Nakajima K, Tamai M, Okaniwa S, Nakamura Y, Kobayashi M, Niwa T, Horigome N, Ito N, Suzuki S, Nishio S, Komatsu M.
- Journal Title
  
  Endocr J
  
  Volume: 60 Issue: 5 Pages: 557-562
- DOI
  10.1507/endocrj.EJ12-0406
- NAID
  10031184522
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591853
[Journal Article] A new experimental model of ATP-sensitive K+channel-independent insulinotropic action of glucose: a permissive role of cAMP for triggering of insulin release from rat pancreatic beta-cells.2013
- Author(s)
  Takei M, Dezaki K, Ishii H, Nishio SI, Sato Y, Suzuki S, Yada T, Komatsu M
- Journal Title
  
  Endocrine journal.
  
  Volume: 60 Pages: 599-607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591128
[Journal Article] Possible Roles of the AP-1 Site in the Cytosolic T3 Binding Protein Promoter and Insights into its Physiological Significance.2013
- Author(s)
  Suzuki S, Nishio SI, Ishii H, Sekido T, Takeshige K,Ohkubo Y, Hiwatashi D, Takeda T, Komatsu M.
- Journal Title
  
  Horm Metab Res.
  
  Volume: Mar 18. Issue: 07 Pages: 501-506
- DOI
  10.1055/s-0033-1337933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591853
[Journal Article] Pituitary resistance to thyroid hormones : pathophysiology and therapeutic options2012
- Author(s)
  Suzuki S, Nishio S, Takeda T, Komatsu M
- Journal Title
  
  Thyroid Res
  
  Volume: 5(1) Issue: 1 Pages: 1-1
- DOI
  10.1186/1756-6614-5-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591853, KAKENHI-PROJECT-23591349
[Journal Article] Bariatric surgery on type 2 dizbetes mellitus patients in Japan. Shinshu2011
- Author(s)
  Mori J, Sato Y, Ishii H, Komatsu M.
- Journal Title
  
  Med J
  
  Volume: 59(4) Pages: 273-279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591128
[Journal Article] Pituitary resistance to thyroid hormones : pathophysiology and therapeutic options2011
- Author(s)
  Suzuki S, Shigematsu S, Inaba H, Takei M, Takeda T, Komatsu M
- Journal Title
  
  Endocrine
  
  Volume: 40(3) Issue: 3 Pages: 366-371
- DOI
  10.1007/s12020-011-9538-2
- Data Source
  KAKENHI-PROJECT-22591853
[Journal Article] Glucose-incretin interaction revisited.2011
- Author(s)
  Ishii H, Sato Y, Takei M, Nishio S, Komatsu M.
- Journal Title
  
  Endocr J
  
  Volume: 58(7) Pages: 519-525
- NAID
  10029589169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591128
[Journal Article] Glucose-incretin interaction revisited [Review]2011
- Author(s)
  Ishii H, Sato Y, Takei M, Nishio S, Komatsu M
- Journal Title
  
  Endocr J
  
  Volume: 58 Issue: 7 Pages: 519-525
- DOI
  10.1507/endocrj.EJ11-0064
- NAID
  10029589169
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591128, KAKENHI-PROJECT-22591853
[Journal Article] 機能的膵β細胞量を標的としたあらたな糖尿病治療-GLP-1治療の展望2010
- Author(s)
  駒津光久
- Journal Title
  
  International Review of Diabetes
  
  Volume: 2 Pages: 24-25
- Data Source
  KAKENHI-PROJECT-21591128
[Journal Article] Transient polyuria related to central diabetes insipidus caused by lymphocytic infundibulo‐neurohypophysitis in a patient treated for Graves'disease2010
- Author(s)
  Yamazaki M, Sato A, Nishio S, Uehara T, Komatsu M
- Journal Title
  
  Intern Med
  
  Volume: 49 Pages: 1885-1890
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591128
[Journal Article] closed-loopとopen-loopによる血糖制御2010
- Author(s)
  駒津光久
- Journal Title
  
