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UEDA Kenji  上田 健治

ORCIDConnect your ORCID iD *help
Researcher Number 90261180
External Links
Affiliation (based on the past Project Information) *help 2013: 独立行政法人国立精神・神経医療研究センター, 副院長室, 研究生
2013: 独立行政法人国立精神・神経医療研究センター, 病院・副院長室, 研究生
2012: 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 研究員
2011: (財)東京都医学総合研究所, 認知症・高次脳機能研究分野, 主任研究員
2010: 財団法人東京都医学研究機構, 東京都精神医学総合研究所, 主任研究員 … More
2008 – 2010: Tokyo Metropolitan Organization for Medical Research, 東京都精神医学総合研究所, 主任研究員
2005: Tokyo Metropolitan Organization for Medical Research, Tokyo Institute of Psychiatry, Senior Research Scientist, 東京都精神医学総合研究所, 主任研究員
2000 – 2004: 財団法人東京都医学研究機構, 東京都精神医学総合研究所, 主任研究員
2001: 財団法人 東京都医学研究機構, 東京都精神医学総合研究所, 主任研究員
1999: 財団法人 東京都医学研究機構, 東京都精神医学総合研究所, 主任研究員
1999: 財団法人 東京都医学研究機構, 神経化学研究部門, 主任研究員
1998: 財団法人東京都精神医学総合研究所, 神経化学研究部門, 主任研究員
1996 – 1998: Tokyo Institute of Psychiatry, Department of Neurochemistry, Senior Research Scientist, 神経化学研究部門, 主任研究員
1995: 財団法人東京都精神医学総合研究所, 分子生物学研究部門, 主任研究員
1994: (財)東京都精神医学総合研究所, 分子生物学研究部門, 主任研究員 Less
Review Section/Research Field
Principal Investigator
Neurochemistry/Neuropharmacology / Neuroscience in general / Neuroscience in general / Neuroscience in general
Except Principal Investigator
Psychiatric science
Keywords
Principal Investigator
NACP / NAC / Alzheimer / synuclein / Parkinson / MAP / Lewy bodies / Lewy小体 / MSA / PNP14 … More / 神経変性 / ドーパミン / ミトコンドリア / シヌクレイン / アミロイド / アルツハイマー / Gene regulation / Tubulin / 細胞毒性 / Synuclein / tubulin / ロテノン / Alzheimaer / neuronal degeneration / signal transduction / 細胞内情報伝達 / パーキンソン病 / アルツハイマー病 / synapse / amyloid / シグナル伝達 / シナプス / 微小管 / αシヌクレイン / カルパイン / 細胞増殖 / 神経突起伸長 / チューブリン / ATP産生 / 複合体I / 免疫電顕 / チロシン水酸酵素 / MN9D細胞 / リン酸化 / ドーパミン作動性ニューロン / 膜電位 / ラット脳 / α-synuclein / RFLP / FISH / 遺伝子座 … More
Except Principal Investigator
synuclein / tau / NACP / fibrinogenesis / conformation disease / Neuronal death / multiple system atrophy / Parkinson's disease / electron microscopy / neuronal death / neurofibrillary tangles / Lewy body / filament pathology / 星状膠細胞 / 多系統萎縮症 / コンフォーメーション病 / 線維凝集 / 封入体形成 / コンフォメーション病 / シヌクレイン / 神経細胞死 / 神経突起変性 / パーキンソン病 Less
  • Research Projects

    (8 results)
  • Research Products

    (36 results)
  • Co-Researchers

    (8 People)
  •  Neuro-cell biological studies of alpha-synucleinPrincipal Investigator

    • Principal Investigator
      UEDA Kenji
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neuroscience in general
    • Research Institution
      独立行政法人国立精神・神経医療研究センター
      Tokyo Metropolitan Institute of Medical Science
  •  Molecular neurobiological studies on the functions of α-SynucleinPrincipal Investigator

    • Principal Investigator
      UEDA Kenji
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neuroscience in general
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Molecular pathophysiology of α-Synuclein : Molecular mechanisms of neurodegenerative diseasesPrincipal Investigator

    • Principal Investigator
      UEDA Kenji
    • Project Period (FY)
      2002 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Immunocytochemical studies of NACP/α-synclein mediated neuronal degeneration

    • Principal Investigator
      ARIMA Kunimasa, 有馬 邦正
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Tokyo Metropolitan Organization of Medical Research
  •  Mechanisms of neurodegeneration with NACP/α-synuclein, a causal gene of Parkinson's diseasePrincipal Investigator

    • Principal Investigator
      UEDA Kenji
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Physiological role of a presynaptic protein, NACP : Involvement in signal transduction systemsPrincipal Investigator

