Yamamoto Keizo 山本惠三

… Alternative Names

YAMAMOTO Keizo 山本惠三

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Researcher Number	90254490
Other IDs
Affiliation (Current)	2025: 奈良県立医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 奈良県立医科大学, 医学部, 准教授 2013 – 2019: 奈良県立医科大学, 医学部, 准教授
Review Section/Research Field	Principal Investigator Laboratory medicine / Basic Section 49050:Bacteriology-related Except Principal Investigator Basic Section 90120:Biomaterials-related / Biomedical engineering/Biomaterial science and engineering / Laboratory medicine
Keywords	Principal Investigator 基質特異性 / X線結晶構造解析 / Ｘ線結晶構造解析 / βーラクタマーゼ / 複合体 / β－ラクタマーゼ / メタロ－β－ラクタマーゼ / 分子動力学的シミュレーション / メタロ―βーラクタマーゼ / 人工進化 … More / 感染症 / 構造解析 / カルバペネマーゼ / 指向性進化法 / 大腸菌 / 大量発現 / クローニング / タンパク質精製 / 多剤耐性 / β―ラクタマーゼ / 構造変化 … More Except Principal Investigator 一酸化炭素 / 蘇生液 / 輸血代替 / リポソーム / 虚血再灌流障害 / 組織酸素化 / DDS / 出血性ショック / 虚血再灌流傷害 / 人工酸素運搬体 / 人工臓器 / 酸化ストレス / 虚血 / 酸素輸送 / メチレンブルー / NADH / 解糖系酵素 / ヘモグロビン / 輸液 / 電子伝達系 / 人工赤血球 / 人工臓器学 / 遺伝子解析 / 大腸菌病原因子 / 新生児髄膜炎 / ゲノム解析 / 髄膜炎 / 病原因子 / 大腸菌 / 敗血症 Less

Resuscitation from hemorrhagic shock by carbon monoxide- and oxygen-carrying capacities of artificial red cells.
- Principal Investigator
  
  Sakai Hiromi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Nara Medical University
Structural analysis of IMP-type metallo-beta-lactamase in complex with its substratePrincipal Investigator
- Principal Investigator
  
  Yamamoto Keizo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Nara Medical University
Comprehensive research of amino acid residues that participate in increasing activity of carbapenemase and structural analysis of mutant enzymesPrincipal Investigator
- Principal Investigator
  
  Yamamoto Keizo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Nara Medical University
Artificial red cells with a defense function to oxidative stress
- Principal Investigator
  
  SAKAI HIROMI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Nara Medical University
Analysis of enlargement mechanism of substrate specificity of CTX-M type beta-lactamase based on protein crystallography.Principal Investigator
- Principal Investigator
  
  YAMAMOTO Keizo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Nara Medical University
Elucidation of factors causing sepsis and establishment of prediction method by clinical analysis and molecular bacteriological approach
- Principal Investigator
  
  NAKAYAMA Akifumi
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Gihu University of Medical Science

All 2023 2022 2021 2019 2018 2016 2014 2013

All Journal Article Presentation Book

[Book] Nanobiotherapeutic Based Blood Substitutes2021
- Author(s)
  Takashi Matsuhira, Keizo Yamamoto and Hiromi Sakai
- Total Pages
  1044
- Publisher
  World Scientific
- ISBN
  9789811228698
- Data Source
  KAKENHI-PROJECT-21K07010
[Journal Article] Structural insights into the substrate specificity of IMP-6 and IMP-1 metallo-β-lactamases.2023
- Author(s)
  Yamamoto K, Tanaka H, Kurisu G, Nakano R, Yano, H, Sakai H
- Journal Title
  
  J Biochem
  
  Volume: 173 Issue: 1 Pages: 21-30
- DOI
  10.1093/jb/mvac080
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07010, KAKENHI-PROJECT-22K08606, KAKENHI-PROJECT-19K08948
[Journal Article] 超分子重合を利用した人工酸素運搬体の構築2021
- Author(s)
  松平崇、山本惠三、酒井宏水
- Journal Title
  
  人工血液
  
  Volume: 29 Pages: 50-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07010
[Journal Article] Ring-opening polymerization of hemoglobin.2019
- Author(s)
  T. Matsuhira, K. Yamamoto, H. Sakai
- Journal Title
  