  内分泌・糖尿病・代謝内科
  
  Volume: 30 Pages: 591-595
- NAID
  40017666413
- Data Source
  KAKENHI-PROJECT-21591128
[Journal Article] Distinct Clinical Courses in Type 1 Diabetes Mellitus Induced by Peg-interferon-alpha Treatment for Chronic Hepatitis C2010
- Author(s)
  Yamazaki M, Sato A, Takeda T, Komatsu M
- Journal Title
  
  Intern Med 49
  
  Pages: 403-407
- NAID
  130000251685
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591128
[Journal Article] C10sed-loopとopen-loopによる血糖制御2010
- Author(s)
  駒津光久
- Journal Title
  
  内分泌等幼猫代謝内科
  
  Volume: 30 Pages: 591-595
- Data Source
  KAKENHI-PROJECT-22591853
[Journal Article] Transient polyuria related to central diabetes insipidus caused by lymphocytic infundibulo-neurohypophysitis in a patient treated for Graves' disease.2010
- Author(s)
  Yamazaki M, Sato A, Nishio S,Ue hara T, Komatsu M.
- Journal Title
  
  Intern Med.
  
  Volume: 49(17) Pages: 1885-1890
- NAID
  130000336870
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591853
[Journal Article] 機能的膵β細胞量を標的としたあらたな糖尿病治療一GLPI治療の展望一2010
- Author(s)
  駒津光久
- Journal Title
  
  International Review of Diabetes
  
  Volume: 2 Pages: 24-25
- Data Source
  KAKENHI-PROJECT-22591853
[Journal Article] Enhancement of the incretin pathway in response to bariatric surgery is important for restoration of beta cell function2009
- Author(s)
  Komatsu M, Aizawa T
- Journal Title
  
  Diabetologia 52
  
  Pages: 374-375
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591128
[Journal Article] Acute and chronic treatment of L-isoleucine ameliorates glucose metabolism inglucose-intolerant and diabetic mice.2008
- Author(s)
  Ikehara O, Kawasaki N, Maezono K, Komatsu M, Konishi A
- Journal Title
  
  Biol Pharm Bull 31
  
  Pages: 469-472
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590956
[Journal Article] Acute and chronic treatment of L-isoleucine ameliorates glucose metabolism in glucose-intolerant and diabetic mice.2008
- Author(s)
  Ikehara O, Kawasaki N, Maezono K, Komatsu M, Konishi A
- Journal Title
  
  Biol Pharm Bull 31
  
  Pages: 469-472
- NAID
  110006623076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590956
[Journal Article] Acute and chronic treatment of L-isoleucine ameliorates glucose metabolism in glucose-intolerant and diabetic mice2008
- Author(s)
  Ikehara, 0., Kawasaki, N., Maezono, K., Komatsu, M., Konishi, A
- Journal Title
  
  Biol Pharm Bull 31
  
  Pages: 469-472
- NAID
  110006623076
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590956
[Journal Article] Adiponectin Inversely Correlates with High Sensitive C-reactive Protein and Triglycerides, but not with Insulin Sensitivity, in Apparently Healthy Japanese Men2007
- Author(s)
  Komatsu, M., Ohfusa, H., Aizawa, T., Hashizume, K
- Journal Title
  
  Endocr J 54
  
  Pages: 553-558
- NAID
  10019809309
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590956
[Journal Article] Adiponectin Inversely Correlates with High Sensitive C-reactive Protein and Triglycerides, but not with Insulin Sensitivity, in Apparently Healthy Japanese Men.2007
- Author(s)
  Komatsu M, Ohfusa K, Aizawa T, Hashizume K
- Journal Title
  
  Endocr J In press
- NAID
  10019809309
- Data Source
  KAKENHI-PROJECT-17590956
[Journal Article] Development, worsening, and improvement of diabetic microangiopathy in older people : six-year prospective study of patients under intensive diabetes control.2007
- Author(s)
  Katakura M, Naka M, Kondo T, Komatsu M et al.
- Journal Title
  
  J Am Geriatr Soc 55
  
  Pages: 541-547
- Data Source
  KAKENHI-PROJECT-17590956
[Journal Article] Normal mortality in the elderly with diabetes under strict glycemic and blood pressure control: Outcome of 6-year prospective study.2007
- Author(s)
  Katakura M, Naka M, Kondo T, Komatsu M, Yamauchi K, Hashizume K, Aizawa T
- Journal Title
  