    • Principal Investigator
      UEDA Kenji
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokyo Institute of Psychiatry
  •  アルツハイマー病アミロイドのβ蛋白以外の構成成分NACのアミロイド形成への関与Principal Investigator

    • Principal Investigator
      上田 健治
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Psychiatry
  •  Physiological role of NACP,the precursor of non-Abeta component of Alzheimer's disease amyloidPrincipal Investigator

    • Principal Investigator
      UEDA Kenji
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neuroscience in general
    • Research Institution
      Tokyo Institute of Psychiatry

All 2013 2012 2011 2010 2009 2008 2006 2004

All Journal Article Presentation Book

  • [Book] Cell Biology Protocols2006

    • Author(s)
      Rickwood D ed., K. Ueda分担執筆
    • Publisher
      John Wiley & Son, Ltd
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14380363
  • [Book] 老年期認知症ナビゲータ2006

    • Author(s)
      平井俊策編(上田健治分担執筆)
    • Publisher
      メディカルレビュー社(印刷中)
    • Data Source
      KAKENHI-PROJECT-14380363
  • [Book] Cell Biology Protocols2006

    • Author(s)
      Harris G.et al.ed.(K.Ueda分担執筆)
    • Publisher
      John Wiley & Sons, Ltd(印刷中)
    • Data Source
      KAKENHI-PROJECT-14380363
  • [Book] 老年期認知症ナビゲータ2006

    • Author(s)
      平井俊策編, 上田健治分担執筆
    • Publisher
      メディカルレビュー社
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14380363
  • [Journal Article] Alpha-Synuclein promotes early neurite outgrowth in primary cultured neurons2013

    • Author(s)
      Liu G, Wang P, Li X, Li Y, Xu S, Ueda K, Chan P, Yu S
    • Journal Title

      J Neural Transm.

      Volume: 120 Issue: 9 Pages: 1331-1343

    • DOI

      10.1007/s00702-013-0999-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23500408
  • [Journal Article] Alpha-synuclein promotes early neurite outgrowth in cultured primary neurons2013

    • Author(s)
      Liu G, Wang P, Li X, Li Y, Xu S, Ueda K, Chan P, Yu S
    • Journal Title

      J. Neural Transm. Epub ahead of print] PMID: 23443897

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23500408
  • [Journal Article] Nuclear translocation of alpha-synuclein increases susceptibility of MES23.5 cells to oxidative stress2013

    • Author(s)
      Zhou M, Xu S, Mi J, Ueda K, Chan P
    • Journal Title

      Brain Res.

      Volume: 1500 Pages: 19-27

    • DOI

      10.1016/j.brainres.2013.01.024

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23500408
  • [Journal Article] Demonstration of three dopamine molecules bound to alopha-synuclein: Implication of oligomerization at the initial stage2012

    • Author(s)
      S Shimotakahara, Y Shiroyama, T Fujimoto, M Akai, T Onoue, H Seki, S Kado, T Machinami, Y Shibusawa, K Ueda, M Tashiro
    • Journal Title

      J. Biophysical Chem.

      Volume: 3 Issue: 02 Pages: 149-155

    • DOI

      10.4236/jbpc.2012.32017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23500408, KAKENHI-PROJECT-24550108
  • [Journal Article] Melatonin reduces the expression of α-synuclein in the dopamine containing neuronal regions of amphetamine-treated postnatal rats2012

    • Author(s)
      Sae-Ung K, Uéda K, Govitrapong P, Phansuwan-Pujito P
    • Journal Title

      J. Pineal Res

      Volume: 52 Issue: 1 Pages: 128-137

    • DOI

      10.1111/j.1600-079x.2011.00927.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23500408
  • [Journal Article] Increase expression of α-synuclein in aged human brain associated with neuromelanin accumulation.2011

    • Author(s)
      Xuan Q, Xu SL, Lu DH, Yu S, Zhou M, Ueda K, Cui YQ, Zhang BY, Chan P
    • Journal Title

      J. Neural Transm.

      Volume: 118 Pages: 1575-1583

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23500408
  • [Journal Article] Phosphorylation of α-synuclein upregulates tyrosine hydroxylase activity in MN9D cells.2011

    • Author(s)
      Ueda K
    • Journal Title

      Acta Histochemica Vol.113

      Pages: 32-35

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20500303
  • [Journal Article] α-Synuclein overexpression impairs mitochondrial function by associating with adenylate translocator.2011

    • Author(s)
      Ueda K
    • Journal Title

      International J.Biochemistry and Cell Biology Vol.43

      Pages: 732-741

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20500303
  • [Journal Article] C-terminal part of α-synuclein mediates its activity in promoting proliferation of dopaminergic cells.2011

    • Author(s)
      Yin J, Han J, Zhang C, Ma QL, Li X, Cheng F, Liu G, Li Y, Ueda K, Chan P, Yu S
    • Journal Title

      J. Neural Transm.

      Volume: 118 Pages: 1155-1164

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23500408
  • [Journal Article] α-Synuclein functions as a negative regulator for expression of tyrosine hydroxylase2011

    • Author(s)
      Li YH, Gao N, Ye YW, Li X, Yu S, Yang H, Ueda K, Chan P
    • Journal Title

      Acta Neurol. Belg.