  Biomacromolecules
  
  Volume: 20(4) Issue: 4 Pages: 1592-1602
- DOI
  10.1021/acs.biomac.8b01789
- NAID
  120007026512
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01367, KAKENHI-PROJECT-17K09018
[Journal Article] Antioxidative Pseudoenzymatic Mechanism of NAD(P)H Coexisting with Oxyhemoglobin for Suppressed Methemoglobin Formation2019
- Author(s)
  Magohei Yamada, Takashi Matsuhira, Keizo Yamamoto, Hiromi Sakai
- Journal Title
  
  Biochemistry
  
  Volume: 58 Issue: 10 Pages: 1400-1410
- DOI
  10.1021/acs.biochem.8b01314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09018, KAKENHI-PROJECT-17H02087
[Journal Article] A Role of Ala219 on the Substrate Specificity of CTX-M Type β-Lactamase2019
- Author(s)
  山本惠三
- Journal Title
  
  SPring-8/SACLA Research Report
  
  Volume: 7 Issue: 2 Pages: 201-205
- DOI
  10.18957/rr.7.2.201
- NAID
  130007969562
- ISSN
  2187-6886
- Year and Date
  2019-08-29
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09018
[Journal Article] Analysis of dimeric αβ subunit exchange between PEGylated and native hemoglobins (α2β2 tetramer) in an equilibrated state by intramolecular ββ-crosslinking.2018
- Author(s)
  T. Matsuhira, T. Kure, K. Yamamoto, H. Sakai
- Journal Title
  
  Biomacromolecules
  
  Volume: 19(8) Issue: 8 Pages: 3412-3420
- DOI
  10.1021/acs.biomac.8b00728
- NAID
  120007026511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01367, KAKENHI-PROJECT-17K09018
[Journal Article] Crystallographic Analysis of IMP-6 Metallo-β-Lactamase2018
- Author(s)
  山本惠三
- Journal Title
  
  SPring-8/SACLA Research Report
  
  Volume: 6 Issue: 2 Pages: 226-229
- DOI
  10.18957/rr.6.2.226
- NAID
  130007969555
- ISSN
  2187-6886
- Year and Date
  2018-08-16
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09018
[Journal Article] The effects of seasonal changes on the molecular weight of Nephila clavata spider silk2016
- Author(s)
  Shigeyoshi Osaki, Keizo Yamamoto, Takashi Matsuhira and Hiromi Sakai
- Journal Title
  
  Polymer Journal
  
  Volume: 48 Issue: 5 Pages: 659-663
- DOI
  10.1038/pj.2015.138
- NAID
  40020808947
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25670277, KAKENHI-PROJECT-24655105, KAKENHI-PROJECT-25288102
[Journal Article] Effects of UV irradiation on the molecular weight of spider silk2013
- Author(s)
  Takashi Matsuhira, Keizo Yamamoto and Shigeyoshi Osaki
- Journal Title
  
