KOBAYASHI Naohiko 小林直彦

Researcher Number	90254945
Other IDs
Affiliation (based on the past Project Information) *help	1999 – 2005: 獨協医科大学, 医学部, 講師 1996 – 1997: 獨協医科大学, 医学部, 講師
Review Section/Research Field	Except Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine / Biological Sciences
Keywords	Except Principal Investigator Y-27632 / リモデリング / eplerenone / quinapril / eNOS / Dahl食塩感受性ラット / 高血圧性心肥大 / Rho-kinase / Dah1食塩感受性ラット / remodeling … More / 心不全 / 心肥大 / BNP / ANP / oxidative stress / betaxolol / heart failure / hypertensive cardiac hypertrophy / Dahl salt sensitive rat / 高血圧性心疾患 / 酸化ストレス / エプレレノン / キナプリル / ベタキソロール / aminoguanidine / celiprolol / Dahl salt sensitive rats / DOCA rats / 高血圧性心不全 / ワートマニン / カンデサルタン / 心筋リモデリング / DOCA食塩高血圧ラット / AII依存性高血圧ラット / アミノグアニジン / セリプロロール / DOCAラット / fibrosis / gene polymorphism / apoptosis / hypertension / renal disease / adrenomedullin / 遺伝子発現 / NF-IL6 / サイトカイン / 腎硬化症 / 血液透析 / 遺伝子的型 / 腎障害 / 糖尿病 / 線維化 / 遺伝子多型 / アポトーシス / 高血圧 / 腎疾患 / アドレノメデュリン / LVH / LVMI / DD genotype / ACE activity / ACE gene polymorphism / 左室心筋重量係数 / DD型 / ACE活性 / ACE遺伝子多型 / 組織細胞化学 / 機能的分化 / 軟骨細胞 Less

Role of intracellular signal transmission and its application to treatment in hypertensive heart failure.
- Principal Investigator
  
  MATSUOKA Hiroaki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Dokkyo Medical University
Role of vasoactive substances and intracellular signal, transmission in hypertensive, heart disease.
- Principal Investigator
  
  MATSUOKA Hiroaki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Dokkyo University School of Medicine
Relation of adrenomedullin and apoptosis in renal diseases
- Principal Investigator
  
  ISHIMITSU Toshihiko
- Project Period (FY)
  1998 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Dokkyo University School of Medicine
PATHOPHYSIOLOGICAL SIGNIFICANCE OF VARIOUS VASOACTIVE SUBSTANCES IN PATIENTS WITH CARDIOVASCULAR DISEASE.
- Principal Investigator
  
  MATSUOKA Hiroaki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Dokkyo University School of Medicine

All 2006 2005 2004

All Journal Article

[Journal Article] Cardioprotective mechanisms of eplerenone on cardiac performance and remodeling in failing rat hearts.2006
- Author(s)
  Kobayashi N, Yoshida K, Nakano S, Ohno T, Honda T, Tsubokou Y, Matsuoka H
- Journal Title
  
  Hypertension 47
  
  Pages: 671-679
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590712
[Journal Article] Cardioprotective mechanisms of eplerenone on cardiac performance and remodeling in failing rat hearts.2006
- Author(s)
  Kobayashi N
- Journal Title
  
  Hypertension (印刷中)
- Data Source
  KAKENHI-PROJECT-16590712
[Journal Article] Antioxidative effect of p38 mitogen-activated protein kinase inhibitor in the kidney of hypertensive rat.2006
- Author(s)
  Tojo A, Onozato ML, Kobayashi N, Goto A, Matsuoka H, Fujita T
- Journal Title
  
  J Hypertens 23
  
  Pages: 165-174
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590712
[Journal Article] Critical role of bradykinin-eNOS and oxidative stress-LOX-1 pathway in cardiovascular remodeling under chronic angiotensin-converting enzyme inhibition.2006
- Author(s)
  Kobayashi N
- Journal Title
  
  Atherosclerosis (印刷中)
- Data Source
  KAKENHI-PROJECT-16590712
[Journal Article] Cardio protective mechanisms of eplerenone on cardiac performance and remodeling in failing rat hearts.2006
- Author(s)
  Kobayashi N
- Journal Title
  
  Hypertension 47・4
  
  Pages: 671-679
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590712
[Journal Article] Cardioprotective mechanisms of Rho-kinase inhibition associated with eNOS and oxidative stress-LOX-1 pathway in Dahl salt-sensitive hypertensive rats.2005
- Author(s)
  Mita S, Kobayashi N, Yoshida K, Nakano S, Matsuoka H
- Journal Title
  