  Diabetes Res Clin Pract 78
  
  Pages: 108-114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590956
[Journal Article] Adiponectin Inversely Correlates with High Sensitive C-reactive Protein and Triglycerides, but not with Insulin Sensitivity, in Apparently Healthy Japanese Men.2007
- Author(s)
  Komatsu M, Ohfusa H, Aizawa T, Hashizume K
- Journal Title
  
  Endocr J 54
  
  Pages: 553-558
- NAID
  10019809309
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590956
[Journal Article] Normal mortality in the elderly with diabetes under strict glycemic and blood pressure control : Outcome of 6-year prospective study.2007
- Author(s)
  Katakura M, Naka M, Kondo T, Komatsu M et al.
- Journal Title
  
  Diabetes Res Clin Pract In press
- Data Source
  KAKENHI-PROJECT-17590956
[Journal Article] Development, worsening, and improvement of diabetic microangiopathy in older people: six-year prospective study of patients under intensive diabetes control.2007
- Author(s)
  Katakura M, Naka M, Kondo T, Komatsu M, Yamauchi K, Hashizume K, Aizawa T
- Journal Title
  
  J Am Geriatr Soc 55
  
  Pages: 541-547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590956
[Journal Article] Effect of Methimazole Treatment for 2 Years on Circulating lL-4, lgE, TBll, and TSAb in Patients with Hyperthayroid Graves' Disease.2006
- Author(s)
  Yamada T, Komiya I, Miyahara Y, Komatsu M et al.
- Journal Title
  
  Endocr J 53
  
  Pages: 783-788
- Data Source
  KAKENHI-PROJECT-17590956
[Journal Article] Rab27a : a new face in beta cell metabolism-secretion Coupling.2005
- Author(s)
  Aizawa T, Komatsu M.
- Journal Title
  
  J Clin Invest 115
  
  Pages: 227-230
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13671151
[Journal Article] Development, progression, and regression of microalbuminuria in Japanese patients with type 2 diabetes under tight glycemic and blood pressure control: the Kashiwa study.2005
- Author(s)
  Yamada T, Komatsu M et al.
- Journal Title
  
  Diabetes Care 28
  
  Pages: 2733-2738
- Data Source
  KAKENHI-PROJECT-17590956
[Journal Article] Rab27a : a new face in beta cell metabolism-secretion coupling2005
- Author(s)
  Aizawa, T., Komatsu, M
- Journal Title
  
  J Clin Invest 115
  
  Pages: 227-230
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590956
[Journal Article] Rab27a: a new face in beta cell metabolism-secretion coupling.2005
- Author(s)
  Aizawa T, Komatsu M
- Journal Title
  
  J Clin Invest 115
  
  Pages: 227-230
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590956
[Journal Article] Pancreatic β-cell, a Unique Fuel Sensor.2005
- Author(s)
  Komatsu M.
- Journal Title
  
  Nutrient and Cell Signaling (K Daksshinamurti, J Zempleni.eds) (Dekker/CRC Press)
  
  Pages: 533-564
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13671151
[Journal Article] Rab27a : a new face in beta cell metabolism-secretion coupling.2005
- Author(s)
  Aizawa T, Komatsu M
- Journal Title
  
  Journal of Clinical Investigation 115
  
  Pages: 227-230
- Data Source
  KAKENHI-PROJECT-17590956
[Journal Article] Rab27a : a new face in beta cell metabolism-secretion coupling.2005
- Author(s)
  Aizawa T, Komatsu M
- Journal Title
  
  J Clin Invest 115
  
  Pages: 227-230
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13671151
[Journal Article] Primacy of beta-cell dysfunction in the development of hyperglycemia : A study in the Japanese general population.2004
- Author(s)
  Katakura M, Komatsu M et al.
- Journal Title
  
  Metabolism 53
  
  Pages: 949-953
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13671151
[Journal Article] Strong inverse correlation between adiponectin level and Heart rate-corrected QT interval in apparently healthy population.2004
- Author(s)
  Komatsu M et al.
- Journal Title
  