      Volume: 111 Pages: 130-135

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23500408
  • [Journal Article] α-Synuclein promotes clathrin-mediated NMDA receptor endocytosis and attenuates NMDA-induced dopaminergic cell death2011

    • Author(s)
      Cheng F, Li X, Li Y, Wang C, Wang T, Liu G, Baskys A, Uéda K, Chan P, Yu S
    • Journal Title

      J. Neurochem

      Volume: 119 Issue: 4 Pages: 815-825

    • DOI

      10.1111/j.1471-4159.2011.07460.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23500408
  • [Journal Article] α-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity.2009

    • Author(s)
      Ueda K
    • Journal Title

      Neuroscience Letters Vol.454

      Pages: 187-192

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20500303
  • [Journal Article] Motor impairment and aberrant production of neurochemicals in human α-synuclein A30P+A53T transgenic mice with α-synuclein pathology.2008

    • Author(s)
      Ueda K
    • Journal Title

      Brain Research Vol.1250

      Pages: 232-241

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20500303
  • [Journal Article] Semi-quantitative analysis of α-synuclein in subcellular pools of rat brain neurons : An immunogold electron microscopic study using a C-terminal specific monoclonal antibody.2008

    • Author(s)
      Ueda K
    • Journal Title

      Brain Research Vol.1244

      Pages: 40-52

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20500303
  • [Journal Article] Characterization of fibrillation process of α-synuclein at the initial stage.2008

    • Author(s)
      Ueda K
    • Journal Title

      Biochem.Biophys.Res.Commun. Vol.369

      Pages: 910-914

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20500303
  • [Journal Article] Microtubule dynamics can be central in Parkinson's disease as well as in Alzheimer's disease.2004

    • Author(s)
      Yoshii M., Ueda K.
    • Journal Title

      Psychogeriatrics 4(In press)

    • NAID

      10018089229

    • Data Source
      KAKENHI-PROJECT-14380363
  • [Presentation] Protective effect of melatonin on the dopamine pathway from amphetamine-induced neurotoxicity in postnatal rats2011

    • Author(s)
      Sae-Ung K, Govitrapong P, Ueda K, Phansuwan-Pujito P
    • Organizer
      The 23rd Biennial Meeting of the International Society for Neurochemistry (ISN)
    • Place of Presentation
      Athens, Greece
    • Data Source
      KAKENHI-PROJECT-23500408
  • [Presentation] Melatonin decreases α-synuclein in mesolimbic pathway of amphetamine-treated postnatal rats.2010

    • Author(s)
      Sae-ung K, Govitrapong P, Ueda K, Phansuwan-Pujito P
    • Organizer
      The 10^<th> Biennial Meeting of the Asian Pacific Society for Neurochemistry, APSN 2010
    • Place of Presentation
      Phuket, Thailand
    • Year and Date
      2010-10-20
    • Data Source
      KAKENHI-PROJECT-20500303
  • [Presentation] Novel microtubule regulatory molecules.2010

    • Author(s)
      Goto A, Ueda K, et al
    • Organizer
      BMB2010 The 33^<rd> Mol.Biol.Soc.Jpn.and The 83^<rd> Jpn.Biochem.Soc.
    • Place of Presentation
      Kobe
    • Year and Date
      2010-12-07
    • Data Source
      KAKENHI-PROJECT-20500303
  • [Presentation] Analysis of contribution of dopamine of oligomeric intermediate in initial stage of α-Synuclein amyloidogenesis and the structural feature.2010

    • Author(s)
      Shiroyama Y, Ueda K, et al. Shimotakahara S
    • Organizer
      BMB2010 The 33^<rd> Mol.Biol.Soc.Jpn.and The 83^<rd> Jpn.Biochem.Soc.
    • Place of Presentation
      Kobe
    • Year and Date
      2010-12-08
    • Data Source
      KAKENHI-PROJECT-20500303
  • [Presentation] Normal expression and biological functions of α-synuclein2009