  Polymer Journal
  
  Volume: 45 Issue: 11 Pages: 1167-1169
- DOI
  10.1038/pj.2013.41
- NAID
  40019844671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23750133, KAKENHI-PROJECT-24655105, KAKENHI-PROJECT-25288102, KAKENHI-PROJECT-25670276, KAKENHI-PROJECT-25670277
[Presentation] IMP-6とIMP-1の基質特異性の相違の解明に向けた構造学的アプローチ2022
- Author(s)
  山本惠三、中野竜一、矢野寿一、酒井宏水
- Organizer
  第33回日本臨床微生物学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21K07010
[Presentation] A hidden cooperative function of NAD(H) and HbO2 for suppressing metHb formation and elucidation of its antioxidative pseudo-enzymatic mechanism2019
- Author(s)
  Yamada M, Matsuhira T, Yamamoto K, Sakai H
- Organizer
  XVII-ISBS-2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09018
[Presentation] Quantification of hybrid a2b2 tetramer formed by spontaneous exchange of dimeric ab subunits between PEGylated and native hemoglobins using intra-molecular cross-linking2019
- Author(s)
  Matsuhira T, Yamamoto K, Sakai H
- Organizer
  XVII-ISBS-2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09018
[Presentation] Ring-opening polymerization of loop-PEGylated hemoglobin2018
- Author(s)
  Takashi Matsuhira, Keizo Yamamoto, Hiromi Sakai
- Organizer
  第67回高分子学会年次大会
- Data Source
  KAKENHI-PROJECT-17K09018
[Presentation] Ring-opening Polymerization of Hemoglobin Using its Reversible Assiciation-Dissociation Equilibrium of α2β2 Subunits2018
- Author(s)
  Takashi Matsuhira, Keizo Yamamoto, Hiromi Sakai
- Organizer
  The International Symposium for Materials Scientists III
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09018
[Presentation] Phycochemical characterization of poly-(PEG-hemoglobin) produced by ring-opening polymerization2018
- Author(s)
  Takashi Matsuhira, Keizo Yamamoto, Hiromi Sakai
- Organizer
  第67回高分子討論会
- Data Source
  KAKENHI-PROJECT-17K09018
[Presentation] ヘモグロビンとNAD(P)Hとの共存により生じる抗酸化作用の機序2018
- Author(s)
  山田孫平、松平崇、山本恵三、酒井宏水
- Organizer
  日本化学会第98春季年会
- Data Source
  KAKENHI-PROJECT-17H02087
[Presentation] IMP-6産生菌の変異獲得による酵素学的性質の変化について2018
- Author(s)
  山本惠三、中野竜一、矢野寿一、酒井宏水
- Organizer
  第29回日本臨床微生物学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17K09018
[Presentation] 新生児髄膜炎由来大腸菌の遺伝子解析2014
- Author(s)
  中山章文、松吉ひろ子、宇野健司、西川文子、山本惠三、河野　久
- Organizer
  第25回日本臨床微生物学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-25670277
[Presentation] 新生児髄膜炎由来大腸菌の遺伝子解析2014
- Author(s)
  中山章文、松吉ひろ子、宇野健司、西川文子、山本惠三、河野　久
- Organizer
  第25回日本臨床微生物学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-25670276
[Presentation] 天然のクモの糸の分子量は一体いくらなのか？2013
- Author(s)
  大﨑茂芳、松平崇、山本惠三
- Organizer
  第６１回高分子討論会（高分子学会）
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-25670277

1. NAKAYAMA Akifumi (70536721)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. SAKAI HIROMI (70318830)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. 矢野寿一 (20374944)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. 松平崇 (20570998)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. KASAHARA Kei (50405403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MATSUYOSHI hiroko (10448772)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 水野文子 (70271202)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 山田孫平 (90839317)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Yamamoto Keizo 山本 惠三

YAMAMOTO Keizo 山本 惠三

Research Projects

Research Products

Co-Researchers

Resuscitation from hemorrhagic shock by carbon monoxide- and oxygen-carrying capacities of artificial red cells.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural analysis of IMP-type metallo-beta-lactamase in complex with its substratePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive research of amino acid residues that participate in increasing activity of carbapenemase and structural analysis of mutant enzymesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Artificial red cells with a defense function to oxidative stress

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of enlargement mechanism of substrate specificity of CTX-M type beta-lactamase based on protein crystallography.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of factors causing sepsis and establishment of prediction method by clinical analysis and molecular bacteriological approach

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Nanobiotherapeutic Based Blood Substitutes2021

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Structural insights into the substrate specificity of IMP-6 and IMP-1 metallo-β-lactamases.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 超分子重合を利用した人工酸素運搬体の構築2021

Author(s)

Journal Title

Data Source

[Journal Article] Ring-opening polymerization of hemoglobin.2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Antioxidative Pseudoenzymatic Mechanism of NAD(P)H Coexisting with Oxyhemoglobin for Suppressed Methemoglobin Formation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Role of Ala219 on the Substrate Specificity of CTX-M Type β-Lactamase2019

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Analysis of dimeric αβ subunit exchange between PEGylated and native hemoglobins (α2β2 tetramer) in an equilibrated state by intramolecular ββ-crosslinking.2018

Author(s)

Journal Title

DOI

Yamamoto Keizo 山本惠三

YAMAMOTO Keizo 山本惠三