  J Hypertens 23
  
  Pages: 87-96
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590712
[Journal Article] Cardioprotective mechanisms of spironolactone associated with the angiotensin-converting enzyme/epidermal growth factor receptor/extracellular signal-regulated kinases, NAD(P)H oxidase/lectin-like oxidized low-density lipoprotein receptor-1, and Rho-kinase pathways in aldosterone/salt-induced hypertensive rats.2005
- Author(s)
  Nakano S, Kobayashi N, Yoshida K, Ohno T, Matsuoka H
- Journal Title
  
  Hypertens Res 28
  
  Pages: 925-936
- NAID
  10017238143
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590712
[Journal Article] Eplerenone shows renoprotective effect by reducing LOX-1-mediated adhesion molecule, PKC ε MAPK-p9ORSK, and Rho-kinase pathway.2005
- Author(s)
  Kobayashi N
- Journal Title
  
  Hypetension (印刷中)
- Data Source
  KAKENHI-PROJECT-16590712
[Journal Article] Eplerenone shows renoprotective effect by reducing LOX-1-mediated adhesion molecule, PKC ε MAPK-p90RSK, and Rho-kinase pathway.2005
- Author(s)
  Kobayashi N
- Journal Title
  
  Hypertension 45・4
  
  Pages: 538-544
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590712
[Journal Article] Eplerenone shows renoprotective effect by reducing LOX-1-mediated adhesion molecule, PKC ε MAPK-p90RSK, and Rho-kinase pathway.2005
- Author(s)
  Kobayashi N, Hara K, Tojo A, Onozato ML, Honda T, Yoshida K, Mita SI, Nakano S, Tsubokou Y, Matsuoka H
- Journal Title
  
  Hypertension 45
  
  Pages: 538-544
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590712
[Journal Article] Betaxolol stimulates eNOS production associated with LOX-1 and VEGF in Dahl salt-sensitive rats.2004
- Author(s)
  Kobayashi N, Yoshida K, Mita S, Honda T, Hara K, Nakano S, Tsubokou Y, Matsuoka H
- Journal Title
  
  J Hypertens 22
  
  Pages: 1397-1402
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590712
[Journal Article] Betaxolol stimulates eNOS production associated with LOX-1 and VEGF in Dahl salt-sensitive rats.2004
- Author(s)
  Kobayashi N
- Journal Title
  
  J Hypertens 22・7
  
  Pages: 1397-1402
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590712

1. MATSUOKA Hiroaki (20111544)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
2. NISHIKIMI Toshio (80291946)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. ISHIMITSU Toshihiko (80232346)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. NUMABE Atsushi (60228278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. HORINAKA Shigeo (90209304)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ONO Hidehiko (70214187)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KOBAYASHI Naohiko 小林 直彦

Research Projects

Research Products

Co-Researchers

Role of intracellular signal transmission and its application to treatment in hypertensive heart failure.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of vasoactive substances and intracellular signal, transmission in hypertensive, heart disease.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Relation of adrenomedullin and apoptosis in renal diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

PATHOPHYSIOLOGICAL SIGNIFICANCE OF VARIOUS VASOACTIVE SUBSTANCES IN PATIENTS WITH CARDIOVASCULAR DISEASE.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Cardioprotective mechanisms of eplerenone on cardiac performance and remodeling in failing rat hearts.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Cardioprotective mechanisms of eplerenone on cardiac performance and remodeling in failing rat hearts.2006

Author(s)

Journal Title

Data Source

[Journal Article] Antioxidative effect of p38 mitogen-activated protein kinase inhibitor in the kidney of hypertensive rat.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Critical role of bradykinin-eNOS and oxidative stress-LOX-1 pathway in cardiovascular remodeling under chronic angiotensin-converting enzyme inhibition.2006

Author(s)

Journal Title

Data Source

[Journal Article] Cardio protective mechanisms of eplerenone on cardiac performance and remodeling in failing rat hearts.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Cardioprotective mechanisms of Rho-kinase inhibition associated with eNOS and oxidative stress-LOX-1 pathway in Dahl salt-sensitive hypertensive rats.2005

Author(s)

Journal Title

Description

Data Source

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Eplerenone shows renoprotective effect by reducing LOX-1-mediated adhesion molecule, PKC ε MAPK-p9ORSK, and Rho-kinase pathway.2005

Author(s)

Journal Title

Data Source

[Journal Article] Eplerenone shows renoprotective effect by reducing LOX-1-mediated adhesion molecule, PKC ε MAPK-p90RSK, and Rho-kinase pathway.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Eplerenone shows renoprotective effect by reducing LOX-1-mediated adhesion molecule, PKC ε MAPK-p90RSK, and Rho-kinase pathway.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Betaxolol stimulates eNOS production associated with LOX-1 and VEGF in Dahl salt-sensitive rats.2004

Author(s)

Journal Title

Description

Data Source

KOBAYASHI Naohiko 小林直彦