    • Author(s)
      Yu S, Ueda K, et al
    • Organizer
      XXXIII Congress of the Italian Society of Histochemistry
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2009-06-09
    • Data Source
      KAKENHI-PROJECT-20500303
  • [Presentation] Immunohistochemical study on α-synuclein expression within nigrostriatal pathway in amphetamine-treated postnatal rats2009

    • Author(s)
      Sae-ung K, Govitrapong P, Ueda K, Phansuwan-Pujito P
    • Organizer
      The 22nd Biennial Meeting of the International Society for Neurochemistry, ISN/APSN Joint Meeting
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2009-08-24
    • Data Source
      KAKENHI-PROJECT-20500303
  • [Presentation] Mitochondrial α-synuclein is highly expressed in the brain regions where degeneration occurs2009

    • Author(s)
      Ueda, et al.
    • Organizer
      Society for Neuroscience : Neuroscience 2009
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2009-10-20
    • Data Source
      KAKENHI-PROJECT-20500303
  • [Presentation] Mitochondrial α-synuclein : Implications in neurodegenerative diseases2009

    • Author(s)
      Ueda K, Yu S, et al
    • Organizer
      The 12th International Conference on Alzheimer's Disease, ICAD2009
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2009-07-15
    • Data Source
      KAKENHI-PROJECT-20500303
  • [Presentation] Mitochondrial α-synuclein is highly expressed in the brain regions where degeneration occurs.2009

    • Author(s)
      Ueda K, Yu S, et al
    • Organizer
      Soc.Neurosci.Abstr.39 : 630.11
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2009-10-20
    • Data Source
      KAKENHI-PROJECT-20500303
  • [Presentation] Role of α-synulcien in microtubule assembly and neurite outgrowth.2009

    • Author(s)
      Yu S, Ueda K
    • Organizer
      The 22nd Biennial Meeting of the International Society for Neurochemistry, ISN, Satellite(Symposium "Synucleinopathies-Mechanisms, models and therapeutic strategies,")
    • Place of Presentation
      Beijing, China
    • Year and Date
      2009-08-29
    • Data Source
      KAKENHI-PROJECT-20500303
  • [Presentation] Wild-type α-Synuclein but not its mutants promotes proliferation of dopaminergic neuronal cells in vitro.2009

    • Author(s)
      Ueda K, Chan P, et al
    • Organizer
      Mol.Biol.Soc.Jpn.
    • Place of Presentation
      Yokohama
    • Year and Date
      2009-12-11
    • Data Source
      KAKENHI-PROJECT-20500303
  • [Presentation] Immunocytochemical study of methamphetamine induced α-synuclein in SK-N-SH cells2009

    • Author(s)
      Boontem P, Phansuwan-Pujito P, Ueda K, Govitrapong P
    • Organizer
      The 22nd Biennial Meeting of the International Society for Neurochemistry, ISN/APSN Joint Meeting
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2009-08-24
    • Data Source
      KAKENHI-PROJECT-20500303
  • [Presentation] α-Synuclein promotes the cell growth of dopaminergic neurons in vitro.2008

    • Author(s)
      Ueda K, Chan P, et al
    • Organizer
      Soc.Neurosci.Abstr.38 : 342.10
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      2008-11-17
    • Data Source
      KAKENHI-PROJECT-20500303
  • [Presentation] The biology and pathology of α-synuclein, Symposium "α-Synuclein in Neurodegenerative Disease"2008

    • Author(s)
      Ueda K
    • Organizer
      The 8th Biennial Meeting of the Asian-Pacific Society for Neurochemistry, APSN 2008
    • Place of Presentation
      Shanghai
    • Year and Date
      2008-06-26
    • Data Source
      KAKENHI-PROJECT-20500303
  • [Presentation] α-Synuclein promotes the cell growth of dopaminergic neurons in vitro2008

    • Author(s)
      Ueda, et al.
    • Organizer
      Society for Neuroscience : Neuroscience 2008
    • Place of Presentation
      Washington, D. C., USA
    • Year and Date
      2008-11-17
    • Data Source
      KAKENHI-PROJECT-20500303
  • [Presentation] The most frequent cause of dementia in a Brazilian sample : A neuropathological study2008

    • Author(s)
      Grinberg LT, Ueda K, et al
    • Organizer
      The 11th International Conference on Alzheimer's Disease, ICAD 2008
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2008-07-27
    • Data Source
      KAKENHI-PROJECT-20500303
  • 1.  ARIMA Kunimasa (40124482)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 2.  YAMAMOTO Akihiro
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  NUKADA Toshihide (80189349)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  SHIMOMURA Yuko (70332377)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  YOSHII Mitsunobu (60091047)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  AIZAWA Takako (40415542)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  HISANAGA Shinichi (20181092)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  有馬 邦正 (20250227)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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