  Diabetes Care 27
  
  Pages: 1237-1238
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13671151
[Journal Article] Strong inverse correlation between adiponectin level and heart rate-corected QT interval in apparently healthy population.2004
- Author(s)
  Komatsu M et al.
- Journal Title
  
  Diabetes Care 27
  
  Pages: 1237-1238
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13671151
[Journal Article] Strong inverse correlation between adiponectin level and heart rate-corrected QT interval in apparently healthy population.2004
- Author(s)
  Komatsu M et al.
- Journal Title
  
  Diabetes Care 27
  
  Pages: 1237-1238
- Data Source
  KAKENHI-PROJECT-13671151
[Journal Article] The retinoic acid-responsive proline-rich protein is identified in promyeloleukemic HL-60 cells.2004
- Author(s)
  Inagaki T, Suzuki S, Miyamoto T, Takeda T, Yamashita K, Komatsu A, Yamauchi K, Hashizume K.
- Journal Title
  
  J Biol Chem 278
  
  Pages: 51685-51692
- Data Source
  KAKENHI-PROJECT-15590972
[Journal Article] Primacy of beta-cell dysfunction in the Development of hyperglycemia : A study in the Japanese general population2004
- Author(s)
  Katakura M, Komatsu M et al.
- Journal Title
  
  Metabolism 53
  
  Pages: 949-953
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13671151
[Journal Article] Presence of functional domains in NADPH-dependent cytosolic 3,5,3'-Triiodo-L-thyronine (T3)-binding protein (p38CTBP) molecule : analyses with deletion mutants.2004
- Author(s)
  Suzuki S, Mori JI, Kobayashi M, Inagaki T, Komatsu A, Yamashita K, Takeda T, Miyamoto T, Ichikawa K, Hashizume K.
- Journal Title
  
  Horm Metab Res 35
  
  Pages: 577-582
- Data Source
  KAKENHI-PROJECT-15590972
[Journal Article] Nutrient modulation of palmitoylated 24-kDa Protein in rat pancreatic islets.2003
- Author(s)
  Yamada S, Komatsu M et al.
- Journal Title
  
  Endocrinology 144
  
  Pages: 5232-5241
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13671151
[Journal Article] Nutrient modulation of palmitoylated 24-kDa protein in rat pancreatic islets.2003
- Author(s)
  Yamada S, Komatsu M et al.
- Journal Title
  
  Endocrinology 144
  
  Pages: 5232-5241
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13671151
[Journal Article] Time-dependent potentiation of the β-cell is a Ca2+-independent phenomenon.2002
- Author(s)
  Yamada S, Komatsu M et al.
- Journal Title
  
  J Endocrinology 172
  
  Pages: 345-354
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13671151
[Journal Article] Time-dependent potentiation of the B-cell is a Ca^<2+>-independent phenomenon.2002
- Author(s)
  Yamada S, Komatsu M et al.
- Journal Title
  
  J Endocrinology 172
  
  Pages: 345-354
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13671151
[Journal Article] Triggering of insulin release by a combination of cAMP signal and nutrients, an ATP sensitive K^+channel-independent phenomenon.2002
- Author(s)
  Komatsu M et al.
- Journal Title
  
  Diabetes
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13671151
[Journal Article] Triggering of insulin release by a combination of cAMP signal and nutrients, an ATP sensitive K+ channel-independent phenomenon.2002
- Author(s)
  Komatsu M et al.
- Journal Title
  
  Diabetes 51
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13671151
[Presentation] マウスにおける甲状腺ホルモン結合蛋白（CRYM）の糖代謝に対する影響2016
- Author(s)
  関戸貴志、大久保洋輔、竹重恵子、北原順一郎、西尾真一、鈴木悟、駒津光久
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  京都　国立国際会議場
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-16K09799
[Presentation] Repression of Insulin Gene Transcription by Estrogen Receptor in Pancreatic Beta Cells2015
- Author(s)
  Keiko Sekido, Yohusuke Ohkubo, Takashi Sekido, Shin-ichi Nishio, Mitsuhisa Komatsu
- Organizer
  American Diabetes Association's (ADA) 75th Scientific Sessions in Boston
- Place of Presentation
  ボストン、USA
- Year and Date
  2015-06-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461383
[Presentation] Tri-iodothyronine acts as prospective factor against hyperglycemia mainly via thyroid hormone receptor β.2015
- Author(s)
  Yohusuke Ohkubo, Takashi Sekido, Keiko Sekido, Shin-ichi Nishio, Mitsuhisa Komatsu
- Organizer
  American Diabetes Association's (ADA) 75th Scientific Sessions in Boston
- Place of Presentation
  ボストン、USA
- Year and Date
  2015-06-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461383
[Presentation] ブドウ糖、プロテインキナーゼC、cAMPはCa2+非依存性にreadily releasable poolを増加させる2014
- Author(s)
  石井宏明、武井真大、関戸貴志、西尾真一、山崎雅則、佐藤吉彦、駒津光久
- Organizer
  第５７回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪市
- Data Source
  KAKENHI-PROJECT-25461383
[Presentation] 糖尿病、肥満症の患者にエキセナチドを導入して著効した3例2012
- Author(s)
  西尾真一、石井宏明、武井真大, 山崎雅則、鈴木悟、駒津光久
- Organizer
  日本糖尿病学会関東甲信越地方会
- Place of Presentation
  東京
- Year and Date
  2012-01-21
- Data Source
  KAKENHI-PROJECT-22591853
[Presentation] Combinationtherapy with low dose glimepiride and sitagliptin is reasonably effective for poorly controlled type 2 diabetes patients2012
- Author(s)
  Ishii H, Takei M, Nisio S, Sato Y, Suzuki S, Komatsu M.
- Organizer
  第48回ヨーロッパ糖尿病学会
- Place of Presentation
  ベルリン、ドイツ
- Year and Date
  2012-10-01
- Data Source
  KAKENHI-PROJECT-21591128
[Presentation] TRβはPAX6、BETA2を介してインスリン転写活性を増強する2011
- Author(s)
  西尾真一、石井宏明、武井真大, 四宮健、宮本高秀、武田貞二、鈴木悟、駒津光久
- Organizer
  日本甲状腺学会
- Place of Presentation
  大阪
- Year and Date
  2011-11-22
- Data Source
  KAKENHI-PROJECT-22591853
[Presentation] Acute triggering of insulin release concomitant with a decrease in cytosolic free Ca^ concentration by a combination of glucose and cAMP.2011
- Author(s)
  Takei M, Ishii H, Nisio S, Sato Y, Komatsu M.
- Organizer
  第47回ヨーロッパ糖尿病学会
- Place of Presentation
  リスボン、ポルトガル
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-21591128
[Presentation] TRβはPAX6、BETA2を介してインスリン転写活性を増強する2011
- Author(s)
  石井宏明、西尾真一、武井真大, 四宮健、宮本高秀、鈴木悟、駒津光久
- Organizer
  日本内分泌学会
- Place of Presentation
  神戸
- Year and Date
  2011-04-22
- Data Source
  KAKENHI-PROJECT-22591853
[Presentation] ERαはPDX-1、BETA2を介してインスリン転写活性を抑制する2011
- Author(s)
  西尾真一、石井宏明、武井真大、鈴木悟、駒津光久
- Organizer
  日本糖尿病学会
- Place of Presentation
  札幌
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-22591853
[Presentation] ゼブラフィッシュレプチン受容体OB-Rbは筋形成に必要である2011
- Author(s)
  西尾真一、武井真大、石井宏明、鈴木悟、駒津光久、Vincent Laudet
- Organizer
  日本内分泌学会
- Place of Presentation
  神戸
- Year and Date
  2011-04-21
- Data Source
  KAKENHI-PROJECT-22591853
[Presentation] 糖尿病、肥満症の患者にエキセナチドを導入して著効した2例2011
- Author(s)
  西尾真一、石井宏明、武井真大, 佐藤亜位、山崎雅則、駒津光久
- Organizer
  日本肥満学会
- Place of Presentation
  淡路
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22591853
[Presentation] Acute triggering of insulin release concomitant with a decrease in cytosolic free Ca2+concentration by a combination of glucose and cAMP2011
- Author(s)
  M.Takei, H.Ishii, S Nisio, Y.Sato, M.Komatsu
- Organizer
  第47回欧州糖尿病学会
- Place of Presentation
  リスボン(ポルトガル)
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-21591128
[Presentation] The Phytoestrogen Genistein Affects Zebrafish Development through Two Different Pathways2011
- Author(s)
  Shin-ichi Nishio, Sana Sassi-Messai, Yann Gibert, Hiroaki Ish-i, Masahiro Takei, Satoru Suzuki, Mitsuhisa Komatsu, Patrick Balaguer, Laudet Vincent
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-22591853
[Presentation] ERαはPDX-1、BETA2を介してインスリン転写活性を抑制する2011
- Author(s)
  武井真大、西尾真一、四宮健、石井宏明、鈴木悟、駒津光久
- Organizer
  日本内分泌学会
- Place of Presentation
  神戸
- Year and Date
  2011-04-21
- Data Source
  KAKENHI-PROJECT-22591853
[Presentation] ゼブラフィッシュレプチン受容体OB-Rbは筋形成に必要である2011
- Author(s)
  西尾真一、石井宏明、武井真大、駒津光久、Vincent Laudet
- Organizer
  日本肥満学会
- Place of Presentation
  淡路
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22591853
[Presentation] SHPはPDX-1プロモーター転写活性を抑制する2011
- Author(s)
  四宮健、西尾真一、石井宏明、武井真大、柿澤供子、宮本高秀, 鈴木悟、駒津光久
- Organizer
  日本内分泌学会
- Place of Presentation
  神戸
- Year and Date
  2011-04-23
- Data Source
  KAKENHI-PROJECT-22591853
[Presentation] Leptin receptor homolog in zebrafish controls morphogenetic movements duringgastrulation and is involved in somite formation.2010
- Author(s)
  西尾真一,石井宏明,武井真大,鈴木悟,駒津光久、ローデヴァンサン
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22591853
[Presentation] Quantitative assessment of diabetic neuropathy using a newly developed device, Pain Vision.2007
- Author(s)
  Komatsu M, Hiramatsu K, Hashizume K
- Organizer
  3rd Scientific Meeting of Asia-Pacific Diabetes and Obesity Study Group
- Place of Presentation
  Taizhou, China
- Year and Date
  2007-08-26
- Data Source
  KAKENHI-PROJECT-17590956
[Presentation] Adiponectin inversely correlates with triglyceride and high-sensitivity C-reactive protein butnot with insulin or insulin resistance index in Japanese men.2006
- Author(s)
  Komatsu M, Ohfusa H, Aizawa T, Hashizume K
- Organizer
  19th World Diabetes Congress
- Place of Presentation
  Cape Town, South Africa
- Year and Date
  2006-12-05
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590956
[Presentation] Adiponectin inversely correlates with triglyceride and high-sensitivity C-reactive protein but not with insulin or insulin resistance index in Japanese men2006
- Author(s)
  Komatsu, M., Ohfusa, H., Aizawa, T., Hashizume, K
- Organizer
  19th World Diabetes Congress
- Place of Presentation
  Cape Town, South Africa
- Year and Date
  2006-12-05
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590956
[Presentation] プレドニゾロン（PSL）が著効した後天性high density lipoprotein cholesterol　(HDL-C)欠損症の1例
- Author(s)
  西尾真一、日高宏哉、有賀雅和、石井宏明、武井真大、山崎雅則、鈴木悟、駒津光久
- Organizer
  日本内分泌学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22591853
[Presentation] 母子共にDUOX2遺伝子へテロ接合変異、TSB-Ab 陽性で母親が甲状腺機能低下症、児が甲状腺機能低下症および甲状腺腫大を来した一例
- Author(s)
  西尾真一、阿部清美、大平哲史、平林佳奈枝、石井宏明、山崎雅則、櫻井晃洋、鈴木悟、長谷川奉延、駒津光久
- Organizer
  日本甲状腺学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22591853
[Presentation] Triiodothyronine acts as protective factor against hyperglycemia mainly via thyroid hormone receptor beta
- Author(s)
  Ohkubo Y, Sekido T, Sekido K, Suzuki S, Sato Y, Nishio S, Komatsu M
- Organizer
  75th the American Diabetes Association's scientific sessions
- Place of Presentation
  Boston, USA
- Year and Date
  2015-06-05 – 2015-06-09
- Data Source
  KAKENHI-PROJECT-25461383
[Presentation] The activation of rat insulin gene II transcription by thyroid hormone receptor beta in pancreatic beta cells.
- Author(s)
  Nishio S, Ishi-i H, Suzuki S, Komatsu M
- Organizer
  日本分子生物学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22591853
[Presentation] 二相性インスリンアナログ製剤(BIAsp)3回投与法の有効性・安全性に関する研究：50BIAspと70BIAspの比較
- Author(s)
  西尾真一、武田貞二、佐藤亜位、鈴木悟、駒津光久
- Organizer
  日本糖尿病学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22591853
[Presentation] ペグミソマントによりコントロール改善した先端巨大症の一例
- Author(s)
  西尾真一、山崎雅則、武田貞二、鈴木悟、駒津光久
- Organizer
  日本内分泌学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22591853
[Presentation] The Phytoestrogen Genistein Affects Zebrafish Development through Two Different Pathways.
- Author(s)
  Nishio S, Sassi-Messai S, Gibert Y, Ish-I H, Takei M, Suzuki S, Komatsu M, Balaguer P, Laudet V
- Organizer
  日本内分泌学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22591853

1. KABURAGI Yasushi (40342927)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. NODA Mitsuhiko (90237850)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. NISHIO Shin-ichi (30467146)

# of Collaborated Projects: 2 results

# of Collaborated Products: 25 results
4. AIZAWA Toru (90150896)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SUZUKI Satoru (30222061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. YAMAUCHI Keishi (30191191)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MIYAMOTO Takahide (20192768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 小島至 (60143492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 大久保洋輔 (70793925)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 相沢徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 13 results

KOMATSU MITSUHISA 駒津 光久

Komatsu Mitsuhisa 駒津 光久

KOMATSU Mitsuhisa 駒津 光久

Research Projects

Research Products

Co-Researchers

ブドウ糖によるインスリン分泌を制御する新規分子PGRMC1の生理的意義の解明Principal Investigator

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Identification of novel molecular mechanisms regulating insulin secretion from pancreatic beta cells and their physiological significancePrincipal Investigator

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Review Section

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Elucidation of three new molecular bases in the mechanisms of insulin secretionPrincipal Investigator

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Insight into mechanisms of insulin secretion induced by KATP-independent action and incretinPrincipal Investigator

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The effect of estrogen for carbohydrate metabolism in pancreatic beta cells

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Identification of novel acylated proteins regulating insulin secretion and exploration of their physiological significancePrincipal Investigator

Principal Investigator

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Search for novel mechanisms of insulin secretion by combination of proteom analysis and HPLCPrincipal Investigator

Principal Investigator

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Cloning of nuclear receptor specific co-factor by phage display system

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A Study on Acylation-Regulated Membrane Proteins Involved in Insulin ExocytosisPrincipal Investigator

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[Book] KATP Channel-Independent Pathway and the Glucoreceptor. In: Kojima I. (eds) Glucose-sensing Receptor in Pancreatic Beta-cells.2018

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[Book] Bariatric surgery on obese type 2 diabetes patients. Advanced Bariatric and Metabolic Surgery2012

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[Book] アミノ酸, 脂肪酸とインスリン分泌 糠尿病学2007

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[Book] Glucose and nutrient-induced increase in insulin secretion in the absence of a rise in[Ca2+]i. In Commentaries on Perspectives in Diabetes2006

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KOMATSU MITSUHISA 駒津光久

Komatsu Mitsuhisa 駒津光久

KOMATSU Mitsuhisa 駒津光久

[Book] アミノ酸, 脂肪酸とインスリン分泌糠尿病学2007

[Journal Article] SU薬のポジショニング　SU薬はもういらないのか2014

[Journal Article] A new experimental model of ATP-sensitive K<sup>+</sup> channel-independent insulinotropic action of glucose: a permissive role of cAMP for triggering of insulin release from rat pancreatic β-cells2013